<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation F53L
Rx >= 1 PI
IncludeMixtures No
References 9
Patients 70
Isolates 71
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Apetrei (2003)AC_Pat1RO.01.IS.01AY333463IDV, Unknown, SQV, NFVNAM46I, I54V, V82A, I84VL24I, K43T, G48W, F53LL10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
Dumans (2004)RES093RES093AY390211IDV, RTV, Unknown>87I54V, V82AT, L90MF53LL10IV, K14R, I15V, G17D, L19I, K20R, E35D, M36I, R41K, D60E, Q61N, L63T, A71V, I72T, T74A, L89M, I93LF
 RES077RES077AY390203SQV192L90MF53LL10V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, D60E, Q61N, T74S, L89MF
Gomez-Carrillo (2004)9260892608AY365481PINAI54V, V82A, L90ML23I, F53LL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72TF
 9698496984AY365538PINAM46L, G48S, I54V, V82A, L90MF53LL10V, T12P, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, Q61D, L63T, E65D, A71V, I72T, I93LF
 9732297322AY365545PINAI54V, V82AL24I, K43T, F53LL10I, T12K, I15V, G16E, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72V, T74SF
 9824098240AY365571PINAM46I, I54V, V82AL24I, L33LF, K43T, F53L, N83DL10I, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, A71V, I93ILF
 104136104136AY365692PINAI54V, V82T, L90MF53L, G73SI15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, H69Y, A71VF
 105358105358AY365725PINAI54V, V82AF53LL10V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, A71V, T74A, I93LF
 107166107166AY365763PINAI54V, V82A, L90MF53LL10V, K14KR, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, T74S, I93LF
 109089109089AY365804PINAI54V, V82A, L90MK43T, F53LL10I, L19I, K20R, E35D, M36I, R41K, Q61N, L63T, E65D, C67E, A71V, I72T, T74S, V77I, I93IMF
 114725114725AY365912PINAI54V, L90MF53L, G73SL10I, I15V, K20R, E35D, M36I, N37S, R41K, R57K, Q61N, L63P, A71V, I72TF
 119531119531AY365966PINAM46L, G48S, I54V, V82A, L90ML33LF, F53LL10V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, Q61D, L63T, E65D, A71V, I72T, I93LF
 120763120763AY365988PINAG48A, I54V, V82AL24I, F53LL10I, T12S, I15V, K20R, E35D, M36I, R41K, R57K, Q61D, T74S, L89MF
 122345122345AY366009PINAG48V, V82AF53LL10V, I15V, G16E, K20M, E35D, M36I, P39Q, R41K, K55R, R57K, Q61N, L63T, T74AF
 122494122494AY366012PINAM46I, I54V, V82AL24I, F53LL10I, I15V, G16E, K20R, E35D, M36I, R41K, K43I, K55R, R57K, Q61N, L63C, L89LMF
 122744122744AY366015PINAM46I, I50V, I54V, V82AF53L, L76ML10I, I15V, K20R, E35D, M36I, R41K, K45R, K55R, R57K, Q61N, L63S, E65D, K70T, A71V, I72E, L89M, I93LF
 123822123822AY366027PINAI54V, V82A, L90MF53LL10IMV, I15V, G16GA, K20R, E35D, M36I, R41K, K55R, R57K, D60DE, Q61DN, L63P, A71V, I72TF
 124260124260AY366031PINAI54V, V82VF, I84IVF53LL10V, K20R, E35D, M36I, R41K, K43KR, K45KEIV, R57K, Q61N, I64V, A71T, I93ILF
 126743126743AY366057PINAV32I, M46I, I47V, I54V, V82AL24I, L33F, F53LL10V, I15V, K20R, E34V, E35D, M36I, R41K, Q61N, I62V, L63P, T74S, L89M, Q92KF
Non-B Workgroup (2005)PL882265161 SQV, IDV, LPV270G48M, I54V, V82AL24I, F53LL10I, T12I, I15V, G17E, K20M, E35D, M36IV, N37K, L38M, K43R, R57K, Q61N, L63PF
Rodrigues (2005)BLF_Pat23BR03SP224AY643169Unknown, RTV, APV>4M46MI, I50V, I54V, V82A, L90ML23I, F53L, L76ML10I, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63A, I64M, L89M, I93LF
Baxter (2006)48-10071007-30609DQ877312PINAM46I, I47V, I54V, V82A, L90MF53LL10V, L19LI, K20R, E35D, M36I, N37D, R41K, K43R, R57K, Q61N, I62V, L63LP, A71V, I85V, I93LF
 48-10631063-30612DQ877316PINAV32I, M46I, I54IV, V82A, L90ML33F, F53L, G73GS, N83DL10I, I13V, I15V, K20R, M36I, R41K, Q61N, L63P, A71V, I72TF
 48-10161016-30617DQ877322PINAM46I, I54V, V82AL24I, F53LL10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, H69Y, A71V, I93LF
 48-10191019-30619DQ877325PINAG48V, I54V, V82AF53LL10I, I15V, K20R, E35D, M36I, R41K, Q61N, I62IV, L63S, I64L, I72T, T74S, L89M, I93LF
 48-11961196-30924DQ877381PINAI54V, V82A, L90MF53LL10I, K20R, E35D, M36I, N37ND, R41K, D60E, Q61N, L63P, H69R, A71V, I85VF
 48-10391039-30619DQ877394PINAI54V, V82T, L90MF53L, G73SI15V, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, H69Y, A71V, T74TS, I85IVF
 48-10271027-30707DQ877408PINAV32I, M46I, I47V, I54V, V82AL24I, L33F, F53LL10V, I15V, K20R, E34V, E35D, M36I, R41K, Q61N, I62V, L63P, T74S, L89M, Q92KF
  1027-31124DQ877409PI, RTV, TPV>20M46MI, I47IV, I54V, V82A, L90ML33LF, F53LL10IV, I15V, K20R, E34EV, E35D, M36I, N37NS, R41K, D60DE, Q61DN, I62V, L63P, A71AV, T74S, L89LM, Q92QKF
 48-11801180-30922DQ877428PINAV32I, M46I, I47V, I54M, L90MF53LL10I, I15V, K20I, E35N, M36I, R41K, R57K, Q61N, L63P, I72IV, T74S, V82I, I85V, L89LIF
 48-12451245-30414DQ877768PINAM46I, I54V, V82T, L90MF53L, G73SL10V, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, I62V, L63P, H69HY, A71IV, I72T, I93LF
 48-22512251-30925DQ877885PINAG48M, I54V, V82AL24I, F53L, G73GCFVL10I, T12I, I15V, G17E, K20M, E35D, M36I, K43R, R57K, Q61N, I62IV, L63P, T91TSF
 48-26142614-30624DQ877904PINAM46L, I54V, V82AL33F, F53LL10V, T12I, I15V, G16E, L19V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, I85V, L89MF
 48-30433043-30305DQ877955PINAM46I, G48M, I54V, L76V, V82A, L90MK43T, F53LT4S, L10V, K14Q, I15V, G16E, L19I, K20R, E35D, M36V, P39S, K55R, R57K, Q61N, I62V, L63T, E65H, H69R, I72V, T74S, L89M, C95CSF
 48-42864286-30910DQ878509PINAI54AV, V82F, L90ML33F, K43T, F53LL10IV, G16E, L19I, K20R, E35D, M36I, N37T, P39T, R41K, D60E, Q61E, I62V, L63P, I64V, H69Q, A71V, I93LF
 48-60236023-30403DQ878622PINAG48M, I54V, V82AL24I, K43KT, F53LL10I, I15V, Q18E, K20R, E35D, M36I, N37NK, R41K, R57K, Q61N, E65D, T74S, L89MF
 48-93499349-30923DQ877289PINAV32I, M46I, I47V, G48M, I54M, V82AL33F, F53LL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I72T, T74S, L89IF
 48-91869186-30901DQ877291PINAM46L, I54V, V82AL24I, L33F, K43T, F53L, T74PL10I, I13V, I15V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I64L, A71V, I72T, L89I, I93LF
 48-91499149-30826DQ877714PINAM46L, I54V, V82AL24I, L33F, K43T, F53LR8P, L10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63P, K70R, L89LM, Q92KF
Dumans (2009)RENA133RENA133FJ405126IDV, SQV, NFV, RTV274I54V, V82A, L90MF53LL10I, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63P, A71VF
 RENA555RENA555FJ405127SQV, NFV, RTV, IDV, Unknown>191I54V, V82A, L90ML33F, K43T, F53L, T74PL10V, I13V, K14R, G16E, K20R, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, I62V, L63H, A71I, I72V, I93LF
 RES314_03RES314_03FJ405155SQV226L90MF53LL10V, I15V, Q18E, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, L89MF
Aulicino (2011)ARM36WMRARM36WMRFJ525826PINAM46I, I47V, I54V, V82AL24I, K43T, F53LL10V, G16X, K20R, E35D, M36I, K55R, R57K, Q61N, L63T, H69R, T74S, L89MF
 ARM730WDARM730WDFJ525838PINAI54V, V82AL24I, F53L, Q58E, N83DL10I, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, A71VF
 ARN311BMSARN311BMSFJ525857PINAM46L, G48Q, I54V, L76V, V82A, L90MV32L, F53L, Q58EL10V, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, D60E, Q61N, I62V, L63P, I64V, A71V, T74S, V77I, I93LF
Jones (2012)128155128155JN669449PINAI54V, V82A, L90MF53LL10V, I15V, G16E, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63A, A71V, I93LF
 130542130542JN669493PINAI54V, V82A, I84VF53LT4TS, L10V, T12E, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, A71V, T74S, I85V, L89IF
 143027143027JN669634PINAG48A, I54V, V82AL24I, F53LL10I, T12S, K14R, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61D, T74S, L89MF
 145844145844JN669665PINAI54V, V82A, L90MF53L, Q58EL10I, I15V, G16E, K20R, E35D, M36V, R41K, K55R, R57K, Q61N, L63T, A71V, I72IATV, I93LF
 148707148707JN669719PINAI54V, V82A, L90ML33I, F53L, G73S, L89VL10I, I13V, K20R, E35D, M36I, K43E, K55R, R57K, D60K, Q61N, I62V, L63P, A71I, I72E, C95LF
 153756153756JN669805PINAM46L, G48GEQR, I54V, V82AL24I, F53LL10I, I15V, G17E, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71AVF
 158844158844JN669935PINAM46I, I47V, I54V, V82SL23I, K43T, F53LL10I, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63A, A71V, I72V, T74S, L89M, I93LF
 159501159501JN669954PINAI54V, V82A, L90MK43T, F53LL10I, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, A71L, T74S, I93LF
 161363161363JN670004PINAI54V, V82A, L90MF53L, T74PL10I, I15V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62V, L63P, A71V, I93L, C95FF
 164492164492JN670077PINAM46L, I54V, V82AL24I, L33LF, K43KT, F53L, G73SL10V, K14R, I15V, L19LI, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I62IV, L63P, A71VF
 171070171070JN670244PINAI54V, V82A, L90MV11VI, L33I, F53L, G73S, L89LVL10IV, I13V, K20R, E35D, M36I, R41RK, K43KE, K55R, R57K, D60EK, Q61N, I62IV, L63P, A71IV, I72EV, C95LF
 177354177354JN670436PINAG48MV, I54V, V82A, L90MF53LL10I, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63LP, G68E, A71V, I93LF
 177430177430JN670439PINA F53LL10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61S, A71V, I72RF
 178718178718JN670488PINAM46L, I54V, V82AL24I, F53LL10V, I15V, K20R, E35D, M36I, N37T, R41K, R57K, Q61N, L63P, C67EF
 179613179613JN670518PINAI54V, V82A, L90MF53LL10I, I15V, G16E, K20R, E35D, M36I, N37T, R41K, R57K, Q61N, L63T, E65D, I72T, V77IF
 180359180359JN670545PINAI54V, V82T, L90MF53LL10I, I15V, L19LI, K20R, L24F, E35D, M36I, N37E, R41K, K55R, R57K, Q61N, L63P, A71I, T74S, Q92KF
 183504183504JN670649PINAM46I, I54V, V82A, L90ML33F, K43KT, F53L, T74PL10V, I15V, K20M, E35N, M36L, N37ND, L38W, R41K, K55R, R57K, Q61N, I62V, L63P, H69R, A71V, I72V, I93LF
 190134190134JN670789PINAI54V, V82SL24I, F53LL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, A71VF
 196067196067JN671012PINAV32I, M46MI, I54IL, I84V, L90MF53LL10I, T12N, I15V, L19I, K20R, E35D, M36I, N37NS, R41K, R57K, Q61D, L63T, I66IV, A71L, I72T, V77VI, I93LF
 196870196870JN671042PINAV32I, M46I, I47V, I54V, V82A, L90LMF53L, G73CL10I, I15V, G16A, K20R, E35D, M36I, N37ND, R41K, K55R, R57K, Q61N, L63P, A71AV, V77VI, I93ILF
 197011197011JN671053PINAI54V, L90MF53L, G73SI15V, L19V, E35D, M36I, R41K, R57K, D60E, Q61N, L63P, A71VF
 198351198351JN671114PINAM46I, I47V, I54V, V82SF53LL10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63Q, I64L, A71V, I93LF
 198678198678JN671129PINAM46L, G48Q, I54V, V82AL24I, F53LL10I, I15V, G17E, K20R, E35D, M36I, N37D, R41K, K55R, R57K, D60E, Q61D, I62V, L63PF
 206165206165JN671393PINAM46L, I54V, I84VL24I, K43T, F53LL10I, I15V, G17D, K20T, E35N, M36I, K55R, Q61N, L63T, E65D, A71V, I72T, T74E, V82I, L89M, I93LF
 207306207306JN671430PINAM46L, I54V, V82AL24I, G48E, F53L, L89VL10I, I13IV, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63P, I64L, H69Y, A71V, Q92K, I93LF