<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation K43T
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 52
Isolates 53
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Apetrei (2003)AC_Pat1RO.00.IS.01AY333462IDV, UnknownNAM46I, I54V, V82AL24I, K43TL10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
  RO.01.IS.01AY333463IDV, Unknown, SQV, NFVNAM46I, I54V, V82A, I84VL24I, K43T, G48W, F53LL10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
Dumans (2004)RG034RG034AY390208NFV131I54V, N88SK43TL10I, K20R, E35D, M36I, R41K, R57K, D60DE, Q61N, I62IV, L63A, I93LF
Gomez-Carrillo (2004)9732297322AY365545PINAI54V, V82AL24I, K43T, F53LL10I, T12K, I15V, G16E, L19I, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72V, T74SF
 9824098240AY365571PINAM46I, I54V, V82AL24I, L33LF, K43T, F53L, N83DL10I, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, A71V, I93ILF
 103279103279AY365676PINAM46I, I54S, V82AL24I, K43TL10I, T12P, I15V, L19I, K20M, E34K, E35D, M36I, R57K, Q61N, L63V, I64V, I72T, T74S, I85VF
 106671106671AY365754PINAM46I, I50V, V82A, L90ML33F, K43TL10I, I13V, I15V, G16E, K20R, E35D, M36L, R41K, R57K, Q61N, L63S, E65D, A71V, T74S, I93LF
 107407107407AY365767PINAI54V, V82AK43TL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61D, I64V, I72TF
 109089109089AY365804PINAI54V, V82A, L90MK43T, F53LL10I, L19I, K20R, E35D, M36I, R41K, Q61N, L63T, E65D, C67E, A71V, I72T, T74S, V77I, I93IMF
 119804119804AY365974PINAM46L, G48V, I54V, L76V, V82A, L90ML33F, K43TL10I, I15V, G16E, K20M, E35H, M36L, R41K, K55R, R57K, Q61N, L63S, E65D, A71V, T74S, I93LF
Non-B Workgroup (2005)BR7BR7AY900887NFV130I54V, N88SK43TL10I, K20R, E35D, M36I, R41K, R57K, D60DE, Q61N, I62IV, L63A, I93LF
 PL36995591 Unknown, LPV>112M46L, G48V, I54V, V82A, L90ML33F, K43TL10V, I15V, G16E, K20M, E35N, M36I, N37ND, R57K, Q61D, G68E, H69R, A71T, I72R, L89I, I93LF
Rodrigues (2005)BLF_Pat8BR03SP01AY643156Unknown, RTV, IDV>51M46L, I54A, V82AL24I, K43TL10I, I15V, L19I, K20R, E35D, M36I, K55R, R57K, Q61N, L63P, A71V, I85V, L89IF
 BLF_Pat17BR02SP88AY643155SQV, IDV, RTV, NFV, LPV285M46L, I50V, I54V, V82T, L90MK43TL10I, T12N, I15V, L19P, K20R, E21Q, E35D, M36I, N37D, K55R, R57K, Q61N, L63P, A71V, I72V, I85V, L89I, Q92KF
 BLF_Pat32BR02SP56AY643153NFV, IDV, Unknown>294V82L, L90MK43TL10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, L89M, I93LF
Baxter (2006)48-10941094-30728DQ877265PINAM46I, I54V, V82S, L90ML33F, K43T, G73SL10I, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61D, L63P, A71V, I72T, I85V, I93LF
 48-11361136-30729DQ877275PINAM46I, I47V, I54V, V82FL33F, K43T, N88D, L89LVL10I, I15V, E35D, M36I, R41K, K55R, R57K, Q61N, L63P, A71V, I85V, I93LF
 48-11031103-30708DQ877410PINAM46L, I54V, L76V, V82A, L90ML33F, K43TL10I, I13V, I15V, G16E, K20M, E35H, M36L, R41K_K, K55R, R57K, Q61N, L63S, E65D, A71V, T74S, L89LM, I93LF
 48-30433043-30305DQ877955PINAM46I, G48M, I54V, L76V, V82A, L90MK43T, F53LT4S, L10V, K14Q, I15V, G16E, L19I, K20R, E35D, M36V, P39S, K55R, R57K, Q61N, I62V, L63T, E65H, H69R, I72V, T74S, L89M, C95CSF
 48-42864286-30910DQ878509PINAI54AV, V82F, L90ML33F, K43T, F53LL10IV, G16E, L19I, K20R, E35D, M36I, N37T, P39T, R41K, D60E, Q61E, I62V, L63P, I64V, H69Q, A71V, I93LF
 48-91869186-30901DQ877291PINAM46L, I54V, V82AL24I, L33F, K43T, F53L, T74PL10I, I13V, I15V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I64L, A71V, I72T, L89I, I93LF
 48-90929092-30827DQ877655PINAM46I, I54V, V82A, L90MK43T, F53FLL10I, K20R, E35D, M36I, R41K, K55KR, R57K, Q61D, I62V, L63T, E65ED, I72T, T74TS, L89MF
 48-91499149-30826DQ877714PINAM46L, I54V, V82AL24I, L33F, K43T, F53LR8P, L10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63P, K70R, L89LM, Q92KF
Dumans (2009)RENA686RENA686FJ405043IDV, NFV326M46I, I54V, V82AL24I, K43T, T74PL10I, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63C, E65D, L89MF
 RENA555RENA555FJ405127SQV, NFV, RTV, IDV, Unknown>191I54V, V82A, L90ML33F, K43T, F53L, T74PL10V, I13V, K14R, G16E, K20R, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, I62V, L63H, A71I, I72V, I93LF
 75PR75PRFJ405164NFV104G48V, I54A, V82TK43TL10I, K20R, E35D, M36I, R41K, R57K, D60E, Q61N, L63E, E65D, I72V, L89M, I93LF
 RENA780RENA780FJ405171IDV200I54V, V82AK43TL10I, K14R, I15V, K20R, E35D, M36I, N37H, R41K, R57K, Q61D, L63P, L89M, I93ILF
 RENA626RENA626FJ405172IDV, SQV, RTV, NFV, LPV335M46L, I50V, I54V, V82T, L90MK43T, L89VL10I, T12N, I15V, L19P, K20R, E21Q, E35D, M36I, N37D, K55R, R57K, Q61N, L63P, A71V, I72V, I85V, Q92KF
Sanabani (2009)56406BR564FJ771008PINAM46L, V82AK43TL10M, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, T74S, I85V, L89TF
Aulicino (2011)ARL449AMAARL449AMAFJ525809PINAM46I, I54V, V82SL24I, K43TL10I, I15V, K20R, E35D, M36I, R41RK, K55R, Q61N, L63P, T74S, Q92KF
 ARM36WMRARM36WMRFJ525826PINAM46I, I47V, I54V, V82AL24I, K43T, F53LL10V, G16X, K20R, E35D, M36I, K55R, R57K, Q61N, L63T, H69R, T74S, L89MF
 ARM896DNGARM896DNGFJ525845PINAM46I, I54L, L76V, V82AL24I, K43TL10I, T12P, I15V, G16E, L19P, K20R, E35D, M36I, N37D, K55R, R57K, Q61D, A71V, I72R, I93LF
 ARN567GMARN567GMFJ525862PINAI54M, V82M, L90MV11I, L33F, K43T, G73S, L89VL10I, I13V, K14R, I15V, G17E, K20T, E35N, M36I, R41K, R57K, Q61N, L63P, T74S, I93LF
 4460-L6744460-L674HQ158242PINAM46I, I54V, L76V, V82AL24I, K43TL10I, T12P, I15V, G16E, L19P, K20R, E35D, M36I, N37D, K55R, R57K, D60E, Q61D, A71V, I72R, I93LF
Jones (2012)128782128782JN669454PINAI54V, V82AL24I, K43TL10I, L19I, K20R, E35D, M36I, N37NH, R41K, R57K, Q61N, L63P, E65ED, A71V, I72T, T74S, V77VI, I93LF
 140218140218JN669583PINAG48V, I54V, V82SK43TL10V, K20R, E35D, M36I, N37T, R41K, R57K, Q61N, L63P, H69Y, A71V, V77I, I93LF
 151368151368JN669761PINAM46L, I54V, V82ML24I, K43TL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, E65D, I72T, I93IFF
 153757153757JN669806PINAM46L, I54V, V82AK43TL10I, I15V, G17E, K20M, E35D, M36I, N37K, R57K, Q61D, L63P, I72R, I85V, I93LF
 157978157978JN669905PINAI54V, V82AK43TL10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63C, I64L, L89M, I93LF
 158844158844JN669935PINAM46I, I47V, I54V, V82SL23I, K43T, F53LL10I, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, L63A, A71V, I72V, T74S, L89M, I93LF
 159110159110JN669944PINAI54V, V82ML24I, K43TL10I, I15V, L19Q, K20R, E35D, M36V, R41K, R57K, Q61N, I62V, L63P, T74S, L89M, Q92KF
 159501159501JN669954PINAI54V, V82A, L90MK43T, F53LL10I, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, A71L, T74S, I93LF
 159510159510JN669955PINAI54V, V82A, L90MK43TL10I, I15V, G16E, K20M, E35D, M36I, R41R_R, R57K, Q61N, I62L, L63C, A71T, I72T, T74S, I85VF
 159810159810JN669966PINAI54S, V82A, L90ML33F, K43TL10I, I13V, I15V, G16E, L19I, K20R, E34R, E35D, M36I, N37T, R41K, R57K, Q61D, A71IL, I72R, V77I, I93LF
 183614183614JN670654PINAM46L, G48A, I54A, V82AK43TL10V, T12K, I15V, L19I, K20R, E35D, M36I, N37T, R41K, R57K, Q61N, E65D, I72TF
 191236191236JN670816PINAM46L, I54V, V82A, I84IVL24I, K43T, F53FLL10IV, I15V, G16E, L19I, K20R, E35D, M36I, K55R, R57K, Q61N, L63N, I64IV, A71T, I72T, T74TA, T91SF
 194437194437JN670934PINAM46L, I54V, V82A, L90MK43T, G73SL10I, T12K, I15V, L19Q, K20I, E21ED, L24F, E35D, M36I, N37D, K55R, R57K, D60E, Q61N, L63P, A71V, I72RF
 194888194888JN670955PINAM46I, I47IV, I54V, L76V, V82AK43T, Q58QEL10IV, I15V, Q18E, L19LI, K20R, E35D, M36I, R41K, K55KR, R57K, D60E, Q61N, I62V, L63P, A71AV, L89M, I93ILF
 204162204162JN671328PINAG48MV, I54V, V82AL24I, K43T, F53FLL10V, I15V, K20R, E35D, M36I, N37D, R57K, Q61D, L63P, I72T, T91TAF
 206020206020JN671383PINAI54V, V82TL33I, K43TI13V, I15V, K20R, E35D, M36I, N37D, R57K, Q61D, L63C, T74A, L89MF
 206165206165JN671393PINAM46L, I54V, I84VL24I, K43T, F53LL10I, I15V, G17D, K20T, E35N, M36I, K55R, Q61N, L63T, E65D, A71V, I72T, T74E, V82I, L89M, I93LF
 206318206318JN671397PINAM46L, I54V, V82A, I84VV11I, L24I, L33LF, K43TL10I, I15V, G16E, L19I, K20R, E35D, M36IV, K55R, R57K, Q61N, L63N, A71T, I72T, T91SF
 207640207640JN671442PINAM46L, G48AEKT, I54V, V82M, I84VL24I, L33I, K43T, F53FLL10I, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62IV, L63IT, E65D, I72T, T74S, P79PS, L89MF