<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation K43R
Rx PI-naive
IncludeMixtures No
References 25
Patients 38
Isolates 38
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Carr (2001)ARMA038ARMA038AY037281None   T12E, I15V, E35D, M36I, R41K, K43R, R57K, Q61D, I93LF
Kijak (2001)ARG04ARG04PRAF328565None   K14R, I15V, E35D, M36I, R41K, K43R, R57K, Q61NF
 ARG05ARG05PRAF328566None   E35D, M36I, R41K, K43R, R57K, Q61NF
Brindeiro (2003)BRP2146BRP2146AY213449None   L10I, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, E65D, V77I, L89M, I93LF
Eshleman (2004)BrRJ126BrRJ126AY444278None   I15IV, E35D, M36I, R41K, K43R, R57K, Q61S, H69Y, L89MF
 3934039340AY444291None   I13V, I15V, L19I, E35D, M36I, R41K, K43R, R57K, Q61N, L63LP, H69Y, I72T, L89MF
Non-B Workgroup (2005)BR1052BR1052AY900940None   L10V, I15V, E35D, M36I, R41K, K43R, R57K, Q61N, L63S, I72T, C95SF
Pando (2006)05AR16305205AR163052DQ383755None   I15V, E35D, M36I, R41K, K43R, R57K, Q61NF
Petroni (2006)AP_ARRP015AP_ARRP015DQ206653None   I15V, K20R, E35D, M36I, R41K, K43R, R57K, Q61N, L63Q, I72E, Q92KF
 AP_ARRP051AP_ARRP051DQ345501None   K14R, I15V, E35D, M36I, N37D, K43R, R57K, Q61D, I72ITF
Dilernia (2007)F006F006EF120077None   L10V, K14KR, I15V, M36I, R41K, K43R, Q61N, L63P, I72V, Q92TF
 F237F237EF120191None   L10IV, I13V, G16E, K20R, M36I, R41K, K43R, R57K, D60E, Q61D, C67Y, I72TF
 F339F339EF120240None   I15V, K20R, E35D, M36I, R41K, K43R, R57K, Q61N, L63Q, I72E, Q92KF
 N51N51EF120308None   I15V, E35D, M36I, R41K, K43R, R57K, Q61NF
 N03N03EF120353None   I15V, K20R, E35D, M36I, R41K, K43R, R57K, Q61N, L63Q, I72E, Q92KF
Liu (2007)fj52fj52EF432685None   L10I, G16E, M36I, R41K, K43R, R57K, Q61D, A71T, I72R, I93LF
Rios (2007)CH110MR_CH110EF194012None   L10V, I15V, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, L89M, I93LF
Cardoso (2009)BRGO3133BRGO3133FJ594169None   E35D, M36I, R41K, K43R, R57K, Q61D, L63A, E65D, L89MF
Cuevas (2009)P1708P1708.1EU822753None   K14R, I15V, E35D, M36I, N37D, R41K, K43R, R57K, Q61N, C67CS, L89MF
Vercauteren (2009)pt7528640409048GQ400272None   L10V, T12K, I15V, K20R, E35D, M36I, N37D, R41K, K43R, I62V, L63P, H69HQ, T74A, L89MF
Aulicino (2011)42-A24342-A243HQ158247None   I15V, E35D, M36I, R41K, K43R, R57K, Q61N, I72M, L89MF
 522-B506522-B506HQ158252None   K14R, I15V, E35D, M36I, R41K, K43R, R57K, Q61N, I72TF
Ferreira (2011)BRMT512BRMT512HQ638761None   T12K, I13V, I15V, L19Q, M36I, R41K, K43R, R57K, Q61N, L63PSF
Kousiappa (2011)CY191CY191JF683744None   L10I, T12K, I15V, L19I, E35D, M36I, R41K, K43R, R57K, L63V, E65DF
 CY212CY212JF683762None   L10V, K14R, E35D, M36I, R41K, K43R, R57K, Q61N, L63S, H69Q, V77I, L89MF
 CY222CY222JF683771None   L10V, T12V, I13V, I15V, E35D, M36I, R41K, K43R, R57K, L63T, E65D, I72T, L89MF
Brooks (2013)CAN2013-223CAN13-223KF727753None   L10M, I13V, K14R, I15V, G17E, L19IV, K20I, E35DN, M36I, R41K, K43R, H69Q, L89MF
 CAN2013-227CAN13-227KF727754None   L10M, I13V, K14R, I15V, G17E, L19I, K20I, E35D, M36I, R41K, K43R, H69Q, L89MF
Frentz (2013)EHR-61454EHR-61454JX300566None   L10V, K14R, E35D, M36I, R41K, K43R, R57K, Q61N, L63S, H69Q, V77I, L89MF
 EHR-86876EHR-86876JX301011None   L10LI, T12K, I15V, L19I, E35D, M36I, R41K, K43R, R57K, L63V, E65DF
Temereanca (2013)SR26SR26JX966503None   I15V, G16E, E35D, M36I, R41K, K43R, R57K, L63T, E65D, I72T, L89M, I93MF
 SR65SR65JX966531None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, R41K, K43R, R57K, L63T, E65D, I72TF
Agyingi (2014)LB089LB089KF576438None   T12S, I15V, K20R, E35D, M36I, N37D, R41K, K43R, I62V, L63P, H69Q, T74A, L89MF
Niculescu (2014)DU2504DU2504KJ194764None   L10I, I13V, I15IV, G16E, K20R, E35D, M36I, N37ND, R41K, K43R, R57K, I62V, L63T, E65D, L89MF
Dauwe (2015)F_05073F_05073KT863844None   L10V, E35D, M36I, R41K, K43R, R57K, Q61N, I72T, L89MF
de Lourdes Teixeira (2015)9RJ1201709RJ120170 None   E35D, M36I, R41K, K43R, R57K, Q61N, V77I, L89M, I93LF
Dos Anjos Silva (2016)AP017AP017KT737285None   T12S, K20M, E35D, M36I, R41K, K43R, R57K, Q61N, T74S, V77I, L89MF
Lam (2016)20420062042006KR867971None   T12I, I13V, I15V, E35D, M36I, R41K, K43R, R57K, Q61D, L63S, I72TF