<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation E35N
Rx >= 1 PI
IncludeMixtures No
References 8
Patients 81
Isolates 81
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gomez-Carrillo (2004)9138591385AY365471PINAI54V, V82A L10I, I15V, G16E, K20M, E35N, M36I, R41K, R57K, D60E, Q61D, I72RF
 116065116065AY365927PINAI54V, V82A, L90ML33FI13V, I15V, K20M, E35N, M36I, R41K, R57K, Q61N, I62V, L63P, H69R, A71V, T74SF
 124797124797AY366034PINAM46L, I54V, V82AL24I, L33F, G73CL10V, I15V, K20M, E35N, M36I, N37D, R41K, K55R, R57K, Q61D, A71V, I72TF
Thomson (2004)99UFRJ_999UFRJ_9AY455783IDV87D30N, M46L E21K, E34K, E35N, M36I, R41K, R57K, Q61H, L89MF
Non-B Workgroup (2005)PL36995591 Unknown, LPV>112M46L, G48V, I54V, V82A, L90ML33F, K43TL10V, I15V, G16E, K20M, E35N, M36I, N37ND, R57K, Q61D, G68E, H69R, A71T, I72R, L89I, I93LF
Rodrigues (2005)BLF_Pat33BR03SP36AY643174SQV, NFV, IDV129M46LL10F, N88TK14R, I15V, K20T, E35N, M36I, R41K, R57K, Q61N, I72V, L89MF
Baxter (2006)48-11801180-30922DQ877428PINAV32I, M46I, I47V, I54M, L90MF53LL10I, I15V, K20I, E35N, M36I, R41K, R57K, Q61N, L63P, I72IV, T74S, V82I, I85V, L89LIF
 48-31113111-30725DQ878019PINAM46L, I54V, V82AL24I, L33FL10V, I15V, L19V, K20M, E35N, M36IL, R41K, R57K, Q61N, I62V, L63P, C67Y, G73V, T74SF
 48-90259025-30825DQ877501PINAM46I, I54S, V82AL33FL10I, I13V, I15V, K20M, E35N, M36I, N37D, R41K, K55R, R57K, Q61N, T74S, L89IF
Aulicino (2011)ARK916CJARK916CJFJ525802PINAV82F, L90ML33FT12E, I13V, K14IV, I15V, K20Q, E35N, M36I, R41K, R57K, Q61N, I62IV, I64V, H69RF
 ARL589CJAARL589CJAFJ525811PINAM46L, I54V, L76V, V82F, L90ML33F, G73A, L89VL10V, I13V, K14R, I15V, G17E, K20T, E35N, M36I, R57K, Q61D, L63P, A71V, I93LF
 ARN156RJEARN156RJEFJ525852PINAD30N, M46I, I54V, V82AL24I, L33F, N83D, N88DL10I, K20R, E35N, M36I, N37D, R41K, K55R, R57K, Q61N, I62V, L63D, A71V, I72PT, T74SF
 ARN204SBDARN204SBDFJ525854PINAM46MI, I47IV, I54V, V82F, L90MQ58EL10IV, I15V, G17D, K20T, E35N, M36I, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, I72R, V77I, I93LF
 ARN567GMARN567GMFJ525862PINAI54M, V82M, L90MV11I, L33F, K43T, G73S, L89VL10I, I13V, K14R, I15V, G17E, K20T, E35N, M36I, R41K, R57K, Q61N, L63P, T74S, I93LF
 ARN926MRDARN926MRDFJ525867PINAD30NN88DL10V, T12I, I15V, K20A, E35N, M36I, N37D, R41K, K45R, R57K, Q61N, L63V, A71V, I72TF
 3343-N414ML3343-N414MLHQ158158PINAD30NN88DL10I, I15V, K20T, E35N, M36I, R41K, R57K, D60E, Q61D, L63P, V77I, I93LF
 3318-K6303318-K630HQ158235PINAD30NN88DI15V, K20T, E35N, M36I, R41K, R57K, Q61N, L63P, I72M, T74SF
Jones (2012)128819128819JN669455PINAV82L, L90M I15V, G17E, K20T, E35N, M36I, R57K, Q61D, I62V, L63P, A71T, I72R, I93LF
 143766143766JN669646PINAD30NN88DI15V, K20T, E35N, M36I, P39PS, R41K, R57K, Q61N, A71T, I72IT, T74S, I93LF
 151017151017JN669756PINAL90M L10V, I13V, I15V, K20V, E35N, M36I, R41K, R57K, Q61N, I62IV, L63LP, A71T, I72T, T74SF
 154303154303JN669816PINAD30N, L90MN88DI13V, I15V, K20T, E35N, M36I, R41K, K43R, K55N, R57K, Q61N, L63P, A71V, Q92KF
 155316155316JN669839PINA  I15V, K20M, E35N, M36I, R41RK, R57K, Q61D, L63LP, I72T, T74TS, Q92QRF
 163316163316JN670061PINAM46L, I54V, V82A, L90ML33F, G73SL10I, I15V, G16E, K20M, E35N, M36I, R41K, K55R, R57K, Q61N, A71I, I72T, I93LF
 163933163933JN670073PINAM46I, I47V, I54V, V82F, L90ML89VL10I, I15V, G17D, K20T, E35N, M36I, R41K, K55KR, R57K, Q61N, I62V, L63P, T74S, V77I, I85V, I93LF
 165724165724JN670114PINAD30NN88DI15IV, K20T, E35N, M36I, N37D, R41K, K45R, R57K, Q61N, L63P, I64L, A71AV, V77I, I93LF
 170845170845JN670236PINAD30NN88DI15V, K20T, E35N, M36I, P39Q, R41K, K45R, R57K, Q61DN, L63AF
 176698176698JN670410PINAM46I, I54V, L76V, V82F L10I, T12I, I13V, I15V, K20I, E35N, M36I, N37D, R41K, R57K, Q61N, L63P, I64VF
 177288177288JN670432PINAM46I, I50V, I54A, V82A, L90ML33F, Q58E, L89VL10I, I13V, I15V, G16Q, K20R, E35N, M36I, P39Q, R41K, K55R, R57K, Q61N, L63P, A71V, I93ILF
 179798179798JN670526PINAM46I, I54V, V82A, L90MG73SL10I, I13V, I15V, K20I, L33L_L, E35N, M36I, R41K, R57K, Q61N, L63P, A71V, I93LF
 180384180384JN670546PINAD30N I15V, K20T, E35N, M36I, R41K, K45Q, R57K, Q61N, L63S, E65DF
 183504183504JN670649PINAM46I, I54V, V82A, L90ML33F, K43KT, F53L, T74PL10V, I15V, K20M, E35N, M36L, N37ND, L38W, R41K, K55R, R57K, Q61N, I62V, L63P, H69R, A71V, I72V, I93LF
 185006185006JN670693PINAL90M L10IV, I13IV, K14KR, I15V, K20T, E35N, M36I, P39PS, R41K, R57K, Q61N, I62V, L63P, I64IV, A71AT, T74S, I93LF
 188259188259JN670751PINA  I15V, G17E, K20T, E35N, M36I, R41K, R57K, Q61D, I72R, I93LF
 189562189562JN670776PINAI54V, V82A, L90M L10I, T12P, K14R, I15V, G16E, K20M, E35N, M36I, N37E, P39Q, R41K, R57K, D60E, Q61D, I62V, A71V, I72T, I93LF
 191242191242JN670817PINAL90M I15IV, K20I, E35N, M36I, R41K, R57K, D60E, Q61D, I62IV, L63P, A71V, T74S, I93LF
 195201195201JN670970PINAD30N, I54VI47ML10I, K20T, E35N, M36I, N37D, K45A, V56A, R57K, Q61N, I62V, L63P, V77I, V82I, N88E, L89MF
 203975203975JN671325PINAM46ML, I54V, V82A, L90ML33F, G73SL10I, I15V, K20T, E35N, M36I, N37DE, R41K, R57K, Q61N, L63P, A71V, I72R, I85VF
 205393205393JN671359PINAI54V, L90MG73SL10I, I15V, K20V, E35N, M36I, R41K, R57K, Q61N, L63P, T74SF
 206165206165JN671393PINAM46L, I54V, I84VL24I, K43T, F53LL10I, I15V, G17D, K20T, E35N, M36I, K55R, Q61N, L63T, E65D, A71V, I72T, T74E, V82I, L89M, I93LF
Diaz (2015)RenG15609RenG15609KT746637PINAI50L, N88SL33FT12N, I13IV, I15V, L19I, K20I, E35N, M36I, N37D, R41K, R57K, Q61N, L63V, I64V, I72V, T74TA, V77VI, L89MF
 RenG15620RenG15620KT746648PINAM46I, I54V, L76V, V82A, L90M L10I, I13V, I15IV, G16E, K20I, E35N, M36I, N37NS, R41RK, K55R, R57K, Q61N, L63H, A71T, I72V, L89I, T91SF
 RenG16649RenG16649KT747677PINAM46L, I54V, V82A, L90MK43T, T74PL10IV, T12K, I13V, K14KR, I15V, K20I, E35N, M36I, R41K, Q61N, L63T, E65D, I72T, L89MF
 RenG16248RenG16248KT747276PINAM46L, I54V, L76V, V82A, L90ML23IL10I, I13V, I15V, K20I, E35N, M36I, R41K, K55R, R57K, Q61N, I62V, L63P, I64L, A71V, I72V, T74S, I93LF
 RenG16813RenG16813KT747841PINAI54V, I84VG73SL10I, K20I, E35N, M36I, R41K, K45R, R57K, Q61N, A71V, I72V, I85V, L89T, Q92QRF
 RenG17442RenG17442KT748470PINAM46I, I47V, I54V, V82F, L90MK43TL10I, I13V, K14R, I15V, K20T, E35N, M36I, R41K, R57K, D60E, Q61D, I72T, V77I, L89IF
 RenG15968RenG15968KT746996PINAM46L, I54V, L76V, V82A, L90ML33F, Q58E, N83DL10I, I13V, G16E, K20R, E35N, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, L89MF
 RenG15848RenG15848KT746876PINAI54L, N88SK43KTL10V, T12TK, K14R, I15V, K20T, E35N, M36I, R41K, R57K, Q61N, L63T, I64V, V77I, L89M, I93LF
 RenG17379RenG17379KT748407PINAD30NN88DL10I, T12I, I13V, I15V, K20T, E35N, M36I, R41K, K45R, R57K, Q61N, L63DG, I72T, L89MF
 RenG17438RenG17438KT748466PINAD30N, M46I, I50L, L90MK43T, N88DI13V, K14R, I15V, K20T, E35N, M36I, R41K, R57K, Q61D, I62V, L63P, A71V, V77I, I85IVF
 RenG17275RenG17275KT748303PINAM46L, I54V, V82A, L90M L10I, I13V, K14R, I15V, L19V, K20T, E35N, M36I, N37D, R41K, Q61N, A71V, I72T, T74S, L89I, I93LF
 RenG16844RenG16844KT747872PINAD30N, M46I, I50L, L90MK43T, N88DI13V, K14R, I15V, K20T, E35N, M36I, R41K, R57K, Q61D, I62V, L63P, A71V, V77I, I85IVF
 RenG14038RenG14038KT745066PINA  I15V, K20T, E35N, M36I, R41K, R57K, Q61N, L63P, T74S, V77I, I85IVF
 RenG14829RenG14829KT745857PINAN88SL33I, Q58EL10I, T12E, I15V, E35N, M36I, P39Q, R41K, R57K, D60E, Q61D, L63Q, I85V, L89MF
 RenG15260RenG15260KT746288PINAM46I, I47V, G48Q, I54V, V82A, L90MF53L, G73TL10V, I15V, K20T, E35N, M36I, R41K, K55R, R57K, Q61N, I62IV, L63P, A71V, T74S, I93LF
 RenG14867RenG14867KT745895PINAM46I, I47AL10F, L33LI, F53LT12I, I13V, I15V, Q18E, K20M, E35N, M36I, R41K, K45R, R57K, Q61N, L89IF
 RenG13653RenG13653KT744681PINAL90M T12K, I15V, L19V, K20T, E35N, M36I, N37E, P39Q, R41K, K43I, R57K, Y59F, D60S, Q61D, L63P, A71TF
 RenG14280RenG14280KT745308PINAI54V, L90ML23I, F53LL10I, K20I, E35N, M36V, R41K, K55KR, R57K, D60E, Q61N, I62IV, L63D, I64IV, E65ED, I66IF, K70R, A71V, I72T, L89M, Q92QK, I93ILF
 RenG13850RenG13850KT744878PINAM46I, I54V, L76V, V82SL24I, L33F, Q58EL10I, I13V, L19I, K20M, E35N, M36I, N37E, K55R, R57K, D60E, Q61N, L63P, C67Q, K70R, I72V, L89MF
 RenG15068RenG15068KT746096PINAI50L, V82AL33F, F53FLT12I, I13V, K14R, I15V, K20T, E35N, M36I, R41K, K55KR, R57K, Q61N, L63T, A71V, T74SF
 RenG13781RenG13781KT744809PINAM46I, I50V, I54V, L76V L10I, I15V, K20T, E35N, M36I, R41K, R57K, Q61D, I62V, L63V, I64IV, A71V, T74A, V82I, L89M, I93LF
 RenG14993RenG14993KT746021PINAM46I, I54V, L76V, V82AQ58EL10LR, T12A, K14R, I15V, G16E, E35N, M36IV, N37D, R41K, K55R, R57K, D60E, Q61D, L63T, I72T, L89MF
 RenG13070RenG13070KT744098PINAD30N T12T*KS, I13V, K14R, I15AV, K20T, E35N, M36I, N37ND, R41K, K45Q, Q61N, L63T, I72T, V77IF
 RenG13456RenG13456KT744484PINAI50L, V82AL33F, F53LL10I, I13V, I15V, K20V, E35N, M36I, R41K, K43S, K55R, R57K, Q61N, L63P, H69HY, A71LV, T74SF
 RenG12914RenG12914KT743942PINAI50L, V82VA, N88SL33FL10I, T12AE, I13V, K14KT, I15IV, K20V, E35N, M36I, N37E, K45R, R57K, Q61N, L63P, I64V, K70T, A71V, V77I, L89M, Q92QKF
 RenG13137RenG13137KT744165PINAM46I, I54A, V82A, L90ML33IL10I, T12P, I15V, L19P, K20V, E35N, M36I, R41K, R57K, Q61N, I62V, K70E, A71V, T74S, G86GA, L89I, T91S, I93LF
 RenG12901RenG12901KT743929PINAM46L, I54V, L76V, V82A, L90ML33F, Q58E, N83DL10I, I13V, G16E, K20R, E35N, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, L89MF
 RenG11986RenG11986KT743014PINAM46L, I54V, V82F, L90MF53LL10V, I15V, K20T, E35N, M36I, R41K, K55R, R57K, Q61N, I64V, G68E, A71V, V77I, I93LF
 RenG12830RenG12830KT743858PINAM46I, I54AV, V82A, L90ML33F, T74TPL10V, I13V, I15V, K20T, E35N, M36I, R41K, K55R, R57K, Q61N, L63S, K70E, A71IV, T91TCS, I93LF
 RenG12449RenG12449KT743477PINAM46I, I54A, V82L, L90MQ58EL10I, K14R, I15V, G16Q, K20T, E35N, M36V, N37S, P39S, R41K, F53FY, R57K, D60E, Q61N, L63T, C67E, H69Y, A71V, I72T, V77I, I93LF
 RenG11967RenG11967KT742995PINAM46L, I54V, L76V, V82A, L90ML33F, Q58E, N83DL10I, I13V, G16E, K20R, E35N, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, L89MF
 RenG12196RenG12196KT743224PINAI54IV, V82A, L90M I15V, G16E, K20M, E35N, M36I, N37D, G40R, R41K, R57K, Q61N, K70R, L89I, L97*F
 RenG11817RenG11817KT742845PINAG48V, I54S, V82ACGSV11I, L33LF, T74PSL10I, T12K, I13V, K14R, I15V, K20T, E35N, M36I, R41P, R57K, Q61N, L89IF
 RenG13129RenG13129KT744157PINAM46L, I54V, V82A, L90MN88DL10V, I13K, I15G, K20I, E35N, M36I, L38F, R41K, R57K, Q61H, L63I, A71T, T74S, L89I, Q92KF
 RenG11775RenG11775KT742803PINAM46L, I54V, L76LV, V82A, L90M L10V, K14R, I15V, G16E, K20MT, E35N, M36I, N37D, R41K, K55KR, R57K, Q61N, I62IV, L63HP, T74S, V77VI, I85V, L89I, I93LF
 RenG11077RenG11077KT742105PINA  I15V, G16E, K20R, E35N, M36I, P39Q, R41K, R57K, Q61N, E65D, I72T, V82I, R87RI, L89MF
 RenG10926RenG10926KT741954PINAM46L, I54V, V82A, L90MV11VI, K43KT, F53FL, G73SL10I, T12N, I15V, L19IMT, K20I, E35N, M36I, R41K, K55R, R57K, Q61D, I62V, L63P, H69Y, A71T, I72T, I85IVF
 RenG10005RenG10005KT741033PINAM46I, I54IL, V82AL24II15V, K20I, E35N, M36I, R41K, K45R, K55KR, R57K, Q61N, L63P, A71AT, I72IT, L89TF
 RenG10845RenG10845KT741873PINAD30N, M46IL23I, L33I, F53L, N88DR8RQ, L10I, I15IV, K20T, E35N, M36I, N37NS, R41K, K45Q, R57K, D60E, Q61N, L63D, I66V, A71T, V77VI, I93LF
 RenG11770RenG11770KT742798PINAM46I, V82F, L90ML33F, K43T, N88GL10IV, I13V, I15V, K20T, E35N, M36I, R57K, Q61D, L63P, A71L, I72T, V77I, L89I, I93LF
 RenG10275RenG10275KT741303PINAI50L T12M, I13IM, I15V, K20V, E35N, M36I, N37D, R41K, F53I, R57K, Q61N, L63LP, I64V, A71V, T74S, I85IV, L89M, Q92RF
 RenG11735RenG11735KT742763PINAM46I, I54V, L76V, L90M L10V, I13V, I15V, K20T, E35N, M36I, R41K, R57K, D60E, Q61N, I62IV, L63P, A71I, L89I, T91S, I93LF