<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation E35N
Rx >= 1 PI
IncludeMixtures No
References 8
Patients 65
Isolates 65
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Thomson (2004)99UFRJ_999UFRJ_9AY455783IDV87D30N, M46L E21K, E34K, E35N, M36I, R41K, R57K, Q61H, L89MF
Non-B Workgroup (2005)PL36995591 Unknown, LPV>112M46L, G48V, I54V, V82A, L90ML33F, K43TL10V, I15V, G16E, K20M, E35N, M36I, N37ND, R57K, Q61D, G68E, H69R, A71T, I72R, L89I, I93LF
Rodrigues (2005)BLF_Pat33BR03SP36AY643174SQV, NFV, IDV129M46LL10F, N88TK14R, I15V, K20T, E35N, M36I, R41K, R57K, Q61N, I72V, L89MF
Baxter (2006)48-90259025-30825DQ877501PINAM46I, I54S, V82AL33FL10I, I13V, I15V, K20M, E35N, M36I, N37D, R41K, K55R, R57K, Q61N, T74S, L89IF
Waleria-Aleixo (2008)08PR06054608PR060546FJ591462PINAI54V, V82A, L90MF53LL10V, T12I, I15V, G16E, K20M, E35N, M36I, N37D, R41K, K55R, R57K, Q61N, I66M, K70KR, A71T, I72T, I85V, L89I, Q92K, C95VF
 08PR05038508PR050385FJ591410PINAL90MN83DL10I, I13V, I15V, K20V, E35N, M36I, N37Q, R41K, R57K, Q61D, I62V, A71T, I72T, T74S, L89IF
 08PR05036008PR050360FJ591386PINAL90M I15V, G17D, K20R, E35N, M36I, K43Q, R57K, Q61DN, L63T, L89MF
 08RJ06050108RJ060501FJ591693PINAL90MT74PL10V, I15V, G16Q, K20T, E35N, M36I, P39T, R41K, R57K, D60E, Q61D, L63T, I64V, I72V, L89MF
Aulicino (2011)ARK916CJARK916CJFJ525802PINAV82F, L90ML33FT12E, I13V, K14IV, I15V, K20Q, E35N, M36I, R41K, R57K, Q61N, I62IV, I64V, H69RF
 ARM522BCEARM522BCEFJ525832PINAM46I, I50V, I54V, V82A, L90ML23I, L33F, K43T, F53L, T74PL10I, I13V, K20R, E35N, M36I, K55R, R57K, Q61N, I62V, L63P, L89IF
 ARN156RJEARN156RJEFJ525852PINAD30N, M46I, I54V, V82AL24I, L33F, N83D, N88DL10I, K20R, E35N, M36I, N37D, R41K, K55R, R57K, Q61N, I62V, L63D, A71V, I72PT, T74SF
 2133-L458JCD2133-L458JCDHQ158169PINAI54V, V82A, L90M L10I, T12E, I15V, K20I, E35N, M36I, R41K, R57K, D60E, Q61N, I62V, L63P, A71TF
Jones (2012)155316155316JN669839PINA  I15V, K20M, E35N, M36I, R41RK, R57K, Q61D, L63LP, I72T, T74TS, Q92QRF
 178038178038JN670468PINAM46I, I50V, I54V, V82A, L90ML23I, L33F, K43T, F53L, T74PL10I, I13V, K20R, E35N, M36I, N37NI, K55R, R57K, Q61N, I62V, L63P, L89IF
 182090182090JN670599PINAM46I, I54V, L76VL89VK20P, E35N, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, T74S, V82I, Q92KF
 184144184144JN670673PINAM46I, I50IL, I54AV, V82AL24I, L33F, Q58EL10I, T12N, I13V, G16GE, K20I, E35N, M36I, N37E, R41K, R57K, D60E, Q61N, L63T, I72T, L89MF
 195201195201JN670970PINAD30N, I54VI47ML10I, K20T, E35N, M36I, N37D, K45A, V56A, R57K, Q61N, I62V, L63P, V77I, V82I, N88E, L89MF
 196676196676JN671032PINAD30NM46MV, N88DL5S, L10IV, I15A, G16E, Q18QR, K20I, E35N, M36I, P39S, R41K, Q61N, L63T, E65D, I72T, T74SF
 206165206165JN671393PINAM46L, I54V, I84VL24I, K43T, F53LL10I, I15V, G17D, K20T, E35N, M36I, K55R, Q61N, L63T, E65D, A71V, I72T, T74E, V82I, L89M, I93LF
Diaz (2015)RenG15609RenG15609KT746637PINAI50L, N88SL33FT12N, I13IV, I15V, L19I, K20I, E35N, M36I, N37D, R41K, R57K, Q61N, L63V, I64V, I72V, T74TA, V77VI, L89MF
 RenG15620RenG15620KT746648PINAM46I, I54V, L76V, V82A, L90M L10I, I13V, I15IV, G16E, K20I, E35N, M36I, N37NS, R41RK, K55R, R57K, Q61N, L63H, A71T, I72V, L89I, T91SF
 RenG17082RenG17082KT748110PINAM46I, I50L, V82A, L90ML10LF, L33F, F53L, L89VI13V, I15V, K20T, E35N, M36I, N37D, R41K, K43R, K55KR, R57K, Q61N, L63P, A71IV, Q92KF
 RenG16649RenG16649KT747677PINAM46L, I54V, V82A, L90MK43T, T74PL10IV, T12K, I13V, K14KR, I15V, K20I, E35N, M36I, R41K, Q61N, L63T, E65D, I72T, L89MF
 RenG16248RenG16248KT747276PINAM46L, I54V, L76V, V82A, L90ML23IL10I, I13V, I15V, K20I, E35N, M36I, R41K, K55R, R57K, Q61N, I62V, L63P, I64L, A71V, I72V, T74S, I93LF
 RenG16813RenG16813KT747841PINAI54V, I84VG73SL10I, K20I, E35N, M36I, R41K, K45R, R57K, Q61N, A71V, I72V, I85V, L89T, Q92QRF
 RenG17442RenG17442KT748470PINAM46I, I47V, I54V, V82F, L90MK43TL10I, I13V, K14R, I15V, K20T, E35N, M36I, R41K, R57K, D60E, Q61D, I72T, V77I, L89IF
 RenG15968RenG15968KT746996PINAM46L, I54V, L76V, V82A, L90ML33F, Q58E, N83DL10I, I13V, G16E, K20R, E35N, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, L89MF
 RenG15848RenG15848KT746876PINAI54L, N88SK43KTL10V, T12TK, K14R, I15V, K20T, E35N, M36I, R41K, R57K, Q61N, L63T, I64V, V77I, L89M, I93LF
 RenG17379RenG17379KT748407PINAD30NN88DL10I, T12I, I13V, I15V, K20T, E35N, M36I, R41K, K45R, R57K, Q61N, L63DG, I72T, L89MF
 RenG17438RenG17438KT748466PINAD30N, M46I, I50L, L90MK43T, N88DI13V, K14R, I15V, K20T, E35N, M36I, R41K, R57K, Q61D, I62V, L63P, A71V, V77I, I85IVF
 RenG17275RenG17275KT748303PINAM46L, I54V, V82A, L90M L10I, I13V, K14R, I15V, L19V, K20T, E35N, M36I, N37D, R41K, Q61N, A71V, I72T, T74S, L89I, I93LF
 RenG16844RenG16844KT747872PINAD30N, M46I, I50L, L90MK43T, N88DI13V, K14R, I15V, K20T, E35N, M36I, R41K, R57K, Q61D, I62V, L63P, A71V, V77I, I85IVF
 RenG14038RenG14038KT745066PINA  I15V, K20T, E35N, M36I, R41K, R57K, Q61N, L63P, T74S, V77I, I85IVF
 RenG14829RenG14829KT745857PINAN88SL33I, Q58EL10I, T12E, I15V, E35N, M36I, P39Q, R41K, R57K, D60E, Q61D, L63Q, I85V, L89MF
 RenG14639RenG14639KT745667PINAM46IL, G48A, I54A, V82AL24I, L33F, Q58EL10I, I13V, K20M, E35N, M36I, N37ND, F53FY, R57K, Q61N, I62IV, L63LP, L89M, Q92QKF
 RenG15231RenG15231KT746259PINAM46L, I50L, V82AL33F, K43TL10V, I15V, G16E, K20R, E35N, M36I, N37NT, P39S, R41K, I62V, L63T, I64V, E65D, A71V, I72T, T74S, I93LF
 RenG14867RenG14867KT745895PINAM46I, I47AL10F, L33LI, F53LT12I, I13V, I15V, Q18E, K20M, E35N, M36I, R41K, K45R, R57K, Q61N, L89IF
 RenG13653RenG13653KT744681PINAL90M T12K, I15V, L19V, K20T, E35N, M36I, N37E, P39Q, R41K, K43I, R57K, Y59F, D60S, Q61D, L63P, A71TF
 RenG14280RenG14280KT745308PINAI54V, L90ML23I, F53LL10I, K20I, E35N, M36V, R41K, K55KR, R57K, D60E, Q61N, I62IV, L63D, I64IV, E65ED, I66IF, K70R, A71V, I72T, L89M, Q92QK, I93ILF
 RenG14682RenG14682KT745710PINAM46I, I54V, V82AN88DL10V, I13V, I15V, G16E, K20I, E35N, M36I, R41K, K45R, K55KR, R57K, Q61N, L63Q, I64V, T74SF
 RenG13850RenG13850KT744878PINAM46I, I54V, L76V, V82SL24I, L33F, Q58EL10I, I13V, L19I, K20M, E35N, M36I, N37E, K55R, R57K, D60E, Q61N, L63P, C67Q, K70R, I72V, L89MF
 RenG15068RenG15068KT746096PINAI50L, V82AL33F, F53FLT12I, I13V, K14R, I15V, K20T, E35N, M36I, R41K, K55KR, R57K, Q61N, L63T, A71V, T74SF
 RenG13781RenG13781KT744809PINAM46I, I50V, I54V, L76V L10I, I15V, K20T, E35N, M36I, R41K, R57K, Q61D, I62V, L63V, I64IV, A71V, T74A, V82I, L89M, I93LF
 RenG14675RenG14675KT745703PINAM46L, I50IL, I54V, V82AV11I, L24I, F53FL, L89LMVL10I, I15V, L19LAPV, K20M, E35N, M36I, R41K, K55R, R57K, Q61N, I62V, L63P, A71IV, I72T, Q92KF
 RenG14993RenG14993KT746021PINAM46I, I54V, L76V, V82AQ58EL10LR, T12A, K14R, I15V, G16E, E35N, M36IV, N37D, R41K, K55R, R57K, D60E, Q61D, L63T, I72T, L89MF
 RenG13456RenG13456KT744484PINAI50L, V82AL33F, F53LL10I, I13V, I15V, K20V, E35N, M36I, R41K, K43S, K55R, R57K, Q61N, L63P, H69HY, A71LV, T74SF
 RenG12914RenG12914KT743942PINAI50L, V82VA, N88SL33FL10I, T12AE, I13V, K14KT, I15IV, K20V, E35N, M36I, N37E, K45R, R57K, Q61N, L63P, I64V, K70T, A71V, V77I, L89M, Q92QKF
 RenG13137RenG13137KT744165PINAM46I, I54A, V82A, L90ML33IL10I, T12P, I15V, L19P, K20V, E35N, M36I, R41K, R57K, Q61N, I62V, K70E, A71V, T74S, G86GA, L89I, T91S, I93LF
 RenG12901RenG12901KT743929PINAM46L, I54V, L76V, V82A, L90ML33F, Q58E, N83DL10I, I13V, G16E, K20R, E35N, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, L89MF
 RenG11986RenG11986KT743014PINAM46L, I54V, V82F, L90MF53LL10V, I15V, K20T, E35N, M36I, R41K, K55R, R57K, Q61N, I64V, G68E, A71V, V77I, I93LF
 RenG12636RenG12636KT743664PINAD30N, V32VI, M46I, I47V, I54LVF53FL, L76LM, N88DL10V, T12IM, I13A, K20T, A22AV, E35N, M36I, N37ND, R41K, K45R, R57K, Q61N, L63C, A71V, T74S, L89T, Q92RF
 RenG12217RenG12217KT743245PINAM46I, I54V, V82F, L90M L10I, I15V, K20T, E35N, M36I, R41KT, K43Q, R57K, D60N, Q61D, I62V, L63P, I64L, V77I, L89I, I93LF
 RenG11967RenG11967KT742995PINAM46L, I54V, L76V, V82A, L90ML33F, Q58E, N83DL10I, I13V, G16E, K20R, E35N, M36I, R41K, K55R, R57K, Q61N, L63T, I72T, L89MF
 RenG12196RenG12196KT743224PINAI54IV, V82A, L90M I15V, G16E, K20M, E35N, M36I, N37D, G40R, R41K, R57K, Q61N, K70R, L89I, L97*F
 RenG12524RenG12524KT743552PINAG48A, I54V, L76V, V82A, I84VV11VI, L24I, L33F, K43T, M46V, F53L, N83DL10Y, L19I, K20R, E35N, M36I, N37D, K55R, R57K, D60E, Q61N, I62V, L63P, H69Y, A71V, I72K, L89I, T91A, Q92KF
 RenG11817RenG11817KT742845PINAG48V, I54S, V82ACGSV11I, L33LF, T74PSL10I, T12K, I13V, K14R, I15V, K20T, E35N, M36I, R41P, R57K, Q61N, L89IF
 RenG13129RenG13129KT744157PINAM46L, I54V, V82A, L90MN88DL10V, I13K, I15G, K20I, E35N, M36I, L38F, R41K, R57K, Q61H, L63I, A71T, T74S, L89I, Q92KF
 RenG11775RenG11775KT742803PINAM46L, I54V, L76LV, V82A, L90M L10V, K14R, I15V, G16E, K20MT, E35N, M36I, N37D, R41K, K55KR, R57K, Q61N, I62IV, L63HP, T74S, V77VI, I85V, L89I, I93LF
 RenG11077RenG11077KT742105PINA  I15V, G16E, K20R, E35N, M36I, P39Q, R41K, R57K, Q61N, E65D, I72T, V82I, R87RI, L89MF
 RenG10926RenG10926KT741954PINAM46L, I54V, V82A, L90MV11VI, K43KT, F53FL, G73SL10I, T12N, I15V, L19IMT, K20I, E35N, M36I, R41K, K55R, R57K, Q61D, I62V, L63P, H69Y, A71T, I72T, I85IVF
 RenG10005RenG10005KT741033PINAM46I, I54IL, V82AL24II15V, K20I, E35N, M36I, R41K, K45R, K55KR, R57K, Q61N, L63P, A71AT, I72IT, L89TF
 RenG10904RenG10904KT741932PINAI54L L10V, I15V, G16E, K20A, E35N, M36I, P39S, R41K, R57K, D60E, I62V, L63T, I64L, E65ED, A71V, I72T, I93LF
 RenG11770RenG11770KT742798PINAM46I, V82F, L90ML33F, K43T, N88GL10IV, I13V, I15V, K20T, E35N, M36I, R57K, Q61D, L63P, A71L, I72T, V77I, L89I, I93LF
 RenG10275RenG10275KT741303PINAI50L T12M, I13IM, I15V, K20V, E35N, M36I, N37D, R41K, F53I, R57K, Q61N, L63LP, I64V, A71V, T74S, I85IV, L89M, Q92RF
 RenG11735RenG11735KT742763PINAM46I, I54V, L76V, L90M L10V, I13V, I15V, K20T, E35N, M36I, R41K, R57K, D60E, Q61N, I62IV, L63P, A71I, L89I, T91S, I93LF