<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L33F
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 78
Isolates 78
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gomez-Carrillo (2004)9629696296AY365523PINAI54V, V82AG, I84V, L90ML33F, Q58EQ7QH, L10I, T12TP, I13IV, K20R, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, A71V, I72RF
 9889798897AY365588PINAI54V, V82A, L90ML33F, K43KTL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61D, I62V, L63I, A71V, I72Q, I93LF
 103183103183AY365671PINAD30N, M46L, I54V, V82A, L90ML33F, N88DI13V, K20R, E35D, M36I, R41K, R57K, Q61N, L63H, A71V, T74S, I93LF
 103828103828AY365686PINAM46L, I54V, V82AL24I, L33FL10V, T12S, I15V, L19IV, K20M, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, G73V, T74SF
 106671106671AY365754PINAM46I, I50V, V82A, L90ML33F, K43TL10I, I13V, I15V, G16E, K20R, E35D, M36L, R41K, R57K, Q61N, L63S, E65D, A71V, T74S, I93LF
 110390110390AY365836PINAI54ML33F, Q58EL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I85VF
 116065116065AY365927PINAI54V, V82A, L90ML33FI13V, I15V, K20M, E35N, M36I, R41K, R57K, Q61N, I62V, L63P, H69R, A71V, T74SF
 116850116850AY365934PINAM46L, I54V, V82AL10F, L24I, L33F, G73CI15V, G16A, L19P, K20I, E35D, M36I, N37D, R41K, R57K, Q61N, L63PF
 119804119804AY365974PINAM46L, G48V, I54V, L76V, V82A, L90ML33F, K43TL10I, I15V, G16E, K20M, E35H, M36L, R41K, K55R, R57K, Q61N, L63S, E65D, A71V, T74S, I93LF
 120891120891AY365993PINAM46I, I50V, I54V, V82AL24I, L33FL10V, I15V, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, A71V, I72TF
 124797124797AY366034PINAM46L, I54V, V82AL24I, L33F, G73CL10V, I15V, K20M, E35N, M36I, N37D, R41K, K55R, R57K, Q61D, A71V, I72TF
 126743126743AY366057PINAV32I, M46I, I47V, I54V, V82AL24I, L33F, F53LL10V, I15V, K20R, E34V, E35D, M36I, R41K, Q61N, I62V, L63P, T74S, L89M, Q92KF
de Sa Filho (2005)BREPM275BREPM275AY771592PINAD30NL33F, N88DL10V, T12K, I13V, I15V, K20T, E35D, M36L, N37E, K55R, R57K, D60E, Q61N, L63S, L89MF
Non-B Workgroup (2005)PL23900101500 Unknown, LPV>58I54V, V82AL33F, N83DL10V, I13V, K20R, E35D, M36I, R41K, R57K, I62V, T74S, L89IF
 PL36995591 Unknown, LPV>112M46L, G48V, I54V, V82A, L90ML33F, K43TL10V, I15V, G16E, K20M, E35N, M36I, N37ND, R57K, Q61D, G68E, H69R, A71T, I72R, L89I, I93LF
 PL4840688662 APV104M46MI, I50IV, V82AL33FL10I, T12I, I13V, I15IV, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, G68E, I72R, L89MF
Baxter (2006)48-10151015-30618DQ877259PINAM46MI, I54IV, V82AL24I, L33F, G73GCL10I, I15V, K20T, E35DN, M36I, R41K, K55R, R57K, Q61N, L63P, I93LF
 48-10941094-30728DQ877265PINAM46I, I54V, V82S, L90ML33F, K43T, G73SL10I, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61D, L63P, A71V, I72T, I85V, I93LF
 48-11361136-30729DQ877275PINAM46I, I47V, I54V, V82FL33F, K43T, N88D, L89LVL10I, I15V, E35D, M36I, R41K, K55R, R57K, Q61N, L63P, A71V, I85V, I93LF
 48-10631063-30612DQ877316PINAV32I, M46I, I54IV, V82A, L90ML33F, F53L, G73GS, N83DL10I, I13V, I15V, K20R, M36I, R41K, Q61N, L63P, A71V, I72TF
 48-10081008-30625DQ877332PINAM46I, I50V, I54V, V82AL24I, L33FL10V, T12TN, I15V, E35D, M36I, R41K, R57K, Q61N, I62IV, L63P, A71V, I72TF
 48-10741074-30626DQ877334PINAV32I, M46I, I47V, I54V, V82A, L90LML24I, L33F, T74PSL10I, I13IV, I15IV, G16E, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63S, E65D, A71AV, V77I, L89M, Q92QK, I93LF
 48-10271027-30707DQ877408PINAV32I, M46I, I47V, I54V, V82AL24I, L33F, F53LL10V, I15V, K20R, E34V, E35D, M36I, R41K, Q61N, I62V, L63P, T74S, L89M, Q92KF
 48-11031103-30708DQ877410PINAM46L, I54V, L76V, V82A, L90ML33F, K43TL10I, I13V, I15V, G16E, K20M, E35H, M36L, R41K_K, K55R, R57K, Q61N, L63S, E65D, A71V, T74S, L89LM, I93LF
 48-12061206-30604DQ877750PINAM46L, I50V, I54V, V82AL24I, L33F, Q58EL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63Q, H69Y, L89MF
 48-12181218-30701DQ877756PINAM46I, I54V, V82A, L90ML33F, G73TL10V, T12S, I13V, K14T, I15V, K20T, E35D, M36I, P39T, R41K, R57K, Q61N, I62V, L63P, A71T, I72T, I93LF
 48-12711271-30923DQ877792PINAG48V, I54V, V82SL24I, L33F, Q58EL10I, I15V, G16E, K20R, E34Q, E35D, M36I, P39PT, R41K, R57K, I62V, L63T, E65D, I72T, L89MF
 48-26142614-30624DQ877904PINAM46L, I54V, V82AL33F, F53LL10V, T12I, I15V, G16E, L19V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, I85V, L89MF
 48-31113111-30725DQ878019PINAM46L, I54V, V82AL24I, L33FL10V, I15V, L19V, K20M, E35N, M36IL, R41K, R57K, Q61N, I62V, L63P, C67Y, G73V, T74SF
 48-32663266-30729DQ878171PINAM46I, I54V, V82AV11VI, L24I, L33F, L89VL10I, I15V, K20A, E35DN, M36L, N37Q, R41K, K55R, R57RK, D60E, Q61E, I62V, L63P, I64L, A71V, I72M, V77I, T91S, I93LF
 48-42864286-30910DQ878509PINAI54AV, V82F, L90ML33F, K43T, F53LL10IV, G16E, L19I, K20R, E35D, M36I, N37T, P39T, R41K, D60E, Q61E, I62V, L63P, I64V, H69Q, A71V, I93LF
 48-61786178-30731DQ878750PINAM46MI, G48GV, I50V, I54V, V82TL33FL10V, I15V, K20R, E35D, M36I, P39PQ, R41K, R57K, Q61N, L63P, T74S, L89M, I93ILF
 48-93499349-30923DQ877289PINAV32I, M46I, I47V, G48M, I54M, V82AL33F, F53LL10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I72T, T74S, L89IF
 48-91869186-30901DQ877291PINAM46L, I54V, V82AL24I, L33F, K43T, F53L, T74PL10I, I13V, I15V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I64L, A71V, I72T, L89I, I93LF
 48-90259025-30825DQ877501PINAM46I, I54S, V82AL33FL10I, I13V, I15V, K20M, E35N, M36I, N37D, R41K, K55R, R57K, Q61N, T74S, L89IF
 48-92509250-30908DQ877602PINAM46L, I54V, V82AV11VI, L24I, L33F, T74PL10I, I13V, G17E, L19I, K20R, E35D, M36I, R41K, R57K, Q61DN, I62V, L63T, E65D, I72T, L89MF
 48-90949094-30827DQ877653PINAV32I, M46I, I47V, I54V, V82AL24LI, L33F, Q58EL10I, I15V, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63PF
 48-91499149-30826DQ877714PINAM46L, I54V, V82AL24I, L33F, K43T, F53LR8P, L10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, L63P, K70R, L89LM, Q92KF
Santos (2006)118118PRAY275778SQV, IDV, RTV, APV, LPV287G48V, I50V, I54S, V82AL33F, Q58EL10I, I13V, I15V, G16E, K20R, E35D, M36I, N37D, Q61N, L63T, I85V, L89MF
Dumans (2009)RENA578RENA578FJ405042IDV, SQV, RTV, NFV, LPV335M46I, I54A, V82AL24I, L33F, Q58EL10I, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, I62V, L63A, L89MF
 RENA555RENA555FJ405127SQV, NFV, RTV, IDV, Unknown>191I54V, V82A, L90ML33F, K43T, F53L, T74PL10V, I13V, K14R, G16E, K20R, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, I62V, L63H, A71I, I72V, I93LF
 RES28_02RES28_02FJ405158IDV, NFV, RTV, APV139M46L, I54V, V82AL33FL10I, G17D, K20R, E35D, M36I, R41K, R57K, Q61N, L63V, E65D, L89MF
Sanabani (2010)81007BR_FPS810HM026459PINAD30N, I50L, V82AL33F, N88DL10V, I13V, I15V, K20R, E35D, M36L, R41K, K45Q, R57K, Q61N, L63P, I64L, A71V, I93LF
Aulicino (2011)ARK916CJARK916CJFJ525802PINAV82F, L90ML33FT12E, I13V, K14IV, I15V, K20Q, E35N, M36I, R41K, R57K, Q61N, I62IV, I64V, H69RF
 ARL589CJAARL589CJAFJ525811PINAM46L, I54V, L76V, V82F, L90ML33F, G73A, L89VL10V, I13V, K14R, I15V, G17E, K20T, E35N, M36I, R57K, Q61D, L63P, A71V, I93LF
 ARN156RJEARN156RJEFJ525852PINAD30N, M46I, I54V, V82AL24I, L33F, N83D, N88DL10I, K20R, E35N, M36I, N37D, R41K, K55R, R57K, Q61N, I62V, L63D, A71V, I72PT, T74SF
 ARN272RLDARN272RLDFJ525856PINAM46L, I54V, V82TL33F, N83DL10I, T12E, E35D, M36L, R41K, K55R, R57K, Q61N, L63P, I64M, K70T, A71V, I72T, Q92KF
 ARN567GMARN567GMFJ525862PINAI54M, V82M, L90MV11I, L33F, K43T, G73S, L89VL10I, I13V, K14R, I15V, G17E, K20T, E35N, M36I, R41K, R57K, Q61N, L63P, T74S, I93LF
Jones (2012)142709142709JN669620PINAM46I, I54V, V82A, I84V, L90ML33F, Q58QEL10I, I15V, G17D, K20T, E35D, M36I, R41RK, R57RK, D60E, Q61D, L63P, A71V, I93LF
 143095143095JN669636PINAM46L, I54V, V82AL33FL10V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, V77I, T91S, I93LF
 146046146046JN669668PINAM46L, I54L, V82A, L90ML33FL10I, T12EQ, I15V, G16E, K20R, E34V, E35D, M36I, P39S, R41K, K55R, R57K, Q61N, I62V, L63T, A71V, I72T, T74S, L89M, I93LF
 156594156594JN669867PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, K14R, Q18E, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63T, E65D, A71V, L89M, I93LF
 157415157415JN669882PINAI50V, I54V, V82AL33F, G73CL10I, I13V, K14R, I15V, Q18LM, K20R, E35D, M36I, R41K, K43Q, K45KR, R57RK, Q61N, L63P, I72IT, I93LF
 157709157709JN669896PINAM46I, I54V, L76V, V82AL33F, K43KTL10I, I15IV, K20R, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, I62V, L63T, H69Y, I72T, L89M, I93LF
 159810159810JN669966PINAI54S, V82A, L90ML33F, K43TL10I, I13V, I15V, G16E, L19I, K20R, E34R, E35D, M36I, N37T, R41K, R57K, Q61D, A71IL, I72R, V77I, I93LF
 163316163316JN670061PINAM46L, I54V, V82A, L90ML33F, G73SL10I, I15V, G16E, K20M, E35N, M36I, R41K, K55R, R57K, Q61N, A71I, I72T, I93LF
 164777164777JN670081PINAI54V, V82A, L90ML33F, G73SL10I, I15V, G16E, K20M, E35D, M36I, R41K, R57K, Q61N, A71T, I72RF
 166335166335JN670126PINAI54M, I84VL33FI15V, E34D, E35D, M36I, R41K, R57K, Q61N, V82IF
 167427167427JN670152PINAM46MI, I54V, V82A, L90LML33F, G73SL10I, I13V, K14R, I15V, Q18L, K20T, E34V, E35D, M36I, R41K, R57K, Q61D, I62V, L63P, I93LF
 167774167774JN670161PINAV32I, I47V, I54M, N88S, L90LML33F, G73S, L89VT12I, I13V, I15V, G16E, K20R, E35ED, M36I, R41K, R57K, Q61N, G68GE, A71IV, I72T, V77VEF
 169723169723JN670207PINAI54L, L90ML33F, Q58EL10LI, I15V, L19LI, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, I72IM, V75IF
 177288177288JN670432PINAM46I, I50V, I54A, V82A, L90ML33F, Q58E, L89VL10I, I13V, I15V, G16Q, K20R, E35N, M36I, P39Q, R41K, K55R, R57K, Q61N, L63P, A71V, I93ILF
 181732181732JN670583PINAM46L, I54V, V82AL24I, L33F, G73CL10I, E35D, M36L, N37ND, R41K, K55R, R57K, Q61N, L63P, Q92KF
 183035183035JN670635PINAI54V, V82A, L90ML33F, N88DL10I, I15V, K20R, E35D, M36I, N37ND, R41K, K45R, R57K, Q61N, L63P, A71V, I72T, I85V, I93LF
 183504183504JN670649PINAM46I, I54V, V82A, L90ML33F, K43KT, F53L, T74PL10V, I15V, K20M, E35N, M36L, N37ND, L38W, R41K, K55R, R57K, Q61N, I62V, L63P, H69R, A71V, I72V, I93LF
 184896184896JN670689PINAM46I, I54V, V82T, I84V, L90ML33F, Q58EL10V, I13V, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63P, A71V, I85V, L89M, I93LF
 188212188212JN670748PINAI54LL33FI15V, G16E, K20Q, E34A, E35D, M36I, P39S, R41K, R57K, D60E, Q61N, I62V, I72TF
 191048191048JN670808PINAM46I, I50V, I54V, V82AL33FL10V, K14KR, I15V, G16GE, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72V, T74S, L89MF
 192040192040JN670842PINAD30N, L90ML33F, N88DL10V, T12I, I13V, I15V, E35D, M36IL, N37D, K43Q, R57K, Q61N, L63T, E65D, A71V, I72V, I93LF
 193364193364JN670895PINAM46L, I54V, V82AL24LI, L33F, G73CL10I, I13V, I15V, K20R, E35D, M36L, N37E, R41K, K55R, R57K, Q61N, I62V, L63P, I72T, T74S, V77VI, I93LF
 193990193990JN670919PINAM46L, I54V, V82A, I84VL24I, L33FL10I, I13V, I15V, K20M, E35D, M36I, R57K, Q61N, L63P, A71V, I72T, I93LF
 196720196720JN671038PINAD30NL33F, N88DI15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63A, T74SF
 200121200121JN671191PINAM46I, I54V, V82T, I84VL33F, G73SL10V, I13V, K14R, I15V, Q18L, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62IV, L63P, A71AT, I72T, T74TI, I93LF
 203975203975JN671325PINAM46ML, I54V, V82A, L90ML33F, G73SL10I, I15V, K20T, E35N, M36I, N37DE, R41K, R57K, Q61N, L63P, A71V, I72R, I85VF
 204182204182JN671332PINAM46I, I50V, I54V, V82AL24I, L33FL10V, I15V, E35D, M36I, R41K, R57K, Q61N, L63P, C67CG, A71V, I72TF
 204754204754JN671350PINAM46I, I50V, I54V, V82AL33F, Q58EL10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, L89MF
 207575207575JN671439PINAM46MI, I50VL33FK14S, I15V, K20KT, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63P, T74A, I85IV, L89MF
Grossman (2014)2727 LPV, SQV257G48M, I54V, V82AL24I, L33F, F53LL10I, I15V, Q18E, K20R, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, L63P, I72V, V75IF