<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation I13V
Rx >= 1 PI
IncludeMixtures No
References 15
Patients 115
Isolates 116
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG8686_w25 NFV8  L10V, I13V, I15V, G16E, K20KR, E35D, M36I, R41K, R57K, L63T, E65D, I72IATV, L89MF
Apetrei (2003)AC_Pat4RO.00.IS.04AY333484IDV, SQV, NFV   L10V, T12S, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MF
 AC_Pat22RO.00.IS.22AY333460IDV, RTV, NFV I54V, V82A L10V, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MF
 AC_Pat33RO.00.IS.33AY333477IDV   L10V, I13V, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72V, L89MF
  RO.01.IS.33AY333478IDV, NFV   L10V, I13V, I15V, K20R, E35D, M36I, R41K, K45R, R57K, L63T, E65D, I72V, L89MF
 AC_Pat36RO.00.IS.36AY333461IDV, RTV, SQV, NFV M46L, I54V, V82A L10V, T12I, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, I62V, L63T, E65D, K70E, I72T, L89MF
Dumans (2004)242242AY390086NFV177D30N, M46IN88DL10V, I13V, R41K, R57K, D60E, Q61D, I64V, V77I, I85VF
Gomez-Carrillo (2004)9488394883AY365506PINA G73ST12TP, I13V, I15V, E35D, M36I, R41K, K43KN, R57KN, Q61N, L63P, V77I, I93LF
 100799100799AY365620PINAM46I, I54V, I84VN83DL10IV, I13V, I15V, E35D, M36I, N37DE, R41K, R57K, Q61N, L63S, I64VF
 103183103183AY365671PINAD30N, M46L, I54V, V82A, L90ML33F, N88DI13V, K20R, E35D, M36I, R41K, R57K, Q61N, L63H, A71V, T74S, I93LF
 103620103620AY365684PINAD30N, L90MN88DI13V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63D, A71T, I72TF
 104950104950AY365714PINAD30NN88DI13V, K20KR, E35D, M36I, R41K, Q61N, I62V, L63P, I64IM, I93ILF
 105988105988AY365741PINAI54V, L90M L10I, I13V, I15V, G16E, K20T, E35D, M36I, P39S, R41K, R57K, Q61N, L63P, A71T, I72TF
 106671106671AY365754PINAM46I, I50V, V82A, L90ML33F, K43TL10I, I13V, I15V, G16E, K20R, E35D, M36L, R41K, R57K, Q61N, L63S, E65D, A71V, T74S, I93LF
 109072109072AY365802PINAM46I, I84V, L90M L10I, I13V, I15V, Q18H, L19I, K20I, E35D, M36I, N37K, R41K, R57K, D60DE, Q61N, L63P, G68E, A71T, I72EF
 109590109590AY365824PINAD30NN83D, N88DL10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, I72R, L89MF
 109919109919AY365827PINAL90M I13V, I15V, G17D, K20T, E35D, M36I, R41K, R57K, Q61N, I62IV, L63H, T74S, I93LF
 114305114305AY365896PINAD30NQ58E, N88DL10I, I13V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63S, I72V, V77I, I93LF
 114347114347AY365900PINAN88S I13V, I15V, L19I, E35D, M36I, R41K, R57K, Q61N, L63P, I93LF
 115855115855AY365925PINAM46ML, I54AV, I84V, L90MV11I, L89VL10I, I13V, G17E, K20V, E35D, M36I, R41K, R57K, Q61N, L63P, A71I, I72R, V82I, Q92KF
 116065116065AY365927PINAI54V, V82A, L90ML33FI13V, I15V, K20M, E35N, M36I, R41K, R57K, Q61N, I62V, L63P, H69R, A71V, T74SF
de Sa Filho (2005)BREPM107BREPM107AY771588PINAI84V, L90M I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, A71VF
 BREPM275BREPM275AY771592PINAD30NL33F, N88DL10V, T12K, I13V, I15V, K20T, E35D, M36L, N37E, K55R, R57K, D60E, Q61N, L63S, L89MF
Non-B Workgroup (2005)PL23900101500 Unknown, LPV>58I54V, V82AL33F, N83DL10V, I13V, K20R, E35D, M36I, R41K, R57K, I62V, T74S, L89IF
 PL4840688662 APV104M46MI, I50IV, V82AL33FL10I, T12I, I13V, I15IV, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, G68E, I72R, L89MF
Rodrigues (2005)BR0169099AY643180IDV4  L10V, T12I, I13V, I15V, L19LI, E35D, M36I, R41K, R57K, Q61N, I72T, L89LMF
 BLF_Pat2BR02SP158AY643139IDV, SQV, RTV153  L10I, I13V, Q18Y, E35D, M36I, R41K, R57K, Q61N, C67Y, K70R, L89MF
 BLF_Pat5BR03SP147AY643162Unknown, IDV>256I54V, V82A L10I, I13V, I15V, G17E, K20I, E35D, M36I, R41K, R57K, Q61N, L63R, E65D, T74S, L89IF
 BLF_Pat9BR03SP182AY643166RTV, SQV, NFV319I54V, V82A, L90M L10I, I13V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71ATF
 BLF_Pat16BR03SP111AY643159SQV, IDV, NFV293D30NN88DL10I, I13V, I15V, K20R, E35D, M36V, N37NS, R41K, R57K, Q61N, I62IV, L63LP, E65D, A71I, I72TF
 BLF_Pat35BR03SP71AY643177IDV, NFV269I54V, L90M L10V, I13V, I15V, K20T, E35D, M36I, N37T, R41K, R57K, Q61N, A71T, T74S, L89IF
 BLF_Pat40BR02SP226AY643142NFV148N88S L10I, I13V, I15IV, K20T, E35D, M36I, R41K, R57K, Q61N, E65D, V77I, L89MF
 BLF_Pat41BR02SP138AY643137Unknown, NFV>11D30N, M46MLN88DL10V, I13V, I15V, K20R, E35D, M36I, N37NI, R41K, K45KR, R57K, Q61D, A71T, I72TF
Baxter (2006)48-10791079-30701DQ877262PINAL90MG73SL10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, T74S, I93LF
 48-10631063-30612DQ877316PINAV32I, M46I, I54IV, V82A, L90ML33F, F53L, G73GS, N83DL10I, I13V, I15V, K20R, M36I, R41K, Q61N, L63P, A71V, I72TF
 48-11031103-30708DQ877410PINAM46L, I54V, L76V, V82A, L90ML33F, K43TL10I, I13V, I15V, G16E, K20M, E35H, M36L, R41K_K, K55R, R57K, Q61N, L63S, E65D, A71V, T74S, L89LM, I93LF
 48-12181218-30701DQ877756PINAM46I, I54V, V82A, L90ML33F, G73TL10V, T12S, I13V, K14T, I15V, K20T, E35D, M36I, P39T, R41K, R57K, Q61N, I62V, L63P, A71T, I72T, I93LF
 48-62856285-30924DQ878833PINAI54V, V82T, I84V T4TS, L10V, I13V, I15V, Q18M, L19Q, K20R, E35D, M36I, N37D, R41K, Q61N, A71V, L89IF
 48-91869186-30901DQ877291PINAM46L, I54V, V82AL24I, L33F, K43T, F53L, T74PL10I, I13V, I15V, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I64L, A71V, I72T, L89I, I93LF
 48-90259025-30825DQ877501PINAM46I, I54S, V82AL33FL10I, I13V, I15V, K20M, E35N, M36I, N37D, R41K, K55R, R57K, Q61N, T74S, L89IF
 48-91969196-30903DQ877572PINAM46I, I50V, I54V, V82AL33I, L76M, N83DL10V, T12E, I13V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63P, I72T, T74S, L89IF
 48-93019301-30917DQ877586PINA  I13V, N37NS, R41K, L63PF
 48-92509250-30908DQ877602PINAM46L, I54V, V82AV11VI, L24I, L33F, T74PL10I, I13V, G17E, L19I, K20R, E35D, M36I, R41K, R57K, Q61DN, I62V, L63T, E65D, I72T, L89MF
Santos (2006)118118PRAY275778SQV, IDV, RTV, APV, LPV287G48V, I50V, I54S, V82AL33F, Q58EL10I, I13V, I15V, G16E, K20R, E35D, M36I, N37D, Q61N, L63T, I85V, L89MF
Rios (2007)CH37MR_CH37.1EF193927NFV D30N L10LV, T12TA, I13V, K14KR, I15IV, K20T, E35D, M36I, R41K, K45Q, R57K, Q61N, L63P, T74SF
von Wyl (2007)1091789954EF449996PINAD30N I13V, I15V, K20R, E35D, M36I, R41K, R57K, Q61D, I62V, L63I, I64M, I72V, L89MF
Cardoso (2009)3062BRGO3062FJ638432PINAI50L T12I, I13V, E35D, M36I, P39Q, R41K, R57K, Q61N, L63P, K70R, L89MF
 3082BRGO3082FJ638437PINA  T12I, I13V, E35D, M36I, R41K, R57K, Q61N, L63LP, L89MF
Dumans (2009)RENA251RENA251FJ405048NFV161N88S L10V, T12K, I13V, K14E, I15V, G16E, K20T, E35D, M36I, R41K, Q61N, E65R, L89MF
 RENA636RENA636FJ405049NFV243D30NN88DI13V, I15V, K20T, E35D, M36I, R41K, Q61D, L63P, T74SF
 RES327_03RES327_03FJ405050RTV, NFV100  I13V, E35D, M36I, R41K, R57K, D60E, Q61E, L63P, V77I, L89MF
 RENA555RENA555FJ405127SQV, NFV, RTV, IDV, Unknown>191I54V, V82A, L90ML33F, K43T, F53L, T74PL10V, I13V, K14R, G16E, K20R, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, I62V, L63H, A71I, I72V, I93LF
 RENA463RENA463FJ405129NFV213L90M I13V, K20T, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, T74S, L89M, I93ILF
 RENA456RENA456FJ405145NFV152  L10V, I13V, I15V, K20R, M36I, R41K, R57K, Q61N, L89MF
 RENA511RENA511FJ405146RTV, IDV, Unknown>61N88S L10V, I13V, I15V, K20R, E35D, M36I, N37T, R41K, K45R, R57K, Q61N, I62V, E65D, I72V, L89MF
 RENA410RENA410FJ405149NFV, Unknown>39  I13V, I15V, E35D, M36I, R41K, R57K, Q61N, L89MF
 RENA651RENA651FJ405167RTV, IDV300M46L, I54V, V82A L10V, T12I, I13V, I15V, G16E, K20R, N37S, R57K, Q61N, L63S, E65D, L89MF
 RENA140RENA140FJ405170NFV91D30NN88DL10I, I13V, I15V, E35D, M36I, R41K, R57K, Q61D, L63C, K70R, I72T, L89MF
 RENA390RENA390FJ405175NFV205L90M I13V, I15V, K20R, E35D, M36I, N37E, P39Q, R41K, R57K, Q61N, I62V, L63P, T74S, L89I, I93LF
Sanabani (2010)81007BR_FPS810HM026459PINAD30N, I50L, V82AL33F, N88DL10V, I13V, I15V, K20R, E35D, M36L, R41K, K45Q, R57K, Q61N, L63P, I64L, A71V, I93LF
Jones (2012)127812127812JN669444PINAL90M L10V, I13V, I15V, K20R, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, I64V, H69YF
 130315130315JN669484PINAL90M L10I, I13V, I15V, E35D, M36I, R41K, R57K, Q61N, L89IF
 130424130424JN669487PINAD30NN88DT12I, I13V, I15V, K20T, E35D, M36I, R41K, K45R, K55R, R57K, Q61N, G68E, A71VF
 147164147164JN669689PINA  L5LF, I13V, I15V, M36I, L38LS, R41K, R57K, Q61N, L63QF
 148707148707JN669719PINAI54V, V82A, L90ML33I, F53L, G73S, L89VL10I, I13V, K20R, E35D, M36I, K43E, K55R, R57K, D60K, Q61N, I62V, L63P, A71I, I72E, C95LF
 151017151017JN669756PINAL90M L10V, I13V, I15V, K20V, E35N, M36I, R41K, R57K, Q61N, I62IV, L63LP, A71T, I72T, T74SF
 151205151205JN669757PINAD30N, L90ML33LF, N88DI13V, I15V, K20R, E35D, M36I, R41K, R57K, Q61D, A71AT, I93LF
 151726151726JN669766PINAI54A, I84V, L90MV11I, G73GDNS, L89VL10I, T12TP, I13V, G17E, K20V, E35D, M36I, N37NDEK, R41K, R57K, Q61N, L63P, A71I, I72R, V82I, Q92KF
 154303154303JN669816PINAD30N, L90MN88DI13V, I15V, K20T, E35N, M36I, R41K, K43R, K55N, R57K, Q61N, L63P, A71V, Q92KF
 155976155976JN669848PINAL90M T12M, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, I72T, V82I, L89I, I93LF
 156594156594JN669867PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, K14R, Q18E, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, L63T, E65D, A71V, L89M, I93LF
 157313157313JN669881PINA  T12V, I13V, I15V, E35D, M36I, N37D, R41K, R57K, Q61N, I64V, I72TF
 157415157415JN669882PINAI50V, I54V, V82AL33F, G73CL10I, I13V, K14R, I15V, Q18LM, K20R, E35D, M36I, R41K, K43Q, K45KR, R57RK, Q61N, L63P, I72IT, I93LF
 157506157506JN669888PINAI54V, V82A, L90M L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, I64V, A71V, T74S, I93LF
 159284159284JN669948PINA  L10V, I13V, I15V, G16E, E35D, R41K, R57K, D60E, Q61N, L63S, K70KRF
 159501159501JN669954PINAI54V, V82A, L90MK43T, F53LL10I, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, A71L, T74S, I93LF
 159810159810JN669966PINAI54S, V82A, L90ML33F, K43TL10I, I13V, I15V, G16E, L19I, K20R, E34R, E35D, M36I, N37T, R41K, R57K, Q61D, A71IL, I72R, V77I, I93LF
 160560160560JN669981PINAM46I, I54V, L76V, L90ML89VL10V, I13V, I15V, K20T, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, T74S, V82I, Q92KF
 162845162845JN670050PINA  T12I, I13V, I15V, E35D, M36I, R41K, R57K, Q61N, I62IV, L63AF
 167427167427JN670152PINAM46MI, I54V, V82A, L90LML33F, G73SL10I, I13V, K14R, I15V, Q18L, K20T, E34V, E35D, M36I, R41K, R57K, Q61D, I62V, L63P, I93LF
 167675167675JN670157PINA  I13V, K14E, I15V, E35D, M36I, R41K, R57K, Q61NF
 167774167774JN670161PINAV32I, I47V, I54M, N88S, L90LML33F, G73S, L89VT12I, I13V, I15V, G16E, K20R, E35ED, M36I, R41K, R57K, Q61N, G68GE, A71IV, I72T, V77VEF
 170718170718JN670231PINAD30NN88DL10I, I13V, I15V, E35D, M36I, N37E, R41RK, R57K, Q61N, L63P, I93LF
 170913170913JN670240PINAN88NS L10I, I13V, I15V, K20R, E35D, M36I, R41K, R57K, Q61D, I62V, L63S, I93LF
 171070171070JN670244PINAI54V, V82A, L90MV11VI, L33I, F53L, G73S, L89LVL10IV, I13V, K20R, E35D, M36I, R41RK, K43KE, K55R, R57K, D60EK, Q61N, I62IV, L63P, A71IV, I72EV, C95LF
 172771172771JN670300PINAI54A, I84V L10I, I13V, I15V, L19I, K20R, E34N, E35D, M36I, R41K, R57K, Q61N, L63P, A71T, I72T, I93LF
 175336175336JN670353PINAD30NN88DI13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63V, I64L, I72E, T74S, L89M, I93LF
 175339175339JN670354PINAL90ML33IL10V, I13V, K14R, K20R, E35D, M36I, N37D, R57K, Q61N, I62V, L63P, T74S, Q92K, I93LF
 176249176249JN670391PINAD30NN88DL10LI, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K43I, R57K, D60N, Q61N, L63A, V75VIF
 176698176698JN670410PINAM46I, I54V, L76V, V82F L10I, T12I, I13V, I15V, K20I, E35N, M36I, N37D, R41K, R57K, Q61N, L63P, I64VF
 177288177288JN670432PINAM46I, I50V, I54A, V82A, L90ML33F, Q58E, L89VL10I, I13V, I15V, G16Q, K20R, E35N, M36I, P39Q, R41K, K55R, R57K, Q61N, L63P, A71V, I93ILF
 177489177489JN670445PINAI54V, V82T, I84VL33IL10V, I13V, I15V, K20R, E34ED, E35D, M36I, N37D, R41K, R57K, Q61N, I62IV, L63P, I64V, A71V, T74S, P79A, I85V, I93LF
 177830177830JN670459PINAL90M I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, I72R, L89MF
 178103178103JN670470PINA  L10V, T12K, I13V, G16E, L19LP, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, L63V, E65ED, I72T, L89MF
 179798179798JN670526PINAM46I, I54V, V82A, L90MG73SL10I, I13V, I15V, K20I, L33L_L, E35N, M36I, R41K, R57K, Q61N, L63P, A71V, I93LF
 182330182330JN670608PINAI54V L10I, I13V, I15V, K20R, E35D, M36I, R41K, Q61N, I62T, L63I, I64V, V82I, I93LF
 184012184012JN670670PINAM46MI, I50IV, I54IV, V82VA L10V, T12TIM, I13V, I15V, K20KR, E35D, M36I, R41K, R57K, Q61N, L63LP, H69HY, I72IT, T74TS, L89LM, I93ILF
 184561184561JN670682PINA  I13V, I15V, E35D, M36I, R41K, R57K, Q61N, L63P, V77I, I93LF
 184896184896JN670689PINAM46I, I54V, V82T, I84V, L90ML33F, Q58EL10V, I13V, I15V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61N, L63P, A71V, I85V, L89M, I93LF
 186960186960JN670725PINA  I13V, I15V, G16E, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72TF
 190411190411JN670797PINAI54V, N88SL33II13V, I15V, E35D, M36I, N37D, R41K, R57K, D60E, Q61N, I62VF
 192040192040JN670842PINAD30N, L90ML33F, N88DL10V, T12I, I13V, I15V, E35D, M36IL, N37D, K43Q, R57K, Q61N, L63T, E65D, A71V, I72V, I93LF
 192640192640JN670859PINAL90M L10I, I13V, I15V, K20R, E35D, M36I, N37NS, R41K, R57K, Q61N, L63P, G68D, I93LF
 193107193107JN670881PINAI54V, V82T L10LI, T12I, I13V, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63DE, I64V, H69Y, A71V, I72TF
 193364193364JN670895PINAM46L, I54V, V82AL24LI, L33F, G73CL10I, I13V, I15V, K20R, E35D, M36L, N37E, R41K, K55R, R57K, Q61N, I62V, L63P, I72T, T74S, V77VI, I93LF
 193990193990JN670919PINAM46L, I54V, V82A, I84VL24I, L33FL10I, I13V, I15V, K20M, E35D, M36I, R57K, Q61N, L63P, A71V, I72T, I93LF
 196419196419JN671023PINAD30NN88DL10I, I13V, I15V, K20KR, E35D, M36V, R41K, R57K, Q61DN, L63AV, I93LF
 197833197833JN671086PINAL90M L10V, I13V, I15V, K20T, E35DN, M36I, P39Q, R57K, D60E, Q61D, L63P, A71AV, V77I, I93LF
 197841197841JN671088PINAL90LM L10I, I13V, I15V, K20KM, E35D, M36I, R41K, R57K, Q61N, V82VI, L89IMF
 198184198184JN671110PINAD30NN88DI13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63S, A71T, I72M, Q92RF
 199010199010JN671147PINAD30N, L90MN88DI13V, I15V, K20R, E35D, M36I, N37NT, R41K, R57K, Q61N, L63P, I93LF
 199593199593JN671177PINA  L10V, T12E, I13V, K14R, I15V, G16E, K20M, E35D, M36I, R41K, R57RK, Q61N, I72TF
 200121200121JN671191PINAM46I, I54V, V82T, I84VL33F, G73SL10V, I13V, K14R, I15V, Q18L, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62IV, L63P, A71AT, I72T, T74TI, I93LF
 201335201335JN671219PINAI54V, V82T L10LV, T12I, I13V, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63D, I64V, H69Y, A71V, I72TF
 202350202350JN671269PINAM46L, I54A, V82AL89VL10I, T12I, I13V, I15V, G16A, L19P, K20L, E35D, M36I, N37ND, R41RK, K45KR, K55KR, R57K, Q61D, A71V, I72TF
 206020206020JN671383PINAI54V, V82TL33I, K43TI13V, I15V, K20R, E35D, M36I, N37D, R57K, Q61D, L63C, T74A, L89MF

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