<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L10I
Rx PI-naive
IncludeMixtures No
References 49
Patients 93
Isolates 94
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Op de Coul (2000)CE97R102CE97R102AF204050None   L10I, T12I, I13V, I15V, G16E, E35D, M36I, R41K, R57K, I62V, L63T, E65D, L89MF
Vergne (2000)LVMP652LVMP652AJ286973None   L10I, E35D, M36I, R41K, K45R, I62V, L63P, H69Q, L89MF
 LVMP1035LVMP1035AJ286977None   L10I, I15V, K20R, E35D, M36I, R41K, K45R, I62V, H69Q, L89M, I93LF
Kijak (2001)ARG01ARG01PRAF328562None   L10I, I13V, K14R, I15V, E35D, M36I, N37D, R41K, R57K, I62V, L63LP, I93LF
 ARG20ARG20PRAF328579None   L10I, K14R, I15V, E35D, M36I, R41K, R57K, Q61N, L63T, I93LF
 ARG35ARG35PRAF328593None   L10I, K14KR, I15IV, L19Q, E35D, M36I, R41K, R57K, Q61N, I93LF
Servais (2001)JS97287JS97287AJ012427None   L10I, T12N, I15V, K20M, E35D, M36I, P39Q, R41K, R57K, Q61N, L63I, I72T, L89M, I93LF
Brindeiro (2002)TVGG18TVGG18AY145826None   L10I, I15V, E35D, M36I, R41K, R57K, D60E, Q61D, L63T, I93LF
Gibb (2002)DMG3232_w-22 None   L10I, T12I, I15V, G16E, E35D, M36I, R41RK, R57K, Q61N, L63T, G68GE, I72V, I93LF
Thomson (2002)A32989A32989AF408630None   L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63V, E65D, I93LF
 A32878A32878AF408632None   L10I, I15V, E35D, M36I, N37D, R41K, R57K, I62V, I93LF
Brindeiro (2003)BRNE270BRNE270AY213340None   L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L89M, C95SF
 BRP2146BRP2146AY213449None   L10I, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, E65D, V77I, L89M, I93LF
 BRP2095BRP2095AY213356None   L10I, E35D, M36I, R41K, R57K, Q61N, L63CF
Njouom (2003)29pol29polAY204321None   L10I, I13IV, K20R, E35D, M36I, R41K, L63PT, E65ED, H69Q, L89MF
Shafer (2003)A384_40794079aEF549324None   L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, L89MF
Soares (2003)BRRJ860BRRJ860AF527352None   L10I, I15V, E35D, M36I, R41K, L63P, E65D, I72V, C95SF
Espinosa (2004)5757AY140150None   L10I, K14KR, I15V, E35D, M36I, R41K, R57K, Q61N, L63V, E65D, C67DG, I72T, V82I, L89M, T96TNF
Gulick (2004)RG5RG5w0 None  V11VIL10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63S, I72T, V77I, I93LF
Konings (2004)KF_Pat1601CM5149AY359698None   L10I, K20R, E35D, M36I, P39Q, R41K, K45R, L63P, H69Q, I72V, V77I, L89MF
Machado (2004)cs272cs272AY569835None   L10I, E35D, M36I, R41K, R57K, D60E, Q61D, V77IF
 N33N33AY569869None   L10I, E35D, M36I, N37D, R41K, D60E, Q61N, L63P, K70R, I72TF
 cs159cs159AY569830None   L10I, I15V, G17E, L19I, N37S, R57K, Q61N, L63C, E65D, I93LF
Non-B Workgroup (2005)BR40BR40AY900890None   L10I, K14R, E35D, M36I, P39Q, R41K, R57K, Q61N, L89MF
Vinoles (2005)01UYTRA102001U_1020AY781128None   L10I, I15V, E35D, M36I, R41K, R57K, Q61N, C67DF
de Sa Filho (2006)BREPM11948BREPM11948DQ085871None   L10I, E35D, M36I, R41K, R57K, Q61N, L63C, C67D, T74S, V77I, L89MF
 BREPM12817BREPM12817DQ085874None   L10I, I13V, G16E, L19P, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72TF
Laurent (2006)CK2-7602CM-76AM279447None   L10I, I13V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, I62V, L63S, H69Q, L89MF
Petroni (2006)AP_ARRP005AP_ARRP005DQ206648None   L10I, I15V, M36I, N37G, P39S, R41K, R57K, Q61D, L63D, A71T, I72T, I93LF
 AP_ARRP028AP_ARRP028DQ206661None   L10I, I15V, G17D, E35D, M36I, R41K, R57K, Q61N, L63A, K70KR, I93LF
 AP_ARRP038AP_ARRP038DQ345495None   L10I, I13V, G16E, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72V, I93VF
 AP_ARRP044AP_ARRP044DQ345497None   L10I, T12K, K14R, I15V, G17E, M36I, R41K, R57K, Q61N, L63C, C67S, K70R, I93LF
Vessiere (2006)AV_M2826NAV_M2826NDQ297242None   L10I, I13V, I15V, E35D, M36I, R41K, H69Q, L89MF
Vidal (2006)NV_KTB04102.KTB041AM041018None   L10I, I15V, E35D, M36I, P39T, R41K, Q61N, L63T, C67Y, L89MF
Dilernia (2007)F035F035EF120096None   L10I, T12E, I15V, L19I, E35D, M36I, R41K, R57K, D60E, Q61D, L63T, I93LF
 F055F055EF120109None   L10I, E35D, M36I, R41K, R57K, Q61N, L63V, C67S, H69QF
 F067F067EF120117None   L10I, I15V, E35D, M36I, R41K, R57K, Q61N, I93LF
 F148F148EF120146None   L10I, I13V, G16E, E35D, M36I, R41K, R57K, Q61NF
 F191F191EF120166None   L10I, G17GE, E35D, M36I, R57K, Q61N, L63ST, E65ED, I93LF
 F196F196EF120167None   L10I, I15L, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, I93LF
 F200F200EF120170None   L10I, I15V, K20KR, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, C67D, I72TF
 F213F213EF120177None   L10I, T12I, I13V, I15V, K20R, M36I, R41K, R57K, Q61N, L63P, I93LF
 F223F223EF120182None   L10I, T12P, K14R, I15IV, Q18L, E35D, M36I, N37D, R41K, R57K, Q61N, C67D, I72V, I93LF
 F325F325EF120231None   L10I, T12K, I15V, E35D, M36I, R41K, R57K, D60E, Q61D, L63T, C67D, I93ILF
 N31N31EF120290None   L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63C, K70KE, I93LF
 N33N33EF120292None   L10I, I15V, E35D, M36I, N37D, R41K, R57K, Q61N, I93LF
 F097F097EF120352None   L10I, E35D, M36I, R41K, Q61KN, L63PT, I72E, I93LF
Paraschiv (2007)21522152_2004JQ082992None   L10I, T12I, I13A, G16E, A22V, E35D, M36I, R41K, R57RK, L63T, L89I, I93LF
 49834983_2004JQ083004None   L10I, T12I, I13V, I15V, E35D, M36I, R41K, R57K, I62V, L63A, L89MF
Rios (2007)CH69MR_CH69EF193963None   L10I, I15V, E35D, M36I, N37E, P39Q, R41K, R57K, D60E, Q61N, I93LF
Derache (2008)BKO-891BKO-891EU330653None   L10I, I15V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, L63T, H69Q, L89MF
Lloyd (2008)CR07503HN_CR075EU312668None   L10I, K20R, E35D, M36I, R41K, I62V, L63S, H69Q, K70R, A71AV, I72IT, L89MF
Ndembi (2008)CMYD-6604CMYD-66DQ990430None   L10I, I15V, K20R, E35D, M36I, R41K, L63C, E65D, H69Q, L89MF
Bartolo (2009)HDC24001AOHDC240EU068232None   L10I, I13V, G16E, E35D, M36I, P39Q, R41K, R57K, I62V, L63V, E65D, T74S, L89MF
Cuevas (2009)X2524_1X2524_1GU326121None   L10I, I13V, I15V, E35D, M36I, R41K, R57K, Q61N, C67D, I72VF
 X2572_1X2572_1GU326140None   L10I, I13V, I15V, E35D, M36I, R41K, R57K, Q61N, C67D, I72VF
Hawkins (2009)Q242ZZQ242FJ931229None   L10I, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69Q, L89M, I93LF
Vercauteren (2009)pt12225860789008GQ399802None   L10I, K14KR, I15V, L19I, E35D, M36I, P39Q, R41K, R57K, D60DE, Q61DN, I93LF
 pt11796113897450GQ399845None   L10I, T12I, I13V, G16E, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, C67G, G68E, I72R, L89MF
 pt66wONy3cv3wrGQ400958None   L10I, I13IV, L19Q, E35D, M36I, N37NS, R41K, R57K, I62V, L63IT, E65D, T74S, L89MF
Djoko (2010)GQ01908GQ019FN557307None  L33IL10I, I13V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, L63T, E65D, H69Q, L89MF
 GQ32308GQ323FN557308None   P1PS, L10I, I13V, G16E, K20R, E35D, M36I, R41K, K45R, I62V, L63T, E65D, H69Q, L89MF
Ferreira (2010)P31DIP31GQ862307None   L10I, I13V, E35D, M36I, P39Q, R41K, R57K, Q61N, L63S, K70R, T80Q, L89MF
 P52DIP52GQ862309None   L10I, K14R, I15V, E35D, M36I, R41K, R57K, Q61N, L63T, I72M, Q92KF
 p053Dip053GQ862341None   L10I, K14R, I15V, E35D, M36I, R41K, L63P, H69Q, K70T, I93LF
Soares (2010)CM04_097CM04_097GU366147None   L10I, K20R, M36I, R57K, D60E, I62L, L63P, H69QF
Yebra (2010)40134007SP401340FJ481662None   L10I, E35D, M36I, R41K, R57K, Q61N, L63S, C67S, H69Q, V77VIF
Aghokeng (2011)HJ1632HJ1632JN639525None   L10I, I13V, I15V, K20R, E35D, M36L, I62V, L63V, I64M, H69Q, L89MF
Aghokeng (2011)SK4006-PISK4006-PIHQ864361None   L10I, I13IV, I15V, L19I, K20R, E35D, M36I, R41K, I62V, L63AFSV, H69Q, I72IGRV, L89MF
Aulicino (2011)128-A227128-A227HQ158203None   L10I, T12S, K14R, I15V, E35D, M36I, R41K, R57K, D60E, Q61N, L63T, I93LF
 3056-E2743056-E274HQ158219None   L10I, E35D, M36I, R41K, R57K, Q61N, C67D, I93LF
 3307-G713307-G71HQ158225None   L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, P79S, I93LF
 3555-G7103555-G710HQ158248None   L10I, I13V, I15V, G16E, M36I, N37S, P39S, R41K, R57K, Q61N, I72T, L89MF
 495-B680495-B680HQ158253None   L10I, K14R, I15V, G17E, E35D, M36I, R41K, R57K, Q61N, I93LF
 125-137125-137HQ158262None   L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I93LF
El Annaz (2011)699699HQ393242None  Q58EL10I, K14T, I15V, L19Q, K20R, E35D, M36I, R57K, L63V, H69Q, L89MF
Ferreira (2011)BRMT2526BRMT2526HQ638704None   L10I, Q18L, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, L89M, I93LF
Florea (2011)1103_20071103_2007JQ083021None   L10I, K14R, I15V, E35D, M36I, R41K, R57K, L63T, E65D, I72T, I93L, T96TIF
 1969_20071969_2007JQ083040None   L10I, I15V, G17E, K20R, E35D, M36I, R41K, R57K, I62V, L63T, E65D, I72IV, L89M, I93LF
Fokam (2011)CIRCB-11643CIRCB-11643JQ796117None   L10I, I13IV, K14R, K20R, E35D, M36I, R41K, K45R, L63T, H69Q, L89MF
 CIRCB-10183CIRCB-10183JQ796165None   L10I, E35D, M36I, R57RK, I62V, L63AP, I64L, H69Q, L89MF
da Silveira (2012)BRMS33BRMS33JF342287None   L10I, I15V, E35D, M36I, R41K, R57K, Q61S, T74A, L89MF
Alencar (2013)RJ2-0023RJ2-0023JQ237950None   L10I, K14R, I15V, G17E, E35D, M36I, R41K, R57K, Q61N, E65D, A71T, I72T, L89MF
 RJ2-0046RJ2-0046JQ238061None   L10I, T12E, I15V, E35DN, M36I, R41K, Q61N, L63S, C67E, K70R, I72T, L89MF
 PE2-0059PE2-0059JQ238129None   L10I, I15V, E35D, M36I, R57K, Q61N, C67D, I72T, L89MF
 PE2-090PE2-090JQ238166None   L10I, I13V, K14R, E35D, M36I, R41K, R57K, Q61D, H69Q, L89MF
 PE2-0086PE2-0086JQ238175None   L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63S, L89M, I93LF
Billong (2013)MR091MR091KF192255None   L10I, I15V, Q18K, E35D, M36I, N37DE, R41K, W42WL, R57K, Q61QP, L63P, C67Y, H69Q, K70RF
Ferreira (2013)BR09SP73BR09SP73HM534056None   L10I, T12M, G16E, E35D, P39S, R41K, R57K, D60E, Q61N, L63T, E65D, K70KR, I72V, V77I, L89MF
 BR09SP191BR09SP191HM534109None   I3V, L10I, K14R, I15V, G17E, E35D, M36I, R41K, R57K, Q61N, L63C, I72V, V77VI, I93LF
 BR09SP363BR09SP363HM534189None   L10I, T12R, I13V, L19V, E35D, M36I, R41K, R57K, Q61N, L63V, L89MF
Frentz (2013)EHR-15157EHR-15157JX299793None   L10I, I15V, G17E, K20R, E35D, M36I, R41K, R57K, I62V, L63T, E65D, I72IV, L89M, I93LF
 EHR-46646EHR-46646JX300318None   L10I, K14R, I15V, E35D, M36I, R41K, R57K, L63T, E65D, I72T, I93L, T96TIF
Temereanca (2013)SR45SR45JX966521None   L10I, I13V, K14R, I15V, G17E, K20R, E35D, M36I, N37D, R41K, R57K, L63T, E65D, A71G, I72T, L89MF