<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype F
Gene PR
Mutation L10I
Rx PI-naive
IncludeMixtures No
References 53
Patients 84
Isolates 84
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Op de Coul (2000)CE97R102CE97R102AF204050None   L10I, T12I, I13V, I15V, G16E, E35D, M36I, R41K, R57K, I62V, L63T, E65D, L89MF
Vergne (2000)LVMP652LVMP652AJ286973None   L10I, E35D, M36I, R41K, K45R, I62V, L63P, H69Q, L89MF
 LVMP1035LVMP1035AJ286977None   L10I, I15V, K20R, E35D, M36I, R41K, K45R, I62V, H69Q, L89M, I93LF
Servais (2001)JS97287JS97287AJ012427None   L10I, T12N, I15V, K20M, E35D, M36I, P39Q, R41K, R57K, Q61N, L63I, I72T, L89M, I93LF
Brindeiro (2003)BRNE270BRNE270AY213340None   L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L89M, C95SF
 BRP2146BRP2146AY213449None   L10I, E35D, M36I, R41K, K43R, R57K, Q61N, L63P, E65D, V77I, L89M, I93LF
Njouom (2003)29pol29polAY204321None   L10I, I13IV, K20R, E35D, M36I, R41K, L63PT, E65ED, H69Q, L89MF
Shafer (2003)A384_40794079aEF549324None   L10I, I15V, E35D, M36I, R41K, R57K, Q61N, L63A, L89MF
Konings (2004)KF_Pat1601CM5149AY359698None   L10I, K20R, E35D, M36I, P39Q, R41K, K45R, L63P, H69Q, I72V, V77I, L89MF
Non-B Workgroup (2005)BR40BR40AY900890None   L10I, K14R, E35D, M36I, P39Q, R41K, R57K, Q61N, L89MF
de Sa Filho (2006)BREPM11948BREPM11948DQ085871None   L10I, E35D, M36I, R41K, R57K, Q61N, L63C, C67D, T74S, V77I, L89MF
 BREPM12817BREPM12817DQ085874None   L10I, I13V, G16E, L19P, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72TF
Laurent (2006)CK2-7602CM-76AM279447None   L10I, I13V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, I62V, L63S, H69Q, L89MF
Niama (2006)CHU51CHU51FM164921None  V11IL10I, I13V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, I62V, L63T, C67Y, H69Q, L89MF
Petroni (2006)AP_ARRP044AP_ARRP044DQ345497None   L10I, T12K, K14R, I15V, G17E, M36I, R41K, R57K, Q61N, L63C, C67S, K70R, I93LF
Vessiere (2006)AV_M2826NAV_M2826NDQ297242None   L10I, I13V, I15V, E35D, M36I, R41K, H69Q, L89MF
Liu (2007)fj52fj52EF432685None   L10I, G16E, M36I, R41K, K43R, R57K, Q61D, A71T, I72R, I93LF
Paraschiv (2007)21522152_2004JQ082992None   L10I, T12I, I13A, G16E, A22V, E35D, M36I, R41K, R57RK, L63T, L89I, I93LF
 49834983_2004JQ083004None   L10I, T12I, I13V, I15V, E35D, M36I, R41K, R57K, I62V, L63A, L89MF
Derache (2008)BKO-891BKO-891EU330653None   L10I, I15V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, L63T, H69Q, L89MF
Lloyd (2008)CR07503HN_CR075EU312668None   L10I, K20R, E35D, M36I, R41K, I62V, L63S, H69Q, K70R, A71AV, I72IT, L89MF
Ndembi (2008)CMYD-6604CMYD-66DQ990430None   L10I, I15V, K20R, E35D, M36I, R41K, L63C, E65D, H69Q, L89MF
Bartolo (2009)HDC24001AOHDC240EU068232None   L10I, I13V, G16E, E35D, M36I, P39Q, R41K, R57K, I62V, L63V, E65D, T74S, L89MF
Hawkins (2009)Q242ZZQ242FJ931229None   L10I, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69Q, L89M, I93LF
Vercauteren (2009)pt11796113897450GQ399845None   L10I, T12I, I13V, G16E, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, C67G, G68E, I72R, L89MF
 pt66wONy3cv3wrGQ400958None   L10I, I13IV, L19Q, E35D, M36I, N37NS, R41K, R57K, I62V, L63IT, E65D, T74S, L89MF
Djoko (2010)GQ32308GQ323FN557308None   P1PS, L10I, I13V, G16E, K20R, E35D, M36I, R41K, K45R, I62V, L63T, E65D, H69Q, L89MF
Ferreira (2010)P31DIP31GQ862307None   L10I, I13V, E35D, M36I, P39Q, R41K, R57K, Q61N, L63S, K70R, T80Q, L89MF
Soares (2010)CM04_097CM04_097GU366147None   L10I, K20R, M36I, R57K, D60E, I62L, L63P, H69QF
Yebra (2010)40134007SP401340FJ481662None   L10I, E35D, M36I, R41K, R57K, Q61N, L63S, C67S, H69Q, V77VIF
Aghokeng (2011)HJ1632HJ1632JN639525None   L10I, I13V, I15V, K20R, E35D, M36L, I62V, L63V, I64M, H69Q, L89MF
Aghokeng (2011)SK4006-PISK4006-PIHQ864361None   L10I, I13IV, I15V, L19I, K20R, E35D, M36I, R41K, I62V, L63AFSV, H69Q, I72IGRV, L89MF
Aulicino (2011)3555-G7103555-G710HQ158248None   L10I, I13V, I15V, G16E, M36I, N37S, P39S, R41K, R57K, Q61N, I72T, L89MF
Charpentier (2011)CR-4CR-4FJ688211None   L10I, I15V, K20R, E35D, M36I, R41K, I62V, L63S, C67Y, H69Q, L89MF
Ferreira (2011)BRMT2526BRMT2526HQ638704None   L10I, Q18L, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, L89M, I93LF
Florea (2011)2142_20072142_2007JQ083042None   L10I, T12AE, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V77I, L89M, I93LF
 3016_20073016_2007JQ083050None   L10I, G16E, L19LI, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89LMF
Fokam (2011)CIRCB-11643CIRCB-11643JQ796117None   L10I, I13IV, K14R, K20R, E35D, M36I, R41K, K45R, L63T, H69Q, L89MF
 CIRCB-10183CIRCB-10183JQ796165None   L10I, E35D, M36I, R57RK, I62V, L63AP, I64L, H69Q, L89MF
Kousiappa (2011)CY191CY191JF683744None   L10I, T12K, I15V, L19I, E35D, M36I, R41K, K43R, R57K, L63V, E65DF
Santos (2011)J352J352_PR_RTJN010735None   L10I, M36I, R41K, I62V, L89MF
da Silveira (2012)BRMS33BRMS33JF342287None   L10I, I15V, E35D, M36I, R41K, R57K, Q61S, T74A, L89MF
Gaspareto (2012)CLPG59CLPG59PTHM752181None   L10I, T12I, I13V, G16E, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, L89MF
Alencar (2013)RJ2-0023RJ2-0023JQ237950None   L10I, K14R, I15V, G17E, E35D, M36I, R41K, R57K, Q61N, E65D, A71T, I72T, L89MF
 RJ2-0046RJ2-0046JQ238061None   L10I, T12E, I15V, E35DN, M36I, R41K, Q61N, L63S, C67E, K70R, I72T, L89MF
 PE2-0059PE2-0059JQ238129None   L10I, I15V, E35D, M36I, R57K, Q61N, C67D, I72T, L89MF
 PE2-090PE2-090JQ238166None   L10I, I13V, K14R, E35D, M36I, R41K, R57K, Q61D, H69Q, L89MF
 PE2-0086PE2-0086JQ238175None   L10I, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63S, L89M, I93LF
Ferreira (2013)BR09SP73BR09SP73HM534056None   L10I, T12M, G16E, E35D, P39S, R41K, R57K, D60E, Q61N, L63T, E65D, K70KR, I72V, V77I, L89MF
 BR09SP191BR09SP191HM534109None   I3V, L10I, K14R, I15V, G17E, E35D, M36I, R41K, R57K, Q61N, L63C, I72V, V77VI, I93LF
 BR09SP363BR09SP363HM534189None   L10I, T12R, I13V, L19V, E35D, M36I, R41K, R57K, Q61N, L63V, L89MF
Frentz (2013)EHR-27715EHR-27715JX300019None   L10I, T12AE, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V77I, L89M, I93LF
 EHR-81275EHR-81275JX300925None   L10I, G16E, L19LI, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89LMF
Temereanca (2013)SR39SR39JX966514None   L10I, I13V, I15V, G16E, E35D, M36I, P39T, R41K, R57K, L63T, E65D, I72T, L89MF
 SR45SR45JX966521None   L10I, I13V, K14R, I15V, G17E, K20R, E35D, M36I, N37D, R41K, R57K, L63T, E65D, A71G, I72T, L89MF
 SR6SR6JX966526None   L10I, T12K, I13V, I15V, K20I, E35D, M36I, R41K, R57K, L63T, E65D, I72V, T74S, L89MF
Bartolo (2014)09AOHDP5409AOHDP54KF853865None  V11IL10I, I13V, I15V, G16E, K20M, E35D, M36I, R41K, R57K, L63T, G73D, L89FF
 09AOHDP19709AOHDP197KF853791None   L10I, T12TM, I13V, G16E, E35D, M36I, R41K, L63T, E65D, I72T, V77I, L89MF
 09AOHDP21609AOHDP216KF853801None   L10I, I13V, G16E, L19P, K20R, E35D, M36I, R41K, R57K, L63T, E65D, H69HNY, K70KR, L89MF
Niculescu (2014)DU3433bhDU3433bhKJ194817None   L10I, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
 DU2504DU2504KJ194764None   L10I, I13V, I15IV, G16E, K20R, E35D, M36I, N37ND, R41K, K43R, R57K, I62V, L63T, E65D, L89MF
 DU457DU457KJ194744None   L10I, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63S, E65D, L89MF
Alexiev (2015)11BG78111BG781KJ765587None   L10I, I13V, I15V, E35D, M36I, R41K, R57K, I62V, L63V, I64IM, L89MF
Bruzzone (2015)HM0141FHM0141FKP889065None   L10I, I15V, K20R, E35D, M36I, R41K, R57K, D60DG, Q61N, L63S, H69S, I72TF
Carvalho (2015)117117KM205961None   L10I, I13V, K14Q, I15V, E35D, M36I, R41K, R57K, Q61N, L63I, K70KE, L89MF
 155155KM205923None   L10I, T12Q, K14Q, I15V, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, L89MF
 170170KM205908None   L10I, I13V, K14Q, I15V, E35D, M36I, R41K, R57K, Q61N, L63IV, L89MF
 154154KM205924None   L10I, T12N, I15V, G17E, K20R, M36I, R57K, Q61H, L63T, L89M, I93LF
de Lourdes Teixeira (2015)9RJ1100709RJ110070 None   L10I, G16E, L19LI, E35D, M36I, R57K, D60E, Q61N, L63T, I72T, V77VI, L89M, I93L, G94NF
 9RJ1200749RJ120074 None   L10I, L19IM, E35D, M36I, R41K, K43KR, R57K, Q61NS, L63P, H69Q, K70KR, L89MF
Delgado (2015)X3568X3568KJ883128None   L10I, I13V, G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, L63X, H69HY, I72T, L89MF
 X3744X3744KJ883135None   L10I, I13V, G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, I62IV, H69Y, I72T, L89M, I93LF
 X3308X3308KJ883150None   L10I, I13V, G16E, E35D, M36I, P39T, R41K, R57K, D60E, Q61N, H69Y, I72T, L89MF
Guimaraes (2015)BRSP502-13BRSP502-13KP115465None   L10I, I15V, K20R, E35D, M36I, N37I, R41K, R57K, Q61S, I64L, C67S, L89MF
Hora (2015)DEMF210CM001DEMF210CM001JX140672None   L10I, I13V, G16E, Q18H, K20R, E35D, M36I, P39T, R41K, K45R, I62V, L63H, H69Q, L89MF
Kouri (2015)C_AIDS19C_AIDS19KP688144None   L10I, I13V, G16E, K20KR, E35D, M36I, R57K, Q61E, L63S, H69Q, K70R, L89MF
Moura (2015)BRMA_242BRMA_242KF782759None   L10I, I13V, E35D, M36I, P39S, R41K, R57K, Q61N, L89MF
Dos Anjos Silva (2016)AP070AP070KT737328None   L10I, K14R, I15V, G17E, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72IT, T74S, L89MF
Lima (2016)08PE09108PE091KX020974None   L10I, I15V, E35D, M36I, N37D, R41K, Q61N, L89M, I93LF
 09PE18809PE188KX021015None   L10I, I15V, G16E, E35D, M36I, R41K, K45R, R57K, Q61N, L63V, I72T, P81T, G86W, R87KF
 07PE04607PE046KX020980None   L10I, T12K, K14M, E35D, M36I, R41K, R57K, Q61N, E65D, I72T, L89MF
 08PE13408PE134KX021014None   L10I, I13V, G16E, K20R, M36I, N37S, P39S, R41K, R57K, D60E, Q61D, C67S, I72T, L89IF
 08PE04908PE049KX020979None   L10I, T12I, I13V, I15V, G16E, E35D, M36I, R41K, R57K, Q61N, L63C, I72TF
 08PE06208PE062KX021018None   L10I, T12N, I15V, G16E, E35D, M36I, P39Q, R41K, R57K, Q61D, L63S, I72V, L89M, I93LF