<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation I93L
Rx PI-naive
IncludeMixtures No
References 52
Patients 81
Isolates 83
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M40M40AY010404None   E35D, M36I, R41K, R57RK, L63P, I64V, I93LD
Cuevas (2002)CU73CU73AF425454None   K14R, L19I, E35D, M36I, N37D, R41K, K43R, Q61D, L63P, H69Q, I93LD
 CU30CU30AF425411None   R41K, K43R, R57K, I62V, L63P, H69Q, A71T, V77I, I93LD
Fonjungo (2002)CM11CM11AF406731None  L33IE35D, M36I, R41K, L63P, I64M, H69Y, I72T, I93LD
 CM238CM238AF406728None   I15V, L19Q, E35D, M36I, L63P, H69Q, I93LD
 CM234CM234AF406726None   I15V, K20R, E35D, M36I, N37D, R41K, I93LD
 CM231CM231AF406725None   I15V, E35D, M36I, R41K, R57K, I93LD
 CM230CM230AF406724None   I15V, E35D, M36I, R41K, R57K, I64V, I93LD
 CM221CM221AF406722None   I15V, E35D, M36I, R41K, L63P, I93LD
 CM175CM175AF406714None   T12S, I15V, L19I, E35D, M36I, R41K, I62V, I93LD
 CM145CM145AF406712None   L10V, I15V, E35D, M36I, R41K, L63P, H69Q, I93LD
 CM132CM132AF406710None   I15V, E35D, M36I, N37D, R41K, I93LD
Hierholzer (2002)SU488SU488AY102484None   I13V, I15V, G16E, N37T, P39S, R41K, D60E, L63P, A71T, I93LD
 SU502SU502AY102485None   I15V, P39A, R41K, L63P, I72V, I93LD
Brindeiro (2003)BRSP544BRSP544AY213221None   I15V, E35D, M36I, R41K, R57K, I62V, L63P, K70R, V77VI, I93LD
Eshleman (2004)ESH_Pat34ESH698AY425354None   T12A, K14R, R41K, L63P, H69Q, V77VI, I93LD
Gulick (2004)RG224RG224w0 None   L10V, T12I, I13V, N37D, L63P, I93LD
Konings (2004)KF_Pat600CM1457AY359688None   L10V, I15V, E35D, M36I, R41K, L63P, H69Q, I93LD
Vidal (2006)NV_KIST10302.KIST103AM041026None   E35D, M36I, R41K, R57K, Q61N, H69Q, I93LD
 NV_LBTB02802.LBTB028AM041013None   T12S, I15V, K20R, E35D, M36I, N37D, R41K, L63P, H69K, K70R, I93LD
 NV_MBFE25202.MBFE252AM041024None   E35D, M36I, R41K, R57K, Q61H, I62V, L63P, H69N, I93LD
Baker (2007)A1040MBA1040-190905EF186213None   I13V, K20R, M36I, P39T, R41K, L63P, A71V, I93LD
Church (2007)698-134930N698EF612112None   T12A, K14R, R41K, L63P, H69Q, V77VI, I93LD
Kassu (2007)ETH-G-230G-230AB285830None   T12P, G16E, L19M, M36I, R41K, L63T, E65D, K70R, I72T, I93LD
von Wyl (2007)5210324616EF449795None   K14R, P39S, R41K, D60E, Q61E, I62V, L63P, A71V, I72M, V77I, P79Q, I93LD
  5511940EF449922None   K14R, P39S, R41K, D60E, Q61E, I62V, L63P, A71V, I72V, V77I, P79Q, I93LD
Derache (2008)SGO-96SGO-96EU330836None   K14R, I15V, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, C67E, H69R, L89M, I93LD
Nyombi (2008)TMS004TMS004EU251785None   M36I, N37D, R41K, R57K, D60DE, I64V, I93LD
 TMS005TMS005EU251786None   M36I, R41K, I64V, I93LD
Cuevas (2009)X2689_1X2689_1GU326173None   T12P, K14R, R41K, L63V, A71V, I72M, V77I, I93LD
Dumans (2009)451_05451_05FJ405054None   I15V, E35D, M36L, R41K, K45R, L63P, K70R, I93LD
Steegen (2009)BV232BV232-1EU872131None  L33II13V, L19IV, K20KM, M36I, R41K, K43KR, R57K, Q61E, L63P, I64V, E65ED, I72IV, I93LD
Castelbranco (2010)090014A090014AHM357731None   E35D, M36I, R41K, D60E, I62V, L63P, K70R, I93LD
Cuevas (2010)X2689-2X2689-2GU362885None   T12P, K14R, R41K, L63V, A71V, I72M, V77I, I93LD
El-Khatib (2010)Pat12011ZA_SAVE2391JF960570None   I13V, G16E, K20R, M36I, R41K, D60E, L63P, I64V, H69K, I93LD
Ndembi (2010)DT3771_05_P13771GQ409624None   I15V, M36I, R41K, I62V, L63P, I93LD
Aghokeng (2011)SK3012-PISK3012-PIHQ864353None   I15V, L19Q, E35D, M36I, R41K, Q61QE, L63P, I93LD
Charpentier (2011)CR-47CR-47FJ688253None   L10LI, K14R, I15V, G17D, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63LP, I93LD
de Medeiros (2011)Pat097RS012JF487926None   N37S, R41K, H69K, T74A, V77I, R87K, L89M, I93LD
Hamers (2011)CP076301994CP076301994HQ995449None   L10V, M36I, R41K, L63P, I93LD
Afonso (2012)ANG49ANG49JN937062None   E35D, M36I, R41K, R57K, Q61N, I93LD
 ANG19ANG19JN937034None   M36I, R41K, K45R, L63P, I93LD
Avila-Rios (2012)M200M6C8O1M200M6C8O1KC169255None   I13V, N37H, R41K, R57RK, I62IV, L63PS, A71AV, V77I, I93LD
 N000MN9ESFN000MN9ESFKC169341None   R41RK, L63P, E65D, K70R, V77VI, I93LD
Delwart (2012)479-2547-7479-2547-7JN215097None   I15V, E35D, M36I, N37D, R41K, K43R, Q61E, L63P, H69Q, A71T, I72V, I93LD
Machado (2012)CUPL0934CUPL0934HQ655367None   E35D, M36I, R41K, L63P, H69Q, K70Q, I93LD
 CUPL0941CUPL0941HQ655374None   T12P, L19I, K20R, E35D, M36I, R41K, L63P, H69Q, K70E, A71T, I93LD
 CUPL1007CUPL1007HQ655384None   M36I, R41K, K43R, I62V, L63P, H69Q, K70R, I72M, V82I, I93LD
 CUPL1015CUPL1015HQ655392None   L10I, E35D, M36I, R41K, L63P, H69Q, K70Q, I93LD
 CUPL1077CUPL1077JN000049None   E35D, N37S, R41K, D60E, Q61E, L63P, H69Q, I93LD
 CUPL1080CUPL1080JN000052None   E35D, M36I, R41K, K43R, I62V, L63P, H69Q, K70Q, A71T, I93LD
 CUPL1096CUPL1096JN000068None  Q58ET12E, I15V, L19I, E35D, M36I, N37D, R41K, K43R, R57K, D60E, Q61E, L63P, H69Q, I93LD
Ragonnet-Cronin (2012)PHAC09_096PHAC09_096JQ675237None   T12A, E35D, N37S, R41K, L63P, V77I, I93LD
Ssemwanga (2012)RCC-TDR-483673RCC-TDR-483673JQ266082None   R41K, L63P, I72T, V77I, I93LD
Alencar (2013)RJ2-0063RJ2-0063JQ238088None   Q7E, T12P, K14R, E35D, M36I, N37D, R41K, L63P, I64L, A71V, I72V, V77I, I93LD
 RJ2-0095RJ2-0095JQ238222None   E35D, M36I, N37D, R41K, L63P, I64L, A71V, I72E, V77I, I93LD
Brooks (2013)CAN2013-151CAN13-151KF727692None   L10LV, T12TS, I15IV, K20R, E35D, M36I, R41K, L63S, H69K, L89M, I93LD
Frentz (2013)EHR-31120EHR-31120JX300073None   T12I, N37H, R41K, L63P, V77I, I93LD
Bartolo (2014)09AOHDP12909AOHDP129KF853765None   L10I, P39T, R41K, L63P, A71V, V77I, I93LD
Crawford (2014)SN-072075SN-072075KF781838None   W6V, I13V, I15V, R41K, L63P, V77I, I93LD
Khairunisa (2014)TD2TD2KM212885None   L10I, K14R, R41K, L63Q, I72V, I93LD
Lee (2014)MBA1040MBA1040KJ906741None   I13V, K20R, M36I, P39T, R41K, I62V, L63P, A71V, V77VI, I93LD
Meixenberger (2014)09-0287009-02870KJ771080None   L10V, I13V, I15L, L33V, R41K, I62V, L63N, I64V, I72V, I93LD
 08-0116108-01161KJ770723None   L10V, I13V, I15L, L33V, R41K, I62V, L63N, I64V, I72V, I93LD
Parczewski (2014)A079_1A079_1KM284554None   L10LV, T12P, I15V, M36I, R41K, L63S, I64IV, I93LD
 934_1934_1JQ305767None   I15IV, L19LI, E35D, M36I, N37ND, R41K, K43KR, K45KR, I62IV, L63P, I64V, I93LD
 787_1787_1GU906874None   I13V, M36I, N37D, R57K, Q61E, L63P, I64V, I93LD
Steegen (2014)10ZAKS07410ZAKS074KJ176356None   R41K, L63T, H69K, I93LD
Velasco-de-Castro (2014)07BRRJRS11107BRRJRS111KF922198None   I15V, Q18A, E35D, R41K, R57K, D60E, I62V, L63P, H69Q, A71T, V77I, I93LD
Alexiev (2015)10BG118110BG1181KJ765415None   L10IM, I15V, G16E, E35D, M36I, P39S, R41K, K45R, R57K, L63PT, H69Q, I93LD
Guimaraes (2015)BRSP718-13BRSP718-13KP115496None   L10I, E35D, M36I, R41K, L63A, H69Q, I93LD
Kouri (2015)AIDS-RP1AIDS-RP1KP688083None   L10I, K14R, I15V, G16E, E35D, M36I, R41K, K43R, L63P, H69K, I93LD
 AIDS-RP14AIDS-RP14KP688088None   T12P, I13V, I15IV, M36I, N37S, R41K, R57K, I62V, L63P, V75I, I93LD
 AIDS-RP29AIDS-RP29KP688104None   E35D, M36I, N37E, R41K, K43KR, D60E, Q61E, L63P, H69Q, I93LD
 AIDS-RP2AIDS-RP2KP688094None   I15V, E35D, M36I, R41K, K43R, I62IV, L63PS, H69K, K70Q, A71T, I93LD
Castley (2016)P109428830P109428830KT228712None   L10V, I13V, E35D, R41K, I64V, A71V, I72V, I93LD
 P119401101P119401101KT228800None   K14R, M36I, R41K, L63P, V77I, I93LD
Lam (2016)9902201499022014KR868125None   L10V, G16E, M36I, N37Q, R41K, D60E, L63T, H69K, I72V, I93LD
Onsongo (2016)3939KM376169None   R41K, K45R, R57K, L63A, I64V, A71T, I72V, V77I, I93LD
Pessoa (2016)10BR_RJ06310BR_RJ063KT427773None   Q7E, T12P, K14R, Q18QH, E35D, M36I, N37D, R41K, L63P, I64L, A71V, I72V, V77I, I93LD
Pouran Yousef (2016)372308-01161KX466501None   L10V, I13V, I15L, L33V, R41K, I62V, L63N, I64V, I72V, I93LD
  09-02870KX466502None   L10V, I13V, I15L, L33V, R41K, I62V, L63N, I64V, I72V, I93LD
Zhao (2016)LS1177LS1177KT378817None   K14R, L19I, M36V, R41K, R57K, L63P, I93LD