<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation I93L
Rx PI-naive
IncludeMixtures No
References 77
Patients 140
Isolates 144
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M40M40AY010404None   E35D, M36I, R41K, R57RK, L63P, I64V, I93LD
Cuevas (2002)CU73CU73AF425454None   K14R, L19I, E35D, M36I, N37D, R41K, K43R, Q61D, L63P, H69Q, I93LD
 CU30CU30AF425411None   R41K, K43R, R57K, I62V, L63P, H69Q, A71T, V77I, I93LD
Fonjungo (2002)CM11CM11AF406731None  L33IE35D, M36I, R41K, L63P, I64M, H69Y, I72T, I93LD
 CM238CM238AF406728None   I15V, L19Q, E35D, M36I, L63P, H69Q, I93LD
 CM234CM234AF406726None   I15V, K20R, E35D, M36I, N37D, R41K, I93LD
 CM231CM231AF406725None   I15V, E35D, M36I, R41K, R57K, I93LD
 CM230CM230AF406724None   I15V, E35D, M36I, R41K, R57K, I64V, I93LD
 CM221CM221AF406722None   I15V, E35D, M36I, R41K, L63P, I93LD
 CM184CM184AF406716None   G16E, K20R, M36I, R41K, I62V, L63N, I72T, I93LD
 CM175CM175AF406714None   T12S, I15V, L19I, E35D, M36I, R41K, I62V, I93LD
 CM145CM145AF406712None   L10V, I15V, E35D, M36I, R41K, L63P, H69Q, I93LD
 CM132CM132AF406710None   I15V, E35D, M36I, N37D, R41K, I93LD
Hierholzer (2002)SU488SU488AY102484None   I13V, I15V, G16E, N37T, P39S, R41K, D60E, L63P, A71T, I93LD
 SU502SU502AY102485None   I15V, P39A, R41K, L63P, I72V, I93LD
Hanna (2003)HG038HG038AY049651None   L10LI, M36I, R41K, I62V, L63S, I64M, I93LD
Eshleman (2004)ESH_Pat34ESH698AY425354None   T12A, K14R, R41K, L63P, H69Q, V77VI, I93LD
Eshleman (2004)182189182189AY444290None   T12Q, I15V, M36I, R41K, L63T, H69K, I93LD
Gulick (2004)RG224RG224w0 None   L10V, T12I, I13V, N37D, L63P, I93LD
Konings (2004)KF_Pat600CM1457AY359688None   L10V, I15V, E35D, M36I, R41K, L63P, H69Q, I93LD
Non-B Workgroup (2005)UK2049UK2049 None   L10I, I13V, I15V, P39Q, R41K, L63P, I93LD
Vidal (2006)NV_KIST10302.KIST103AM041026None   E35D, M36I, R41K, R57K, Q61N, H69Q, I93LD
 NV_LBS04802.LBS048AM041002None   I13V, K14I, I15V, L19Q, K20R, M36I, R41K, D60E, Q61H, L63S, H69K, L89M, I93LD
 NV_LBTB02802.LBTB028AM041013None   T12S, I15V, K20R, E35D, M36I, N37D, R41K, L63P, H69K, K70R, I93LD
 NV_MBFE25202.MBFE252AM041024None   E35D, M36I, R41K, R57K, Q61H, I62V, L63P, H69N, I93LD
Baker (2007)A1040MBA1040-190905EF186213None   I13V, K20R, M36I, P39T, R41K, L63P, A71V, I93LD
Church (2007)698-134930N698EF612112None   T12A, K14R, R41K, L63P, H69Q, V77VI, I93LD
Gonsalez (2007)94HIV_94GU288749None   L10I, E35D, M36I, I62V, L63S, A71T, I72M, V77I, I93LD
Kassu (2007)ETH-G-230G-230AB285830None   T12P, G16E, L19M, M36I, R41K, L63T, E65D, K70R, I72T, I93LD
Novitsky (2007)16171617_9067EF026216None   Q18E, K20R, M36I, R41K, Q61E, H69K, L89M, I93LD
von Wyl (2007)5210324616EF449795None   K14R, P39S, R41K, D60E, Q61E, I62V, L63P, A71V, I72M, V77I, P79Q, I93LD
  5511940EF449922None   K14R, P39S, R41K, D60E, Q61E, I62V, L63P, A71V, I72V, V77I, P79Q, I93LD
Chang (2008)TW2195aTW2195a None  Q58EL5F, Q7H, L10V, I15V, E35D, M36I, R41K, L63P, K70T, I93LD
Derache (2008)SGO-96SGO-96EU330836None   K14R, I15V, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, C67E, H69R, L89M, I93LD
Jacobs (2008)1078C1078CEF602171None   T12S, I15IV, L19LI, E35D, M36MI, R41K, L63P, L89LM, I93LD
Nyombi (2008)TBK093TBK093EU251775None   T12S, I13V, I15V, L19I, E35D, R41K, L63T, H69KQ, A71T, V82I, I93LD
 TMS004TMS004EU251785None   M36I, N37D, R41K, R57K, D60DE, I64V, I93LD
 TMS005TMS005EU251786None   M36I, R41K, I64V, I93LD
 TMS148TMS148EU251837None   I13V, G16E, E35D, M36I, R41K, Q61H, L63H, H69K, I72V, T74S, L89M, I93LD
 TMS347TMS347EU251880None   I13V, G16E, M36I, P39T, R41K, D60E, L63P, H69K, L89M, I93LD
Bartolo (2009)HJM11501AOHJM115EU068253None   T12N, K14R, I15V, E35D, M36I, R41K, K45R, L63T, H69K, L89M, I93LD
Brumme (2009)A2508A2508GQ371768None   I13V, Q18L, M36I, I62V, L63P, A71V, I93LD
 F8527F8527GQ371881None   L10I, I13V, G16E, M36I, R41K, L63T, I93LD
Cuevas (2009)X2689_1X2689_1GU326173None   T12P, K14R, R41K, L63V, A71V, I72M, V77I, I93LD
Dumans (2009)451_05451_05FJ405054None   I15V, E35D, M36L, R41K, K45R, L63P, K70R, I93LD
Steegen (2009)BV232BV232-1EU872131None  L33II13V, L19IV, K20KM, M36I, R41K, K43KR, R57K, Q61E, L63P, I64V, E65ED, I72IV, I93LD
Vercauteren (2009)pt334JdJQ82G02JGQ400690None   R41K, L63P, I64L, I93LD
 pt50XIKx8mkPdWGQ400974None   L10I, I15L, L33V, R41K, L63P, I93LD
Castelbranco (2010)090014A090014AHM357731None   E35D, M36I, R41K, D60E, I62V, L63P, K70R, I93LD
Cuevas (2010)X2689-2X2689-2GU362885None   T12P, K14R, R41K, L63V, A71V, I72M, V77I, I93LD
Djoko (2010)658CD0729FR666658None   I13IV, K14I, I15V, L19Q, K20R, M36I, N37S, R41K, L63T, H69K, L89M, I93LD
El-Khatib (2010)Pat12011ZA_SAVE2391JF960570None   I13V, G16E, K20R, M36I, R41K, D60E, L63P, I64V, H69K, I93LD
Gonzalez (2010)MO_3MO_3GQ433873None   G16E, E35D, M36I, P39S, R41K, K45R, D60E, Q61E, L63P, H69K, L89M, I93LD
Hattori (2010)C08-20672875C08-20672875AB864181None   E35D, L63P, G68E, A71V, V77I, I93LD
 C08-20922862C08-20922862AB864178None   E35D, L63P, G68E, A71V, V77I, I93LD
 C08-2066429C08-2066429AB864138None   L10V, T12P, I15V, M36I, R41K, L63T, I64L, I93LD
Ndembi (2010)DT3771_05_P13771GQ409624None   I15V, M36I, R41K, I62V, L63P, I93LD
Aghokeng (2011)SK3012-PISK3012-PIHQ864353None   I15V, L19Q, E35D, M36I, R41K, Q61QE, L63P, I93LD
Charpentier (2011)CR-47CR-47FJ688253None   L10LI, K14R, I15V, G17D, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63LP, I93LD
de Medeiros (2011)Pat097RS012JF487926None   N37S, R41K, H69K, T74A, V77I, R87K, L89M, I93LD
El Annaz (2011)1573715737HQ393321None   T12S, I13V, K14I, I15V, L19Q, K20R, E34EG, M36I, N37NHRS, L63T, H69K, T74S, L89M, I93LD
Hamers (2011)300117CP076300117HM119694None   E35D, M36I, R41K, L63P, H69K, I93LD
 300252CP076300252HM119804None   I15V, L19I, E35D, M36L, N37ND, R41K, R57K, D60E, Q61QE, L63P, H69K, I93LD
 CP076301919CP076301919HQ995391None   M36I, R41K, I62V, L63P, I93LD
 CP076301994CP076301994HQ995449None   L10V, M36I, R41K, L63P, I93LD
Afonso (2012)ANG49ANG49JN937062None   E35D, M36I, R41K, R57K, Q61N, I93LD
 ANG19ANG19JN937034None   M36I, R41K, K45R, L63P, I93LD
Avila-Rios (2012)M200M6C8O1M200M6C8O1KC169255None   I13V, N37H, R41K, R57RK, I62IV, L63PS, A71AV, V77I, I93LD
Delwart (2012)479-2547-7479-2547-7JN215097None   I15V, E35D, M36I, N37D, R41K, K43R, Q61E, L63P, H69Q, A71T, I72V, I93LD
 479-7344-2479-7344-2JN215100None   L10V, I13V, M36I, K45R, L63P, I64L, V77I, I93LD
Hunt (2012)GP09_2391GP09_2391KF736753None  Q58ET12S, L19I, E35D, M36I, R41K, R57K, D60E, Q61E, L63P, H69K, L89M, I93LD
Iweriebor (2012)07M20ZA07M20ZAGU201815None   L10I, L19V, M36I, R41K, L63S, H69K, I93LD
Machado (2012)CUPL0934CUPL0934HQ655367None   E35D, M36I, R41K, L63P, H69Q, K70Q, I93LD
 CUPL0941CUPL0941HQ655374None   T12P, L19I, K20R, E35D, M36I, R41K, L63P, H69Q, K70E, A71T, I93LD
 CUPL1007CUPL1007HQ655384None   M36I, R41K, K43R, I62V, L63P, H69Q, K70R, I72M, V82I, I93LD
 CUPL1015CUPL1015HQ655392None   L10I, E35D, M36I, R41K, L63P, H69Q, K70Q, I93LD
 CUPL1077CUPL1077JN000049None   E35D, N37S, R41K, D60E, Q61E, L63P, H69Q, I93LD
 CUPL1080CUPL1080JN000052None   E35D, M36I, R41K, K43R, I62V, L63P, H69Q, K70Q, A71T, I93LD
 CUPL1096CUPL1096JN000068None  Q58ET12E, I15V, L19I, E35D, M36I, N37D, R41K, K43R, R57K, D60E, Q61E, L63P, H69Q, I93LD
Ndase (2012)5300730253007302KC900699None   G16E, E35D, M36I, L63HPQ, H69K, K70Q, L89M, I93LD
Ssemwanga (2012)RCC-TDR-483673RCC-TDR-483673JQ266082None   R41K, L63P, I72T, V77I, I93LD
Alencar (2013)RJ2-0063RJ2-0063JQ238088None   Q7E, T12P, K14R, E35D, M36I, N37D, R41K, L63P, I64L, A71V, I72V, V77I, I93LD
 MG2-0036MG2-0036JQ238127None   L10V, I15V, L19I, K20Q, M36I, R41K, K45R, R57K, I62V, L63P, I72IV, I93LD
 RJ2-0095RJ2-0095JQ238222None   E35D, M36I, N37D, R41K, L63P, I64L, A71V, I72E, V77I, I93LD
Bila (2013)MZQUE300HIV-1KF927433None   E35D, M36I, R41K, L63P, H69K, L89M, I93LD
Brooks (2013)CAN2013-151CAN13-151KF727692None   L10LV, T12TS, I15IV, K20R, E35D, M36I, R41K, L63S, H69K, L89M, I93LD
Frentz (2013)EHR-43863EHR-43863JX300279None   L10I, L33V, M36MI, N37X, P39Q, R41RK, L63P, I93LD
Han (2013)LCGA497ILCGA497IJX070509None   L19I, M36V, R41K, R57K, L63P, I93LD
Li (2013)hnr129hnr129KC988061None   I15V, E35D, M36I, R41K, L63T, H69K, L89M, I93LD
Nzeyimana (2013)201_1856201_1856HG780723None   I15V, M36I, R41K, L63P, I64L, H69K, I93LD
Smolen-Dzirba (2013)LJE610LJE610JN811569None   L10I, I13V, I15V, N37S, P39Q, R41K, I62V, L63P, I93LD
Van Zyl (2013)531411.ZA.EC106KC423716None   I15V, L19V, E35D, M36I, R41K, R57K, L63P, H69K, I93LD
Bartolo (2014)09AOHDP12909AOHDP129KF853765None   L10I, P39T, R41K, L63P, A71V, V77I, I93LD
Crawford (2014)SN-072075SN-072075KF781838None   W6V, I13V, I15V, R41K, L63P, V77I, I93LD
Khairunisa (2014)TD2TD2KM212885None   L10I, K14R, R41K, L63Q, I72V, I93LD
Lee (2014)MBA1040MBA1040KJ906741None   I13V, K20R, M36I, P39T, R41K, I62V, L63P, A71V, V77VI, I93LD
Martin (2014)ACU66ACU66KJ869965None   I13V, P39Q, L63T, I64L, A71V, I93LD
Meixenberger (2014)10-0259710-02597KJ771389None   I13V, P39Q, I62V, L63T, I64L, A71V, I72M, I93LD
 11-0131811-01318KJ771509None   T12A, E35D, N37S, R41K, D60E, Q61N, I62V, L63P, V77I, I93LD
 05-0059305-00593KJ770051None   I13V, P39Q, L63T, I64L, A71V, I93LD
 07-0045907-00459KJ770448None   I13V, E35D, P39Q, L63T, I64L, A71V, V77VI, I93LD
 10-0279810-02798KJ771438None   T12A, R41K, Q61H, L63P, I93LD
 08-0107808-01078KJ770716None   L10IM, L33V, E35ED, N37S, P39S, R41K, L63P, I64V, I93LD
 12-0021112-00211KJ771681None   K20R, E35D, M36I, R41K, L63P, I64L, H69K, V82I, L89M, I93LD
 10-0243610-02436KJ771372None   I13V, P39Q, I62V, L63T, I64L, A71V, I72M, I93LD
 10-0276710-02767KJ771432None   K20R, E35D, M36I, R41K, L63P, I64L, H69K, V82I, L89M, I93LD
 10-0276910-02769KJ771433None   L10M, E35D, R41K, L63T, I93LD
 11-0314611-03146KJ771580None   L10MV, E35D, R41K, L63T, I93LD
 11-0021111-00211KJ771469None   L10M, E35D, R41K, I93LD
 11-0338011-03380KJ771594None   T12A, E35D, N37S, R41K, D60E, Q61N, I62V, L63P, V77I, I93LD
 11-0443511-04435KJ771662None   I13V, P39Q, I62V, L63T, I64L, A71V, I72M, I93LD
Parczewski (2014)A079_1A079_1KM284554None   L10LV, T12P, I15V, M36I, R41K, L63S, I64IV, I93LD
 934_1934_1JQ305767None   I15IV, L19LI, E35D, M36I, N37ND, R41K, K43KR, K45KR, I62IV, L63P, I64V, I93LD
 787_1787_1GU906874None   I13V, M36I, N37D, R57K, Q61E, L63P, I64V, I93LD
Steegen (2014)10ZAKS07410ZAKS074KJ176356None   R41K, L63T, H69K, I93LD
Alexiev (2015)791_0109791_0109JQ259134None   W6L, L10V, I15V, G16E, E35D, M36I, R41K, K45R, L63T, H69Q, I93LD
 10BG118110BG1181KJ765415None   L10IM, I15V, G16E, E35D, M36I, P39S, R41K, K45R, R57K, L63PT, H69Q, I93LD
de Lourdes Teixeira (2015)9RJ1103969RJ110396 None   G17E, N37ND, R57K, D60E, I62V, L63P, H69Q, V77I, I93LD
Guimaraes (2015)BRSP718-13BRSP718-13KP115496None   L10I, E35D, M36I, R41K, L63A, H69Q, I93LD
Kouri (2015)AIDS-RP1AIDS-RP1KP688083None   L10I, K14R, I15V, G16E, E35D, M36I, R41K, K43R, L63P, H69K, I93LD
 AIDS-RP14AIDS-RP14KP688088None   T12P, I13V, I15IV, M36I, N37S, R41K, R57K, I62V, L63P, V75I, I93LD
 AIDS-RP29AIDS-RP29KP688104None   E35D, M36I, N37E, R41K, K43KR, D60E, Q61E, L63P, H69Q, I93LD
 AIDS-RP2AIDS-RP2KP688094None   I15V, E35D, M36I, R41K, K43R, I62IV, L63PS, H69K, K70Q, A71T, I93LD
Moura (2015)BRMA_263BRMA_263KF782776None   T12S, G17E, L19I, N37K, R41K, R57K, L63P, A71T, I93LD
Yao (2015)CN.iso72CN.iso72KC924480None   E35D, M36I, R41K, K55Q, D60E, Q61E, L63P, C67F, H69K, L89M, I93LD
 CN.iso71CN.iso71KC924479None   E35D, M36I, R41K, D60E, L63P, H69K, I85M, G86E, R87E, N88H, L89M, I93LD
 CN.iso116CN.iso116KC924513None   M36I, R41K, D60E, L63P, H69K, L89M, I93LD
Dos Anjos Silva (2016)AP019AP019KT737286None   T12P, I15V, G17D, L19V, K20R, M36I, R57K, L63P, I93LD
Hosaka (2016)03JP-5091K2795091K279AB859012None   M36I, N37S, R41K, L63P, H69N, A71V, V77I, I93LD
Lam (2016)9902201499022014KR868125None   L10V, G16E, M36I, N37Q, R41K, D60E, L63T, H69K, I72V, I93LD
Pessoa (2016)10BR_RJ06310BR_RJ063KT427773None   Q7E, T12P, K14R, Q18QH, E35D, M36I, N37D, R41K, L63P, I64L, A71V, I72V, V77I, I93LD
Pouran Yousef (2016)433710-02798KX466984None   T12A, R41K, Q61H, L63P, I93LD
 433310-02769KX466979None   L10M, E35D, R41K, L63T, I93LD
 259605-00593KX465766None   I13V, P39Q, L63T, I64L, A71V, I93LD
  07-00459KX465767None   I13V, E35D, P39Q, L63T, I64L, A71V, V77VI, I93LD
 447511-03380KX467063None   T12A, E35D, N37S, R41K, D60E, Q61N, I62V, L63P, V77I, I93LD
 427810-02436KX466944None   I13V, P39Q, I62V, L63T, I64L, A71V, I72M, I93LD
 433210-02767KX466977None   K20R, E35D, M36I, R41K, L63P, I64L, H69K, V82I, L89M, I93LD
  12-00211KX466978None   K20R, E35D, M36I, R41K, L63P, I64L, H69K, V82I, L89M, I93LD
 430110-02597KX466950None   I13V, P39Q, I62V, L63T, I64L, A71V, I72M, I93LD
  11-04435KX466951None   I13V, P39Q, I62V, L63T, I64L, A71V, I72M, I93LD
Steegen (2016)GFKZB060GFKZB060KU127926None   L19V, E35D, M36I, R41K, L63P, H69K, L89M, I93LD
Zhao (2016)LS1177LS1177KT378817None   K14R, L19I, M36V, R41K, R57K, L63P, I93LD
 LS1160LS1160KT378810None   L19I, M36V, R41K, R57K, L63P, I93LD