<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation I93L
Rx PI-naive
IncludeMixtures No
References 46
Patients 96
Isolates 97
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M40M40AY010404None   E35D, M36I, R41K, R57RK, L63P, I64V, I93LD
Cuevas (2002)CU73CU73AF425454None   K14R, L19I, E35D, M36I, N37D, R41K, K43R, Q61D, L63P, H69Q, I93LD
 CU30CU30AF425411None   R41K, K43R, R57K, I62V, L63P, H69Q, A71T, V77I, I93LD
Fonjungo (2002)CM11CM11AF406731None  L33IE35D, M36I, R41K, L63P, I64M, H69Y, I72T, I93LD
 CM238CM238AF406728None   I15V, L19Q, E35D, M36I, L63P, H69Q, I93LD
 CM231CM231AF406725None   I15V, E35D, M36I, R41K, R57K, I93LD
 CM230CM230AF406724None   I15V, E35D, M36I, R41K, R57K, I64V, I93LD
 CM221CM221AF406722None   I15V, E35D, M36I, R41K, L63P, I93LD
 CM184CM184AF406716None   G16E, K20R, M36I, R41K, I62V, L63N, I72T, I93LD
 CM175CM175AF406714None   T12S, I15V, L19I, E35D, M36I, R41K, I62V, I93LD
 CM145CM145AF406712None   L10V, I15V, E35D, M36I, R41K, L63P, H69Q, I93LD
Hierholzer (2002)SU488SU488AY102484None   I13V, I15V, G16E, N37T, P39S, R41K, D60E, L63P, A71T, I93LD
 SU502SU502AY102485None   I15V, P39A, R41K, L63P, I72V, I93LD
Eshleman (2004)ESH_Pat34ESH698AY425354None   T12A, K14R, R41K, L63P, H69Q, V77VI, I93LD
Gulick (2004)RG224RG224w0 None   L10V, T12I, I13V, N37D, L63P, I93LD
Konings (2004)KF_Pat600CM1457AY359688None   L10V, I15V, E35D, M36I, R41K, L63P, H69Q, I93LD
Vidal (2006)NV_KIST10302.KIST103AM041026None   E35D, M36I, R41K, R57K, Q61N, H69Q, I93LD
 NV_KTB24202.KTB242AM040997None   I15V, G16E, K20R, E35D, M36I, R41K, K45R, L63A, H69K, L89M, I93LD
 NV_MBFE25202.MBFE252AM041024None   E35D, M36I, R41K, R57K, Q61H, I62V, L63P, H69N, I93LD
Baker (2007)A1040MBA1040-190905EF186213None   I13V, K20R, M36I, P39T, R41K, L63P, A71V, I93LD
Church (2007)698-134930N698EF612112None   T12A, K14R, R41K, L63P, H69Q, V77VI, I93LD
Dilernia (2007)F099F099EF120131None  L33IR41K, K43R, L63S, A71V, I72E, V77I, I93LD
Kassu (2007)ETH-G-230G-230AB285830None   T12P, G16E, L19M, M36I, R41K, L63T, E65D, K70R, I72T, I93LD
von Wyl (2007)5210324616EF449795None   K14R, P39S, R41K, D60E, Q61E, I62V, L63P, A71V, I72M, V77I, P79Q, I93LD
  5511940EF449922None   K14R, P39S, R41K, D60E, Q61E, I62V, L63P, A71V, I72V, V77I, P79Q, I93LD
Nyombi (2008)TBK093TBK093EU251775None   T12S, I13V, I15V, L19I, E35D, R41K, L63T, H69KQ, A71T, V82I, I93LD
 TMS004TMS004EU251785None   M36I, N37D, R41K, R57K, D60DE, I64V, I93LD
 TMS005TMS005EU251786None   M36I, R41K, I64V, I93LD
Brumme (2009)A2508A2508GQ371768None   I13V, Q18L, M36I, I62V, L63P, A71V, I93LD
 F8527F8527GQ371881None   L10I, I13V, G16E, M36I, R41K, L63T, I93LD
Cuevas (2009)X2713_1X2713_1GU326183None   Q18H, M36I, Q61E, L63P, I64V, I72V, I93LD
Steegen (2009)BV232BV232-1EU872131None  L33II13V, L19IV, K20KM, M36I, R41K, K43KR, R57K, Q61E, L63P, I64V, E65ED, I72IV, I93LD
Castelbranco (2010)090014A090014AHM357731None   E35D, M36I, R41K, D60E, I62V, L63P, K70R, I93LD
Ndembi (2010)DT3771_05_P13771GQ409624None   I15V, M36I, R41K, I62V, L63P, I93LD
Aghokeng (2011)SK3012-PISK3012-PIHQ864353None   I15V, L19Q, E35D, M36I, R41K, Q61QE, L63P, I93LD
Aulicino (2011)526-B431526-B431HQ158213None   L10V, I15V, E35D, M36I, R41K, R57K, Q61N, I93LD
Bunupuradah (2011)pt002pt002Pr None   L10I, I13V, I15V, M36I, R41K, I62V, L63P, I64V, I93LD
Carvalho (2011)O17-83O17-83GU214097None   L10V, T12Q, I15V, M36I, N37E, R57K, L63P, I72T, I93LD
Florea (2011)1933_20071933_2007JQ083039None   L10V, I15V, L19I, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M, I93LD
 2142_20072142_2007JQ083042None   L10I, T12AE, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V77I, L89M, I93LD
Hamers (2011)CP076301919CP076301919HQ995391None   M36I, R41K, I62V, L63P, I93LD
 CP076301994CP076301994HQ995449None   L10V, M36I, R41K, L63P, I93LD
Ndembi (2011)NTCPS728NTCPS728HQ702642None   M36I, R41K, L63A, I64V, K70R, I93LD
Santos (2011)J331J331_PRJN010705None   M36I, N37T, R41K, I62V, L63P, H69K, I72V, L89M, I93LD
Avila-Rios (2012)M0CFM68ISMM0CFM68ISMKC169240None   L10V, N37E, R41K, D60N, L63P, I72E, V77I, I93LD
 M200M6C8O1M200M6C8O1KC169255None   I13V, N37H, R41K, R57RK, I62IV, L63PS, A71AV, V77I, I93LD
 D000F84QWND000F84QWNKC168237None   K14KR, I15IV, N37D, R41K, D60E, I62V, C67CS, H69HY, I72T, V77I, I93LD
 P2F0MBCLYRP2F0MBCLYRKC169567None   L10V, K14R, N37D, L63P, I64M, E65K, A71V, V77I, I93LD
 S000MM8MV6S000MM8MV6KC169618None   T12P, I13V, M36MI, N37NY, R41K, R57RK, L63P, V77I, I93LD
 G000M83RTSG000M83RTSKC168850None   M36I, R41K, I62V, L63P, I64L, I93LD
Chen (2012)YN09DH0005YN09DH0005JQ658478None   L10M, I13IM, L19I, M36V, R41K, R57K, L63PS, I93LD
 YN09DH0036YN09DH0036JQ658506None   T12S, K14R, L19I, M36I, R41K, R57K, L63P, I93LD
 YN09DH0038YN09DH0038JQ658508None   T12P, K14R, I15V, L19T, M36I, R41K, L63P, I72V, I93LD
 YN09DH0070YN09DH0070JQ658539None   T12S, K14KR, I15V, L19I, M36IV, R41K, D60DE, I62V, L63P, A71AT, I93LD
 YN09DH0104YN09DH0104JQ658567None   I15V, L19I, K20R, M36V, R41K, I62V, L63P, I93LD
 YN09DH0134YN09DH0134JQ658593None   T12S, I13V, K14R, I15V, L19I, M36V, R41K, I62V, L63P, A71V, I93LD
 YN10DH0008YN10DH0008JQ658634None   K14R, L19I, M36V, R41K, K45R, R57K, L63P, I93LD
 YN10DH0009YN10DH0009JQ658635None   K14R, L19I, M36V, R41K, K45KR, R57K, I62IMV, L63P, A71AV, I72IV, I93LD
 YN10DH0062YN10DH0062JQ658685None   T12TA, K14R, L19I, M36L, R41K, R57K, I62IV, L63P, V82I, I93LD
 YN10DH0096YN10DH0096JQ658717None   T12S, I13V, K14R, I15V, L19I, M36MI, R41RK, K45KR, D60DE, I62IV, L63P, I64IL, H69HKNQ, K70KR, A71AV, L89LM, I93LD
 YN10DH0131YN10DH0131JQ658751None   L19M, E34G, M36I, R41K, R57K, L63P, I64L, I93LD
da Silveira (2012)BRMS05_10BRMS05_10JF342316None   E35D, M36I, R41K, R57K, Q61N, L63P, I64L, I93LD
Delwart (2012)479-5106-8479-5106-8JN214942None   R41K, I62V, L63P, V77I, I93LD
 479-2547-7479-2547-7JN215097None   I15V, E35D, M36I, N37D, R41K, K43R, Q61E, L63P, H69Q, A71T, I72V, I93LD
 479-7344-2479-7344-2JN215100None   L10V, I13V, M36I, K45R, L63P, I64L, V77I, I93LD
Machado (2012)CUPL0934CUPL0934HQ655367None   E35D, M36I, R41K, L63P, H69Q, K70Q, I93LD
 CUPL0941CUPL0941HQ655374None   T12P, L19I, K20R, E35D, M36I, R41K, L63P, H69Q, K70E, A71T, I93LD
 CUPL1007CUPL1007HQ655384None   M36I, R41K, K43R, I62V, L63P, H69Q, K70R, I72M, V82I, I93LD
 CUPL1015CUPL1015HQ655392None   L10I, E35D, M36I, R41K, L63P, H69Q, K70Q, I93LD
 CUPL1077CUPL1077JN000049None   E35D, N37S, R41K, D60E, Q61E, L63P, H69Q, I93LD
 CUPL1080CUPL1080JN000052None   E35D, M36I, R41K, K43R, I62V, L63P, H69Q, K70Q, A71T, I93LD
 CUPL1081CUPL1081JN000053None   M36I, R41K, I62V, L63P, I93LD
 CUPL1096CUPL1096JN000068None  Q58ET12E, I15V, L19I, E35D, M36I, N37D, R41K, K43R, R57K, D60E, Q61E, L63P, H69Q, I93LD
Murillo (2012)1128311283KC412753None   L10I, M36I, N37NK, R41K, I62V, L63P, I64MV, H69Y, I72M, V82VI, I93LD
 1144811448KC412778None   L10IV, G16E, E35D, M36I, P39S, R41K, D60E, I62V, L63P, I93LD
Musyoki (2012)DGM.2DGM.2JN176287None   T12S, I15V, L19I, E35D, M36I, P39T, R41K, L63V, H69K, L89M, I93LD
Ssemwanga (2012)RCC-TDR-483673RCC-TDR-483673JQ266082None   R41K, L63P, I72T, V77I, I93LD
Alencar (2013)PE2-0038PE2-0038JQ238029None   I15V, Q18QH, M36I, R41K, L63A, I93LD
 RJ2-0063RJ2-0063JQ238088None   Q7E, T12P, K14R, E35D, M36I, N37D, R41K, L63P, I64L, A71V, I72V, V77I, I93LD
 MG2-0036MG2-0036JQ238127None   L10V, I15V, L19I, K20Q, M36I, R41K, K45R, R57K, I62V, L63P, I72IV, I93LD
 RJ2-0095RJ2-0095JQ238222None   E35D, M36I, N37D, R41K, L63P, I64L, A71V, I72E, V77I, I93LD
Bila (2013)MZNAC60HIV-1KF927425None   G16E, M36I, R41K, L63V, H69K, L89M, I93LD
 MZ10-262HIV-1KF927351None   L19I, M36I, R41K, K43KR, L63V, H69K, T74S, L89M, I93LD
Brooks (2013)CAN2013-038CAN13-038KF727942None   L10V, R57K, I62V, L63S, A71V, I72T, V77I, I93LD
Chow (2013)MY1IM781MY1IM781KC478036None   L10I, I13V, E35D, M36I, N37D, R41K, K43R, L63T, A71V, I72IT, I93LD
Frentz (2013)EHR-27715EHR-27715JX300019None   L10I, T12AE, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V77I, L89M, I93LD
 EHR-40586EHR-40586JX300226None   L10I, I13V, I15V, E35D, P39Q, R41K, I62V, L63P, I93LD
 EHR-43863EHR-43863JX300279None   L10I, L33V, M36MI, N37X, P39Q, R41RK, L63P, I93LD
Han (2013)LCGA497ILCGA497IJX070509None   L19I, M36V, R41K, R57K, L63P, I93LD
Holguin (2013)ES142ES142JX467006None   L10V, T12R, I15V, Q18L, L19V, R41K, L63P, I72V, V77I, I93LD
Kiertiburanakul (2013)R75038R75038KC962535None   E35D, M36I, R41K, L63P, K70T, A71AV, V77VI, I93LD
Leye (2013)SN.MS605SN.MS605FM210727None   L10V, I15V, M36I, R57K, L63P, I64L, I93LD
Smolen-Dzirba (2013)WJK11WJK11JN811577None   L10I, I13V, I15V, L19I, E35N, P39Q, R41K, I62V, L63P, I93LD
 AJK10AJK10JN811576None   L10I, I13V, E35D, P39Q, R41K, I62V, L63P, I93LD
 LJE610LJE610JN811569None   L10I, I13V, I15V, N37S, P39Q, R41K, I62V, L63P, I93LD
Van Zyl (2013)949599KC424161None   I15V, L19I, M36I, R41K, L63A, I93LD
 251503KC424099None   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LD