<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation I93L
Rx >= 1 PI
IncludeMixtures No
References 18
Patients 78
Isolates 80
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Cuevas (2002)CU105CU105AF425486IDV   G16D, M36I, R41K, K43R, Q61E, L63P, H69K, I93LD
Gibb (2002)DMG7272_w15 NFV15  E35D, M36MI, R41K, R57K, I62V, L63H, I66IM, I93LD
Monno (2003)ML_Pat89ML_Pat89 PINAI54IV, I84V, L90MG73TL10I, I15V, G16E, L19Q, K20M, I62V, L63N, A71V, I72T, P79D, I93LD
Dumans (2004)268268AY390063SQV, RTV, NFV239  I13V, K55R, L63P, V77I, T91I, I93LD
Gomez-Carrillo (2004)9543795437AY365508PINAM46L, V82VA Q7QH, L10LI, T12TP, I15V, K20R, M36I, R41K, K55R, R57RK, L63P, I64V, I93LD
 101028101028AY365623PINAI54V, L76V, V82A L10I, I13V, I15V, K20M, E35D, M36I, R41K, Q61N, L63P, A71V, I72T, L89I, I93LD
 113575113575AY365879PINAD30N E35D, M36I, N37T, R41RK, L63C, I64V, A71V, I93LD
Montes (2004)MB_patMOL00_MOLL719AJ577953SQV, RTV, IDV, NFV143D30N Q7E, E35D, M36I, P39Q, R41K, I62V, L63P, I64L, A71V, I72V, V77I, I93LD
Snoeck (2004)BE40BE40AY900743SQV, IDV, NFV236L90M L10I, I15V, K20M, R41K, D60E, I62V, L63P, A71T, I72V, V75I, L89M, I93LD
Non-B Workgroup (2005)TK1028TK1028 RTV, IDV, NFV207M46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028a RTV, IDV, NFV231M46I, I54V, V82TL24IP1PS, L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028b RTV, IDV, NFV308M46L, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 TK2001TK2001 SQV, RTV, NFV94M46I, I84VN83DL10I, I13V, A22V, E35G, M36I, I62V, L63P, I64V, A71V, I93LD
 TK5006TK5006 SQV, RTV, NFV79L90MQ58EL10I, R41K, L63A, I64V, I72V, V77I, I93LD
 PL37067100781 IDV, RTV161  L19I, L33V, R41K, H69HQ, I93LD
Rhee (2005)ASRU017ASRU017 SQV, IDV, RTV91I84V, L90M L10I, T12S, I15V, K20T, E35G, M36I, R41K, I64V, A71T, I85V, I93LD
Baxter (2006)48-14291429-30424DQ877819PINAM46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 48-14391439-30929DQ877829PINAM46I, I54V, L76LV, V82A, L90ML10FII13V, K20I, E34EK, M36I, R41K, I62V, L63P, I64IV, A71T, L89LI, I93LD
 48-22442244-30722DQ877883PINAV32I, M46I, I54V, V82A, L90MK43T, G73TL10V, I15V, K20R, M36I, R41N, K55R, D60E, L63P, H69HR, K70R, A71V, I93L, C95VD
 48-30563056-30318DQ877968PINAM46I, I54V, L76V, V82TL10F, L89VI13V, K20M, M36I, R41K, I62V, L63P, A71V, I72V, I93LD
Cardoso (2009)3117BRGO3117FJ638454PINAM46I, I54V, L76V, V82A, L90ML33FL10V, I13V, I15V, K20R, E35D, M36I, K55R, R57K, D60E, I62V, L63P, A71V, I72V, I93LD
Koyalta (2009)8TCHAD-8FJ688175IDV26V82A L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63P, K70E, A71T, I93LD
Dau (2010)07823A07823AGU581871PINAM46I, L90M L10V, I13V, N37A, K55R, R57K, I62V, L63P, I64IV, I72IT, T74S, V77I, L89LM, I93LD
 07867A07867AGU581877PINAV32I, M46I, I47A, L90ML10F, L89VT4A, I13V, K20T, L33V, I62V, L63P, H69Y, A71V, I93LD
El-Khatib (2010)Pat11211ZA_SAVE2283JF960562LPV   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LD
Rangel (2010)HIV244bHIV244bGU807502PINA  L10I, R41K, L63T, I93LD
Aulicino (2011)ARL636VSQARL636VSQFJ525813PINAM46I, I47V, I54V, V82AL24I, L33F, K43T, F53L, Q58EL10V, G16A, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71V, I93LD
 ARM856HJMARM856HJMFJ525843PINAD30N, M46L, I54V, L90MN88DL10V, I13V, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63P, A71T, I72V, I93LD
 ARN397RLRARN397RLRFJ525859PINAM46L, I54L, V82T, I84VL24I, L33F, K43TE35D, M36I, N37E, R41K, R57K, D60N, Q61N, L63T, I64L, A71I, I72T, L89M, I93LD
 444-O288CCR444-O288CCRHQ158164PINAD30NN88DL10I, I13V, I15V, K20T, E35N, M36I, R41K, Q61N, L63P, I72T, T74M, V77I, I93LD
 476-O345RMS476-O345RMSHQ158190PINA  G16E, E35D, M36I, R41K, R57K, Q61N, I62T, L63T, A71V, I72M, I93LD
El Annaz (2012)1365013650.PRJN185268IDV52M46L, I54A, V82A L10I, K20R, E35D, M36I, N37D, R57K, L63P, I64V, K70T, A71V, I93LD
Jones (2012)127025127025JN669433PINAL90M L10I, E35D, M36I, R41K, Q61N, L63S, I64L, I93LD
 133389133389JN669521PINAI54L, I84VL33FL10I, K14R, E35D, M36I, R41K, D60E, L63P, A71V, I93LD
 147583147583JN669693PINAI54V, V82T, L90M L10I, K20R, E35D, M36I, N37E, R41K, R57K, Q61N, L63A, E65D, A71V, T74S, I93LD
 147603147603JN669694PINA  L10V, I15IV, G16E, M36I, R41K, K43R, R57K, Q61N, L63C, I93L, T96TAD
 151637151637JN669765PINAD30NN88NDK14R, I15IV, E35D, M36I, R41K, R57K, Q61N, L63P, I64L, A71AV, I93LD
 156350156350JN669863PINA  L10V, K20KR, E35D, M36I, R41K, R57K, Q61N, L63Q, P79D, I93LD
 157949157949JN669903PINAM46MI, I54V, L76LV, V82F, L90ML33FL10I, I13V, K20IT, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, I64L, C67D, A71AV, I72IT, I93LD
 159279159279JN669946PINAI47V, I54V, V82A, L90ML33F, G48W, F53L, Q58EL10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, C67E, A71V, I93LD
 159304159304JN669949PINAV82T, N88S L10I, I15V, K20KM, M36I, N37ND, R41K, K45R, R57K, Q61N, L63P, I85IV, I93LD
 159787159787JN669960PINAI54V L10V, I13V, K20R, E35D, M36I, R41K, R57K, Q61N, I64IV, A71V, I72T, T74S, Q92R, I93LD
 161350161350JN670003PINAM46MI, I47IV, I54IV, V82VFL, I84IVV11VI, L33LF, K43KT, N88ND, L89LVL10LIM, I13IV, I15V, E35D, M36I, R41K, K55R, R57K, Q61N, L63AP, A71AV, I85IV, I93LD
 162069162069JN670025PINAL90M L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, A71V, T74S, I93LD
 162542162542JN670041PINA  L10I, I15V, K20R, M36I, R41K, K43R, R57K, Q61N, L63T, C67S, I93LD
 163678163678JN670068PINAL90LM L10V, I13V, I15V, K20T, E35D, M36I, R41K, K43R, R57K, Q61N, L63T, I64L, I72T, T74S, I93LD
 166915166915JN670139PINAM46I, I54V, V82A L10I, I13A, K20R, A22V, E35ED, M36I, N37D, K55R, R57K, Q61DN, I62IV, L63P, A71T, I72T, T74S, N83S, Q92QK, I93LD
 171752171752JN670267PINAD30NN88DL10V, I13V, I15IV, E35D, M36I, N37D, R41K, K45R, R57K, Q61N, L63P, V75I, I93LD
 171784171784JN670271PINAI54IV, V82A, L90ML33LFL10V, I13V, K20KR, E35D, M36I, R41K, R57K, Q61D, I62V, L63PT, A71V, I72T, T74S, I93LD
 171988171988JN670278PINA  L10I, E35D, M36I, R41K, R57K, D60E, Q61N, L63S, I72T, I93LD
 172862172862JN670305PINAM46L, I54V, V82A, L90ML33FL10V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62IV, L63P, I64L, A71V, Q92K, I93LD
 173626173626JN670339PINAI54V, V82T, N88S L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71IV, I93LD
 176324176324JN670393PINAD30N K20T, E35D, M36I, N37D, K45Q, R57K, D60E, Q61D, L63A, A71V, I93LD
 176581176581JN670402PINA  L10V, M36I, N37S, R41K, L63P, I64V, I93LD
 177590177590JN670450PINAD30NN88DL10V, I13V, I15V, K20R, E35D, M36I, R41K, Q61D, L63P, V75I, I93LD
 178114178114JN670471PINAI54V, V82A, L90M L10V, K20R, M36I, R41K, R57K, Q61N, L63A, A71V, T74S, I93LD
 178433178433JN670483PINAM46I, I54V, L76V, V82F, L90MQ58EL10I, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, I64V, A71V, I72V, I93LD
 179481179481JN670511PINA  L10I, Q18E, E35D, M36I, R41K, Q61N, L63T, I72T, I93LD
 179876179876JN670531PINA  L10V, E35D, M36I, R41K, R57K, Q61D, L63P, I93LD
 182041182041JN670597PINAL90M L10V, I13V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, I93LD
 182997182997JN670632PINAL90M L10LV, I13V, L19I, K20T, E35D, M36I, R41K, Q61N, L63P, A71AT, T74S, I93LD
 183366183366JN670645PINA  L10I, I13V, I15V, M36I, N37D, L63T, I64L, I93LD
 183927183927JN670665PINAL90M L10V, I13V, K20R, E35D, M36I, N37D, R41K, R57K, Q61DN, I64V, I72T, I93LD
 184334184334JN670676PINAG48V, L90M L10I, L19Q, K20R, E35D, M36I, N37NT, R41K, R57K, D60E, Q61D, I62V, L63P, A71V, I72T, V82I, I85V, I93LD
 185641185641JN670705PINAI54LV, V82T, L90ML33F, F53FL, T74PSL10I, I13V, K20R, E35D, M36I, N37E, R41K, R57K, Q61N, L63AT, E65D, A71V, I72V, T80TI, L89LM, I93LD
 185997185997JN670710PINAL90M L10I, I13V, K20T, E35D, M36I, R41K, R57RK, D60E, Q61N, I62V, L63T, I64L, C67D, I72T, V82VI, I93LD
 187220187220JN670729PINAM46L, I54V, I84V, L90MG48E, L89VL10I, I13V, K20MT, E35D, M36I, R57K, Q61N, I62V, L63P, C67Y, G68E, H69Y, A71V, Q92K, I93LD
 187443187443JN670732PINAG48A, I54V, V82A, I84VL33F, N83ND, L89VL10I, K14R, K20KR, E35D, M36I, R41K, D60E, L63P, A71V, T91S, Q92QR, I93LD
 189796189796JN670781PINAI54V, L90ML23LIL10V, I13V, I15V, L19LV, K20T, E35D, M36I, N37D, R41RK, R57K, D60E, Q61D, I62V, L63P, A71I, T74S, I93LD
 193836193836JN670912PINAM46I, I54V, V82A L10I, I13A, K20R, A22V, E35D, M36I, N37D, K55R, R57K, Q61D, I62V, L63P, A71T, I72T, T74S, N83S, Q92K, I93LD
 194025194025JN670920PINAM46L, I54V, V82A, L90ML33F, K43T, G73SL10I, I13L, Q18E, K20R, E34Q, E35D, M36I, K55R, R57K, Q61N, I62V, L63P, A71V, I72T, I93LD
 194683194683JN670947PINAM46I, I54V, L76V, V82A, L90M L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, I72T, I93LD
 195199195199JN670968PINAD30NL33F, N88DL10M, I13V, I15IV, E35D, M36L, R41K, R57K, Q61N, L63A, I93LD
 195946195946JN671004PINAI54V, V82A L10V, I15V, K20R, E35D, M36I, N37D, R41K, Q61D, L63P, I93LD
 198096198096JN671100PINAM46L, I54V, V82A, L90MF53L, Q58E, T74PL10I, I15V, G16A, K20R, E35D, M36I, R41K, I62V, L63P, A71V, I85V, I93LD
 201210201210JN671216PINAI54V, V82T, I84VL33F, F53LL10I, I15V, K20R, E35D, M36I, N37D, R41K, Q61N, L63S, I64L, A71V, I72T, T74S, I85V, L89M, I93LD
 202598202598JN671278PINAL90M L10V, I15V, K20T, E35D, M36I, N37ND, R41K, R57K, Q61D, L63P, I72T, I93LD
 204389204389JN671339PINAD30N, M46IN88DL10I, I15V, G17E, K20T, M36I, N37K, R41K, R57K, Q61D, L63P, I72R, I93LD
 207305207305JN671429PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, K20T, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, I64L, C67D, A71V, I72T, I93LD
 207507207507JN671437PINA  I15V, E35D, M36I, R41K, I62V, L63P, H69Y, A71V, I93LD