<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation I93L
Rx >= 1 PI
IncludeMixtures No
References 16
Patients 64
Isolates 67
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gonzales (2001)CA3896CA9647AY030901IDV, SQV, RTV135I54V, L90M L10I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, I93LD
Cuevas (2002)CU105CU105AF425486IDV   G16D, M36I, R41K, K43R, Q61E, L63P, H69K, I93LD
Gibb (2002)DMG7272_w15 NFV15  E35D, M36MI, R41K, R57K, I62V, L63H, I66IM, I93LD
Monno (2003)ML_Pat89ML_Pat89 PINAI54IV, I84V, L90MG73TL10I, I15V, G16E, L19Q, K20M, I62V, L63N, A71V, I72T, P79D, I93LD
Montes (2004)MB_patMOL00_MOLL719AJ577953SQV, RTV, IDV, NFV143D30N Q7E, E35D, M36I, P39Q, R41K, I62V, L63P, I64L, A71V, I72V, V77I, I93LD
Non-B Workgroup (2005)TK1028TK1028 RTV, IDV, NFV207M46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028a RTV, IDV, NFV231M46I, I54V, V82TL24IP1PS, L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028b RTV, IDV, NFV308M46L, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 TK2001TK2001 SQV, RTV, NFV94M46I, I84VN83DL10I, I13V, A22V, E35G, M36I, I62V, L63P, I64V, A71V, I93LD
 TK3005TK3005 SQV, IDV, NFV262L90MG73SL10I, G16A, R41K, K45R, Q61N, G68E, H69Q, A71V, V77I, I93LD
  TK3005a SQV, IDV, NFV262L90MG73SL10I, G16A, R41K, K45R, Q61N, G68E, H69Q, A71V, V77I, I93LD
 TK3013TK3013 SQV, NFV205L90MG73SL10V, R41K, L63P, A71I, V77I, L89M, I93LD
 TK5006TK5006 SQV, RTV, NFV79L90MQ58EL10I, R41K, L63A, I64V, I72V, V77I, I93LD
 PL37067100781 IDV, RTV161  L19I, L33V, R41K, H69HQ, I93LD
Rhee (2005)CA1290CA4541AY796605SQV, IDV, NFV, RTV129M46I, G48GV, V82AT, I84IV, L90MK43T, F53FL, G73TL10I, I15V, M36I, N37D, L63P, C67CF, H69K, A71AV, I93LD
 ASRU017ASRU017 SQV, IDV, RTV91I84V, L90M L10I, T12S, I15V, K20T, E35G, M36I, R41K, I64V, A71T, I85V, I93LD
Baxter (2006)12-11341134-30326DQ876024PINAV32I, M46I, I47V, I54M, I84V, L90ML10F, L33F, L89VI13V, I15V, K20T, M36I, N37S, R41K, L63P, A71V, G73D, I93LD
 12-14811481-30812DQ876616PINAD30N, I54V, L90ML10F, N88DE35D, M36I, N37S, R41K, I62V, L63P, A71T, I72M, I93LD
 48-12181218-30701DQ877756PINAM46I, I54V, V82A, L90ML33F, G73TL10V, T12S, I13V, K14T, I15V, K20T, E35D, M36I, P39T, R41K, R57K, Q61N, I62V, L63P, A71T, I72T, I93LD
 48-14291429-30424DQ877819PINAM46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 48-14391439-30929DQ877829PINAM46I, I54V, L76LV, V82A, L90ML10FII13V, K20I, E34EK, M36I, R41K, I62V, L63P, I64IV, A71T, L89LI, I93LD
 48-22442244-30722DQ877883PINAV32I, M46I, I54V, V82A, L90MK43T, G73TL10V, I15V, K20R, M36I, R41N, K55R, D60E, L63P, H69HR, K70R, A71V, I93L, C95VD
 48-30563056-30318DQ877968PINAM46I, I54V, L76V, V82TL10F, L89VI13V, K20M, M36I, R41K, I62V, L63P, A71V, I72V, I93LD
 48-30583058-30401DQ877970PINAI54L, V82A, L90ML33F, K43KTL10I, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, T74S, L89M, I93LD
 48-50225022-30606DQ878556PINAM46I, I54V, L76V, I84V, L90ML10F, V11I, Q58E, G73A, L89VI13V, K20I, L33V, E35K, M36I, K55R, D60E, I62V, L63P, I64V, A71V, T91S, I93LD
 48-63726372-30930DQ878882PINAI54V, V82A, L90M L10V, I15V, K20R, M36I, R41K, I62V, L63P, A71V, I93LD
 48-90069006-30923DQ877670PINAI54A, V82AL24I, Q58E, L89VL10Y, I13IMV, I15V, K20I, E34KQ, E35D, M36I, N37NS, R41K, R57K, D60E, I62IV, L63P, A71V, I93LD
Waleria-Aleixo (2008)08RJ06049308RJ060493FJ591685PINA  I15V, G17D, N37T, L63P, V77I, I93LD
 08RJ06051308RJ060513FJ591705PINA  E35D, M36I, R41K, L63P, A71V, V77I, I93LD
Koyalta (2009)8TCHAD-8FJ688175IDV26V82A L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63P, K70E, A71T, I93LD
Rangel (2010)HIV244bHIV244bGU807502PINA  L10I, R41K, L63T, I93LD
Jones (2012)133389133389JN669521PINAI54L, I84VL33FL10I, K14R, E35D, M36I, R41K, D60E, L63P, A71V, I93LD
 178433178433JN670483PINAM46I, I54V, L76V, V82F, L90MQ58EL10I, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, I64V, A71V, I72V, I93LD
 183366183366JN670645PINA  L10I, I13V, I15V, M36I, N37D, L63T, I64L, I93LD
 187443187443JN670732PINAG48A, I54V, V82A, I84VL33F, N83ND, L89VL10I, K14R, K20KR, E35D, M36I, R41K, D60E, L63P, A71V, T91S, Q92QR, I93LD
 191520191520JN670829PINA  T12E, I15V, L19I, E35D, R41K, L63P, H69HNPT, A71V, I85IT, I93LD
Kouri (2012)CU373-10CU373-10JQ585388PINAM46I, I54V, L76V, V82AL24I, L33FL10I, I13V, K20R, E35D, M36I, N37D, R41K, D60E, I62V, L63P, A71V, I93LD
 CU345-10CU345-10JQ585387PINAI54IV, V82VA W6G, L10I, K20R, E35D, M36I, R41K, Q61DN, L63P, H69Q, K70T, I93LD
 CU25-10CU25-10JQ585358PINAM46L, I54V, V82A, L90ML33F, K43T, F53L, G73SL10V, I13V, L19LI, K20R, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71I, I93LD
 CU1316-09CU1316-09JQ585291PINAI84V, L90M E35D, M36I, R41K, L63P, H69K, L89M, I93LD
 CU546-11CU546-11JQ585509PINA  T12A, E35D, M36I, R41K, Q61N, I62IV, L63P, H69Q, K70Q, I93LD
 CU1805-09CU1805-09JQ585313PINAM46I, I54V, V82A, L90M L10I, K20I, M36I, N37D, R41K, K43KR, Q61N, L63P, I64L, H69Q, A71V, I72IV, I93LD
 CU461-09CU461-09JQ585253PINAI54V, L90MG73SL10I, K20R, E35D, M36I, R41K, I62V, L63P, H69Q, A71V, I93LD
 CU2076-10CU2076-10JQ585452PINAL90M E35D, M36I, L63P, H69K, L89M, I93LD
 CU1960-09CU1960-09JQ585327PINAV82VA I13V, K14R, M36I, R41K, R57K, I62V, L63P, I93LD
 CU422-11CU422-11JQ585500PINA  T12P, L19I, E35D, M36I, R41K, K43R, L63P, I93LD
 CU1708-09CU1708-09JQ585308PINA  L10V, E21K, E35D, M36I, R41K, K43R, I62V, L63P, H69Q, A71T, I72IT, I93LD
 CU1959-09CU1959-09JQ585326PINAM46L, I54L, V82T, L90ML33F, T74PL10I, I13V, E35D, M36I, R41K, K43R, K55R, L63P, H69Q, A71V, I93LD
 CU2043-09CU2043-09JQ585337PINA  I15V, K20R, E35D, M36I, R41K, K43R, I62V, L63P, H69Q, K70E, A71T, I93LD
Van Zyl (2013)364111.ZA.GT1597KC423388LPV   L10V, G16E, M36I, N37Q, R41K, D60E, L63T, H69K, I72V, I93LD
Diaz (2015)RenG16880RenG16880KT747908PINAM46L, I54V, V82ML24I, F53LL10V, T12P, K20R, E35D, M36I, N37Q, R41K, L63P, A71V, V77I, I93LD
 RenG16432RenG16432KT747460PINAI50L, N88SQ58EL10V, G16E, K20R, E35D, M36I, N37T, L63T, E65ED, H69K, A71V, I72T, L89M, I93LD
 RenG15698RenG15698KT746726PINAV32I, M46ML, I47A L10I, I13V, K14KIR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, I62V, L63LP, I64L, H69Y, I93LD
 RenG15022RenG15022KT746050PINA  W6L, L10R, I15R, M36I, R41K, I62V, L63P, I93L, N98ID
 RenG14314RenG14314KT745342PINA G73GSQ7E, L10I, R41K, D60DE, I62V, L63P, I72V, V77I, I93LD
 RenG15170RenG15170KT746198PINA G73STL10V, T12S, I15V, K20T, E35D, M36I, N37DE, R41K, K43KR, I62V, L63P, T74S, I93LD
 RenG13686RenG13686KT744714PINAM46I, I47V, I54V, V82F, L90MQ58EL10V, I13V, K20I, E35D, M36I, R41K, I62V, L63P, I64V, A71V, I93LD
 RenG14154RenG14154KT745182PINAM46MIL, I54V, V82FL33LIL10V, I13IV, I15V, K20RT, E35DN, M36I, R41K, Y59YH, D60DE, I62V, L63PS, I64IL, A71V, I72T, T74AS, V77VI, I93LD
 RenG13289RenG13289KT744317PINA  I15V, L19I, E35D, M36I, R41K, I62V, I93LD
 RenG13110RenG13110KT744138PINA  R41K, L63P, E65D, V77I, I93LD
 RenG12928RenG12928KT743956PINA  T12E, I15V, L19I, M36IV, L63P, H69K, I93LD
 RenG12819RenG12819KT743847PINAI54V, V82S, L90ML33F, F53LQ7D, L10I, I13V, K20T, E34N, E35D, M36I, N37NT, R41K, I62V, L63AP, I64L, A71M, I72V, T74S, V77L, I93LD
 RenG12091RenG12091KT743119PINAM46I, I54V, V82A, L90MG73S, L89VL10V, I13V, K20T, L33L_L, M36I, R41K, K55R, I62IV, L63P, I64IL, A71V, I93L, N98ID
 RenG10992RenG10992KT742020PINA  Q7E, T12TP, K14R, E35D, M36I, N37D, R41K, L63P, I64L, A71V, I72IV, V77I, I93LD
 RenG11287RenG11287KT742315PINAM46I, I54V, V82A, L90ML10F, K43T, G73TQ7DE, P9PL, I13M, I15V, K20I, E21EQ, E35N, M36I, R41RK, K55R, R57RK, I62IV, L63P, I64V, A71V, I72T, I85V, I93LD
 RenG10528RenG10528KT741556PINA  Q7E, R41K, L63P, I72IV, V77I, I93LD
Rossouw (2015)RP085RP085KT032027RTV, LPV218  G16E, E35D, M36I, R41K, D60E, I62V, L63P, H69K, I93LD