<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L90M
Rx >= 1 PI
IncludeMixtures No
References 16
Patients 74
Isolates 78
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gonzales (2001)CA3896CA9647AY030901IDV, SQV, RTV135I54V, L90M L10I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, I93LD
Monno (2003)ML_Pat89ML_Pat89 PINAI54IV, I84V, L90MG73TL10I, I15V, G16E, L19Q, K20M, I62V, L63N, A71V, I72T, P79D, I93LD
Gomez-Carrillo (2004)9827298272AY365573PINAI54V, I84V, L90ML33F, T74PL10I, L19V, I62V, L63P, H69Q, A71V, T91SD
 104461104461AY365704PINAV82L, L90M I15V, L19I, K20R, E35D, M36I, I62V, L63P, H69Q, I72CD
Machado (2004)cs232cs232AY502101Unknown, NFVNAI84V, L90MG73SL10I, E35D, M36I, R41K, L63P, A71VD
Montes (2004)MB_patESTU01_ESTU702AJ577887SQV, RTV, NFV, IDV309M46I, I84V, L90MV11I, G73SL10V, I13V, K20I, L33V, I62V, L63PD
Non-B Workgroup (2005)UK1392UK1392AY900799SQV161L90M L10V, I13V, R41K, L63P, I64V, K70R, I72IV, T74SD
 TK3003TK3003 SQV, NFV247I54V, L90M K20T, E35D, M36I, N37DE, R41K, D60E, I62V, L63S, I64V, V77VI, V82ID
 TK3005TK3005 SQV, IDV, NFV262L90MG73SL10I, G16A, R41K, K45R, Q61N, G68E, H69Q, A71V, V77I, I93LD
  TK3005a SQV, IDV, NFV262L90MG73SL10I, G16A, R41K, K45R, Q61N, G68E, H69Q, A71V, V77I, I93LD
 TK3006TK3006 RTV157I54IV, V82F, L90ML33FI13V, I15V, R41K, I62IV, I64GVD
  TK3006a RTV, NFV194I54V, V82F, L90ML33FI13V, I15V, R41K, I64VD
 TK3013TK3013 SQV, NFV205L90MG73SL10V, R41K, L63P, A71I, V77I, L89M, I93LD
 TK5006TK5006 SQV, RTV, NFV79L90MQ58EL10I, R41K, L63A, I64V, I72V, V77I, I93LD
Rhee (2005)CA1290CA4541AY796605SQV, IDV, NFV, RTV129M46I, G48GV, V82AT, I84IV, L90MK43T, F53FL, G73TL10I, I15V, M36I, N37D, L63P, C67CF, H69K, A71AV, I93LD
 CA1556CA20616AY796778IDV, NFV, SQV, RTV, APV, LPV228V32VI, I54V, I84V, L90ML10F, V11I, L33LF, G73GS, L89VT12P, I13V, I15V, L19LP, K20T, E35G, M36I, I62V, L63LP, A71X, P79AD
 ASRU017ASRU017 SQV, IDV, RTV91I84V, L90M L10I, T12S, I15V, K20T, E35G, M36I, R41K, I64V, A71T, I85V, I93LD
 CA6426CA37700AY797403IDV, NFV, SQV, RTV, LPV, APV352M46I, I54IV, I84IV, L90ML10F, G73GISVI13V, K20I, M36MI, I62IV, L63P, T74TS, L89MTD
Baxter (2006)12-11341134-30326DQ876024PINAV32I, M46I, I47V, I54M, I84V, L90ML10F, L33F, L89VI13V, I15V, K20T, M36I, N37S, R41K, L63P, A71V, G73D, I93LD
 12-10121012-30717DQ876218PINAV32I, M46I, I47V, I54M, I84V, L90ML10F, L33F, G73S, L89VI13V, I15V, L19I, K20T, E35D, M36I, R41N, F53Y, K55N, D60E, L63P, I64L, I66F, H69K, A71V, V77I, Q92K, T96SD
 12-14811481-30812DQ876616PINAD30N, I54V, L90ML10F, N88DE35D, M36I, N37S, R41K, I62V, L63P, A71T, I72M, I93LD
 12-17561756-30527DQ876870PINAI54V, V82A, L90MK43T, G73SL10I, I15V, K20R, E35D, M36I, I62V, L63P, H69R, A71VD
 12-30313031-30303DQ877211PINAM46MI, I54V, I84V, L90ML10F, V11I, G73ST4TP, I13V, I15V, K20I, E35NS, M36I, R41K, D60DE, I62V, L63P, A71T, I72LD
  3031-30825DQ876734PI, RTV, TPV>25M46I, I54V, I84V, L90ML10F, V11I, G73SI13V, I15V, K20I, E35NS, M36I, R41K, D60DE, I62V, L63P, A71T, I72LD
 48-12181218-30701DQ877756PINAM46I, I54V, V82A, L90ML33F, G73TL10V, T12S, I13V, K14T, I15V, K20T, E35D, M36I, P39T, R41K, R57K, Q61N, I62V, L63P, A71T, I72T, I93LD
 48-12501250-30522DQ877773PINAL90M L10I, E35D, M36I, R41K, Q61N, I62V, L63R, K70ED
  1250-40809DQ877774PI, RTV, TPV>64L90M L10I, E35D, M36I, R41K, Q61N, I62V, L63R, K70ED
 48-14391439-30929DQ877829PINAM46I, I54V, L76LV, V82A, L90ML10FII13V, K20I, E34EK, M36I, R41K, I62V, L63P, I64IV, A71T, L89LI, I93LD
 48-22442244-30722DQ877883PINAV32I, M46I, I54V, V82A, L90MK43T, G73TL10V, I15V, K20R, M36I, R41N, K55R, D60E, L63P, H69HR, K70R, A71V, I93L, C95VD
 48-30583058-30401DQ877970PINAI54L, V82A, L90ML33F, K43KTL10I, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, T74S, L89M, I93LD
 48-30833083-30313DQ877992PINAV32I, M46I, I47V, I54V, V82A, L90MK43T, F53L, G73S, L89VL10V, T12I, I13V, G16A, K20I, M36I, K55R, L63P, A71VD
 48-32573257-30710DQ878161PINAI54V, V82A, L90ML10F, V11I, Q58E, G73SI13V, I15V, K20I, M36I, D60E, Q61E, I62V, L63P, A71V, I72TD
 48-40244024-30630DQ878258PINAV32I, M46I, I47V, I54L, I84V, L90ML10F, V11I, L33F, L89VK14R, I15V, K20V, E35H, M36IL, R41K, L63P, C67CY, A71I, I85V, Q92KD
 48-41454145-30530DQ878377PINAV32I, M46I, I54M, I84V, L90ML33F, K43T, G73S, L89VL10V, I13V, G16A, K20L, F53Y, D60E, L63P, I66F, A71V, I72L, P79ND
 48-50225022-30606DQ878556PINAM46I, I54V, L76V, I84V, L90ML10F, V11I, Q58E, G73A, L89VI13V, K20I, L33V, E35K, M36I, K55R, D60E, I62V, L63P, I64V, A71V, T91S, I93LD
 48-60286028-30409DQ878627PINAI54V, V82F, L90MV11VI, L33LF, F53LL10V, I13IV, R41K, K45V, I62V, L63P, H69K, A71V, I72V, T74A, V77ID
 48-61576157-30704DQ878733PINAG48A, I54V, V82A, I84V, L90ML33F, Q58E, G73GS, L89LVT4S, L10I, K20R, E35D, M36L, R57RK, I62V, L63P, A71V, I72ILM, Q92KD
 48-63726372-30930DQ878882PINAI54V, V82A, L90M L10V, I15V, K20R, M36I, R41K, I62V, L63P, A71V, I93LD
 48-71347134-30729DQ878972PINAV32I, M46L, V82A, L90MK43T, L89VI13V, K20R, M36I, I62V, L63P, A71VD
von Wyl (2007)1285248038EF449884PINAL90ML24IL10I, I13V, E35G, M36I, R41K, I62V, L63P, A71T, T74A, V75ID
Waleria-Aleixo (2008)RG44RG44FJ592052PINAM46MI, L90MG73CL10I, K20I, E35D, M36I, I62V, L63P, I64V, T74SD
 08PR06075308PR060753FJ591549PINAV32I, M46MI, I54V, L90ML33I, K43T, F53LL10V, I13V, G16E, L19LI, K20M, E35EG, M36I, L63R, I66F, H69R, A71V, I72IVD
 08RJ06060708RJ060607FJ591767PINAM46I, I54V, I84V, L90ML10F, L33F, T74PK20I, E35N, M36I, N37DE, I62V, L63P, I64M, C67F, H69K, A71V, I72V, T91TS, Q92KD
 08PR05023208PR050232FJ591261PINAI54L, V82A, L90ML33F, K43T, F53LL10V, I13V, I15IV, K20R, E35D, M36I, R41K, I62V, L63P, H69K, A71I, T74S, I93IMD
Charpentier (2010)T076006T076006HQ717826PI, DRV, RTVNAG48M, I54T, V82A, L90ML33F, Q58EL10I, T12M, I13V, G16E, K20R, E35D, M36I, R41K, L63T, E65D, I72T, T74A, L89MD
Rhee (2010)CA8386CA63933GQ211811NFV269M46MI, L90M T12S, I13V, I15V, L19I, K20T, M36I, R41RK, K55KR, R57RK, D60E, I62V, L63P, I64V, I93ILD
Aulicino (2011)321-L82321-L82HQ158268PINAL90M I15V, K20T, E35N, M36I, R41K, I62V, L63P, T74SD
Jones (2012)178433178433JN670483PINAM46I, I54V, L76V, V82F, L90MQ58EL10I, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, I64V, A71V, I72V, I93LD
 200084200084JN671190PINAM46I, I54IV, I84V, L90ML33F, K43KT, T74PL10I, I13V, K20KR, M36I, R41RK, K55KR, I62V, L63P, H69K, K70KT, A71V, T91SD
Kouri (2012)CU25-10CU25-10JQ585358PINAM46L, I54V, V82A, L90ML33F, K43T, F53L, G73SL10V, I13V, L19LI, K20R, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71I, I93LD
 CU1627-09CU1627-09JQ585302PINAI54V, V82A, I84V, L90M L10I, K20I, E35G, M36I, R41K, D60E, I62V, L63P, H69HQ, A71VD
 CU1316-09CU1316-09JQ585291PINAI84V, L90M E35D, M36I, R41K, L63P, H69K, L89M, I93LD
 CU1806-09CU1806-09JQ585314PINAL90MQ58EL10I, E35DN, M36I, N37D, R41K, L63P, H69Q, A71TD
 CU1805-09CU1805-09JQ585313PINAM46I, I54V, V82A, L90M L10I, K20I, M36I, N37D, R41K, K43KR, Q61N, L63P, I64L, H69Q, A71V, I72IV, I93LD
 CU461-09CU461-09JQ585253PINAI54V, L90MG73SL10I, K20R, E35D, M36I, R41K, I62V, L63P, H69Q, A71V, I93LD
 CU2076-10CU2076-10JQ585452PINAL90M E35D, M36I, L63P, H69K, L89M, I93LD
 CU90-10CU90-10JQ585361PINAI50V, I54L, L90ML10F, L33F, K43T, F53L, L89VQ2P, L5F, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37G, R41K, D60E, L63P, H69HY, A71IV, V77I, V82I, I93ILD
 CU1483-09CU1483-09JQ585297PINAM46I, L90M I13V, E35D, M36I, R41K, L63P, H69QD
 CU1959-09CU1959-09JQ585326PINAM46L, I54L, V82T, L90ML33F, T74PL10I, I13V, E35D, M36I, R41K, K43R, K55R, L63P, H69Q, A71V, I93LD
 CU311-10CU311-10JQ585381PINAI50V, I54L, L90ML33F, K43T, F53L, L89VV11L, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37D, R41K, D60E, L63P, H69Y, A71I, V77I, V82ID
Diaz (2015)RenG16786RenG16786KT747814PINAI54V, L90MF53L, G73SL10I, K14KE, I15V, K20R, E34EAD, E35D, M36I, R41K, L63P, A71VD
 RenG16175RenG16175KT747203PINAM46I, I54V, V82S, L90MV11I, G73STL10I, T12P, I15V, G16A, L19Q, K20I, M36I, K45R, K55R, L63P, C67G, A71V, I72L, I85VD
 RenG16031RenG16031KT747059PINAL90MV11IL10I, I15V, L19Q, K20T, E35G, M36I, P39S, R41K, I62V, L63P, H69Y, A71V, I72L, T74SD
 RenG15645RenG15645KT746673PINAM46I, I54V, I84V, L90ML10F, F53L, T74PI13V, K20R, E35D, M36I, R41K, K55H, R57K, L63P, H69R, A71V, L89I, T91S, Q92KD
 RenG17066RenG17066KT748094PINAI54L, L90MG73SI15IV, K20T, E35D, M36I, R41K, K45KR, L63P, A71VD
 RenG16766RenG16766KT747794PINAV32I, M46I, I54L, I84V, L90ML10F, V11I, L33F, G73T, L89VI13V, K20M, M36I, I62V, L63P, I66V, A71T, I72V, C95ID
 RenG15911RenG15911KT746939PINAL90MG73GSI13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71AITV, T74SD
 RenG16895RenG16895KT747923PINAM46I, I47V, I54V, V82A, L90MV11I, F53L, G73S, L89VL10IV, I13V, I15V, L19LAPV, K20I, E35G, M36I, L63P, A71V, I72L, Q92KD
 RenG17154RenG17154KT748182PINAN88NS, L90MF53FL, G73GST12M, I13V, I15V, L19V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, V77VI, Q92KD
 RenG13686RenG13686KT744714PINAM46I, I47V, I54V, V82F, L90MQ58EL10V, I13V, K20I, E35D, M36I, R41K, I62V, L63P, I64V, A71V, I93LD
 RenG13261RenG13261KT744289PINAM46I, I54V, I84V, L90MV11I, G73CL10I, I13AV, K14KI, I15IV, Q18H, K20I, E35D, M36I, N37ND, I62V, L63P, I64V, C67Y, I72L, T74S, T91TCSD
 RenG12659RenG12659KT743687PINAI50L, L90MG73SK14R, I15V, G17D, K20T, E35DN, M36I, R41K, K45R, R57K, Q61N, L63P, A71VD
 RenG12819RenG12819KT743847PINAI54V, V82S, L90ML33F, F53LQ7D, L10I, I13V, K20T, E34N, E35D, M36I, N37NT, R41K, I62V, L63AP, I64L, A71M, I72V, T74S, V77L, I93LD
 RenG13053RenG13053KT744081PINAV32I, M46L, G48GV, I50IL, V82A, L90ML33F, G73GS, L89VL10I, I13V, L19I, L24LF, E34EQ, E35ED, M36I, N37S, R41K, K55HQ, I62IV, L63A, I64L, A71VD
 RenG12091RenG12091KT743119PINAM46I, I54V, V82A, L90MG73S, L89VL10V, I13V, K20T, L33L_L, M36I, R41K, K55R, I62IV, L63P, I64IL, A71V, I93L, N98ID
 RenG11287RenG11287KT742315PINAM46I, I54V, V82A, L90ML10F, K43T, G73TQ7DE, P9PL, I13M, I15V, K20I, E21EQ, E35N, M36I, R41RK, K55R, R57RK, I62IV, L63P, I64V, A71V, I72T, I85V, I93LD
 RenG10591RenG10591KT741619PINAL90ML23I, F53LL10I, T12K, I13L, I15V, L19Q, K20T, E35D, M36I, N37NADT, R41K, K55R, R57K, I62V, L63P, I66IV, A71V, T74S, V75ID
 RenG10617RenG10617KT741645PINAV32I, M46I, I47V, I54V, V82A, L90MV11I, L33F, G73S, L89VL10V, I13V, I15V, L19P, K20R, M36I, N37D, K55R, R57K, I62V, L63P, I64L, A71V, I72VD