<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L89M
Rx PI-naive
IncludeMixtures No
References 36
Patients 47
Isolates 47
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Holguin (2000)AHHC17HolgHC17AF188349None   L10I, E35D, M36I, R41K, L63A, C67D, H69K, L89MD
Servais (2001)JS97510JS97510AJ279673None   I15IM, L19T, N37K, R41N, H69K, L89MD
Cuevas (2002)CU70CU70AF425451None   L10V, T12P, E35D, M36I, R41K, Q61E, L63P, C67Y, H69Q, L89MD
Papathanasopoulos (2002)99ZACM499ZACM4AF411964None   I13V, K20I, E35D, M36I, N37S, R41K, I64M, K70R, L89MD
Huang (2003)SE365SE365AF447843None   L10V, T12A, I13V, E35D, M36I, P39PS, R41K, R57K, Q61N, L89MD
Soares (2003)BRBS530BRBS530AF527186None   G16GE, K20R, E35D, M36I, R41K, I62V, H69HY, K70KR, I72E, L89M, C95SD
Konings (2004)KF_Pat900CM2636AY359691None   L10I, G16E, E35D, M36I, N37D, R41K, I62V, L89MD
Yang (2004)99KE57099KE570AY492778None   R41K, L63P, L89MD
Lama (2006)Pt37593759 None   I13V, E35D, M36I, R41K, I62V, L63S, I64M, L89MD
Njai (2006)MP102098CM.1020AM279379None   I15V, G16E, M36V, R41K, L89MD
Vidal (2006)NV_KTB18302.KTB183AM040990None   T12D, L19K, K20R, L23P, D29H, E35D, M36I, R41K, L63A, L89MD
 NV_LBS03802.LBS038AM041035None   K20R, M36I, R41K, Q61E, L89MD
Galluzzo (2007)23610RW_23610JQ220051None   I13V, E35D, M36I, R41K, H69K, L89MD
Derache (2008)SGO-96SGO-96EU330836None   K14R, I15V, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, C67E, H69R, L89M, I93LD
Kousiappa (2009)CY007CY007EU673377None   T12S, I15V, E35D, M36I, R41K, K43KQ, L89MD
Koyalta (2009)74TCHAD-74FJ688204None  Q58ET4S, K14R, I15V, K20R, E35D, M36I, R41K, L89MD
 85TCHAD-85FJ688209None  Q58ET4S, K14R, I15V, K20R, E35D, M36I, R41K, L89MD
de Medeiros (2011)Pat097RS012JF487926None   N37S, R41K, H69K, T74A, V77I, R87K, L89M, I93LD
Hamers (2011)CP076301750CP076301750HQ993739None   Q18I, L19V, E35D, M36I, R41K, L63T, I64L, H69Y, I72T, L89MD
 CP076300814CP076300814HQ994946None   I13V, K14R, I15V, R41K, H69K, L89MD
 CP076302004CP076302004HQ995017None   L19I, R41K, L89MD
 CP076303068CP076303068HQ995248None   I13V, K14KR, M36I, R41K, L63LP, L89MD
Hamers (2012)CP076304736CP076304736JQ480234None   I13V, K14R, I15V, R41K, H69K, L89MD
Brooks (2013)CAN2013-151CAN13-151KF727692None   L10LV, T12TS, I15IV, K20R, E35D, M36I, R41K, L63S, H69K, L89M, I93LD
Inzaule (2013)3636JQ914100None   G17E, R41K, H69Y, I72IV, V77I, L89MD
Kiptoo (2013)KTL019KTL019KC516995None   I13V, M36I, R41K, L89MD
 SNH081SNH081KC516957None   I13V, L19I, M36I, R41K, L63Q, I64IK, E65ED, I66IMV, H69HQ, I72I*KL, L89MD
Pircher (2013)A1011A1011JX110260None   I13V, K20R, E35D, M36I, P39Q, R41K, I62V, L63P, I64IM, H69Y, I72V, L89MD
Rusine (2013)712H712HKC841736None   L10V, T12TS, I13V, I15IV, G17GE, E35D, M36I, R41K, K45KR, L63P, I72V, L89MD
Bracho (2014)9261073592610735HF567873None   I13X, K14R, K20I, M36I, N37D, R41K, I64M, L89MD
Chung (2014)KVE_34_KA453eKVE_34_KA453eKF544262None   K14R, E35D, M36I, R57K, L63T, H69K, V77I, L89MD
Lee (2014)MBA1467MBA1467KJ907145None   L10I, I13V, K20V, M36I, R41K, C67Y, L89MD
 MBA1294MBA1294KJ906984None   L10I, I13V, K14KR, G16GE, L19P, K20I, M36I, R41K, L63A, E65D, L89MD
Hattori (2016)F12_99348F12-2099348-1AB866547None   T4AP, L5LF, L10V, T12P, I13V, E35D, M36IV, R41K, K43KR, D60E, L63P, K70R, L89MD
Kityo (2016)JFP086JFP086m0KT348073None   L10V, I13V, K20R, M36I, P39S, R41K, K45R, L63P, L89MD
Steegen (2016)GFWCB012GFWCB012KU127778None   E35D, M36I, R41K, L63A, H69K, L89MD
Vubil (2016)NPL070NPL070KT729428None   I13V, E35D, M36I, R41K, R57K, L63Q, H69K, L89MD
Zeh (2016)3001990_053001990_05KU248696None   M36I, R41K, I62IV, L63Q, I64IMV, L89MD
Chaplin (2017)NJIH0256NJIH0256MF622807None   L10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70R, L89MD
 NJIH0255NJIH0255MF622806None   L10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70R, L89MD
Dow (2017)1610216102KY747364None   T12A, I13V, K14R, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, L89MD
Kityo (2017)JCR067JCR067m0KT347943None   I13V, L19V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89MD
 JCR116JCR116m0KT347990None   I13V, G16E, E35D, M36I, R41K, K45R, R57K, H69K, K70R, L89MD
 JFP008JFP008m0KT348003None   I13V, K14R, G16A, E35D, M36I, R41K, R57K, L63LR, H69K, L89MD
 MBA008MBA008m0KT348108None   I13V, G16E, K20R, M36I, R41K, R57K, H69K, T74S, L89MD
Posada Cespedes (2017)472614.ZA.GT3822KY205508None   K14G, I15V, K20R, M36I, R41K, L63V, E65D, H69K, L89MD
Verhofstede (2017)09240924MF754525None   E35D, M36I, R41K, R57K, L89MD