<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L89M
Rx PI-naive
IncludeMixtures No
References 68
Patients 105
Isolates 106
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Pieniazek (1998)LE-4LE4AF025740None   L10I, E35D, M36I, R41K, L63V, H69K, L89M, T91PD
Becker-Pergola (2000)225.745BPG225.745AF176038None   E35D, M36I, R41K, L63T, H69K, L89MD
Holguin (2000)AHHC17HolgHC17AF188349None   L10I, E35D, M36I, R41K, L63A, C67D, H69K, L89MD
Servais (2001)JS97510JS97510AJ279673None   I15X, L19T, N37K, R41N, H69K, L89MD
Cuevas (2002)CU60CU60AF425441None   I13V, K14R, G16E, K20M, E35D, M36I, R41K, K43R, L63P, H69Q, L89MD
Eshleman (2002)138430v138430vAF410231None   E35D, M36I, R41K, R57RK, L63P, H69K, K70R, L89MD
Pandrea (2002)IP_97CIRMF2297CIRMF22AY140617None   T12S, K14R, L19V, M36I, R41K, L63A, H69K, L89M, G94SD
Papathanasopoulos (2002)99ZACM499ZACM4AF411964None   I13V, K20I, E35D, M36I, N37S, R41K, I64M, K70R, L89MD
Shafer (2003)A384_03730373aEF548940None   I13V, E35ED, M36I, R41K, H69K, L89MD
Soares (2003)BRBS530BRBS530AF527186None   G16GE, K20R, E35D, M36I, R41K, I62V, H69HY, K70KR, I72E, L89M, C95SD
Lama (2006)Pt37593759 None   I13V, E35D, M36I, R41K, I62V, L63S, I64M, L89MD
Marechal (2006)JF_122JF_122DQ443704None   I13V, E35D, M36I, R41K, D60E, Q61N, L63T, E65D, H69K, V77I, L89MD
Njai (2006)MP102098CM.1020AM279379None   I15V, G16E, M36V, R41K, L89MD
Rousseau (2006)Pt6303PS119MB1DQ351238None   L10I, E35D, M36I, R41K, L63Q, H69K, L89MD
Vidal (2006)NV_KTB18302.KTB183AM040990None   T12D, L19K, K20R, L23P, D29H, E35D, M36I, R41K, L63A, L89MD
 NV_LBS03802.LBS038AM041035None   K20R, M36I, R41K, Q61E, L89MD
 NV_LBS04802.LBS048AM041002None   I13V, K14I, I15V, L19Q, K20R, M36I, R41K, D60E, Q61H, L63S, H69K, L89M, I93LD
Vidal (2006)KTB1397.KTB13AM000054None   L10I, I13V, E35D, M36I, R41K, H69K, L89MD
Galluzzo (2007)23290RW_23290JQ220045None   I13V, E35D, M36I, R41K, I62V, L63S, H69K, L89MD
 23610RW_23610JQ220051None   I13V, E35D, M36I, R41K, H69K, L89MD
Novitsky (2007)16171617_9067EF026216None   Q18E, K20R, M36I, R41K, Q61E, H69K, L89M, I93LD
Caron (2008)1652Gab1652PEU556467None   L10V, I15V, G16E, E35D, M36I, R41K, H69K, L89MD
Church (2008)318990H318990HEU380720None   E35D, M36I, R41K, H69K, L89MD
Derache (2008)SGO-96SGO-96EU330836None   K14R, I15V, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, C67E, H69R, L89M, I93LD
Matthews (2008)PS119PS119FJ199691None   L10I, E35D, M36I, R41K, L63Q, H69K, L89MD
Nyombi (2008)TMS148TMS148EU251837None   I13V, G16E, E35D, M36I, R41K, Q61H, L63H, H69K, I72V, T74S, L89M, I93LD
 TMS347TMS347EU251880None   I13V, G16E, M36I, P39T, R41K, D60E, L63P, H69K, L89M, I93LD
Bartolo (2009)HJM11501AOHJM115EU068253None   T12N, K14R, I15V, E35D, M36I, R41K, K45R, L63T, H69K, L89M, I93LD
Eshleman (2009)E13257W207-156981FJ389087None   E35D, M36I, R41K, H69K, K70R, L89MD
Kousiappa (2009)CY007CY007EU673377None   T12S, I15V, E35D, M36I, R41K, K43KQ, L89MD
Koyalta (2009)74TCHAD-74FJ688204None  Q58ET4S, K14R, I15V, K20R, E35D, M36I, R41K, L89MD
 85TCHAD-85FJ688209None  Q58ET4S, K14R, I15V, K20R, E35D, M36I, R41K, L89MD
Steegen (2009)BV245BV245-1EU872132None   I13V, K20R, E35D, M36I, N37D, K45R, R57K, L63T, H69K, L89MD
Castelbranco (2010)090044A090044AHM357751None   T4S, L10V, T12TI, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MD
Djoko (2010)658CD0729FR666658None   I13IV, K14I, I15V, L19Q, K20R, M36I, N37S, R41K, L63T, H69K, L89M, I93LD
Djoko (2010)GQ26708GQ267FN557340None   I13V, L19I, E35D, M36I, N37D, D60E, I62V, L63P, L89MD
Gonzalez (2010)MO_3MO_3GQ433873None   G16E, E35D, M36I, P39S, R41K, K45R, D60E, Q61E, L63P, H69K, L89M, I93LD
Ndembi (2010)13306D_P113306GQ409553None   L10V, I13V, I15V, K20I, E35D, M36I, R41K, L63P, I64M, N83H, L89MD
de Medeiros (2011)Pat097RS012JF487926None   N37S, R41K, H69K, T74A, V77I, R87K, L89M, I93LD
El Annaz (2011)1573715737HQ393321None   T12S, I13V, K14I, I15V, L19Q, K20R, E34EG, M36I, N37NHRS, L63T, H69K, T74S, L89M, I93LD
Hamers (2011)300405CP076300405HM119832None   T12S, K14R, I15V, L19I, K20R, E35D, M36I, R41K, R57K, H69K, L89MD
 CP076301542CP076301542HQ993585None  I50KE35D, M36T, R41K, D60E, L63P, H69K, V77I, L89MD
 CP076301579CP076301579HQ993618None   L10I, I13V, E35D, M36I, R41K, H69K, L89MD
 CP076301718CP076301718HQ993711None   L5X, L10V, I13V, E35D, M36I, R41K, D60E, Q61E, I62V, L63P, H69K, L89MD
 CP076301750CP076301750HQ993739None   Q18I, L19V, E35D, M36I, R41K, L63T, I64L, H69Y, I72T, L89MD
 CP076301773CP076301773HQ993759None   P9PFLS, E35D, M36I, N37D, R57K, L63S, H69K, L89MD
 CP076304254CP076304254HQ993942None   K14KR, E35ED, M36I, R41K, H69K, L89MD
 CP076300814CP076300814HQ994946None   I13V, K14R, I15V, R41K, H69K, L89MD
 CP076301880CP076301880HQ995009None   K20R, E35D, M36I, R57K, I62V, I64IM, H69K, K70R, L89MD
 CP076302004CP076302004HQ995017None   L19I, R41K, L89MD
 CP076300870CP076300870HQ995128None   I13V, E35D, M36I, R41K, L89MD
 CP076303068CP076303068HQ995248None   I13V, K14KR, M36I, R41K, L63LP, L89MD
 CP076301900CP076301900HQ995379None   I13V, I15V, E35D, M36I, R41K, H69K, I72IM, L89MD
 CP076301966CP076301966HQ995430None   L10I, I13V, E35D, M36I, R41K, L63T, C67Y, H69K, L89MD
Kasang (2011)3264432644HM572414None   I15V, L19I, E35D, M36I, N37D, R41K, H69K, L89MD
 3265532655HM572419None   E35D, M36I, R41K, L63M, H69K, L89MD
Ndembi (2011)AICPS283AICPS283HQ702652None  L33FI13V, E35D, M36I, R41K, I62V, L63P, I64L, H69K, K70R, L89M, F99LD
De Gascun (2012)IRL19192IRL19192JN622358None   I13V, L19V, R41K, I62V, L63P, I64L, H69K, L89MD
Hunt (2012)GP09_2391GP09_2391KF736753None  Q58ET12S, L19I, E35D, M36I, R41K, R57K, D60E, Q61E, L63P, H69K, L89M, I93LD
Ndase (2012)5300730253007302KC900699None   G16E, E35D, M36I, L63HPQ, H69K, K70Q, L89M, I93LD
Ssemwanga (2012)0765HR0765HRJF800190None   I13V, I15V, E35D, M36I, R41K, H69K, L89MD
Antoniadou (2013)GR136GR136KF671844None   L10I, I13V, L19I, E35D, M36I, R41K, K45R, R57K, D60E, L63T, C67Y, H69Q, L89MD
Bila (2013)MZ10-212HIV-1KF927311None   T12S, K14KR, I15V, L19T, M36L, N37Q, R41K, D60E, I62V, L63P, H69K, I72M, L89MD
 MZQUE300HIV-1KF927433None   E35D, M36I, R41K, L63P, H69K, L89M, I93LD
Brooks (2013)CAN2013-151CAN13-151KF727692None   L10LV, T12TS, I15IV, K20R, E35D, M36I, R41K, L63S, H69K, L89M, I93LD
Frentz (2013)EHR-41871EHR-41871JX300248None   E35D, M36I, N37D, R41K, L63S, H69K, L89MD
Hassan (2013)RS09000982RS09000982HQ441717None   L10V, L19P, E35D, M36I, N37D, R57K, L63T, H69K, L89MD
 RS11000311RS11000311JQ698393None   I13V, E35D, M36I, N37D, R41K, H69K, L89MD
Inzaule (2013)3636JQ914100None   G17E, R41K, H69Y, I72IV, V77I, L89MD
Kemal (2013)77477747JQ364525None   I13V, K20R, E35D, M36I, R41K, Q61D, L63T, E65D, H69K, I72T, L89MD
 82218221JQ364536None   E35D, M36I, R41K, I62V, H69K, L89MD
Kiptoo (2013)KAP041KAP041KC516893None   I13V, K14KR, E35DN, M36I, R41K, H69K, L89MD
 KTL019KTL019KC516995None   I13V, M36I, R41K, L89MD
 SNH081SNH081KC516957None   I13V, L19I, M36I, R41K, L63Q, I64IK, E65ED, I66IMV, H69HQ, I72I*KL, L89MD
 KAP001KAP001KC516873None   W6W*, I13V, E35D, M36I, R41K, H69K, L89MD
Li (2013)hnr129hnr129KC988061None   I15V, E35D, M36I, R41K, L63T, H69K, L89M, I93LD
Ong (2013)08MYKL04608MYKL046KC181215None   L5F, M36I, R41K, L63I, H69K, L89MD
Pircher (2013)A1011A1011JX110260None   I13V, K20R, E35D, M36I, P39Q, R41K, I62V, L63P, I64IM, H69Y, I72V, L89MD
Rusine (2013)713H713HKC841778None   I13V, I15IV, E35D, M36I, R41K, L63AV, H69K, L89MD
 712H712HKC841736None   L10V, T12TS, I13V, I15IV, G17GE, E35D, M36I, R41K, K45KR, L63P, I72V, L89MD
 487H487HKC841722None   I13V, I15IV, G16GE, M36I, R41K, I62IV, L63LP, H69IK, I72IR, L89MD
Agyingi (2014)LB065LB065KF576458None   I15X, K20R, E35S, M36I, N37D, R41K, L63P, I72T, L89MD
Bartolo (2014)09AOHDP23009AOHDP230KF853811None   I13V, K14R, L19V, E35D, M36I, N37D, R41K, H69K, L89MD
Chung (2014)KVE_34_KA453eKVE_34_KA453eKF544262None   K14R, E35D, M36I, R57K, L63T, H69K, V77I, L89MD
Lee (2014)MBA1467MBA1467KJ907145None   L10I, I13V, K20V, M36I, R41K, C67Y, L89MD
 AMU019AMU019KJ906640None   T12P, I13V, K14KR, G16E, E35D, M36I, R41K, H69K, L89MD
 MBA1517MBA1517KJ907191None   L10V, I15V, E35D, M36I, R41K, K43R, R57K, L63P, H69K, L89MD
 MBA1294MBA1294KJ906984None   L10I, I13V, K14KR, G16GE, L19P, K20I, M36I, R41K, L63A, E65D, L89MD
 MBA1509MBA1509KJ907185None   E35D, M36I, R41K, H69K, L89MD
Meixenberger (2014)12-0021112-00211KJ771681None   K20R, E35D, M36I, R41K, L63P, I64L, H69K, V82I, L89M, I93LD
 10-0276710-02767KJ771432None   K20R, E35D, M36I, R41K, L63P, I64L, H69K, V82I, L89M, I93LD
Cheriro (2015)NLHG-79NLHG-79KT370901None   I15X, E35D, M36I, N37D, R41K, R57K, H69K, L89MD
 NLHG-119NLHG-119KT370877None   I13V, K20R, M36I, P39PS, R41K, I62V, I64M, L89MD
Skhosana (2015)12ZALS13012ZALS130KM115865None   I13V, M36I, R41K, L63A, H69K, V75I, L89MD
Sutherland (2015)77_PREKT351843None   L10LV, I13V, E35D, M36I, R41K, H69K, L89MD
Yao (2015)CN.iso72CN.iso72KC924480None   E35D, M36I, R41K, K55Q, D60E, Q61E, L63P, C67F, H69K, L89M, I93LD
 CN.iso71CN.iso71KC924479None   E35D, M36I, R41K, D60E, L63P, H69K, I85M, G86E, R87E, N88H, L89M, I93LD
 CN.iso116CN.iso116KC924513None   M36I, R41K, D60E, L63P, H69K, L89M, I93LD
Inzaule (2016)1.0410.4.51.0410.4.5KR138542None   I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89MD
Pouran Yousef (2016)433210-02767KX466977None   K20R, E35D, M36I, R41K, L63P, I64L, H69K, V82I, L89M, I93LD
  12-00211KX466978None   K20R, E35D, M36I, R41K, L63P, I64L, H69K, V82I, L89M, I93LD
Steegen (2016)GFKZB060GFKZB060KU127926None   L19V, E35D, M36I, R41K, L63P, H69K, L89M, I93LD
 GFGPB128GFGPB128KU128176None   T4TS, K14E, I15V, K20R, E35D, M36I, I62V, L63AV, E65D, H69K, V82I, L89MD
 GFWCB012GFWCB012KU127778None   E35D, M36I, R41K, L63A, H69K, L89MD
Witaningrum (2016)PB37PB37KU596500None   I13V, Q18L, M36I, R41K, I62V, L63P, A71T, L89MD
Zeh (2016)3001990_053001990_05KU248696None   M36I, R41K, I62IV, L63Q, I64IMV, L89MD