<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L89M
Rx PI-naive
IncludeMixtures No
References 38
Patients 103
Isolates 105
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Holguin (2000)AHHC18HolgHC19AF188350None   I13V, K14R, I15V, K20I, E35Q, M36I, R41K, R57K, I64M, C67E, H69K, V82I, I85M, L89MD
Eshleman (2001)SE414SE414AF388141None   I13V, E35D, M36I, P39Q, R41K, K45R, R57K, L63P, H69K, L89MD
 SE561SE561AF388093None   I13IV, K14KN, L19LI, K20KR, E35D, M36I, N37DE, R41K, H69K, K70R, L89MD
 SE249SE249AF388073None   I13V, G16E, E35D, M36I, R41K, R57K, D60E, H69K, L89MD
Weidle (2001)PW_UG458PW_UG458AF358752None   I13V, G16E, E35D, M36I, R41K, R57K, H69K, L89MD
Cuevas (2002)CU60CU60AF425441None   I13V, K14R, G16E, K20M, E35D, M36I, R41K, K43R, L63P, H69Q, L89MD
 CU57CU57AF425438None   I13V, L19I, K20I, E35D, M36I, R41K, H69K, V82I, L89MD
 CU45CU45AF425426None   L10I, I13V, K20I, E35D, M36I, R41K, K45R, L63P, H69Q, L89MD
Dowling (2002)KER2017KER2017AF457056None   I13V, E35D, M36I, N37D, R41K, H69K, L89MD
Eshleman (2004)SE561SE561_7dAY428694None   I13IV, K14KN, G16GE, L19LI, K20KR, E35D, M36I, N37D, R41K, H69K, K70R, L89MD
Eshleman (2004)ESH_Pat17ESH182AY435242None   I13V, K14R, E35D, M36I, R41K, R57K, L63S, H69K, I72IT, L89MD
 ESH_Pat70ESH634AY435326None   I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89MD
 ESH_Pat75ESH66AY435235None   I13V, K20R, M36I, R41K, H69K, L89MD
Eshleman (2004) SE66_7dAY428674None   I13V, K20R, M36I, R41K, H69K, L89MD
Eshleman (2004)ESH_Pat86ESH207AY435254None   I13V, E35D, M36I, R41K, K45KR, H69K, L89MD
 ESH_Pat90ESH428AY435277None   I13V, K20KR, E35D, M36I, R41K, K45R, R57K, I64L, H69K, L89MD
 ESH_Pat115ESH729AY435342None   I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89MD
 ESH_Pat177ESH531AY435308None   I13V, K14R, E35D, M36I, R41K, R57K, L63S, H69K, K70KR, L89MD
Yang (2004)97KE00497KE004AY492752None   I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89MD
Koizumi (2006)YK_04CM063YK_04CM063DQ461854None   I13V, K14R, K20I, M36I, R41K, H69K, L89MD
Niama (2006)CHU08CHU08FM164900None   I15V, E35D, M36I, R41K, I62V, L63A, V82VI, L89MD
Ojesina (2006)AIO_DDJ134AIO_DDJ134DQ273935None   I13V, I15V, E35D, M36I, R41K, R57K, L63I, H69K, L89MD
Rodrigues (2006)BR04RS109BR04RS109DQ070615None   L10V, I15V, M36I, N37K, R41N, H69K, L89MD
 BR04RS114BR04RS114DQ070614None   I15V, M36I, N37K, R41N, D60E, H69K, L89MD
Vidal (2006)NV_KTB24202.KTB242AM040997None   I15V, G16E, K20R, E35D, M36I, R41K, K45R, L63A, H69K, L89M, I93LD
 NV_LBS03802.LBS038AM041035None   K20R, M36I, R41K, Q61E, L89MD
Brumme (2007)1432PRRT_1432EF368742None   I13V, G16A, E21G, E35D, M36I, R41K, R57K, H69K, L89MD
Church (2007)497-126960M497EF612046None   I13V, K14KR, E35D, M36I, R41K, E65ED, H69K, L89MD
Somi (2008)BG-05-957BG-05-957JQ616954None   I13V, K14R, K20KQ, E35D, M36I, R41K, K45KR, H69K, L89MD
Bartolo (2009)CSE11601AOCSE116EU068199None   L10V, I13V, K14T, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MD
 HAB8301AOHAB83EU068217None   L10V, I13V, I15V, G16E, E35D, M36I, N37S, R41K, R57K, L63T, L89MD
 HAB8501AOHAB85EU068218None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, H69S, L89MD
Kousiappa (2009)CY007CY007EU673377None   T12S, I15V, E35D, M36I, R41K, K43KQ, L89MD
Koyalta (2009)74TCHAD-74FJ688204None  Q58ET4S, K14R, I15V, K20R, E35D, M36I, R41K, L89MD
 85TCHAD-85FJ688209None  Q58ET4S, K14R, I15V, K20R, E35D, M36I, R41K, L89MD
Hattori (2010)F08-5112131F08-5112131AB866767None   L10V, I13V, M36I, I62V, L63P, L89MD
 C08-2069050C08-2069050AB868202None   K14R, I15V, M36I, R41K, L63A, L89M, I93LD
 C08-51110698C08-51110698AB865105None   K14R, I15V, M36I, R41K, L63A, L89MD
Florea (2011)105_2008105_2008JQ083016None   L10V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, L63T, E65D, I72T, T74S, L89MD
 1091_20071091_2007JQ083019None   T12P, I13V, I15V, G16E, E35D, M36I, R41K, R57K, L63A, L89MD
 1121_20071121_2007JQ083024None   L10V, T12S, I13V, I15V, G16E, L19I, K20R, E35D, M36I, R57K, L63T, E65D, I72T, L89MD
 1572_20071572_2007JQ083028None   I13V, I15V, L19LI, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V82VI, L89MD
 1636_20071636_2007JQ083030None   L10V, T12I, I13V, I15V, G16E, E35D, M36I, N37D, R41K, K45R, R57K, I62V, L63T, E65D, I72T, T74TA, L89MD
 1649_20071649_2007JQ083031None   L10V, G16E, K20R, E35D, M36I, R41K, R57K, I62V, L63T, L89MD
 1679_20071679_2007JQ083034None   K20KR, E35D, M36I, R41K, I62IV, L63T, I64ILM, E65D, I72IT, V82VI, L89MD
 1933_20071933_2007JQ083039None   L10V, I15V, L19I, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M, I93LD
 2142_20072142_2007JQ083042None   L10I, T12AE, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V77I, L89M, I93LD
 2360_20082360_2008JQ083043None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MD
 3004_20073004_2007JQ083048None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
 3160_20073160_2007JQ083051None   T12TKPQ, I15IV, G16GE, L19LI, E35D, M36I, R41K, K45KR, R57K, I62V, L63T, E65D, I72IT, V82I, L89MD
 4638_20084638_2008JQ083062None   L10V, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MD
 4646_20074646_2007JQ083068None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, P39T, R41K, L63T, E65D, I72T, L89MD
 4887_20074887_2007JQ083075None   L10V, I13V, I15IV, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
Hamers (2011)CP076301750CP076301750HQ993739None   Q18I, L19V, E35D, M36I, R41K, L63T, I64L, H69Y, I72T, L89MD
 CP076303180CP076303180HQ994196None   K14G, I15V, K20R, M36I, R41K, I62V, L63V, E65D, H69K, I72V, T74S, L89MD
 CP076302004CP076302004HQ995017None   L19I, R41K, L89MD
 CP076300870CP076300870HQ995128None   I13V, E35D, M36I, R41K, L89MD
 CP076303068CP076303068HQ995248None   I13V, K14KR, M36I, R41K, L63LP, L89MD
Santos (2011)J331J331_PRJN010705None   M36I, N37T, R41K, I62V, L63P, H69K, I72V, L89M, I93LD
De Gascun (2012)IRL19192IRL19192JN622358None   I13V, L19V, R41K, I62V, L63P, I64L, H69K, L89MD
Musyoki (2012)DGM.2DGM.2JN176287None   T12S, I15V, L19I, E35D, M36I, P39T, R41K, L63V, H69K, L89M, I93LD
Ragonnet-Cronin (2012)C05_049C05_049JX014987None   E35ED, N37ND, L38LM, R41K, L63P, V77I, L89M, I93ILD
Ssemwanga (2012)RCC_TDR_359989RCC_TDR_359989JQ266063None   T12I, I13V, E35D, M36I, R41K, L63M, H69K, L89MD
Ssemwanga (2012)2946HR2946HRJF800223None   I13V, E35D, M36I, R41K, K45R, R57K, D60E, L63S, I64L, H69K, L89MD
Antoniadou (2013)GR043GR043KF671770None   L10V, I13V, G16GE, K20R, E35D, M36I, R41K, K45KR, R57K, L63T, E65D, L89MD
Bila (2013)MZ10-212HIV-1KF927311None   T12S, K14KR, I15V, L19T, M36L, N37Q, R41K, D60E, I62V, L63P, H69K, I72M, L89MD
 MZNAC60HIV-1KF927425None   G16E, M36I, R41K, L63V, H69K, L89M, I93LD
 MZ10-262HIV-1KF927351None   L19I, M36I, R41K, K43KR, L63V, H69K, T74S, L89M, I93LD
Ferreira (2013)BR09SP224BR09SP224HM534026None   E35D, M36I, R41K, R57K, L63S, E65D, L89MD
Frentz (2013)EHR-00912EHR-00912JX299555None   L10V, I13V, I15IV, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
 EHR-20296EHR-20296JX299872None   L10V, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MD
 EHR-25339EHR-25339JX299981None   L10V, G16E, K20R, E35D, M36I, R41K, R57K, I62V, L63T, L89MD
 EHR-27129EHR-27129JX300011None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
 EHR-27715EHR-27715JX300019None   L10I, T12AE, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V77I, L89M, I93LD
 EHR-41487EHR-41487JX300244None   K20KR, E35D, M36I, R41K, I62IV, L63T, I64ILM, E65D, I72IT, V82VI, L89MD
 EHR-49656EHR-49656JX300366None   T12N, I15V, L19I, K20R, E35D, M36I, R41K, R57K, L63T, I72T, T74S, L89MD
 EHR-64659EHR-64659JX300626None   L10V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, L63T, E65D, I72T, T74S, L89MD
 EHR-71598EHR-71598JX300747None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, P39T, R41K, L63T, E65D, I72T, L89MD
 EHR-76782EHR-76782JX300855None   L10V, T12I, I13V, I15V, G16E, E35D, M36I, N37D, R41K, K45R, R57K, I62V, L63T, E65D, I72T, T74TA, L89MD
 EHR-94228EHR-94228JX301102None   I13V, I15V, L19LI, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V82VI, L89MD
Inzaule (2013)410410JQ914085None   I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89MD
Kiptoo (2013)KTL019KTL019KC516995None   I13V, M36I, R41K, L89MD
 SNH081SNH081KC516957None   I13V, L19I, M36I, R41K, L63Q, I64IK, E65ED, I66IMV, H69HQ, I72I*KL, L89MD
Pircher (2013)A1013A1013JX110262None   I15IV, D29DN, E35DN, M36I, R41K, R57K, L63A, R87RK, L89MD
 A1011A1011JX110260None   I13V, K20R, E35D, M36I, P39Q, R41K, I62V, L63P, I64IM, H69Y, I72V, L89MD
Rusine (2013)712H712HKC841736None   L10V, T12TS, I13V, I15IV, G17GE, E35D, M36I, R41K, K45KR, L63P, I72V, L89MD
Temereanca (2013)SR16SR16JX966491None   L10V, I13V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, L63T, E65D, I72T, L89MD
 SR20SR20JX966497None   L10V, I13V, I15V, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M, I93MD
 SR25SR25JX966502None   I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M, T96ND
 SR39SR39JX966514None   L10I, I13V, I15V, G16E, E35D, M36I, P39T, R41K, R57K, L63T, E65D, I72T, L89MD
 SR42SR42JX966518None   L10V, I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63N, L89M, Q92KD
 SR5SR5JX966523None   K14Q, I15V, K20R, T26S, E35D, M36I, R41K, R57K, L63T, E65D, I66V, I72V, L89MD
 SR6SR6JX966526None   L10I, T12K, I13V, I15V, K20I, E35D, M36I, R41K, R57K, L63T, E65D, I72V, T74S, L89MD
 SR60SR60JX966527None   L10V, I13V, I15V, G16E, K20R, M36I, R41K, R57K, L63T, E65D, T74S, V82I, L89MD
 SR66SR66JX966532None   L10V, I15V, E35D, M36I, R41K, V56G, R57K, L63T, E65D, A71N, I72T, T74S, L89MD
 SR111SR111 None   T12P, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63A, E65D, H69Y, I72T, L89MD
 SR110SR110 None   T12S, L19I, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72V, L89MD
Bartolo (2014)09AOHDP3309AOHDP33KF853856None   L10V, I13V, I15V, G16E, E35D, M36I, R41K, R57K, I62V, L63T, E65D, H69Y, I72T, L89MD
 09AOHDP19709AOHDP197KF853791None   L10I, T12TM, I13V, G16E, E35D, M36I, R41K, L63T, E65D, I72T, V77I, L89MD
 09AOHDP9509AOHDP95KF853890None   I13IV, K20R, M36I, R41K, I62V, L63T, E65D, H69Y, K70Q, I72T, L89MD
 09AOHDP19109AOHDP191KF853788None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
 09AOHDP13109AOHDP131KF853767None   L10V, I13V, I15V, G16E, E35D, M36I, N37S, R41K, K45R, R57K, Q61H, L63T, E65D, C67Y, K70R, L89MD
 09AOHDP22709AOHDP227KF853809None   L10V, I13V, G16E, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
 09AOHDP7809AOHDP78KF853883None   L10V, I13V, I15V, G16E, K20KR, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
 09AOHDP10909AOHDP109KF853757None   L10V, T12I, I13V, I15V, G16E, E35D, M36I, N37D, R41K, R57K, L63T, E65D, H69C, I72T, L89MD