<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L89M
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 28
Isolates 28
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Montes (2004)MB_patRAM01_RAM707AJ577979Unknown, RTV, IDV>90M46L, G48V, I54V, V82T L10V, I13V, K20I, M36I, R41K, I66F, H69K, K70R, L89MD
Snoeck (2004)BE40BE40AY900743SQV, IDV, NFV236L90M L10I, I15V, K20M, R41K, D60E, I62V, L63P, A71T, I72V, V75I, L89M, I93LD
Baxter (2006)48-42664266-30612DQ878498PINAM46L, I54V, V82VA, L90LML10FI, L24LI, L33IMV, Q58QEI13IV, K14KR, L19I, K20KT, P39PA, R41RK, K55KR, R57RK, I62V, L63E, I64V, A71AV, T74AE, L89MD
von Wyl (2007)310371422EF449968RTV, PINAM46I, I54V, L76V, V82ML24I, L33FL10V, I13V, K20R, E35D, M36I, N37DE, K55R, R57K, D60E, I62V, L63P, V75I, L89M, T91SD
Aulicino (2011)ARN397RLRARN397RLRFJ525859PINAM46L, I54L, V82T, I84VL24I, L33F, K43TE35D, M36I, N37E, R41K, R57K, D60N, Q61N, L63T, I64L, A71I, I72T, L89M, I93LD
Jones (2012)196487196487JN671026PINAM46I, I54V, L76V, V82AQ58EL10V, I15V, L19LI, K20R, M36I, R41K, D60DE, I62V, L63LP, I64IV, L89MD
 201210201210JN671216PINAI54V, V82T, I84VL33F, F53LL10I, I15V, K20R, E35D, M36I, N37D, R41K, Q61N, L63S, I64L, A71V, I72T, T74S, I85V, L89M, I93LD
Kouri (2012)CU2073-09CU2073-09JQ585339PINAM46L, I54V, V82AF53LL10I, I13V, G16E, K20R, E35D, M36I, N37DE, R41K, K55R, R57K, Q61H, L63T, E65D, I72T, T74A, L89MD
 CU772-10CU772-10JQ585416PINAM46L, I54AV, V82AL33F, T74AP, N83NDL10I, I13V, I15IV, G16E, K20R, E35D, M36I, N37D, R41K, R57K, L63T, E65D, L89MD
 CU1017-09CU1017-09JQ585271PINAI54V L10I, I13V, K20RT, E35D, M36I, N37ND, R41K, K45V, K55T, V56VA, R57K, I62V, L63P, V77I, L89MD
Inzaule (2013)410410JQ914067LPV   I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89MD
Diaz (2015)RenG17266RenG17266KT748294PINAM46MFIL, I54V, V82AL10FK20R, E34EG, E35D, M36I, N37ND, R41K, R57K, Q61N, L63A, H69CY, I72EV, L89MD
 RenG16023RenG16023KT747051PINAV32I, M46L, I47V, I50L, V82A, I84VL33F, Q58ET12N, I13V, I15V, K20R, E35D, M36I, N37E, Q61QH, L63T, I64V, A71V, I72V, G78GV, R87RI, L89MD
 RenG17358RenG17358KT748386PINAM46L, I50V, I54IV, V82VAL33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, R41K, K55R, R57K, I62V, L63P, T74S, L89MD
 RenG14385RenG14385KT745413PINAM46L, G48Q, I54V, L76V, I84VL24IL10I, I15V, G16E, K20R, E35D, M36I, R41K, R57RK, Q61N, L63T, I64L, I72T, V82VI, L89M, Q92QKD
 RenG14088RenG14088KT745116PINA  I13V, E35D, M36I, R41K, Q61N, L63T, E65D, I72T, L89MD
 RenG15471RenG15471KT746499PINA  I13V, E35D, R41K, R57K, Q61N, L63P, I64L, V77I, L89M, I93LD
 RenG12432RenG12432KT743460PINAM46L, I54V, I84VL24I, G48EL10I, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, I64L, I72T, V82VI, L89M, Q92KD
 RenG12299RenG12299KT743327PINAM46I, I54V, V82AL24I, L33F, F53L, T74PP9PR, L10I, T12TA, I13V, I15V, K20M, E35D, M36I, N37D, R41K, K45I, K55R, I62V, L63E, I64IV, E65D, L89MD
 RenG12504RenG12504KT743532PINAI50L T12I, G17E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, I64V, V82I, L89MD
 RenG10466RenG10466KT741494PINA  K14R, I15V, E35D, M36I, R41K, R57K, V82I, L89MD
 RenG11659RenG11659KT742687PINAM46L, V82AL24I, Q58EL10V, I15V, L19I, K20R, M36I, R41K, L63P, I64L, H69K, I72V, L89MD
 RenG10236RenG10236KT741264PINA  L10V, I13V, I15V, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72V, L89MD
 RenG10814RenG10814KT741842PINA  L10V, T12A, I13V, K14R, M36I, R41K, Q61N, L63P, L89MD
 RenG10029RenG10029KT741057PINAI50L I13V, K20T, E35D, M36I, R41K, K45KI, R57K, D60E, Q61D, L63P, E65D, V77I, L89MD
 RenG10815RenG10815KT741843PINA  L10V, G16GR, E35D, M36I, R41K, K45KR, R57K, Q61H, I72T, L89MD
 RenG10170RenG10170KT741198PINAM46L, I54V, V82A L10I, I13V, G16E, K20R, M36I, N37ND, R41K, Q61N, L63T, I64IL, E65ED, L89MD
Sutherland (2015)77_POSTKT351842LPV   I13V, E35D, M36I, R41K, H69K, L89MD