<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation V77I
Rx >= 1 PI
IncludeMixtures No
References 14
Patients 54
Isolates 57
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG8181_w56 NFV55D30NN88DI13V, R41K, L63P, A71T, V77ID
Dumans (2004)268268AY390063SQV, RTV, NFV239  I13V, K55R, L63P, V77I, T91I, I93LD
Gomez-Carrillo (2004)9881798817AY365582PINAD30N N37A, R41K, L63C, V77ID
Montes (2004)MB_patMOL00_MOLL719AJ577953SQV, RTV, IDV, NFV143D30N Q7E, E35D, M36I, P39Q, R41K, I62V, L63P, I64L, A71V, I72V, V77I, I93LD
 MB_patDER02_DER736AJ577878NFV179D30NN88DL10Y, I13V, E35D, M36I, I62V, L63P, I64V, T74S, V77ID
Non-B Workgroup (2005)TK1003TK1003 IDV, SQV, RTV100  I13V, I15V, R41K, I62IV, I64V, E65D, V77ID
  TK1003a IDV, SQV, RTV100  I13V, I15V, R41K, I62V, I64V, E65D, V77ID
 TK1028TK1028 RTV, IDV, NFV207M46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028a RTV, IDV, NFV231M46I, I54V, V82TL24IP1PS, L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028b RTV, IDV, NFV308M46L, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 TK2014TK2014 SQV, RTV, IDV, NFV307M46L, I54V, V82A L10V, R41K, D60E, L63P, I66IF, A71V, T74S, V77ID
 TK4014TK4014 SQV, RTV, NFV98  T12TP, I13V, I15IV, K20R, M36MI, R41K, L63H, I64V, I72IV, V77ID
 TK5006TK5006 SQV, RTV, NFV79L90MQ58EL10I, R41K, L63A, I64V, I72V, V77I, I93LD
Weber (2005)F75744F75744AY677393NFV76  I13V, R41K, D60E, L63LP, I64V, H69HY, V77ID
Baxter (2006)48-12251225-30417DQ877757PINAI84V, L90LM Q7E, L10I, G16GE, P39S, R41K, D60E, L63P, I64V, V77I, I85IVD
 48-14291429-30424DQ877819PINAM46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 48-33733373-30620DQ878231PINAM46L, G48V, I54V, V82A L10V, I15V, L19I, R41K, I62V, L63S, I64L, V77ID
Waleria-Aleixo (2008)08RJ06051308RJ060513FJ591705PINA  E35D, M36I, R41K, L63P, A71V, V77I, I93LD
Dau (2010)07823A07823AGU581871PINAM46I, L90M L10V, I13V, N37A, K55R, R57K, I62V, L63P, I64IV, I72IT, T74S, V77I, L89LM, I93LD
Aulicino (2011)444-O288CCR444-O288CCRHQ158164PINAD30NN88DL10I, I13V, I15V, K20T, E35N, M36I, R41K, Q61N, L63P, I72T, T74M, V77I, I93LD
Jones (2012)159280159280JN669947PINA  L10V, T12I, E35D, M36I, R41K, R57K, Q61N, I72M, V77ID
 187807187807JN670741PINAM46L, I54V, V82A, L90ML33F, K43T, G73SQ7QH, L10V, I13V, K20R, E35D, M36I, L38LS, R41K, I62V, L63P, H69R, A71T, I72T, V77ID
 193544193544JN670904PINAI54LK43T, F53FL, G73ST12K, I13V, I15V, K20T, E35D, M36I, N37S, R41K, R57K, Q61D, I62V, L63P, E65ED, H69HY, A71T, I72R, T74S, V77I, I93IMD
 195598195598JN670988PINAM46I, V82A L10V, E35D, M36I, R41K, R57K, Q61D, L63T, E65D, I72T, V77ID
 203943203943JN671324PINAV32I, M46I, I54V, V82AL24I, L33F, K43T, F53LL10I, I13V, G16E, K20R, E35D, M36I, N37D, P39PS, R57K, Q61N, L63S, E65D, K70Q, A71V, T74S, V77I, L89TD
Kouri (2012)CU691-09CU691-09JQ585261PINAD30N, V32I, M46I, I47V, I54L, V82AL10LF, L33F, F53FL, Q58E, N88DI13V, I15V, L19I, K20R, E35D, M36L, N37T, R41T, K45R, D60E, L63P, H69Q, K70R, I72V, V77I, L89FD
 CU1270-09CU1270-09JQ585285PINA  I15V, G16E, K20M, P39S, R41K, K43R, Q61N, L63P, V77ID
 CU116-10CU116-10JQ585365PINA  E35D, M36I, R41K, K43R, R57K, I62V, L63P, I64V, H69Q, A71T, V77I, I93LD
 CU163-10CU163-10JQ585454PINA  Q2H, L10V, I13V, E35D, M36I, R41K, K45R, R57K, D60E, L63P, H69Q, V77ID
 CU645-09CU645-09JQ585259PINA  L19I, E35D, M36I, R41K, L63P, V77ID
 CU90-10CU90-10JQ585361PINAI50V, I54L, L90ML10F, L33F, K43T, F53L, L89VQ2P, L5F, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37G, R41K, D60E, L63P, H69HY, A71IV, V77I, V82I, I93ILD
 CU1017-09CU1017-09JQ585271PINAI54V L10I, I13V, K20RT, E35D, M36I, N37ND, R41K, K45V, K55T, V56VA, R57K, I62V, L63P, V77I, L89MD
 CU311-10CU311-10JQ585381PINAI50V, I54L, L90ML33F, K43T, F53L, L89VV11L, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37D, R41K, D60E, L63P, H69Y, A71I, V77I, V82ID
Reynolds (2012)G0715G0715-2JN652208LPV   L10V, I13V, R41K, R57K, I64V, T74S, V77ID
Diaz (2015)RenG15993RenG15993KT747021PINAM46L, I47V, L76V, V82TF53L, L89VL10V, I13V, I15V, Q18H, K20I, E34EK, E35EK, M36I, N37E, K55R, I62V, L63P, K70KT, A71V, V77ID
 RenG16880RenG16880KT747908PINAM46L, I54V, V82ML24I, F53LL10V, T12P, K20R, E35D, M36I, N37Q, R41K, L63P, A71V, V77I, I93LD
 RenG15826RenG15826KT746854PINA  E35N, M36I, N37E, R41K, I62V, L63P, I64V, E65D, V77ID
 RenG16020RenG16020KT747048PINAM46I, I54A, V82AL24I, K43TL10I, I15IV, K20R, E35D, M36I, N37H, R41K, I62V, L63E, I64V, A71V, I72V, V77I, I93LD
 RenG17355RenG17355KT748383PINAM46I, I84V, L90ML10F, G73CSTK20R, E35D, M36I, N37ND, R41K, I62V, L63P, H69K, A71AV, T74S, V77I, I85V, I93LD
 RenG17289RenG17289KT748317PINAD30N, M46I, I54IV, V82A, L90ML10F, L33F, F53FL, N88DI13V, R41K, I62V, L63P, H69Y, A71T, I72T, V77ID
 RenG16155RenG16155KT747183PINA  I15V, E35D, M36I, R41K, R57K, Q61N, L63S, V77I, I93LD
 RenG15415RenG15415KT746443PINAM46I, N88SQ58EL10V, I13IV, I15V, K20T, K55KR, L63P, A71V, V77I, T91SD
 RenG15468RenG15468KT746496PINA  Q7E, L10I, K14R, E35D, M36I, R41K, L63S, I64V, I72V, V77I, I93LD
 RenG14314RenG14314KT745342PINA G73GSQ7E, L10I, R41K, D60DE, I62V, L63P, I72V, V77I, I93LD
 RenG13674RenG13674KT744702PINAV82A, L90ML33F, K43T, G73SL10V, I13V, I15V, L19I, K20T, E35D, M36I, R41K, L63P, A71V, T74S, V77I, I93LD
 RenG15471RenG15471KT746499PINA  I13V, E35D, R41K, R57K, Q61N, L63P, I64L, V77I, L89M, I93LD
 RenG15072RenG15072KT746100PINAM46L, I54V, L76V, V82A, L90ML33F, Q58EL10V, I13V, K14R, G16E, K20R, E35D, M36I, N37E, P39S, R41RK, K55R, R57K, D60DE, Q61N, I62V, L63T, I64V, K70KT, V77ID
 RenG14833RenG14833KT745861PINAM46ML, I54V, V82F, L90M L10V, I13V, I15V, K20IT, E35N, M36I, N37D, R41K, R57K, D60E, Q61N, L63P, I64IV, T74S, V77I, L89LIM, I93LD
 RenG13110RenG13110KT744138PINA  R41K, L63P, E65D, V77I, I93LD
 RenG12217RenG12217KT743245PINAM46I, I54V, V82F, L90M L10I, I15V, K20T, E35N, M36I, R41KT, K43Q, R57K, D60N, Q61D, I62V, L63P, I64L, V77I, L89I, I93LD
 RenG13330RenG13330KT744358PINA  I13V, K20KR, R41K, K43R, L63P, I64V, V77ID
 RenG10992RenG10992KT742020PINA  Q7E, T12TP, K14R, E35D, M36I, N37D, R41K, L63P, I64L, A71V, I72IV, V77I, I93LD
 RenG11503RenG11503KT742531PINAM46I, I50V, I54V, V82AK43T, F53LL10V, I15V, K20T, E35D, M36I, N37D, R41K, L63LP, I64V, A71V, V77ID
 RenG10029RenG10029KT741057PINAI50L I13V, K20T, E35D, M36I, R41K, K45KI, R57K, D60E, Q61D, L63P, E65D, V77I, L89MD
 RenG10974RenG10974KT742002PINA  I15V, G16E, M36I, R41K, V77ID
 RenG10051RenG10051KT741079PINAL90ML23I, F53L, G73SL10LI, K14KN, I15V, K20T, E34EQ, E35D, M36I, R41K, K45R, I62IV, L63P, I66IV, A71IL, I72T, V77I, I93LD
 RenG10528RenG10528KT741556PINA  Q7E, R41K, L63P, I72IV, V77I, I93LD