<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation T74S
Rx >= 1 PI
IncludeMixtures No
References 9
Patients 56
Isolates 56
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gomez-Carrillo (2004)118423118423AY365949PINAL90M L10V, I13V, K14R, K20T, E35D, M36I, N37D, R41K, Q61N, L63P, A71T, I72T, T74SD
Montes (2004)MB_patDER02_DER736AJ577878NFV179D30NN88DL10Y, I13V, E35D, M36I, I62V, L63P, I64V, T74S, V77ID
Non-B Workgroup (2005)UK1392UK1392AY900799SQV161L90M L10V, I13V, R41K, L63P, I64V, K70R, I72IV, T74SD
 TK1014TK1014 RTV, SQV, NFV, IDV246M46I, I84IVL24LIL10LV, I13V, K20I, E35D, M36I, R41K, L63P, H69K, T74S, T80TA, V82X, L89IMD
 TK2005TK2005b RTV, IDV, APV, SQV213I54V, V82ATL10LFI13V, I15IV, K20KT, R41K, L63P, I64V, A71AV, T74SD
 TK2014TK2014 SQV, RTV, IDV, NFV307M46L, I54V, V82A L10V, R41K, D60E, L63P, I66IF, A71V, T74S, V77ID
 TK3011TK3011 SQV, NFV231D30NN88DI13V, I15V, K20T, E35D, M36I, N37NY, R41K, I64V, T74SD
Baxter (2006)48-14321432-30818DQ877822PINAM46I, I54V, L76V, V82TL24IL10I, I13A, K20I, E35D, M36I, R41K, Q61H, L63P, H69K, T74S, L89ID
 48-50525052-30515DQ878573PINAM46MI, G48M, I54V, V82A, L90MF53L, L89IVT4S, L10IV, I13V, K14R, G17DE, K20I, L33L_L, M36V, R41K, L63P, H69K, K70R, A71T, T74S, Q92KD
Dau (2010)07059A07059AGU581816PINAM46MI, I54V, V82A, L90LM L10I, I13V, I15V, K20V, M36I, R41K, I62V, L63Q, I64V, E65D, I72V, T74SD
 07823A07823AGU581871PINAM46I, L90M L10V, I13V, N37A, K55R, R57K, I62V, L63P, I64IV, I72IT, T74S, V77I, L89LM, I93LD
Aulicino (2011)ARN394FGLARN394FGLFJ525858PINAI54V, V82A, L90M L10V, K20R, E35D, M36I, N37D, R41K, R57K, Q61D, I62V, L63V, A71V, I72V, T74SD
 ARN571EAEARN571EAEFJ525863PINA  L10V, I13V, K14N, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, E65D, A71T, T74S, Q92KD
 321-L82321-L82HQ158268PINAL90M I15V, K20T, E35N, M36I, R41K, I62V, L63P, T74SD
Jones (2012)147583147583JN669693PINAI54V, V82T, L90M L10I, K20R, E35D, M36I, N37E, R41K, R57K, Q61N, L63A, E65D, A71V, T74S, I93LD
 159048159048JN669940PINAV32I, I47V, I54M, L90MV11VIL10I, T12K, I13IV, K20I, E21ED, E35N, M36I, R41K, R57K, Q61N, L63P, I64IV, T74S, V82I, I85VD
 159787159787JN669960PINAI54V L10V, I13V, K20R, E35D, M36I, R41K, R57K, Q61N, I64IV, A71V, I72T, T74S, Q92R, I93LD
 162069162069JN670025PINAL90M L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, A71V, T74S, I93LD
 163239163239JN670057PINAM46I, V82T, I84VL10FT12K, I13V, G16E, L19P, K20R, M36I, L63T, I64V, E65D, I72T, T74SD
 163678163678JN670068PINAL90LM L10V, I13V, I15V, K20T, E35D, M36I, R41K, K43R, R57K, Q61N, L63T, I64L, I72T, T74S, I93LD
 166308166308JN670124PINAM46I, I54V, V82TL33F, L76IL10V, T12Q, I13V, I15V, L19I, K20KR, E35D, M36IL, R41K, K55R, R57K, Q61N, L63P, I64V, A71V, T74SD
 166915166915JN670139PINAM46I, I54V, V82A L10I, I13A, K20R, A22V, E35ED, M36I, N37D, K55R, R57K, Q61DN, I62IV, L63P, A71T, I72T, T74S, N83S, Q92QK, I93LD
 171784171784JN670271PINAI54IV, V82A, L90ML33LFL10V, I13V, K20KR, E35D, M36I, R41K, R57K, Q61D, I62V, L63PT, A71V, I72T, T74S, I93LD
 178114178114JN670471PINAI54V, V82A, L90M L10V, K20R, M36I, R41K, R57K, Q61N, L63A, A71V, T74S, I93LD
 182041182041JN670597PINAL90M L10V, I13V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, I93LD
 182997182997JN670632PINAL90M L10LV, I13V, L19I, K20T, E35D, M36I, R41K, Q61N, L63P, A71AT, T74S, I93LD
 189796189796JN670781PINAI54V, L90ML23LIL10V, I13V, I15V, L19LV, K20T, E35D, M36I, N37D, R41RK, R57K, D60E, Q61D, I62V, L63P, A71I, T74S, I93LD
 193544193544JN670904PINAI54LK43T, F53FL, G73ST12K, I13V, I15V, K20T, E35D, M36I, N37S, R41K, R57K, Q61D, I62V, L63P, E65ED, H69HY, A71T, I72R, T74S, V77I, I93IMD
 193836193836JN670912PINAM46I, I54V, V82A L10I, I13A, K20R, A22V, E35D, M36I, N37D, K55R, R57K, Q61D, I62V, L63P, A71T, I72T, T74S, N83S, Q92K, I93LD
 201210201210JN671216PINAI54V, V82T, I84VL33F, F53LL10I, I15V, K20R, E35D, M36I, N37D, R41K, Q61N, L63S, I64L, A71V, I72T, T74S, I85V, L89M, I93LD
 202646202646JN671284PINAI54L, L90ML33FL10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63H, T74S, Q92QKD
 203943203943JN671324PINAV32I, M46I, I54V, V82AL24I, L33F, K43T, F53LL10I, I13V, G16E, K20R, E35D, M36I, N37D, P39PS, R57K, Q61N, L63S, E65D, K70Q, A71V, T74S, V77I, L89TD
Reynolds (2012)G0715G0715-2JN652208LPV   L10V, I13V, R41K, R57K, I64V, T74S, V77ID
Diaz (2015)RenG16031RenG16031KT747059PINAL90MV11IL10I, I15V, L19Q, K20T, E35G, M36I, P39S, R41K, I62V, L63P, H69Y, A71V, I72L, T74SD
 RenG17221RenG17221KT748249PINAI54V, V82A L10I, I13V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, I72V, T74SD
 RenG16303RenG16303KT747331PINAL90ML33I, F53L, G73ST12I, I15V, Q18H, K20V, E35G, M36I, N37D, R41K, L63P, A71I, T74S, I85V, I93LD
 RenG15911RenG15911KT746939PINAL90MG73GSI13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71AITV, T74SD
 RenG17271RenG17271KT748299PINAM46L, G48Q, I54V, L76V, V82AL33I, F53LL10V, I13V, K14KR, L19V, K20M, M36I, D60E, Q61N, I62IV, L63P, T74S, L89I, T91SD
 RenG17358RenG17358KT748386PINAM46L, I50V, I54IV, V82VAL33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, R41K, K55R, R57K, I62V, L63P, T74S, L89MD
 RenG17355RenG17355KT748383PINAM46I, I84V, L90ML10F, G73CSTK20R, E35D, M36I, N37ND, R41K, I62V, L63P, H69K, A71AV, T74S, V77I, I85V, I93LD
 RenG14914RenG14914KT745942PINAM46L, I54V, V82A, L90M L10V, I13V, G17E, Q18H, K20I, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63AT, E65D, A71V, I72IV, T74S, I93LD
 RenG13765RenG13765KT744793PINAM46I, I47V, I54V, V82AL24I, K43T, F53LL10V, L19I, K20R, E35D, M36I, N37H, R41K, R57K, Q61N, I62IV, L63V, I64V, E65D, I72V, T74SD
 RenG15235RenG15235KT746263PINAI54V, V82A, L90M L10V, I15IV, K20M, E35D, M36IV, R41K, R57K, Q61N, L63P, I64V, A71AV, T74S, I93LD
 RenG14846RenG14846KT745874PINAM46L, I54V, V82A, L90ML33FL10V, I15V, G16E, K20M, E35N, M36I, L38LF, R41K, K55R, R57K, Q61D, I62V, L63C, I64IL, E65ED, A71V, I72IT, T74S, T91A, I93LD
 RenG14658RenG14658KT745686PINAL90M L10V, I15V, K20T, E35D, M36I, P39PS, R41K, Q61QH, I62V, L63P, T74S, I93LD
 RenG13674RenG13674KT744702PINAV82A, L90ML33F, K43T, G73SL10V, I13V, I15V, L19I, K20T, E35D, M36I, R41K, L63P, A71V, T74S, V77I, I93LD
 RenG15170RenG15170KT746198PINA G73STL10V, T12S, I15V, K20T, E35D, M36I, N37DE, R41K, K43KR, I62V, L63P, T74S, I93LD
 RenG14682RenG14682KT745710PINAM46I, I54V, V82AN88DL10V, I13V, I15V, G16E, K20I, E35N, M36I, R41K, K45R, K55KR, R57K, Q61N, L63Q, I64V, T74SD
 RenG14833RenG14833KT745861PINAM46ML, I54V, V82F, L90M L10V, I13V, I15V, K20IT, E35N, M36I, N37D, R41K, R57K, D60E, Q61N, L63P, I64IV, T74S, V77I, L89LIM, I93LD
 RenG13073RenG13073KT744101PINAD30N, I50L, V82AL33F, N88DL10I, I13V, K20R, E35D, M36I, N37E, K45I, I62IV, L63T, I64V, A71AITV, T74S, I93LD
 RenG12819RenG12819KT743847PINAI54V, V82S, L90ML33F, F53LQ7D, L10I, I13V, K20T, E34N, E35D, M36I, N37NT, R41K, I62V, L63AP, I64L, A71M, I72V, T74S, V77L, I93LD
 RenG11212RenG11212KT742240PINAD30N, I54LL10F, L33I, N83D, N88DI13V, K14R, A22V, E34N, M36I, N37D, L63P, H69K, A71V, I72V, T74SD
 RenG10591RenG10591KT741619PINAL90ML23I, F53LL10I, T12K, I13L, I15V, L19Q, K20T, E35D, M36I, N37NADT, R41K, K55R, R57K, I62V, L63P, I66IV, A71V, T74S, V75ID
 RenG11171RenG11171KT742199PINAI54V, L90M L10V, I15V, K20T, E35G, M36I, N37D, R41K, I62V, L63P, A71V, T74S, I85IV, I93LD
 RenG10437RenG10437KT741465PINAI54V, V82A, L90M L10V, T12E, I15V, L19I, K20T, E35N, M36I, R41K, I62V, L63P, I64M, A71V, T74S, I93LD
 RenG11705RenG11705KT742733PINAL90M L10IV, T12IV, I13V, G16E, K20IL, E35G, M36I, N37NT, P39Q, R41K, R57K, Q61N, I62K, L63V, I64IV, I72IV, T74S, I93LD