<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation T74S
Rx >= 1 PI
IncludeMixtures No
References 7
Patients 18
Isolates 18
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)UK1392UK1392AY900799SQV161L90M L10V, I13V, R41K, L63P, I64V, K70R, I72IV, T74SD
 TK2005TK2005b RTV, IDV, APV, SQV213I54V, V82ATL10LFI13V, I15IV, K20KT, R41K, L63P, I64V, A71AV, T74SD
 TK2014TK2014 SQV, RTV, IDV, NFV307M46L, I54V, V82A L10V, R41K, D60E, L63P, I66IF, A71V, T74S, V77ID
 TK3011TK3011 SQV, NFV231D30NN88DI13V, I15V, K20T, E35D, M36I, N37NY, R41K, I64V, T74SD
Baxter (2006)48-92949294-30930DQ877624PINAM46MI, V82AL24IL10I, I15IV, E35D, M36I, N37ND, R41K, I62V, L63P, T74SD
Waleria-Aleixo (2008)08PR06072008PR060720FJ591542PINAI54V, V82TL24I, F53LL10V, I13V, K20R, E35D, M36V, N37T, R41K, R57K, I62V, L63P, I64V, A71V, T74SD
 RG44RG44FJ592052PINAM46MI, L90MG73CL10I, K20I, E35D, M36I, I62V, L63P, I64V, T74SD
 RG42RG42FJ592051PINAD30NL33F, N88DL10LV, E35D, M36I, R41K, I62V, L63ADHP, A71T, T74SD
 08PR05023208PR050232FJ591261PINAI54L, V82A, L90ML33F, K43T, F53LL10V, I13V, I15IV, K20R, E35D, M36I, R41K, I62V, L63P, H69K, A71I, T74S, I93IMD
Dau (2010)07059A07059AGU581816PINAM46MI, I54V, V82A, L90LM L10I, I13V, I15V, K20V, M36I, R41K, I62V, L63Q, I64V, E65D, I72V, T74SD
Aulicino (2011)321-L82321-L82HQ158268PINAL90M I15V, K20T, E35N, M36I, R41K, I62V, L63P, T74SD
Reynolds (2012)G0715G0715-2JN652208LPV   L10V, I13V, R41K, R57K, I64V, T74S, V77ID
Diaz (2015)RenG15911RenG15911KT746939PINAL90MG73GSI13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71AITV, T74SD
 RenG16632RenG16632KT747660PINAD30N, L90LML23I, L33F, F53L, N88DI13V, K14KR, I15V, K20V, E35G, R41K, D60E, L63P, A71I, T74S, V77I, L89I, I93LD
 RenG17154RenG17154KT748182PINAN88NS, L90MF53FL, G73GST12M, I13V, I15V, L19V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, V77VI, Q92KD
 RenG15170RenG15170KT746198PINA G73STL10V, T12S, I15V, K20T, E35D, M36I, N37DE, R41K, K43KR, I62V, L63P, T74S, I93LD
 RenG12819RenG12819KT743847PINAI54V, V82S, L90ML33F, F53LQ7D, L10I, I13V, K20T, E34N, E35D, M36I, N37NT, R41K, I62V, L63AP, I64L, A71M, I72V, T74S, V77L, I93LD
 RenG11632RenG11632KT742660PINAG48V, I54S, V82A, L90MQ58EL10I, I13V, L19T, K20I, L33L*, E34Q, E35D, M36I, N37D, D60E, I62V, L63Q, I64V, T74SD