<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L63T
Rx PI-naive
IncludeMixtures No
References 39
Patients 69
Isolates 69
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Cornelissen (1997)92UG02192UG021AF009396None   I13V, M36I, R41K, L63T, I64V, E65DD
Eshleman (2002)137554u137554uAF410229None   I13V, M36I, R41K, L63T, I64V, E65EDD
Shafer (2003)A384_40004000aEF548416None   G16E, R41K, K43R, I62IV, L63T, I64L, I72IT, V77ID
Galluzzo (2007)M21740UG_M21740JQ220089None   K20R, M36I, R41K, I62V, L63T, I64V, E65D, H69Y, I72EVD
Gatanaga (2007)C04-5555-6386-1C04-5555-6386-1AB640462None   I13V, I15IV, G16GE, M36I, N37ND, R41K, L63T, I64V, E65D, I72VD
Kassu (2007)ETH-G-230G-230AB285830None   T12P, G16E, L19M, M36I, R41K, L63T, E65D, K70R, I72T, I93LD
Church (2008)428544C428544CEU380761None  L33FI13V, I15L, L19I, P39Q, R41K, L63T, E65D, I72T, V77ID
Land (2008)ML1956ML1956EU110089None   L10I, I13V, I15V, M36I, R41K, L63T, H69QD
Ndembi (2008)CMYD-5604CMYD-56DQ990421None   L10V, I13V, G17D, K20R, E35D, M36I, R41K, L63T, H69QD
Nyombi (2008)TBK014TBK014EU251723None  L33FI13V, P39L, R41K, L63T, I64V, H69QD
 TBK020TBK020EU251727None   M36I, R41K, L63T, I64VD
 TBK025TBK025EU251731None  L33FI13V, P39L, R41K, L63T, I64V, H69Q, V77ID
Eshleman (2009)D08444W307-156544FJ389051None   L10V, I13V, K20R, M36I, R41K, L63T, I64V, E65D, I72VD
Hawkins (2009)P650ZZP650FJ931154None  L33FL10V, I13V, K20V, M36I, N37S, P39S, R41K, L63T, I64V, E65D, I72VD
Ndembi (2010)15730D_P115730GQ409578None   L19Q, K20R, M36I, N37D, R41K, L63T, I64V, E65DD
 16535D_P116535GQ409634None  Q58EI13V, L19I, M36I, R41K, L63T, I64V, E65DD
Hamers (2011)CP076301677CP076301677HQ993673None   I13V, G16E, R41K, I62IV, L63T, I64L, I72V, V77ID
 CP076301713CP076301713HQ993707None   L10V, T12PQ, I13V, G16E, R41K, L63T, E65D, V77ID
 CP076301750CP076301750HQ993739None   Q18I, L19V, E35D, M36I, R41K, L63T, I64L, H69Y, I72T, L89MD
 CP076304223CP076304223HQ993918None   L10I, I13V, G17E, M36L, P39P*QS, R41K, Q61H, I62V, L63T, I64V, E65DD
 CP076304226CP076304226HQ993921None   L19V, L63T, I64V, E65DD
 CP076301885CP076301885HQ995013None  V11IL10M, I13V, E35D, R41K, L63T, I64VD
 CP076302052CP076302052HQ995021None   L10I, I13V, G16E, M36I, R41K, L63T, I64V, C67S, I72IVD
 CP076302982CP076302982HQ995059None   Q7H, L10I, I13V, I15V, Q18H, K20M, M36I, N37D, R41K, L63T, I64V, E65D, K70RD
 CP076303037CP076303037HQ995098None   L10LI, T12A, I13V, M36I, R41RK, L63T, I64V, I72IVD
 CP076302972CP076302972HQ995218None   I13V, M36I, N37D, L63T, I64V, E65D, K70R, I72VD
 CP076303084CP076303084HQ995261None   I13V, M36I, N37D, R41K, L63T, I64V, E65D, K70RD
 CP076301898CP076301898HQ995377None   I13V, K20R, M36I, R41K, I62V, L63T, I64V, E65D, I72VD
 CP076302895CP076302895HQ995468None   I15V, G16E, K20R, M36I, R41K, L63T, E65D, I72TD
Kasang (2011)2873328733HM572334None   I13V, R41K, L63T, I64L, V82ID
 1719917199HM572345None   I13V, I15V, L19I, M36I, R41K, L63T, I64V, E65DD
 20242024HM572357None   I13V, K20R, M36I, R41K, I62V, L63T, I64IV, E65DD
 1719517195HM572359None   I13V, R41K, L63T, I64L, V82ID
Ndembi (2011)AICPS339AICPS339HQ702643None   L10V, I13V, R41K, L63T, I64V, E65DD
Yang (2011)KN-20KN-20JQ616941None   T12S, I13V, I15V, M36I, R41K, L63T, I64VD
Afonso (2012)ANG24ANG24JN937038None   M36I, R41K, I62V, L63TD
Karlsson (2012)SE_82SE_82JQ698720None  Q58EI13V, R41K, D60E, I62V, L63T, I64V, E65D, V77I, V82ID
Machado (2012)CUPL1138CUPL1138JX194217None   K20R, E35D, M36I, N37D, R41K, R57K, L63T, E65D, H69R, I72MD
Ndase (2012)5214815252148152KC900584None   G16E, M36I, R41K, Q58QR, I62V, L63T, I64V, E65DD
 5214387252143872KC900606None   G16E, M36I, R41K, I62V, L63T, I64V, E65DD
 5405555254055552KC900711None   I13V, E21EQ, M36I, N37D, R41K, L63T, I64V, E65DD
Serrano (2012)20106934482010693448JQ616887None   Q18E, E35D, M36I, R41K, Q61N, L63T, E65D, I72TD
Ssemwanga (2012)RCC_TDR_359881RCC_TDR_359881JQ266022None   I13V, I15V, E35D, M36I, R41K, L63T, I64V, E65DD
 RCC_TDR_359885RCC_TDR_359885JQ266030None   I13V, I15V, E35D, M36I, R41K, L63T, I64V, E65DD
Billong (2013)MR106MR106KF192113None   I15V, E35D, M36I, P39PS, R41K, I62V, L63T, I64V, V77VID
Kiptoo (2013)KAP048KAP048KC516897None   M36I, R41K, L63T, I64V, E65DD
Sigaloff (2013)MBA094_0MBA094_0JX182026None   I13V, M36I, N37D, L63T, I64V, E65D, K70R, I72VD
Bartolo (2014)09AOHDP11609AOHDP116KF853760None   L10I, I13V, K20KR, E35D, M36I, N37D, R41K, L63TD
Chung (2014)KVE_34_KA453eKVE_34_KA453eKF544262None   K14R, E35D, M36I, R57K, L63T, H69K, V77I, L89MD
Lee (2014)MBA1331MBA1331KJ907017None   L10IV, I13V, M36I, R41K, L63T, I64VD
 MBA1330MBA1330KJ907016None   L10I, E35D, M36I, R41K, R57RK, L63T, H69KD
 AMU028AMU028KJ906648None   M36I, R41K, I62IV, L63T, I64IV, E65D, I72TD
 MBA1392MBA1392KJ907078None   L10V, T12K, I13V, K14KR, G16E, K20KR, M36I, R57K, L63T, I64IV, E65D, L89LFD
 MBA1315MBA1315KJ907004None   I13IV, K20R, M36I, R41K, R57K, I62V, L63T, I64V, E65DD
 MBA1457MBA1457KJ907136None   I13IV, G16E, K20R, M36I, R41K, I62V, L63T, I64LV, E65D, I72VD
Steegen (2014)10ZAKS07410ZAKS074KJ176356None   R41K, L63T, H69K, I93LD
Wallis (2014)4107341073KM458594None   I13V, R41K, L63T, I64V, E65DD
 4114641146KM458617None   L10I, I13V, M36I, N37D, R41K, D60E, L63T, I64VD
Budambula (2015)MK54MK54KP792048None   I15V, G16E, E35D, R41K, L63T, E65D, H69Y, I72TD
Dauwe (2015)D_05069D_05069KT863837None   T12P, I13IV, G16E, E35ED, M36I, R41K, I62V, L63T, I64V, E65DD
Hora (2015)DEMD10UG004DEMD10UG004KF716479None   I13V, M36I, R41K, L63T, I64V, E65DD
 DEMD08UG001DEMD08UG001KC596072None   I13V, L33V, R41K, L63T, I64V, E65D, H69Y, I72VD
Meini (2015)109258109258KM438243None   L10I, R41K, L63T, I72VD
Billings (2016)KE963379V4KE963379V4KT022411None   L10I, I13V, I15V, G16E, M36I, R41K, I62V, L63T, I64V, C67W, H69YD
Castley (2016)P060344001P060344001KT228392None   I13V, R41K, L63T, I64V, E65D, F99XD
Lam (2016)9902201499022014KR868125None   L10V, G16E, M36I, N37Q, R41K, D60E, L63T, H69K, I72V, I93LD
Otecko (2016)406813406813KX306407None   T12TA, I13IV, K14KR, I15V, K20M, E35D, M36I, R41K, L63T, I64V, H69HYD
 406084406084KX306404None   K14R, I15V, M36MI, R41K, L63T, E65D, I72TD
 408933408933KX306428None   I13V, I15V, K20R, M36I, R41K, L63T, I64L, I72TD