<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L63T
Rx PI-naive
IncludeMixtures No
References 39
Patients 103
Isolates 104
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Cornelissen (1997)92UG02192UG021AF009396None   I13V, M36I, R41K, L63T, I64V, E65DD
Eshleman (2002)137554u137554uAF410229None   I13V, M36I, R41K, L63T, I64V, E65EDD
Soares (2003)BRP2072BRP2072AF527282None   L10I, I13V, G17E, R57K, Q61N, L63T, N98KD
Eshleman (2004)ESH_Pat49ESH55AY435230None   E35D, M36I, N37ND, R41RK, Q61QH, L63T, I64V, E65D, I72IVD
Eshleman (2004) SE55_7dAY428673None   E35D, M36I, N37ND, R41RK, L63T, I64V, E65D, I72IVD
Non-B Workgroup (2005)TK2009TK2009 None   T12A, I15V, M36I, R41K, D60E, I62V, L63T, I64V, I72TD
Church (2007)055-111458T055EF612006None   E35D, M36I, N37ND, R41RK, L63T, I64V, E65D, I72VD
Galluzzo (2007)M21740UG_M21740JQ220089None   K20R, M36I, R41K, I62V, L63T, I64V, E65D, H69Y, I72EVD
Gatanaga (2007)C04-5555-6386-1C04-5555-6386-1AB640462None   I13V, I15IV, G16GE, M36I, N37ND, R41K, L63T, I64V, E65D, I72VD
Kassu (2007)ETH-G-230G-230AB285830None   T12P, G16E, L19M, M36I, R41K, L63T, E65D, K70R, I72T, I93LD
Church (2008)428544C428544CEU380761None  L33FI13V, I15L, L19I, P39Q, R41K, L63T, E65D, I72T, V77ID
Land (2008)ML1956ML1956EU110089None   L10I, I13V, I15V, M36I, R41K, L63T, H69QD
Ndembi (2008)CMYD-5604CMYD-56DQ990421None   L10V, I13V, G17D, K20R, E35D, M36I, R41K, L63T, H69QD
Nyombi (2008)TBK014TBK014EU251723None  L33FI13V, P39L, R41K, L63T, I64V, H69QD
 TBK020TBK020EU251727None   M36I, R41K, L63T, I64VD
 TBK025TBK025EU251731None  L33FI13V, P39L, R41K, L63T, I64V, H69Q, V77ID
 TBK093TBK093EU251775None   T12S, I13V, I15V, L19I, E35D, R41K, L63T, H69KQ, A71T, V82I, I93LD
Bartolo (2009)CSE11601AOCSE116EU068199None   L10V, I13V, K14T, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MD
 HAB8301AOHAB83EU068217None   L10V, I13V, I15V, G16E, E35D, M36I, N37S, R41K, R57K, L63T, L89MD
 HAB8501AOHAB85EU068218None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, H69S, L89MD
Brumme (2009)F8527F8527GQ371881None   L10I, I13V, G16E, M36I, R41K, L63T, I93LD
 G3542G3542GQ371895None   T12IKM, G16GE, E35D, M36L, N37E, R41K, R57K, I62V, L63T, I64V, H69YD
Eshleman (2009)D08444W307-156544FJ389051None   L10V, I13V, K20R, M36I, R41K, L63T, I64V, E65D, I72VD
Hawkins (2009)P650ZZP650FJ931154None  L33FL10V, I13V, K20V, M36I, N37S, P39S, R41K, L63T, I64V, E65D, I72VD
Ndembi (2010)15730D_P115730GQ409578None   L19Q, K20R, M36I, N37D, R41K, L63T, I64V, E65DD
 16535D_P116535GQ409634None  Q58EI13V, L19I, M36I, R41K, L63T, I64V, E65DD
Yang (2010)20106934482010693448JQ616887None   Q18E, E35D, M36I, R41K, Q61N, L63T, E65D, I72TD
Carvalho (2011)O01-43O01-43GU214066None   I15V, E35D, M36V, R41K, L63TD
El Annaz (2011)92059205HQ393293None   I13V, Q18H, E35D, M36I, R41K, K45R, R57RK, L63T, I64V, E65DD
 96689668HQ393295None   I13V, Q18H, E35D, M36I, R41K, K45R, L63T, I64V, E65DD
 1150911509HQ393307None   I13V, M36I, N37D, L63T, I64V, E65D, I72IVD
Florea (2011)105_2008105_2008JQ083016None   L10V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, L63T, E65D, I72T, T74S, L89MD
 1121_20071121_2007JQ083024None   L10V, T12S, I13V, I15V, G16E, L19I, K20R, E35D, M36I, R57K, L63T, E65D, I72T, L89MD
 1572_20071572_2007JQ083028None   I13V, I15V, L19LI, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V82VI, L89MD
 1636_20071636_2007JQ083030None   L10V, T12I, I13V, I15V, G16E, E35D, M36I, N37D, R41K, K45R, R57K, I62V, L63T, E65D, I72T, T74TA, L89MD
 1649_20071649_2007JQ083031None   L10V, G16E, K20R, E35D, M36I, R41K, R57K, I62V, L63T, L89MD
 1679_20071679_2007JQ083034None   K20KR, E35D, M36I, R41K, I62IV, L63T, I64ILM, E65D, I72IT, V82VI, L89MD
 1933_20071933_2007JQ083039None   L10V, I15V, L19I, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M, I93LD
 2142_20072142_2007JQ083042None   L10I, T12AE, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V77I, L89M, I93LD
 2360_20082360_2008JQ083043None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MD
 3004_20073004_2007JQ083048None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
 3016_20073016_2007JQ083050None   L10I, G16E, L19LI, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89LMD
 3160_20073160_2007JQ083051None   T12TKPQ, I15IV, G16GE, L19LI, E35D, M36I, R41K, K45KR, R57K, I62V, L63T, E65D, I72IT, V82I, L89MD
 4171_20074171_2007JQ083056None   L10V, I13V, I15V, G16E, E35D, M36I, R41K, R57K, I62V, L63T, E65D, I72TD
 4175_20074175_2007JQ083057None   L10V, I13V, I15V, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72TD
 4638_20084638_2008JQ083062None   L10V, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MD
 4646_20074646_2007JQ083068None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, P39T, R41K, L63T, E65D, I72T, L89MD
 4887_20074887_2007JQ083075None   L10V, I13V, I15IV, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
Hamers (2011)CP076301677CP076301677HQ993673None   I13V, G16E, R41K, I62IV, L63T, I64L, I72V, V77ID
 CP076301713CP076301713HQ993707None   L10V, T12PQ, I13V, G16E, R41K, L63T, E65D, V77ID
 CP076301750CP076301750HQ993739None   Q18I, L19V, E35D, M36I, R41K, L63T, I64L, H69Y, I72T, L89MD
 CP076304223CP076304223HQ993918None   L10I, I13V, G17E, M36L, P39P*QS, R41K, Q61H, I62V, L63T, I64V, E65DD
 CP076304226CP076304226HQ993921None   L19V, L63T, I64V, E65DD
 CP076301885CP076301885HQ995013None  V11IL10M, I13V, E35D, R41K, L63T, I64VD
 CP076302052CP076302052HQ995021None   L10I, I13V, G16E, M36I, R41K, L63T, I64V, C67S, I72IVD
 CP076302982CP076302982HQ995059None   Q7H, L10I, I13V, I15V, Q18H, K20M, M36I, N37D, R41K, L63T, I64V, E65D, K70RD
 CP076303037CP076303037HQ995098None   L10LI, T12A, I13V, M36I, R41RK, L63T, I64V, I72IVD
 CP076302972CP076302972HQ995218None   I13V, M36I, N37D, L63T, I64V, E65D, K70R, I72VD
 CP076303084CP076303084HQ995261None   I13V, M36I, N37D, R41K, L63T, I64V, E65D, K70RD
 CP076301898CP076301898HQ995377None   I13V, K20R, M36I, R41K, I62V, L63T, I64V, E65D, I72VD
 CP076302895CP076302895HQ995468None   I15V, G16E, K20R, M36I, R41K, L63T, E65D, I72TD
Kasang (2011)2873328733HM572334None   I13V, R41K, L63T, I64L, V82ID
 1719917199HM572345None   I13V, I15V, L19I, M36I, R41K, L63T, I64V, E65DD
 20242024HM572357None   I13V, K20R, M36I, R41K, I62V, L63T, I64IV, E65DD
 1719517195HM572359None   I13V, R41K, L63T, I64L, V82ID
Ndembi (2011)AICPS339AICPS339HQ702643None   L10V, I13V, R41K, L63T, I64V, E65DD
Delwart (2012)480-0722-4480-0722-4JN214951None   I15V, G16E, K20R, M36I, N37K, R41K, Q61E, I62V, L63T, E65D, I72T, V82ID
Karlsson (2012)SE_82SE_82JQ698720None  Q58EI13V, R41K, D60E, I62V, L63T, I64V, E65D, V77I, V82ID
Machado (2012)CUPL1138CUPL1138JX194217None   K20R, E35D, M36I, N37D, R41K, R57K, L63T, E65D, H69R, I72MD
Ssemwanga (2012)RCC_TDR_359881RCC_TDR_359881JQ266022None   I13V, I15V, E35D, M36I, R41K, L63T, I64V, E65DD
 RCC_TDR_359885RCC_TDR_359885JQ266030None   I13V, I15V, E35D, M36I, R41K, L63T, I64V, E65DD
 RCC_TDR-480876RCC_TDR-480876JQ266086None   M36ML, R41K, L63T, H69Y, I72IV, V77ID
Yang (2012)KN-20KN-20JQ616941None   T12S, I13V, I15V, M36I, R41K, L63T, I64VD
Antoniadou (2013)GR043GR043KF671770None   L10V, I13V, G16GE, K20R, E35D, M36I, R41K, K45KR, R57K, L63T, E65D, L89MD
Billong (2013)MR106MR106KF192113None   I15V, E35D, M36I, P39PS, R41K, I62V, L63T, I64V, V77VID
Brooks (2013)CAN2013-116CAN13-116KF727755None  L89MVL10IV, I13V, I15IV, G16E, E35D, M36L, R41K, R57K, L63TD
Chow (2013)MY1IM781MY1IM781KC478036None   L10I, I13V, E35D, M36I, N37D, R41K, K43R, L63T, A71V, I72IT, I93LD
Frentz (2013)EHR-00826EHR-00826JX299551None   T12A, I15V, G16E, M36I, R41K, D60E, I62V, L63T, I64V, I72TD
 EHR-00912EHR-00912JX299555None   L10V, I13V, I15IV, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
 EHR-20296EHR-20296JX299872None   L10V, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MD
 EHR-25339EHR-25339JX299981None   L10V, G16E, K20R, E35D, M36I, R41K, R57K, I62V, L63T, L89MD
 EHR-27129EHR-27129JX300011None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
 EHR-27715EHR-27715JX300019None   L10I, T12AE, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V77I, L89M, I93LD
 EHR-41487EHR-41487JX300244None   K20KR, E35D, M36I, R41K, I62IV, L63T, I64ILM, E65D, I72IT, V82VI, L89MD
 EHR-49656EHR-49656JX300366None   T12N, I15V, L19I, K20R, E35D, M36I, R41K, R57K, L63T, I72T, T74S, L89MD
 EHR-64659EHR-64659JX300626None   L10V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, L63T, E65D, I72T, T74S, L89MD
 EHR-71598EHR-71598JX300747None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, P39T, R41K, L63T, E65D, I72T, L89MD
 EHR-75565EHR-75565JX300825None   T12A, I15V, G16E, M36I, R41K, D60E, I62V, L63T, I64V, I72TD
 EHR-76782EHR-76782JX300855None   L10V, T12I, I13V, I15V, G16E, E35D, M36I, N37D, R41K, K45R, R57K, I62V, L63T, E65D, I72T, T74TA, L89MD
 EHR-81275EHR-81275JX300925None   L10I, G16E, L19LI, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89LMD
 EHR-94228EHR-94228JX301102None   I13V, I15V, L19LI, E35D, M36I, R41K, R57K, L63T, E65D, I72T, V82VI, L89MD
Heipertz (2013)306347_RT306347_RTJX863949None   I15V, G16E, M36I, N37K, R41K, Q61E, I62V, L63T, E65D, I72T, V82ID
Kiptoo (2013)KAP048KAP048KC516897None   M36I, R41K, L63T, I64V, E65DD
Temereanca (2013)SR16SR16JX966491None   L10V, I13V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, L63T, E65D, I72T, L89MD
 SR20SR20JX966497None   L10V, I13V, I15V, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M, I93MD
 SR25SR25JX966502None   I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M, T96ND
 SR30SR30JX966507None   L10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, I93VD
 SR39SR39JX966514None   L10I, I13V, I15V, G16E, E35D, M36I, P39T, R41K, R57K, L63T, E65D, I72T, L89MD
 SR5SR5JX966523None   K14Q, I15V, K20R, T26S, E35D, M36I, R41K, R57K, L63T, E65D, I66V, I72V, L89MD
 SR6SR6JX966526None   L10I, T12K, I13V, I15V, K20I, E35D, M36I, R41K, R57K, L63T, E65D, I72V, T74S, L89MD
 SR60SR60JX966527None   L10V, I13V, I15V, G16E, K20R, M36I, R41K, R57K, L63T, E65D, T74S, V82I, L89MD
 SR65SR65JX966531None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, R41K, K43R, R57K, L63T, E65D, I72TD
 SR66SR66JX966532None   L10V, I15V, E35D, M36I, R41K, V56G, R57K, L63T, E65D, A71N, I72T, T74S, L89MD
 SR110SR110 None   T12S, L19I, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72V, L89MD