<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L63T
Rx >= 1 PI
IncludeMixtures No
References 8
Patients 18
Isolates 18
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)TK2025TK2025a IDV, RTV, SQV, LPV347  L10I, I13V, M36I, R41K, D60E, L63T, I64V, I72VD
Riddler (2008)RG27158RG27158w108 LPV103  K14R, I15V, M36I, R41K, L63T, E65D, I72TD
Charpentier (2010)T076006T076006HQ717826PI, DRV, RTVNAG48M, I54T, V82A, L90ML33F, Q58EL10I, T12M, I13V, G16E, K20R, E35D, M36I, R41K, L63T, E65D, I72T, T74A, L89MD
Rangel (2010)HIV244bHIV244bGU807502PINA  L10I, R41K, L63T, I93LD
Jones (2012)145636145636JN669661PINA  L10I, I13V, E35D, M36I, R41K, Q61D, L63T, K70F, I72TD
 163239163239JN670057PINAM46I, V82T, I84VL10FT12K, I13V, G16E, L19P, K20R, M36I, L63T, I64V, E65D, I72T, T74SD
 183366183366JN670645PINA  L10I, I13V, I15V, M36I, N37D, L63T, I64L, I93LD
Kouri (2012)CU749-09CU749-09JQ585263PINAM46L, I84VN83DL10I, I15V, G16E, K20R, M36I, R41K, D60E, I62IV, L63T, V82I, L89LFD
Van Zyl (2013)364111.ZA.GT1597KC423388LPV   L10V, G16E, M36I, N37Q, R41K, D60E, L63T, H69K, I72V, I93LD
Diaz (2015)RenG16432RenG16432KT747460PINAI50L, N88SQ58EL10V, G16E, K20R, E35D, M36I, N37T, L63T, E65ED, H69K, A71V, I72T, L89M, I93LD
 RenG15900RenG15900KT746928PINA  L10I, T12S, I15V, K20R, E35D, M36I, R41K, L63TD
 RenG16023RenG16023KT747051PINAV32I, M46L, I47V, I50L, V82A, I84VL33F, Q58ET12N, I13V, I15V, K20R, E35D, M36I, N37E, Q61QH, L63T, I64V, A71V, I72V, G78GV, R87RI, L89MD
 RenG13657RenG13657KT744685PINA  W6R, Q7R, L10*, V11C, I15V, K20R, E35D, M36I, R41K, L63T, I72TD
 RenG14611RenG14611KT745639PINA  L10I, I15IV, G16E, E35D, M36I, R41K, I62V, L63T, E65D, I72IMD
 RenG13801RenG13801KT744829PINA  I15V, M36I, R41K, I62IV, L63TD
 RenG11579RenG11579KT742607PINA  I15V, E35D, M36I, R41K, L63T, I72TD
 RenG10332RenG10332KT741360PINA  T12A, I15V, L19I, E35D, M36I, R41K, L63T, I72TD
 RenG10085RenG10085KT741113PINA  I15V, K20R, E35D, M36I, R41K, L63T, I72TD