<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L63S
Rx PI-naive
IncludeMixtures No
References 53
Patients 124
Isolates 127
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Vergne (2000)LVMP634LVMP634AJ286968None   L10V, I15V, L19V, E35D, M36I, R41K, R57K, I62V, L63S, H69Q, K70Q, V77ID
Eshleman (2001)SE676SE676AF388112None   R41K, L63S, I64V, H69YD
Hierholzer (2002)SU250SU250AY102504None   I13V, G16E, R41K, R57K, D60E, Q61N, L63S, E65D, V77ID
Holguin (2002)AH_M1296AH_M1296AF247021None   L19I, M36I, R41K, R57K, L63SD
Pandrea (2002)IP_97CIRMF0897CIRMF08AY140611None  L33IL10I, I13V, M36I, R41K, Q61N, L63S, I64V, C67YD
Eshleman (2004)SE868SE868pAY435400None   I13V, M36I, R41K, I62V, L63S, I64V, H69YD
  SE868_7dAY428731None   I13V, M36I, R41K, I62V, L63S, I64V, H69YD
 SE676SE676_7dAY428707None   R41K, L63S, I64V, H69YD
Eshleman (2004)ESH_Pat17ESH182AY435242None   I13V, K14R, E35D, M36I, R41K, R57K, L63S, H69K, I72IT, L89MD
 ESH_Pat83ESH857AY435383None   L10GV, I13V, M36I, R41K, L63S, I64VD
 ESH_Pat177ESH531AY435308None   I13V, K14R, E35D, M36I, R41K, R57K, L63S, H69K, K70KR, L89MD
Konings (2004)KF_Pat100CM3147AY359683None   I15V, E35D, M36I, R41K, L63S, I64V, I72V, V77I, N98ID
Rodrigues (2006)BR04RS195BR04RS195DQ070596None   K14T, I15V, L19Q, K20R, M36I, N37K, R41E, R57K, D60Y, Q61N, I62V, L63SD
Baker (2007)0351NG04-0351NGAY803476None   M36I, R41K, I62V, L63S, I64MD
 P0086P0086-230305EF186141None   I13V, M36I, R41K, I62V, L63S, I64V, H69Y, N98KD
 P0169P0169-300505EF186144None   T12K, I15V, L19Q, K20R, M36I, R41K, L63S, V77ID
 A1014MBA1014-090805EF186202None   T12Q, I13V, M36I, R41K, I62V, L63S, I64VD
 A1031MBA1031-240805EF186209None   I13V, N37AT, R41K, Q61N, L63S, I64V, E65D, H69Y, V77ID
Church (2007)676-135396j676EF612103None   R41K, L63S, I64V, H69Y, I72ITD
 857-146456T857EF612171None   L10V, I13V, M36I, R41K, L63S, I64VD
Dilernia (2007)F099F099EF120131None  L33IR41K, K43R, L63S, A71V, I72E, V77I, I93LD
Galluzzo (2007)M20490UG_M20490JQ220111None   I13V, L33V, M36L, R41K, I62V, L63S, I64V, E65DD
 M21170UG_M21170JQ220131None   M36I, R41K, L63S, I64VD
von Wyl (2007)801797997EF449958None   T12A, I13V, L19I, E35D, M36I, R41K, Q61N, L63S, I72TD
Ndembi (2008)IAEAM009IAEAM009EU306748None   L10V, I13V, G16E, M36I, P39L, R41K, I62V, L63S, I64V, H69Y, I72VD
 IAEM036IAEM036EU306767None   I13V, M36I, R41K, L63S, I64VD
 IAEM074IAEM074EU306791None   I13V, K20R, L33V, R41K, L63S, I64V, E65DD
Nyombi (2008)TMS013TMS013EU251793None   I13V, R41K, L63S, I64V, H69Y, I72VD
 TMS017TMS017EU251796None   I13V, L19I, R41K, L63S, I64V, H69Y, I72TD
 TMS120TMS120EU251820None   K14R, R41K, L63SD
Eshleman (2009)K10192W107-156972FJ389082None   M36I, R41K, I62V, L63S, I64V, E65DD
 J00596W208-101579FJ389130None   M36I, R41K, L63S, I64V, K70RD
 K31818R908-101584FJ389131None   T12A, I13V, K20R, M36I, R41K, I62V, L63S, I64VD
Vercauteren (2009)pt169231B1W2XiW5GQ399332None   I13V, K20R, L33V, M36I, R41K, I62V, L63S, I64VD
Djoko (2010)681CD4715FR666681None   L19I, M36I, N37D, R41K, R57K, L63S, I64V, E65N, G78ED
Ferreira (2010)P20DIP20GQ862305None   I15V, M36I, R41K, L63SD
Mosha (2010)S17PolS17PolJQ071463None   I13V, R41K, L63S, I64V, G73DD
Ndembi (2010)DT2626_05_P12626GQ409607None   G16E, R41K, D60E, I62V, L63S, I64V, H69C, I72V, V77ID
 DT3952_05_P13952GQ409627None   I13V, I15V, R41K, L63S, I64V, E65D, I72V, V77ID
Soares (2010)CM04_050CM04_050GU366145None   L19I, E35D, M36I, R41K, R57K, I62V, L63S, A71T, I72V, V77ID
Towler (2010)315998-Z315998-ZHM037834None   I13V, R41K, L63S, I64V, V77ID
 320707-D320707-DHM037841None   I13V, K20KR, M36I, R41K, I62V, L63S, I64VD
 427985-P427985-PHM037875None   I13V, R41K, Q61E, L63S, I64V, E65D, H69Y, V77ID
Aghokeng (2011)SK1025-PISK1025-PIHQ864357None   L19I, E35D, M36I, R41K, I62V, L63S, I72IV, V77VID
Hamers (2011)CP076301547CP076301547HQ993590None   I13V, L19I, R41K, L63S, I64V, H69YD
 CP076301689CP076301689HQ993685None   L19X, E35D, M36I, N37S, R41K, I62V, L63S, I64IVD
 CP076302198CP076302198HQ993807None   T4S, L10I, I15V, M36I, R41K, I62V, L63S, I64V, E65D, C67NSD
 CP076304185CP076304185HQ993896None   T12N, K14KR, R41K, K45R, I62V, L63S, I64V, V77I, I85VD
 CP076304259CP076304259HQ993947None   Q18H, K20R, M36I, R41K, I62V, L63S, I64V, E65D, I72V, I85VD
 CP076300893CP076300893HQ994968None   R41K, Q61H, L63S, E65D, I72T, V82VID
 CP076301846CP076301846HQ994991None   I13V, M36I, R41K, K45R, L63S, I64V, E65D, I72VD
 CP076301883CP076301883HQ995011None  L33IT12P, I13V, K20M, M36I, R41K, L63S, I64VD
 CP076302993CP076302993HQ995065None   I13V, M36I, R41K, D60E, I62V, L63S, I64VD
 CP076303018CP076303018HQ995082None   I13V, K14R, G16E, R41K, L63S, I64VD
 CP076303030CP076303030HQ995092None   I13V, L19V, M36I, R41K, I62V, L63S, I64V, H69Y, I72VD
 CP076300872CP076300872HQ995129None   I13V, R41K, D60E, L63S, I64V, V77ID
 CP076302049CP076302049HQ995201None   L10I, R41K, R57K, L63S, I64VD
 CP076301931CP076301931HQ995399None   L19I, M36I, R41K, L63S, I64V, E65DD
Kasang (2011)3264232642HM572336None   R41K, I62IV, L63S, H69H*QY, I72IT, V77ID
 20282028HM572346None   I13V, N37S, R41K, I62V, L63S, I64V, E65D, V77ID
 20252025HM572352None   K14R, R41K, L63S, I64V, E65D, V77ID
Ndembi (2011)AICPS034AICPS034HQ702681None   I13V, R41K, L63S, I64V, E65DD
Ng (2011)HM091HM091JN029803None   I13V, G16E, M36I, N37D, I62V, L63S, I64V, E65DD
Afonso (2012)ANG56ANG56JN937069None   E35D, M36I, N37D, R41K, Q61N, L63S, C67W, I72T, G86KD
 ANG32ANG32JN937045None   E35D, M36I, R41K, Q61N, L63S, I64M, H69K, I72TD
Avila-Rios (2012)B000M90TS9B000M90TS9KC168115None   T12S, I13V, G16E, L19V, K20R, M36I, R57K, L63S, I64V, E65D, I72VD
 E000M61ISRE000M61ISRKC168527None   T12TS, I13V, G16E, M36I, P39S, R41K, K45R, I62V, L63S, I64V, E65D, T91VD
Karlsson (2012)SE_187SE_187JQ698795None   I13V, R41K, I62V, L63S, I64V, E65DD
Machado (2012)CUPL0904CUPL0904HQ655337None   K20R, E35D, M36I, N37S, R41K, K43R, Q61N, L63S, H69QD
 CUPL1018CUPL1018HQ655395None   L10I, I13V, G16E, E35D, M36I, R41K, I62V, L63S, I64V, H69Q, V75ID
 CUPL1054CUPL1054JN000026None   L10I, I13V, G16E, E35D, M36I, R41K, G49E, I62V, L63S, H69QD
Nazziwa (2012)30392013039201JX498992None   M36I, D60E, L63S, I64V, V77ID
 30392023039202JX498993None   M36I, D60E, L63S, I64V, V77ID
Reynolds (2012)D0397D0397-0JN652146None   I13V, L33V, R41K, K43KR, R57K, L63S, I64V, E65DD
  D0397-1JN652179None   I13V, L33V, R41K, R57K, L63S, I64V, E65DD
Ssemwanga (2012)RCC_TDR_480650RCC_TDR_480650JQ266026None   M36I, R41K, L63S, I64VD
 RCC_TDR_481346RCC_TDR_481346JQ266040None   K14R, L19I, M36I, R41K, L63S, I64V, E65DD
 RCC_TDR_359957RCC_TDR_359957JQ266045None   T12A, L19I, E35D, M36I, R41K, Q61N, L63S, I64V, E65D, V77ID
 RCC_TDR_807857RCC_TDR_807857JQ266069None   M36I, R41K, L63S, I64VD
 RCC_TDR_483540RCC_TDR_483540JQ266071None   L19V, M36L, R41K, L63S, I64V, E65DD
 RCC_TDR-353759RCC_TDR-353759JQ266089None   I13V, M36I, R41K, I62V, L63S, I64V, E65D, H69YD
Ssemwanga (2012)3204HR3204HRJF800197None   I13V, M36I, R41K, Q61N, L63S, I64V, E65DD
 2946HR2946HRJF800223None   I13V, E35D, M36I, R41K, K45R, R57K, D60E, L63S, I64L, H69K, L89MD
Yang (2012)KN-14KN-14JQ616915None   T12S, I13V, M36I, R41K, I62V, L63S, I64VD
Alencar (2013)RJ2-0044RJ2-0044JQ238060None   T12N, K14R, L19I, M36I, R57K, Q61S, L63S, I64VD
Brooks (2013)CAN2013-038CAN13-038KF727942None   L10V, R57K, I62V, L63S, A71V, I72T, V77I, I93LD
Ferreira (2013)BR09SP224BR09SP224HM534026None   E35D, M36I, R41K, R57K, L63S, E65D, L89MD
Frentz (2013)EHR-65454EHR-65454JX300642None   L10I, I13V, L33LV, M36I, I62V, L63S, I64V, C67E, I72LD
Hassan (2013)RS11000327RS11000327JQ698404None   L10I, I13V, R41K, L63S, I64V, K70KR, I72LM, V77ID
Hawke (2013)2299032522990325KC238076None   M36I, R41K, I62V, L63S, E65D, I72T, Q92QK, I93ILD
Holguin (2013)ES113ES113JX466982None   L63S, I64LD
Inzaule (2013)317317JQ914102None   I13V, I15V, M36I, R41K, I62V, L63S, I64V, E65DD
Kiertiburanakul (2013)R71TS285R71TS285KC921754None   T12P, I13V, E35D, M36I, R41K, I62V, L63SD
 R75025R75025KC962523None   I13V, E35D, M36I, R41K, I62V, L63SD
 R71TS024R71TS024KC921504None   I13V, E35D, M36I, R41K, I62V, L63SD
 X12045X12045KC994377None   L10I, I13V, L19MV, E35D, M36I, R41K, L63SD
 R75009R75009KC962514None   L10I, I13V, M36I, R41K, I62V, L63S, I64VD
 R71TS210R71TS210KC921681None   I13V, E35D, M36I, R41K, I62V, L63S, I64VD
 R71TS045R71TS045KC921524None   I13V, E34Q, M36I, R41K, I62V, L63SD
 R71TS262R71TS262KC921731None   I13V, M36I, R41K, I62V, L63SD
 R71204R71204KC921439None   I13V, E35D, M36I, R41K, I62V, L63SD
 R71243R71243KC921472None   I13V, E35D, M36I, R41K, I62V, L63SD
 R72117R72117KC856951None   I13V, G16E, E35D, M36I, R41K, I62V, L63SD
Kiptoo (2013)KTL230KTL230KC517047None   I13V, K14R, M36MI, N37S, R41K, L63S, I64V, I72VD
 KAP023KAP023KC516883None   I13IV, I15V, M36I, R41K, L63S, I64V, I72VD
 KTL075KTL075KC517014None   I13V, G16E, E35D, M36I, R41K, R57K, L63S, I64V, E65DD
 SNH007SNH007KC516930None   L10V, I13V, K14KR, G16E, M36I, R41K, L63S, I64V, I72VD
Mulu (2013)ETH-G-5768ETH-G-5768KF026185None   G16E, M36I, R41K, I62V, L63S, E65D, I72T, V82ID
Sigaloff (2013)JCR111_0JCR111_0JX182003None   L10V, I13V, M36I, R41K, I62V, L63S, I64VD
 JCR118_0JCR118_0JX182007None   I13V, E35D, R41K, L63S, I64VD
 JCR099_0JCR099_0JX181999None   L10V, I13V, G16E, E35D, M36I, P39S, R41K, I62V, L63S, I64V, E65DD
Bartolo (2014)09AOHDP26409AOHDP264KF853833None   T12P, L19V, E35D, M36I, R41K, I62V, L63S, C67N, H69KD
 09AOHDP1509AOHDP15KF853772None   L10I, L19V, E35D, M36I, N37D, R41K, Q61N, I62IV, L63S, E65D, I72T, N83NSD
 09AOHDP10109AOHDP101KF853753None   I15V, L19I, M36I, L63S, H69QD
Lee (2014)MBA1443MBA1443KJ907125None   T12K, I13V, I15V, M36I, N37D, R41K, L63S, I64V, H69YD
 MBA1298MBA1298KJ906988None   I13V, M36I, R41K, D60E, L63S, I64V, V77ID
 MBA1014MBA1014KJ906719None   T12Q, I13IV, G16GE, M36I, R41K, I62V, L63S, I64V, I72IVD
 MBA1150MBA1150KJ906848None   L10V, T12TI, I13V, K14KR, I15IV, R41K, K45KR, L63S, I64V, I72IVD
 MBA1031MBA1031KJ906734None   I13V, N37NADT, R41K, Q61N, L63S, I64V, E65D, H69Y, V77ID
 MBA1385MBA1385KJ907071None   G16E, R41K, K43E, K45R, L63S, I64VD
 AMU093AMU093KJ906703None   I13V, M36I, R41K, I62V, L63S, I64VD
 MBA1460MBA1460KJ907139None   L10V, K14R, I15IV, G16E, E35D, R41K, L63S, I72VD
 AMU076AMU076KJ906693None   I13V, M36I, R41K, I62IV, L63S, I64VD
 MBA1454MBA1454KJ907133None   L10V, L33V, N37T, R41K, L63S, I64IVD
 AMU069AMU069KJ906687None   L10V, I13V, I15IV, G16GE, N37NT, R41K, D60E, Q61N, I62IV, L63S, E65ED, V77ID
Meixenberger (2014)11-0243211-02432KJ771545None   L10V, I13V, I15V, G16E, K20I, M36I, R41K, R57K, D60E, Q61E, I62V, L63S, I64V, A71V, P79D, I93LD
 11-0069111-00691KJ771491None  V11IL10I, N37D, R41K, I62V, L63S, I64M, A71V, V77I, I93LD