<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L63Q
Rx PI-naive
IncludeMixtures No
References 40
Patients 111
Isolates 117
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Cornelissen (1997)92UG05392UG053AF009402None   R41K, D60E, L63Q, I64VD
Caumont (2001)AC12AC12AF326192None   N37D, L38V, R41K, Q61N, L63QD
Eshleman (2001)SE765SE765AF388124None   L10I, I13V, K20KR, M36I, R41K, L63Q, I64V, H69QD
 SE638SE638AF388105None   I13V, L33V, R41K, L63Q, I64VD
Weidle (2001)PW_UG465PW_UG465AF358755None   I13V, I15V, M36I, R41K, L63Q, I64V, I72VD
  PW_UG465a None   I13V, I15V, M36I, R41K, L63Q, I64V, I72VD
  PW_UG465b None   I13V, I15V, M36I, R41K, L63Q, I64V, I72VD
Eshleman (2002)150140g150140gAF410254None   I13V, R41RK, L63Q, I64VD
Eshleman (2004)SE638SE638pAY435395None   I13V, L33V, R41K, L63Q, I64VD
  SE638_7dAY428708None   I13V, L33V, R41K, L63Q, I64V, T96PD
Eshleman (2004)ESH_Pat126ESH1AY435220None   I13V, G16E, E35D, R41K, L63Q, I64V, K70R, V77ID
Eshleman (2004) SE1_7dAY428667None   I13V, G16E, E35D, R41K, L63Q, I64V, K70R, V77ID
Eshleman (2004)ESH_Pat137ESH515AY425350None   I13V, M36MI, R41K, L63Q, I64V, E65DD
Konings (2004)KF_Pat400CM4877AY359686None   L10V, T12S, L19I, E35D, M36I, R41K, L63Q, I64VD
 KF_Pat500CM1911AY359687None   I15V, E35D, M36I, R41K, L63QD
Yang (2004)99KE58899KE588AY492789None  L33II13V, L19I, E35D, N37S, R41K, L63Q, I64V, E65D, H69YD
Ciccozzi (2005)MC_AY611648D59AY611648None   M36I, R41K, L63Q, I64V, E65D, V77ID
K'Aluoch (2005)OK_TC008803TC008803DQ079849None   L10LI, I13V, Q18E, M36I, R41K, L63Q, I64VD
Non-B Workgroup (2005)UK1972UK1972AY900826None   E35D, M36I, R41K, L63Q, I64V, E65DD
Weber (2005)M85579M85579AY677482None   M36IL, R41K, L63QD
Vidal (2006)NV_LBR03202.LBR032AM041025None   L10V, N37S, R41K, L63Q, I64V, H69Y, V77ID
Baker (2007)P0219P0219-130705EF186147None   L19I, R41K, L63Q, I72VD
 P0285P0285-070905EF186149None   I13V, K20R, M36I, R41K, L63Q, I64VD
 A1059MBA1059-081105EF186220None   I13V, L33V, M36I, N37T, P39S, R41K, L63Q, I64V, I72V, V82VID
Brumme (2007)1602PRRT_1602EF368912None   L33V, R41K, L63Q, I64V, H69Y, V77ID
Church (2007)001-106667R001EF611990None   I13V, G16E, E35D, R41K, L63Q, I64V, K70R, V77ID
 515-128487Q515EF612053None   I13V, N37NT, R41K, L63Q, I64V, E65DD
 765-140409O765EF612137None   L10I, I13V, K20KR, M36I, R41K, L63Q, I64V, H69QD
Galluzzo (2007)M22490UG_M22490JQ220069None   I13V, E35D, M36I, R41K, L63Q, I64V, K70RD
 M22720UG_M22720JQ220093None   I13V, M36I, R41K, L63Q, I64VD
 M20340UG_M20340JQ220105None   I13V, R41K, L63Q, I64V, V77ID
 M20610UG_M20610JQ220115None  L33LFW6G, I13V, K20R, E35ED, M36IL, N37H, R41K, I62V, L63Q, I64V, H69QD
 M21400UG_M21400JQ220139None   I13IV, M36MI, R41K, R57RK, D60E, L63Q, I64VD
Church (2008)368341X368341XEU380736None   I13V, K14R, I15V, R41K, L63Q, I64V, V82ID
Ndembi (2008)IAEM066IAEM066EU306785None   I13V, K20R, M36I, N37S, R41K, R57K, L63Q, I64V, E65DD
Nyombi (2008)TBK089TBK089EU251772None   I13V, N37S, R41K, L63Q, I64V, E65D, H69YD
 TMS111TMS111EU251811None   Q7E, I15V, L19I, R41K, D60E, L63Q, I64V, I72V, V77ID
 TMS308TMS308EU251859None   I13V, G16E, M36I, R41K, D60E, I62V, L63Q, I64VD
Somi (2008)BG-05-166BG-05-166JQ616945None   I13V, M36I, R41K, D60E, L63Q, I64V, I72VD
Eshleman (2009)G49070R907-156545FJ389052None   I13V, K20R, M36I, R41K, L63Q, I64V, E65DD
 E40578W107-156559FJ389054None   I13V, K20R, M36I, R41K, I62V, L63Q, I64V, E65DD
 B22943W307-156987FJ389092None   I13V, R41K, L63Q, I64V, H69Y, I72E, V77ID
 K13985B607-157000FJ389102None   I13V, I15V, M36I, N37S, P39S, R41K, L63Q, I64VD
 C25290W308-102854FJ389144None   L10V, I13V, G16E, M36I, R41K, L63Q, I64V, V75VID
Hattori (2010)C08-20672670C08-20672670AB864157None   I13V, M36I, R41K, D60E, I62V, L63Q, I64V, I72ED
Ndembi (2010)14318D_P114318GQ409566None   I13V, L33V, M36MI, R41K, L63Q, I64V, E65DD
 DT0917_05_P1917GQ409596None   I13V, M36I, R41K, L63Q, I64V, E65DD
 DT3211_05_P13211GQ409613None   I13V, I15V, N37S, R41K, L63QD
Hamers (2011)CP076301623CP076301623HQ993659None   M36L, N37D, R41K, L63Q, I64VD
 CP076303149CP076303149HQ994171None   I13V, L19LV, M36I, N37ND, R41K, L63Q, I64VD
 CP076300841CP076300841HQ994957None  L33II13V, K20M, E35D, M36I, R41K, L63Q, I64V, I72VD
 CP076300866CP076300866HQ994961None   M36I, R41K, L63Q, I64V, E65DD
 CP076300879CP076300879HQ994963None   I13V, M36I, N37H, R41K, L63Q, I64V, E65D, I72VD
 CP076300894CP076300894HQ994969None  Q58EI13V, L33V, M36I, P39Q, R41K, I62IV, L63Q, I64V, E65D, I72VD
 CP076300900CP076300900HQ994971None   L10V, I13V, I15V, R57RK, L63Q, I64VD
 CP076303000CP076303000HQ995068None   K20R, R41K, L63Q, I64V, E65DD
 CP076300892CP076300892HQ995140None   I13V, R41K, L63Q, I64V, E65D, H69Y, V77ID
 CP076300896CP076300896HQ995142None   L10V, I15L, L33V, L63Q, I64VD
 CP076301841CP076301841HQ995168None   I13V, R41K, L63Q, I64V, E65DD
 CP076303067CP076303067HQ995247None   I13V, R41K, D60E, L63Q, I64V, H69Y, V77ID
 CP076300734CP076300734HQ995323None   I13V, G16E, E35D, M36I, R41K, I62V, L63Q, I64VD
 CP076300786CP076300786HQ995350None   L10I, I13V, M36I, R41K, I62V, L63Q, I64V, H69YD
 CP076300798CP076300798HQ995359None   I13V, K14KR, K20KR, M36I, N37D, R41K, L63Q, I64V, E65D, I72VD
 CP076301896CP076301896HQ995375None   I13V, L19I, R41K, R57K, L63Q, I64V, V77ID
 CP076301972CP076301972HQ995436None  V11IL10V, K20V, M36I, P39T, R41K, L63Q, I93MD
 CP076302920CP076302920HQ995480None   I13IV, I15IV, L19I, K20T, E34EK, M36MI, R41RK, L63Q, I64L, V77ID
Kasang (2011)3264932649HM572340None   I13V, R41K, L63Q, I64V, H69Y, I72T, V77ID
 20352035HM572348None   I13V, M36I, R41K, K43KR, L63Q, I64VD
Ndembi (2011)AICPS439AICPS439HQ702639None   M36I, N37D, L63Q, I64VD
Karlsson (2012)SE_209SE_209JQ698814None   L10I, I13V, I15V, G16E, E35N, M36I, N37D, R41K, K43R, I62V, L63Q, I64V, H69QD
Nazziwa (2012)10236201023620JX498972None   L10V, I13V, I15V, E35D, M36I, N37S, R41K, K45R, R57K, L63Q, I64VD
 10055011005501JX498974None   I13V, I15V, M36I, N37D, P39L, R41K, L63Q, I64V, E65DD
 30364013036401JX498975None   I13V, L33V, M36I, R41K, L63Q, I64V, E65DD
 30535013053501JX498979None   I13V, M36I, R41K, L63Q, I64VD
 31537013153701JX498981None   I13V, K20R, M36I, N37D, R41K, L63Q, I64V, E65D, I72VD
Reynolds (2012)C0717C0717-0JN652144None   I13IV, M36I, R41K, K45KR, L63Q, I72VD
  C0717-1JN652177None   I13V, M36I, R41K, L63Q, I72VD
 F0719F0719-1JN652192None  V11IL10I, I13V, E35D, M36I, R41K, L63Q, I64VD
 G0772G0772-1JN652195None   L10I, V11L, T12P, I13V, L19I, E35D, M36I, R41K, L63Q, I64V, I72VD
Sigaloff (2012)KELKN210KELKN210JN628484None   L10V, I13V, I15V, M36L, R41K, L63Q, I64VD
Ssemwanga (2012)RCC_TDR_358745RCC_TDR_358745JQ266021None   L10I, I13V, M36I, R41K, L63Q, I64V, I72VD
 RCC_TDR_480631RCC_TDR_480631JQ266033None   I13V, L19I, M36I, R41K, Q61N, L63Q, I64V, E65D, H69Y, I72TD
 RCC_TDR_483644RCC_TDR_483644JQ266043None   G16E, K20R, M36I, P39S, R41K, L63Q, I64V, H69Y, K70KRD
 RCC_TDR_483451RCC_TDR_483451JQ266048None   I13V, K20R, M36I, R41K, L63Q, I64V, E65D, V75ID
 RCC_TDR_480013RCC_TDR_480013JQ266064None   G16E, K20R, M36I, P39L, R41K, L63Q, I64VD
 RCC_TDR_483555RCC_TDR_483555JQ266068None   G16E, K20R, M36I, P39S, R41K, L63Q, I64VD
Ssemwanga (2012)1420HR1420HRJF800192None   I13V, I15V, E35D, M36I, R41K, L63Q, I64V, I72V, V77ID
 0322HR0322HRJF800213None   I13V, M36I, R41K, L63Q, I64V, K70RD
Hassan (2013)RS11000235RS11000235JQ698340None   I13V, M36I, R41K, K45KR, D60E, I62V, L63Q, I64V, H69YD
 RS11000294RS11000294JQ698381None  L33FI13V, G16E, L19LP, M36I, N37D, R41K, L63Q, I64V, K70KR, V75ID
Kiptoo (2013)SNH081SNH081KC516957None   I13V, L19I, M36I, R41K, L63Q, I64IK, E65ED, I66IMV, H69HQ, I72I*KL, L89MD
 SNH085SNH085KC516989None   I13V, L63Q, I64V, E65DD
 KAP067KAP067KC516914None   I13V, M36I, N37ND, R41K, L63Q, I64V, I72ITD
Sigaloff (2013)JCR092_0JCR092_0JX181997None   I13V, K20R, M36I, R41K, L63Q, I64V, H69CD
 JCR046_0JCR046_0JX181987None   I13V, M36I, R41K, L63Q, I64VD
 JCR011_0JCR011_0JX181983None   M36I, N37D, L63Q, I64VD
 JCR101_0JCR101_0JX182000None   I3N, I13V, K14R, I15V, R41K, L63Q, I64V, V82ID
Van Zyl (2013)1819851KC424318None   T12A, I13V, L19I, M36I, R41K, L63Q, I64VD
Chung (2014)LJJ_3_KA227eLJJ_3_KA227eKF544276None   M36I, R41K, L63Q, I64V, E65D, I72VD
Lee (2014)MBA1487MBA1487KJ907164None   T12P, I13V, R41K, R57K, L63Q, I64V, V77ID
 MBA1197MBA1197KJ906894None   I13V, I15V, M36I, R41K, L63Q, I64V, E65DD
 MBA1275MBA1275KJ906967None   T12A, I13V, K20M, M36I, R41K, L63Q, I64V, K70R, I72VD
 MBA1307MBA1307KJ906996None   M36I, R41K, R57K, L63Q, I64V, E65DD
 MBA1112MBA1112KJ906812None   I13V, L33V, M36I, R41K, K45R, L63Q, I64V, E65DD
 AMU055AMU055KJ906675None   I13IV, L19LI, M36I, R41K, L63Q, I64VD
 AMU083AMU083KJ906699None   I13V, I15IV, K20R, M36I, R41K, R57K, L63Q, I64V, I72VD
 MBA1283MBA1283KJ906974None   L10V, I13V, K14KR, L33V, R41K, L63Q, I64VD
 MBA1118MBA1118KJ906816None   I13V, L33V, M36I, R41K, K45R, L63Q, I64V, E65DD
 MBA1156MBA1156KJ906854None   M36I, R41K, D60E, L63Q, I64V, H69HYD
 MBA1352MBA1352KJ907038None   I13IV, K20R, M36I, R41K, L63Q, I64V, E65EDD
 MBA1123MBA1123KJ906821None   I13V, K14R, R41K, L63Q, I64V, E65D, I72IV, V77ID
 MBA1456MBA1456KJ907135None   I13V, I15IV, E35D, M36MI, R41RK, L63Q, I64V, E65ED, V77VID
 AMU077AMU077KJ906694None   I13V, K14KR, G16GE, M36MI, R41K, L63Q, I64VD
 MBA1070MBA1070KJ906771None   T12TA, I13V, G16E, M36I, R41K, L63Q, I64V, I72VD
 MBA1341MBA1341KJ907027None   L33V, M36MI, R41AT, L63Q, I64V, T74QD
 MBA1057MBA1057KJ906758None   I13V, M36I, R41K, I62IV, L63Q, I64V, H69YD
 MBA1375MBA1375KJ907061None   L10LI, T12TA, I13V, K14KR, M36I, R41K, L63Q, I64VD