<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L63P
Rx >= 1 PI
IncludeMixtures No
References 22
Patients 117
Isolates 123
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Rousseau (2000)MNR18MNRMP1263AJ405965SQV, NFV69I84V, L90MG73SL10I, L19T, K20R, E35D, M36I, N37D, I62V, L63P, H69Y, A71T, I72TD
Cuevas (2002)CU105CU105AF425486IDV   G16D, M36I, R41K, K43R, Q61E, L63P, H69K, I93LD
 CU104CU104AF425485IDV   E35D, M36I, R41K, K43R, D60E, L63P, H69QD
 CU95CU95AF425476IDV   I13V, I15V, K20M, M36I, R41K, L63P, I64L, H69QD
 CU80CU80AF425461IDV   L10V, E35D, M36I, R41K, K43R, L63P, H69Q, V82ID
 CU54CU54AF425435SQV, IDV   I13V, E35D, M36I, N37D, R41K, K43R, L63PD
 CU51CU51AF425432IDV   I15V, M36I, N37D, R41K, K43R, L63P, H69QD
Gibb (2002)DMG8181_w56 NFV55D30NN88DI13V, R41K, L63P, A71T, V77ID
 DMG8989_w21 NFV21  I13V, L33V, N37X, P39PQ, R41K, D60E, L63P, K70KR, N88NKD
Holguin (2002)AH_14024AH_14024AF354018IDV, RTV   T12S, E35D, M36I, R41K, I62V, L63P, H69YD
 AH_17335AH_17335AF354017SQV, RTV, NFV, IDV57  T12S, E35D, M36T, R41K, I62V, L63P, H69YD
Vergne (2003)VL01SN160HALD01SN160AJ583742IDV  N88DQ7L, T12S, I15V, E35D, M36I, R41K, Q61N, I62V, L63P, A71TD
Dumans (2004)268268AY390063SQV, RTV, NFV239  I13V, K55R, L63P, V77I, T91I, I93LD
Gomez-Carrillo (2004)9543795437AY365508PINAM46L, V82VA Q7QH, L10LI, T12TP, I15V, K20R, M36I, R41K, K55R, R57RK, L63P, I64V, I93LD
 101028101028AY365623PINAI54V, L76V, V82A L10I, I13V, I15V, K20M, E35D, M36I, R41K, Q61N, L63P, A71V, I72T, L89I, I93LD
 103136103136AY365669PINAD30N, V82AN83D, N88DL10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, Q61N, L63P, A71VD
 104461104461AY365704PINAV82L, L90M I15V, L19I, K20R, E35D, M36I, I62V, L63P, H69Q, I72CD
 113381113381AY365875PINAI54L, V82A, L90ML33F, K43T, F53LT12M, I13V, I15V, Q18H, K20R, E35D, M36I, N37DE, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71I, I72LD
 118423118423AY365949PINAL90M L10V, I13V, K14R, K20T, E35D, M36I, N37D, R41K, Q61N, L63P, A71T, I72T, T74SD
Montes (2004)MB_patESTU01_ESTU702AJ577887SQV, RTV, NFV, IDV309M46I, I84V, L90MV11I, G73SL10V, I13V, K20I, L33V, I62V, L63PD
 MB_patMOL00_MOLL719AJ577953SQV, RTV, IDV, NFV143D30N Q7E, E35D, M36I, P39Q, R41K, I62V, L63P, I64L, A71V, I72V, V77I, I93LD
 MB_patHAN00_HAN704AJ577911RTV, NFV155  R41K, L63P, I64L, H69QD
 MB_patDER02_DER736AJ577878NFV179D30NN88DL10Y, I13V, E35D, M36I, I62V, L63P, I64V, T74S, V77ID
Snoeck (2004)BE36bBE36bAY900739NFV41  M36I, R41K, L63P, H69Q, I72IV, I93ILD
 BE40BE40AY900743SQV, IDV, NFV236L90M L10I, I15V, K20M, R41K, D60E, I62V, L63P, A71T, I72V, V75I, L89M, I93LD
Non-B Workgroup (2005)UK1392UK1392AY900799SQV161L90M L10V, I13V, R41K, L63P, I64V, K70R, I72IV, T74SD
 UK1557UK1557AY900679NFV, SQV104D30NN88DL10V, I13V, E35D, M36I, R41K, L63PD
 UK1979UK1979 NFV D30N I13V, I15V, E35D, M36I, R41K, L63PD
 TK1009TK1009 IDV, NFV, RTV177M46ML I13V, K14KR, E35D, M36I, R41K, K45KR, R57RK, L63P, H69KQ, A71AV, L89TD
  TK1009a IDV, NFV, RTV, LPV239M46I, I54V, V82AL24IL10I, M36I, N37D, R41K, L63P, I64V, A71AV, I72VD
 TK1014TK1014 RTV, SQV, NFV, IDV246M46I, I84IVL24LIL10LV, I13V, K20I, E35D, M36I, R41K, L63P, H69K, T74S, T80TA, V82X, L89IMD
 TK1024TK1024 IDV, NFV, RTV, LPV234  I13V, K20M, M36I, R41K, K45KR, L63P, I64V, H69HY, I72E, P79PAD
  TK1024a IDV, NFV, RTV, LPV277  I13V, K20M, M36I, R41K, I62IV, L63P, I64V, H69HY, I72E, P79XD
 TK1028TK1028 RTV, IDV, NFV207M46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028a RTV, IDV, NFV231M46I, I54V, V82TL24IP1PS, L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028b RTV, IDV, NFV308M46L, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 TK2001TK2001 SQV, RTV, NFV94M46I, I84VN83DL10I, I13V, A22V, E35G, M36I, I62V, L63P, I64V, A71V, I93LD
  TK2001a SQV, RTV, NFV, LPV97M46MI, I84IVN83NDL10I, I13V, K14KR, A22AV, E35EG, M36I, I62V, L63P, I64V, A71AV, I93ILD
 TK2005TK2005 RTV, IDV135I54IV K20KT, R41K, L63P, I64V, T74TS, V82ID
  TK2005b RTV, IDV, APV, SQV213I54V, V82ATL10LFI13V, I15IV, K20KT, R41K, L63P, I64V, A71AV, T74SD
 TK2014TK2014 SQV, RTV, IDV, NFV307M46L, I54V, V82A L10V, R41K, D60E, L63P, I66IF, A71V, T74S, V77ID
 TK3008TK3008 SQV, NFV344I84VN83DL10I, I13V, A22V, M36I, R41K, I62V, L63P, I64V, H69HYD
 TK3037TK3037 RTV196I54V, V82A L10V, T12TA, I13V, K14R, G16A, R41K, K43R, I62V, L63P, A71TD
 TK5013TK5013a SQV, IDV, NFV340D30DN, M46MI, I54IV, V82VAL24LIL10LI, I15IV, K20KR, E35D, M36I, N37DE, R41K, D60DE, I62V, L63P, I64IV, E65ED, C67CY, T74TSD
Weber (2005)F69976F69976AY714463NFV, Unknown, LPV>135  T12S, E35ED, M36I, R41K, L63P, I64V, I72IVD
Baxter (2006)48-12121212-30812DQ877754PINAM46L, I54V, V82AL24I, L33FL10V, I15V, E35D, M36I, N37ND, R41K, I62V, L63PD
 48-12251225-30417DQ877757PINAI84V, L90LM Q7E, L10I, G16GE, P39S, R41K, D60E, L63P, I64V, V77I, I85IVD
 48-14291429-30424DQ877819PINAM46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 48-14321432-30818DQ877822PINAM46I, I54V, L76V, V82TL24IL10I, I13A, K20I, E35D, M36I, R41K, Q61H, L63P, H69K, T74S, L89ID
 48-14391439-30929DQ877829PINAM46I, I54V, L76LV, V82A, L90ML10FII13V, K20I, E34EK, M36I, R41K, I62V, L63P, I64IV, A71T, L89LI, I93LD
 48-22442244-30722DQ877883PINAV32I, M46I, I54V, V82A, L90MK43T, G73TL10V, I15V, K20R, M36I, R41N, K55R, D60E, L63P, H69HR, K70R, A71V, I93L, C95VD
 48-30563056-30318DQ877968PINAM46I, I54V, L76V, V82TL10F, L89VI13V, K20M, M36I, R41K, I62V, L63P, A71V, I72V, I93LD
 48-41654165-30410DQ878398PINAM46MI, I54V, V82SL24IL10I, I13V, L19I, K20IM, M36I, R41K, L63P, A71VD
 48-50145014-30514DQ878549PINAM46I, I54V, V82A, L90LML10F, Q58EI13V, K20I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, N83SD
 48-50525052-30515DQ878573PINAM46MI, G48M, I54V, V82A, L90MF53L, L89IVT4S, L10IV, I13V, K14R, G17DE, K20I, L33L_L, M36V, R41K, L63P, H69K, K70R, A71T, T74S, Q92KD
Laurent (2006)CK2-8402CM-84AM279448NFV105 L10F, L33I, N88GI13V, E35D, M36I, N37E, R41K, V56A, I62V, L63P, H69Y, A71T, I72TD
 CK2-9802CM-98AM279450IDV30  L10V, I15V, E35D, M36I, R41K, L63P, H69QD
von Wyl (2007)1285248038EF449884PINAL90ML24IL10I, I13V, E35G, M36I, R41K, I62V, L63P, A71T, T74A, V75ID
 310371422EF449968RTV, PINAM46I, I54V, L76V, V82ML24I, L33FL10V, I13V, K20R, E35D, M36I, N37DE, K55R, R57K, D60E, I62V, L63P, V75I, L89M, T91SD
Cardoso (2009)3117BRGO3117FJ638454PINAM46I, I54V, L76V, V82A, L90ML33FL10V, I13V, I15V, K20R, E35D, M36I, K55R, R57K, D60E, I62V, L63P, A71V, I72V, I93LD
Koyalta (2009)8TCHAD-8FJ688175IDV26V82A L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63P, K70E, A71T, I93LD
 39TCHAD-39FJ688186IDV26  T12P, L19V, M36I, N37D, R41K, D60E, L63P, I64V, C67SD
 68TCHAD-68FJ688199IDV26M46I, L76V T12P, I15V, L19V, K20I, E35N, M36I, N37D, R41K, R57K, D60E, I62V, L63P, I64V, K70R, I85VD
Dau (2010)07823A07823AGU581871PINAM46I, L90M L10V, I13V, N37A, K55R, R57K, I62V, L63P, I64IV, I72IT, T74S, V77I, L89LM, I93LD
 07867A07867AGU581877PINAV32I, M46I, I47A, L90ML10F, L89VT4A, I13V, K20T, L33V, I62V, L63P, H69Y, A71V, I93LD
 09705A09705AGU581977PINAM46L, I54V, V82AT, I84V, L90ML33F, F53L, L89VL10I, I13V, I15V, K20T, E35D, M36I, N37D, K55R, D60E, I62V, L63P, I66F, K70E, A71V, Q92KD
 13578A13578AGU582074PINAV32I, M46I, I54V, L76V, I84V, L90ML10F, L33F, K43TI13V, K20R, E35D, M36I, R41RK, K55KR, D60E, L63P, I64V, L89ID
Aulicino (2011)ARL636VSQARL636VSQFJ525813PINAM46I, I47V, I54V, V82AL24I, L33F, K43T, F53L, Q58EL10V, G16A, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71V, I93LD
 ARM522BCEARM522BCEFJ525832PINAM46I, I50V, I54V, V82A, L90ML23I, L33F, K43T, F53L, T74PL10I, I13V, K20R, E35N, M36I, K55R, R57K, Q61N, I62V, L63P, L89ID
 ARM856HJMARM856HJMFJ525843PINAD30N, M46L, I54V, L90MN88DL10V, I13V, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63P, A71T, I72V, I93LD
 444-O288CCR444-O288CCRHQ158164PINAD30NN88DL10I, I13V, I15V, K20T, E35N, M36I, R41K, Q61N, L63P, I72T, T74M, V77I, I93LD
 321-L82321-L82HQ158268PINAL90M I15V, K20T, E35N, M36I, R41K, I62V, L63P, T74SD
El Annaz (2012)1365013650.PRJN185268IDV52M46L, I54A, V82A L10I, K20R, E35D, M36I, N37D, R57K, L63P, I64V, K70T, A71V, I93LD
Jones (2012)127508127508JN669438PINAI54V, V82A, L90ML33I, F53L, G73SL10I, I13V, K20R, E35D, M36I, R41K, K43KE, K55R, R57K, D60EK, Q61N, I62IV, L63P, A71IV, I72V, G94GD, C95LD
 129393129393JN669468PINAV82A, L90MN88DL10I, I13A, A22V, E35D, M36I, N37D, R41K, K45R, R57K, Q61N, L63P, A71VD
 133389133389JN669521PINAI54L, I84VL33FL10I, K14R, E35D, M36I, R41K, D60E, L63P, A71V, I93LD
 146099146099JN669672PINAL90LM L10V, I13V, K14R, K20M, E35D, M36I, N37D, R57RK, Q61N, L63P, A71T, I72TD
 151637151637JN669765PINAD30NN88NDK14R, I15IV, E35D, M36I, R41K, R57K, Q61N, L63P, I64L, A71AV, I93LD
 155242155242JN669835PINA  I13V, K14R, G17E, R41K, R57K, Q61N, L63P, I64V, V77VID
 159048159048JN669940PINAV32I, I47V, I54M, L90MV11VIL10I, T12K, I13IV, K20I, E21ED, E35N, M36I, R41K, R57K, Q61N, L63P, I64IV, T74S, V82I, I85VD
 159304159304JN669949PINAV82T, N88S L10I, I15V, K20KM, M36I, N37ND, R41K, K45R, R57K, Q61N, L63P, I85IV, I93LD
 162069162069JN670025PINAL90M L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, A71V, T74S, I93LD
 166308166308JN670124PINAM46I, I54V, V82TL33F, L76IL10V, T12Q, I13V, I15V, L19I, K20KR, E35D, M36IL, R41K, K55R, R57K, Q61N, L63P, I64V, A71V, T74SD
 166915166915JN670139PINAM46I, I54V, V82A L10I, I13A, K20R, A22V, E35ED, M36I, N37D, K55R, R57K, Q61DN, I62IV, L63P, A71T, I72T, T74S, N83S, Q92QK, I93LD
 170719170719JN670232PINAI54V, V82A, L90ML33IL10I, I13V, K14R, K20M, E35D, M36I, N37D, R41K, Q61N, L63P, A71T, I72TD
 171752171752JN670267PINAD30NN88DL10V, I13V, I15IV, E35D, M36I, N37D, R41K, K45R, R57K, Q61N, L63P, V75I, I93LD
 172708172708JN670297PINAD30NN88DI13V, I15V, E35D, M36I, R41K, R57K, Q61N, L63P, A71T, I72TD
 172862172862JN670305PINAM46L, I54V, V82A, L90ML33FL10V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62IV, L63P, I64L, A71V, Q92K, I93LD
 173203173203JN670314PINA  I13V, K20R, M36I, R41K, R57K, Q61N, L63P, I64LD
 173626173626JN670339PINAI54V, V82T, N88S L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71IV, I93LD
 175535175535JN670365PINA  T12V, I13V, L33LV, M36I, R41K, K55R, R57K, Q61N, L63PD
 176223176223JN670390PINA  K14KR, E35D, M36IT, R41K, Q61N, L63PD
 176581176581JN670402PINA  L10V, M36I, N37S, R41K, L63P, I64V, I93LD
 177590177590JN670450PINAD30NN88DL10V, I13V, I15V, K20R, E35D, M36I, R41K, Q61D, L63P, V75I, I93LD
 178433178433JN670483PINAM46I, I54V, L76V, V82F, L90MQ58EL10I, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, I64V, A71V, I72V, I93LD
 179876179876JN670531PINA  L10V, E35D, M36I, R41K, R57K, Q61D, L63P, I93LD
 181706181706JN670581PINA  T12P, K14R, E35D, N37H, R41K, L63P, H69QD
 182041182041JN670597PINAL90M L10V, I13V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, I93LD
 182997182997JN670632PINAL90M L10LV, I13V, L19I, K20T, E35D, M36I, R41K, Q61N, L63P, A71AT, T74S, I93LD
 184334184334JN670676PINAG48V, L90M L10I, L19Q, K20R, E35D, M36I, N37NT, R41K, R57K, D60E, Q61D, I62V, L63P, A71V, I72T, V82I, I85V, I93LD
 187220187220JN670729PINAM46L, I54V, I84V, L90MG48E, L89VL10I, I13V, K20MT, E35D, M36I, R57K, Q61N, I62V, L63P, C67Y, G68E, H69Y, A71V, Q92K, I93LD
 187443187443JN670732PINAG48A, I54V, V82A, I84VL33F, N83ND, L89VL10I, K14R, K20KR, E35D, M36I, R41K, D60E, L63P, A71V, T91S, Q92QR, I93LD
 187807187807JN670741PINAM46L, I54V, V82A, L90ML33F, K43T, G73SQ7QH, L10V, I13V, K20R, E35D, M36I, L38LS, R41K, I62V, L63P, H69R, A71T, I72T, V77ID
 189796189796JN670781PINAI54V, L90ML23LIL10V, I13V, I15V, L19LV, K20T, E35D, M36I, N37D, R41RK, R57K, D60E, Q61D, I62V, L63P, A71I, T74S, I93LD
 192858192858JN670869PINA  L10I, I13V, L63P, I64V, H69ND
 193544193544JN670904PINAI54LK43T, F53FL, G73ST12K, I13V, I15V, K20T, E35D, M36I, N37S, R41K, R57K, Q61D, I62V, L63P, E65ED, H69HY, A71T, I72R, T74S, V77I, I93IMD
 193836193836JN670912PINAM46I, I54V, V82A L10I, I13A, K20R, A22V, E35D, M36I, N37D, K55R, R57K, Q61D, I62V, L63P, A71T, I72T, T74S, N83S, Q92K, I93LD
 194025194025JN670920PINAM46L, I54V, V82A, L90ML33F, K43T, G73SL10I, I13L, Q18E, K20R, E34Q, E35D, M36I, K55R, R57K, Q61N, I62V, L63P, A71V, I72T, I93LD
 194683194683JN670947PINAM46I, I54V, L76V, V82A, L90M L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, I72T, I93LD
 195176195176JN670967PINAI54V, V82A, L90ML33LI, L89LVL10I, I13V, K14R, K20IM, E35D, M36I, N37D, R41K, Q61N, L63P, A71T, I72TD
 195946195946JN671004PINAI54V, V82A L10V, I15V, K20R, E35D, M36I, N37D, R41K, Q61D, L63P, I93LD
 198096198096JN671100PINAM46L, I54V, V82A, L90MF53L, Q58E, T74PL10I, I15V, G16A, K20R, E35D, M36I, R41K, I62V, L63P, A71V, I85V, I93LD
 198098198098JN671101PINA  T12R, M36I, R41K, R57K, Q61N, L63P, E65DD
 199016199016JN671148PINAG48V, I54V, V82A L10I, I15V, K20R, E35D, M36I, R41K, R57K, D60E, Q61E, L63P, I72TD
 200084200084JN671190PINAM46I, I54IV, I84V, L90ML33F, K43KT, T74PL10I, I13V, K20KR, M36I, R41RK, K55KR, I62V, L63P, H69K, K70KT, A71V, T91SD
 201919201919JN671244PINAI84V, L90MF53LL10I, T12I, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, A71I, I72TD
 202598202598JN671278PINAL90M L10V, I15V, K20T, E35D, M36I, N37ND, R41K, R57K, Q61D, L63P, I72T, I93LD
 204389204389JN671339PINAD30N, M46IN88DL10I, I15V, G17E, K20T, M36I, N37K, R41K, R57K, Q61D, L63P, I72R, I93LD
 205762205762JN671371PINA  E35D, M36I, R41K, K43R, K55KE, R57K, Q61D, L63P, L89LPD
 206936206936JN671417PINA  T12S, I15V, L19Q, N37D, L63P, H69N, Q92KD
 207507207507JN671437PINA  I15V, E35D, M36I, R41K, I62V, L63P, H69Y, A71V, I93LD
Mollan (2012)MK133MK133w70 RTV, ATV70  M36I, R41K, L63P, E65D, I72VD
Reynolds (2012)E0580E0580-2JN652206LPV   E35D, R41K, R57K, L63P, I64V, H69Y, I72VD