<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L63H
Rx PI-naive
IncludeMixtures No
References 27
Patients 44
Isolates 46
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG8888_w-21 None   I13V, K14R, K20M, M36I, R41K, L63H, I64V, I72VD
Hierholzer (2002)SU053SU053AY102493None   G16E, M36I, P39T, R41K, I62V, L63H, A71TD
 SU224SU224AY102496None   I15V, G16E, M36I, R41K, L63H, I72VD
Eshleman (2004)SE602SE602_7dAY428700None   I13V, G16E, R41K, L63HD
Eshleman (2004)ESH_Pat172ESH675AY435338None   M36I, R41K, K43KR, K45KR, I62V, L63H, I64MD
Yang (2004)97KE49197KE491AY492770None   I13V, R41K, L63H, I64V, K70RD
K'Aluoch (2005)OK_TC020504TC020504DQ079840None   I13V, G16GE, R41K, R57K, L63H, I64VD
Church (2007)602-132594b602EF612078None   I13V, G16E, R41K, L63HD
Nyombi (2008)TMS106TMS106EU251809None  L23I, L33II13V, D25DV, M36T, L38LS, P39S, R41K, D60E, I62V, L63H, I64VD
Aghokeng (2009)CYN1003CYN1003GU191593None   T12S, I15V, G16E, L19I, E35D, M36I, P39S, R41K, Q61D, L63HD
Eshleman (2009)K09623B607-156971FJ389081None   I13V, R41K, L63H, I64VD
 K45887W308-101589FJ389133None   I13V, R41K, L63H, I64V, I72ILVD
 E21365W208-102874FJ389148None   I13V, R41K, L63H, I64V, K70T, I72M, V77ID
Fokam (2011)CIRCB-9860CIRCB-9860JQ796162None   T12S, I15V, G16E, L19I, E35D, M36MI, P39S, R41K, D60DE, Q61DN, L63HD
Hamers (2011)CP076301686CP076301686HQ993682None   L10V, I13V, G16E, M36I, R41K, D60DE, L63H, I64V, H69C, I72VD
 CP076303031CP076303031HQ995093None   L10I, M36I, R41K, L63H, I64VD
 CP076300864CP076300864HQ995125None   I13V, N37D, R41K, L63H, I64V, E65D, V77ID
 CP076300705CP076300705HQ995311None   L10V, T12K, I13V, G16E, L19V, N37S, R41K, L63H, I64V, V77ID
 CP076300709CP076300709HQ995312None   I13V, I15V, M36I, R41K, L63H, I64V, E65D, N98KD
 CP076301886CP076301886HQ995365None   I13V, G16E, K20R, M36I, R41K, I62V, L63H, I64V, E65DD
Kasang (2011)3264832648HM572351None   I13V, G16E, E35D, M36I, R41K, I62V, L63H, I64V, E65DD
Yang (2011)KN-16KN-16JQ616916None   T12S, L19T, M36I, R41K, L63H, I64MD
 KEN-32TKEN-32T None   R8P, V11F, I13V, G16E, M36I, R41K, L63H, K70KR, I72VD
De Gascun (2012)IRL17894IRL17894JN622303None   T12TP, I13V, K14R, G16E, N37NS, R41K, L63H, I64VD
Hamers (2012)CP076306005CP076306005JQ480267None   I13V, G16E, M36I, R41K, L63H, I64VD
Ndase (2012)5800056258000562KC900777None   I15V, L19I, R41K, I62V, L63H, H69YD
 5200269252002692KC900782None   T12A, I13V, G16E, P39PS, R41K, L63H, I64VD
Reynolds (2012)B0717B0717-0JN652142None   I13V, R41K, L63H, I64V, K70T, I72V, V77ID
  B0717-1JN652174None   I13V, R41K, L63H, I64V, K70T, I72V, V77ID
 J7221J7221-0JN652165None   I13V, I15V, M36I, R41K, I62V, L63H, I64V, K70RD
  J7221-1JN652201None   I13V, I15V, M36I, R41K, I62V, L63H, I64V, K70RD
Ssemwanga (2012)5832HR5832HRJF800204None   I13V, G16E, N37S, R41K, L63H, I64L, I72VD
Billong (2013)MR019MR019KF192114None   I13V, G16E, E35D, M36I, P39S, R41K, I62V, L63H, I64VD
Hassan (2013)RS09000876RS09000876HQ441621None   I13V, G16E, R41K, L63H, I64V, E65ED, H69HR, K70KR, I72IVD
 RS11000303RS11000303JQ698388None   I13V, M36I, N37S, R41K, I62IV, L63H, I64VD
 RS11000305RS11000305JQ698390None   I13V, K14R, I15V, M36I, N37D, R41K, I62V, L63HD
Kiptoo (2013)KTL033KTL033KC517001None   I15V, M36I, R41K, L63H, I64V, E65DD
Chung (2014)LJJ_2_KA222eLJJ_2_KA222eKF544277None   M36I, R41K, I62V, L63H, I64V, I72V, V77ID
Lee (2014)AMU050AMU050KJ906670None   I13IV, M36MI, R41K, L63H, I64VD
 MBA1394MBA1394KJ907080None   I13V, G16E, K20R, M36ML, R41K, L63H, I64L, I72VD
 MBA1461MBA1461KJ907140None   I13V, G16GE, R41K, I62V, L63H, I64V, E65D, K70R, V77ID
 MBA1408MBA1408KJ907093None   I13V, N37S, R41K, L63H, I64V, V77VID
Zeh (2016)0516680_040516680_04KU248613None   R41K, L63H, I64VD
Kityo (2017)JCR059JCR059m0KT347936None   I13V, G16E, K20R, M36I, R41K, R57K, L63H, H69KD
 JFP028JFP028m0KT348020None   I13V, L19I, R41K, L63HD
Verhofstede (2017)15071507MF754586None   T12S, G16E, L19I, R41K, L63HD