<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L63A
Rx PI-naive
IncludeMixtures No
References 36
Patients 60
Isolates 60
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Eshleman (2004)ESH_Pat95ESH719AY435348None   G16GE, E35DH, M36I, N37NH, R41K, L63AD
Niama (2006)CHU08CHU08FM164900None   I15V, E35D, M36I, R41K, I62V, L63A, V82VI, L89MD
Vidal (2006)NV_KTB24202.KTB242AM040997None   I15V, G16E, K20R, E35D, M36I, R41K, K45R, L63A, H69K, L89M, I93LD
Baker (2007)A1051MBA1051-201005EF186217None   I13V, R41K, I62V, L63A, H69YD
 AR012MBAR012-140405EF186224None   I13V, L33V, R41K, L63AD
Delgado (2008)GH_056GH_056EU177926None   T12A, R41K, Q61N, L63A, A71T, I72IM, V77ID
Ndembi (2008)IAEM070IAEM070EU306789None   I13V, G16E, M36I, N37D, L63A, I64V, E65D, K70R, I72VD
 IAEM071IAEM071EU306790None   I13V, G16GE, M36I, N37D, L63A, I64V, E65D, K70R, I72VD
Somi (2008)RB-05-083RB-05-083JQ616962None   I13V, R41K, R57K, L63A, H69YD
Aghokeng (2009)HU_0137HU_0137GU191676None   I15V, K20R, M36I, N37ND, R41K, L63A, I64L, I72IT, V75ID
Bartolo (2009)HM19901AOHM199EU068334None   I3V, I13IV, G16E, R41K, L63A, I93MD
Eshleman (2009)D39781W208-101514FJ389113None   M36IT, R41K, L63A, I64V, E65DD
Hawkins (2009)R61ZZR61FJ931300None   I13V, K20R, M36I, R41K, I62V, L63A, I64V, E65DD
 Q967ZZQ967FJ931372None   I13V, K14KR, K20I, M36I, R41K, L63A, I64LD
Koyalta (2009)71TCHAD-71FJ688202None   K20R, E35D, M36I, R41K, L63AD
Smith (2009)CR223US2007CR223 None   I15V, L19I, M36I, R41K, I62V, L63A, I72T, I85IV, L89FD
Hattori (2010)C06-51110334C06-51110334AB864741None   I15V, M36I, R41K, L63A, I64VD
 C08-51110667C08-51110667AB865074None   T12D, L19I, M36I, I62V, L63A, I93LD
 C08-51110719C08-51110719AB865126None   T12I, I15V, M36I, R41K, L63A, I93LD
 C08-2069050C08-2069050AB868202None   K14R, I15V, M36I, R41K, L63A, L89M, I93LD
 C08-51110698C08-51110698AB865105None   K14R, I15V, M36I, R41K, L63A, L89MD
Aghokeng (2011)SK1002-PISK1002-PIHQ864352None   K14KR, I15V, E35D, M36I, N37ND, R41K, R57RK, I62V, L63A, E65EDD
Aghokeng (2011)SK9016-M18SK9016-M18HQ864355None   I13V, Q18QH, L19LM, K20R, M36I, R41K, K45KR, L63AD
Charpentier (2011)160CP 001 1090 None   I15V, M36MI, R41K, L63A, H69Y, I72ITD
El Annaz (2011)50445044HQ393263None   I13IV, E35D, M36I, R41K, I62V, L63A, I64IVD
 76037603HQ393285None   I13V, K14KR, I15V, K20I, E35N, M36I, R41K, K45R, L63AD
 1410714107HQ393314None  L33II13V, I15IL, E35D, M36I, N37I, R41K, R57K, L63A, I64V, E65D, I72IVD
Florea (2011)1091_20071091_2007JQ083019None   T12P, I13V, I15V, G16E, E35D, M36I, R41K, R57K, L63A, L89MD
Hamers (2011)CP076304217CP076304217HQ993913None   I13V, K20R, M36I, R41K, L63A, I64V, I72IVD
 CP076304396CP076304396HQ993971None   E35D, M36I, N37ND, R41K, L63AD
 CP076300886CP076300886HQ994966None   I13V, L33V, P39S, R41K, R57K, I62V, L63A, I64V, E65DD
 CP076301970CP076301970HQ995434None   I15V, G16E, E35D, L63A, K70RD
Kao (2011)Pat11936404HQ657921None   T12TI, R41K, I62V, L63A, I72M, V77ID
Ndembi (2011)NTCPS728NTCPS728HQ702642None   M36I, R41K, L63A, I64V, K70R, I93LD
Avila-Rios (2012)OF00M98GSHOF00M98GSHKC169487None   L10V, I15V, M36I, R41K, L63AD
Chen (2012)YN10DH0055YN10DH0055JQ658678None   T12S, K14R, I15V, L19I, M36V, R41K, I62V, L63A, V82VID
Ssemwanga (2012)RCC_TDR_483689RCC_TDR_483689JQ266025None   L19I, M36I, R41K, I62V, L63A, I64V, E65D, H69Y, I72VD
 RCC-TDR-359889RCC-TDR-359889JQ266073None   I13V, K20R, M36I, R41K, W42W*, G51GE, L63A, I64VD
Ssemwanga (2012)7498HR7498HRJF800212None   I13V, M36I, R41K, L63A, I64VD
Ugbena (2012)2-1-1362-1-136JX084250None   K20R, E35D, M36I, R41K, L63A, V82VID
Alencar (2013)PE2-0038PE2-0038JQ238029None   I15V, Q18QH, M36I, R41K, L63A, I93LD
Bila (2013)MzJun186HIV-1KF927382None   I3N, I13V, R41K, D60E, L63A, I64V, H69Q, V77I, V82ID
Kiptoo (2013)KAP043KAP043KC516905None   I13V, M36L, R41K, I62V, L63A, I64V, K70KR, V75I, V82VID
Pircher (2013)A1013A1013JX110262None   I15IV, D29DN, E35DN, M36I, R41K, R57K, L63A, R87RK, L89MD
Sigaloff (2013)JCR113_0JCR113_0JX182004None   L10V, I13V, M36I, R41K, I62V, L63AD
Temereanca (2013)SR111SR111 None   T12P, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63A, E65D, H69Y, I72T, L89MD
Van Zyl (2013)949599KC424161None   I15V, L19I, M36I, R41K, L63A, I93LD
 251503KC424099None   T12S, I15V, L19I, M36I, R41K, L63A, H69K, I93LD
Chikata (2014)KI-108KI-108AB873964None   T12I, I13V, M36I, R41K, R57K, I62V, L63A, I64VD
 KI-946KI-946AB874232None   T12A, E35D, R41K, I62V, L63A, A71T, I72TD
 KI-818KI-818AB874134None   T12A, E35D, R41K, I62V, L63A, A71T, I72TD
 KI-825KI-825AB874149None   T12A, E35D, R41K, I62V, L63A, A71T, I72TD
Lee (2014)MBA1429MBA1429KJ907112None   L10V, I13V, M36I, R41K, L63A, I64VD
 MBA1137MBA1137KJ906835None   I13V, R41K, L63A, H69Y, V77ID
 MBA1075MBA1075KJ906775None   I13V, I15IV, M36I, R41K, I62V, L63AD
 MBA1232MBA1232KJ906926None   I13V, R41K, I62IV, L63A, H69Y, I72M, V77ID
 MBA1311MBA1311KJ907000None   I13V, K20R, M36I, R41K, D60E, Q61E, I62V, L63A, I64V, V82ID
 MBA1294MBA1294KJ906984None   L10I, I13V, K14KR, G16GE, L19P, K20I, M36I, R41K, L63A, E65D, L89MD
 MBA1051MBA1051KJ906752None   I13V, R41K, I62V, L63A, H69YD
 MBA1128MBA1128KJ906826None   I13V, M36I, N37D, L63A, I64V, E65D, K70RD