<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L63A
Rx PI-naive
IncludeMixtures No
References 38
Patients 55
Isolates 55
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Holguin (2000)AHHC17HolgHC17AF188349None   L10I, E35D, M36I, R41K, L63A, C67D, H69K, L89MD
Pandrea (2002)IP_97CIRMF2297CIRMF22AY140617None   T12S, K14R, L19V, M36I, R41K, L63A, H69K, L89M, G94SD
Eshleman (2004)ESH_Pat95ESH719AY435348None   G16GE, E35DH, M36I, N37NH, R41K, L63AD
Vidal (2006)NV_KTB18302.KTB183AM040990None   T12D, L19K, K20R, L23P, D29H, E35D, M36I, R41K, L63A, L89MD
Baker (2007)A1051MBA1051-201005EF186217None   I13V, R41K, I62V, L63A, H69YD
 AR012MBAR012-140405EF186224None   I13V, L33V, R41K, L63AD
Delgado (2008)GH_056GH_056EU177926None   T12A, R41K, Q61N, L63A, A71T, I72IM, V77ID
Ndembi (2008)IAEM070IAEM070EU306789None   I13V, G16E, M36I, N37D, L63A, I64V, E65D, K70R, I72VD
 IAEM071IAEM071EU306790None   I13V, G16GE, M36I, N37D, L63A, I64V, E65D, K70R, I72VD
Somi (2008)RB-05-083RB-05-083JQ616962None   I13V, R41K, R57K, L63A, H69YD
Aghokeng (2009)AV_0274AV_0274GU191655None   I15V, G16E, E35D, M36I, R41K, R57K, Q61QH, L63A, E65EDD
 HU_0137HU_0137GU191676None   I15V, K20R, M36I, N37ND, R41K, L63A, I64L, I72IT, V75ID
Bartolo (2009)HM19901AOHM199EU068334None   I3V, I13IV, G16E, R41K, L63A, I93MD
Eshleman (2009)D39781W208-101514FJ389113None   M36IT, R41K, L63A, I64V, E65DD
Hawkins (2009)R61ZZR61FJ931300None   I13V, K20R, M36I, R41K, I62V, L63A, I64V, E65DD
 Q967ZZQ967FJ931372None   I13V, K14KR, K20I, M36I, R41K, L63A, I64LD
Koyalta (2009)71TCHAD-71FJ688202None   K20R, E35D, M36I, R41K, L63AD
Smith (2009)CR223US2007CR223 None   I15V, L19I, M36I, R41K, I62V, L63A, I72T, I85IV, L89FD
Aghokeng (2011)SK1002-PISK1002-PIHQ864352None   K14KR, I15V, E35D, M36I, N37ND, R41K, R57RK, I62V, L63A, E65EDD
Aghokeng (2011)SK9016-M18SK9016-M18HQ864355None   I13V, Q18QH, L19LM, K20R, M36I, R41K, K45KR, L63AD
Charpentier (2011)160CP0011090 None   I15V, M36MI, R41K, L63A, H69Y, I72ITD
El Annaz (2011)1410714107HQ393314None  L33II13V, I15IL, E35D, M36I, N37I, R41K, R57K, L63A, I64V, E65D, I72IVD
Ferreira (2011)BRMT1410BRMT1410HQ638786None   L10I, I13V, L19Q, R41K, Q61N, L63A, I64L, C67W, H69K, V77ID
Hamers (2011)CP076304217CP076304217HQ993913None   I13V, K20R, M36I, R41K, L63A, I64V, I72IVD
 CP076304396CP076304396HQ993971None   E35D, M36I, N37ND, R41K, L63AD
 CP076300886CP076300886HQ994966None   I13V, L33V, P39S, R41K, R57K, I62V, L63A, I64V, E65DD
 CP076301970CP076301970HQ995434None   I15V, G16E, E35D, L63A, K70RD
Ssemwanga (2012)RCC_TDR_483689RCC_TDR_483689JQ266025None   L19I, M36I, R41K, I62V, L63A, I64V, E65D, H69Y, I72VD
Ssemwanga (2012)7498HR7498HRJF800212None   I13V, M36I, R41K, L63A, I64VD
Bila (2013)MzJun186HIV-1KF927382None   I3N, I13V, R41K, D60E, L63A, I64V, H69Q, V77I, V82ID
Kiptoo (2013)KAP043KAP043KC516905None   I13V, M36L, R41K, I62V, L63A, I64V, K70KR, V75I, V82VID
Sigaloff (2013)JCR113_0JCR113_0JX182004None   L10V, I13V, M36I, R41K, I62V, L63AD
Thiam (2013)67-HPD67-HPDJN673595None   I13V, I15V, T31TP, M36I, R57KN, L63A, H69KD
Lee (2014)MBA1429MBA1429KJ907112None   L10V, I13V, M36I, R41K, L63A, I64VD
 MBA1137MBA1137KJ906835None   I13V, R41K, L63A, H69Y, V77ID
 MBA1075MBA1075KJ906775None   I13V, I15IV, M36I, R41K, I62V, L63AD
 MBA1232MBA1232KJ906926None   I13V, R41K, I62IV, L63A, H69Y, I72M, V77ID
 MBA1311MBA1311KJ907000None   I13V, K20R, M36I, R41K, D60E, Q61E, I62V, L63A, I64V, V82ID
 MBA1294MBA1294KJ906984None   L10I, I13V, K14KR, G16GE, L19P, K20I, M36I, R41K, L63A, E65D, L89MD
 MBA1051MBA1051KJ906752None   I13V, R41K, I62V, L63A, H69YD
 MBA1128MBA1128KJ906826None   I13V, M36I, N37D, L63A, I64V, E65D, K70RD
Ross (2014)839839KF262937None   I15V, E35D, M36I, R41K, L63A, K70R, V77VID
Budambula (2015)MK26MK26KP792020None   L10I, I13V, I15V, M36I, R41K, I62V, L63A, I64V, C67YD
 MK92MK92KP792086None   I13V, G16E, E35N, M36I, N37D, R41K, R57K, L63A, I64V, E65DD
Chew (2015)12US_213312US_2133KJ680936None   K20R, M36I, I62V, L63A, I64V, I72ED
Diallo (2015)2-1-1362-1-136JX084250None   K20R, E35D, M36I, R41K, L63A, V82VID
Guimaraes (2015)BRSP599-13BRSP599-13KP115482None   T12I, I62V, L63AD
 BRSP600-13BRSP600-13KP115484None   T12I, I62V, L63AD
 BRSP718-13BRSP718-13KP115496None   L10I, E35D, M36I, R41K, L63A, H69Q, I93LD
Hora (2015)DEURF09UG005DEURF09UG005KF859747None   M36I, N37D, R41K, L63A, I64V, E65DD
Skhosana (2015)12ZALS13012ZALS130KM115865None   I13V, M36I, R41K, L63A, H69K, V75I, L89MD
Delatorre (2016)13BRRJGN3313BRRJGN33KX357251None   R41K, L63A, I64L, H69Q, V77ID
Escoto-Delgadillo (2016)GDL349GDL349_prKX253924None   L10V, I13V, I15V, M36I, R41K, I62V, L63A, I64IMD
Otecko (2016)411891411891KX306456None   L63A, H69HKNQ, V77VID
Steegen (2016)GFWCB012GFWCB012KU127778None   E35D, M36I, R41K, L63A, H69K, L89MD