<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation Q58E
Rx >= 1 PI
IncludeMixtures No
References 7
Patients 31
Isolates 33
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)TK5006TK5006 SQV, RTV, NFV79L90MQ58EL10I, R41K, L63A, I64V, I72V, V77I, I93LD
  TK5006a SQV, RTV, NFV, LPV158V82VA, L90LMQ58EL10LI, R41K, L63AS, I64V, H69HY, I72IV, I85IVD
  TK5006b SQV, RTV, NFV, LPV160 Q58EL10I, R41K, L63A, I64V, I72V, V77VI, I93ILD
Baxter (2006)48-50145014-30514DQ878549PINAM46I, I54V, V82A, L90LML10F, Q58EI13V, K20I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, N83SD
 48-80168016-30826DQ879061PINAM46L, I54LL10F, Q58EI13V, K20T, E35ED, M36I, N37ND, R41K, L63Q, I64VD
Aulicino (2011)ARL636VSQARL636VSQFJ525813PINAM46I, I47V, I54V, V82AL24I, L33F, K43T, F53L, Q58EL10V, G16A, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71V, I93LD
Jones (2012)159279159279JN669946PINAI47V, I54V, V82A, L90ML33F, G48W, F53L, Q58EL10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, C67E, A71V, I93LD
 178433178433JN670483PINAM46I, I54V, L76V, V82F, L90MQ58EL10I, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, I64V, A71V, I72V, I93LD
 196487196487JN671026PINAM46I, I54V, L76V, V82AQ58EL10V, I15V, L19LI, K20R, M36I, R41K, D60DE, I62V, L63LP, I64IV, L89MD
 198096198096JN671100PINAM46L, I54V, V82A, L90MF53L, Q58E, T74PL10I, I15V, G16A, K20R, E35D, M36I, R41K, I62V, L63P, A71V, I85V, I93LD
Kouri (2012)CU691-09CU691-09JQ585261PINAD30N, V32I, M46I, I47V, I54L, V82AL10LF, L33F, F53FL, Q58E, N88DI13V, I15V, L19I, K20R, E35D, M36L, N37T, R41T, K45R, D60E, L63P, H69Q, K70R, I72V, V77I, L89FD
 CU1806-09CU1806-09JQ585314PINAL90MQ58EL10I, E35DN, M36I, N37D, R41K, L63P, H69Q, A71TD
 CU1209-09CU1209-09JQ585279PINAM46L, I54M, V82AL10F, L24I, L33F, Q58EI13V, K20R, M36I, R41K, K43KR, I62V, L63P, E65ED, A71VD
Van Zyl (2013)4782100KC423617LPV156M46I, I54V, L76LV, V82AQ58EL10V, T12P, I13V, G16GE, K20R, M36I, R41K, Q61QR, I64V, P79PHD
Diaz (2015)RenG17196RenG17196KT748224PINAD30N, L90LML10F, Q58E, N88DI13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63HQ, I64VD
 RenG17468RenG17468KT748496PINAM46I, I54V, V82A, N88SL24I, L33F, Q58EL10I, I13V, I15V, K20T, E35G, M36I, R41K, K55KR, D60E, I62V, L63P, A71TD
 RenG17301RenG17301KT748329PINAI50LV32A, L33F, Q58EL10V, I13V, L19I, K20T, E34N, E35D, M36I, L63P, I64IL, A71V, I72T, V77IL, I93LD
 RenG15928RenG15928KT746956PINAM46L, I54V, V82AL24I, Q58E, G73SL10I, T12N, I15V, L19P, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, L63P, A71V, I72LD
 RenG16023RenG16023KT747051PINAV32I, M46L, I47V, I50L, V82A, I84VL33F, Q58ET12N, I13V, I15V, K20R, E35D, M36I, N37E, Q61QH, L63T, I64V, A71V, I72V, G78GV, R87RI, L89MD
 RenG17358RenG17358KT748386PINAM46L, I50V, I54IV, V82VAL33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, R41K, K55R, R57K, I62V, L63P, T74S, L89MD
 RenG16495RenG16495KT747523PINAM46I, I50L, V82AQ58E, G73SL10V, L33V, E35D, M36I, N37S, R41K, K45R, D60E, I62V, L63P, I64V, I72L, I85VD
 RenG15014RenG15014KT746042PINAM46I, I54A, V82AL33I, Q58E, N83DL10V, I13A, K14R, K20R, A22V, E35N, M36I, N37D, I62V, L63P, I64V, H69K, A71V, Q92KD
 RenG15415RenG15415KT746443PINAM46I, N88SQ58EL10V, I13IV, I15V, K20T, K55KR, L63P, A71V, V77I, T91SD
 RenG13694RenG13694KT744722PINAV32I, I47V, G48V, I54V, V82A, L90ML33F, F53L, Q58E, L89VL10I, I13V, K14E, I15V, K20R, E34Q, E35D, M36I, N37D, R41K, K55R, V56I, R57K, D60E, I62V, L63P, A71V, I85V, Q92KD
 RenG13605RenG13605KT744633PINAI50L, V82A, L90ML33F, F53L, Q58E, T74PSL10V, T12E, I13V, K14R, I15V, G16E, K20T, E35D, M36I, P39T, R41K, I62V, L63T, I64V, H69K, A71L, V77VL, I93LD
 RenG13686RenG13686KT744714PINAM46I, I47V, I54V, V82F, L90MQ58EL10V, I13V, K20I, E35D, M36I, R41K, I62V, L63P, I64V, A71V, I93LD
 RenG15072RenG15072KT746100PINAM46L, I54V, L76V, V82A, L90ML33F, Q58EL10V, I13V, K14R, G16E, K20R, E35D, M36I, N37E, P39S, R41RK, K55R, R57K, D60DE, Q61N, I62V, L63T, I64V, K70KT, V77ID
 RenG12366RenG12366KT743394PINAM46I, I54V, V82AL24I, L33F, Q58EL10V, I13V, K20R, M36I, R41K, K55R, R57K, Q61N, L63P, A71T, I72T, T91SD
 RenG13236RenG13236KT744264PINAM46I, V82A, N88GSL33F, Q58EL10V, I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71T, I72TD
 RenG12872RenG12872KT743900PINAM46L, I54V, I84V, L90ML10F, V11VI, Q58E, G73SI15V, K20KM, M36I, N37E, R41K, K55R, R57RK, I62V, L63P, A71V, N83SD
 RenG11659RenG11659KT742687PINAM46L, V82AL24I, Q58EL10V, I15V, L19I, K20R, M36I, R41K, L63P, I64L, H69K, I72V, L89MD
 RenG10088RenG10088KT741116PINAM46I, I54V, I84V, L90MQ58EL10I, I13A, K14IM, L19Q, K20R, A22V, E35D, M36I, K55R, R57K, I62V, L63P, I64V, I66V, V82I, Q92K, I93L, C95FD
 RenG11215RenG11215KT742243PINAM46L, I54V, V82F, I84V, L90ML33F, Q58EL10IV, I15V, K20KR, E35N, M36IV, N37E, R41K, R57RK, I62V, I64V, A71V, I93LD