<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation M46L
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 52
Isolates 52
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gomez-Carrillo (2004)9543795437AY365508PINAM46L, V82VA Q7QH, L10LI, T12TP, I15V, K20R, M36I, R41K, K55R, R57RK, L63P, I64V, I93LD
Montes (2004)MB_patRAM01_RAM707AJ577979Unknown, RTV, IDV>90M46L, G48V, I54V, V82T L10V, I13V, K20I, M36I, R41K, I66F, H69K, K70R, L89MD
Non-B Workgroup (2005)TK1028TK1028b RTV, IDV, NFV308M46L, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 TK2014TK2014 SQV, RTV, IDV, NFV307M46L, I54V, V82A L10V, R41K, D60E, L63P, I66IF, A71V, T74S, V77ID
Baxter (2006)48-12121212-30812DQ877754PINAM46L, I54V, V82AL24I, L33FL10V, I15V, E35D, M36I, N37ND, R41K, I62V, L63PD
 48-33733373-30620DQ878231PINAM46L, G48V, I54V, V82A L10V, I15V, L19I, R41K, I62V, L63S, I64L, V77ID
 48-42664266-30612DQ878498PINAM46L, I54V, V82VA, L90LML10FI, L24LI, L33IMV, Q58QEI13IV, K14KR, L19I, K20KT, P39PA, R41RK, K55KR, R57RK, I62V, L63E, I64V, A71AV, T74AE, L89MD
 48-80168016-30826DQ879061PINAM46L, I54LL10F, Q58EI13V, K20T, E35ED, M36I, N37ND, R41K, L63Q, I64VD
Dau (2010)09705A09705AGU581977PINAM46L, I54V, V82AT, I84V, L90ML33F, F53L, L89VL10I, I13V, I15V, K20T, E35D, M36I, N37D, K55R, D60E, I62V, L63P, I66F, K70E, A71V, Q92KD
Aulicino (2011)ARM856HJMARM856HJMFJ525843PINAD30N, M46L, I54V, L90MN88DL10V, I13V, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63P, A71T, I72V, I93LD
 ARN397RLRARN397RLRFJ525859PINAM46L, I54L, V82T, I84VL24I, L33F, K43TE35D, M36I, N37E, R41K, R57K, D60N, Q61N, L63T, I64L, A71I, I72T, L89M, I93LD
El Annaz (2012)1365013650.PRJN185268IDV52M46L, I54A, V82A L10I, K20R, E35D, M36I, N37D, R57K, L63P, I64V, K70T, A71V, I93LD
Jones (2012)172862172862JN670305PINAM46L, I54V, V82A, L90ML33FL10V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62IV, L63P, I64L, A71V, Q92K, I93LD
 175531175531JN670363PINAM46L, I54IV, V82AL24I, L33LFL10V, I15V, K20M, E35DN, M36I, N37D, R41K, K55KR, R57K, Q61D, A71V, I72TD
 187220187220JN670729PINAM46L, I54V, I84V, L90MG48E, L89VL10I, I13V, K20MT, E35D, M36I, R57K, Q61N, I62V, L63P, C67Y, G68E, H69Y, A71V, Q92K, I93LD
 187807187807JN670741PINAM46L, I54V, V82A, L90ML33F, K43T, G73SQ7QH, L10V, I13V, K20R, E35D, M36I, L38LS, R41K, I62V, L63P, H69R, A71T, I72T, V77ID
 194025194025JN670920PINAM46L, I54V, V82A, L90ML33F, K43T, G73SL10I, I13L, Q18E, K20R, E34Q, E35D, M36I, K55R, R57K, Q61N, I62V, L63P, A71V, I72T, I93LD
 198096198096JN671100PINAM46L, I54V, V82A, L90MF53L, Q58E, T74PL10I, I15V, G16A, K20R, E35D, M36I, R41K, I62V, L63P, A71V, I85V, I93LD
Kouri (2012)CU1373-09CU1373-09JQ585294PINAV32I, M46L, L76V, V82AL10F, L33F, L89VI13V, K20R, M36I, N37D, R41K, K43R, Q61N, L63P, A71V, Q92KD
 CU25-10CU25-10JQ585358PINAM46L, I54V, V82A, L90ML33F, K43T, F53L, G73SL10V, I13V, L19LI, K20R, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71I, I93LD
 CU749-09CU749-09JQ585263PINAM46L, I84VN83DL10I, I15V, G16E, K20R, M36I, R41K, D60E, I62IV, L63T, V82I, L89LFD
 CU2073-09CU2073-09JQ585339PINAM46L, I54V, V82AF53LL10I, I13V, G16E, K20R, E35D, M36I, N37DE, R41K, K55R, R57K, Q61H, L63T, E65D, I72T, T74A, L89MD
 CU772-10CU772-10JQ585416PINAM46L, I54AV, V82AL33F, T74AP, N83NDL10I, I13V, I15IV, G16E, K20R, E35D, M36I, N37D, R41K, R57K, L63T, E65D, L89MD
 CU1209-09CU1209-09JQ585279PINAM46L, I54M, V82AL10F, L24I, L33F, Q58EI13V, K20R, M36I, R41K, K43KR, I62V, L63P, E65ED, A71VD
 CU1959-09CU1959-09JQ585326PINAM46L, I54L, V82T, L90ML33F, T74PL10I, I13V, E35D, M36I, R41K, K43R, K55R, L63P, H69Q, A71V, I93LD
Diaz (2015)RenG15993RenG15993KT747021PINAM46L, I47V, L76V, V82TF53L, L89VL10V, I13V, I15V, Q18H, K20I, E34EK, E35EK, M36I, N37E, K55R, I62V, L63P, K70KT, A71V, V77ID
 RenG16880RenG16880KT747908PINAM46L, I54V, V82ML24I, F53LL10V, T12P, K20R, E35D, M36I, N37Q, R41K, L63P, A71V, V77I, I93LD
 RenG15928RenG15928KT746956PINAM46L, I54V, V82AL24I, Q58E, G73SL10I, T12N, I15V, L19P, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, L63P, A71V, I72LD
 RenG16023RenG16023KT747051PINAV32I, M46L, I47V, I50L, V82A, I84VL33F, Q58ET12N, I13V, I15V, K20R, E35D, M36I, N37E, Q61QH, L63T, I64V, A71V, I72V, G78GV, R87RI, L89MD
 RenG17271RenG17271KT748299PINAM46L, G48Q, I54V, L76V, V82AL33I, F53LL10V, I13V, K14KR, L19V, K20M, M36I, D60E, Q61N, I62IV, L63P, T74S, L89I, T91SD
 RenG17358RenG17358KT748386PINAM46L, I50V, I54IV, V82VAL33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, R41K, K55R, R57K, I62V, L63P, T74S, L89MD
 RenG14914RenG14914KT745942PINAM46L, I54V, V82A, L90M L10V, I13V, G17E, Q18H, K20I, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63AT, E65D, A71V, I72IV, T74S, I93LD
 RenG14385RenG14385KT745413PINAM46L, G48Q, I54V, L76V, I84VL24IL10I, I15V, G16E, K20R, E35D, M36I, R41K, R57RK, Q61N, L63T, I64L, I72T, V82VI, L89M, Q92QKD
 RenG14846RenG14846KT745874PINAM46L, I54V, V82A, L90ML33FL10V, I15V, G16E, K20M, E35N, M36I, L38LF, R41K, K55R, R57K, Q61D, I62V, L63C, I64IL, E65ED, A71V, I72IT, T74S, T91A, I93LD
 RenG15072RenG15072KT746100PINAM46L, I54V, L76V, V82A, L90ML33F, Q58EL10V, I13V, K14R, G16E, K20R, E35D, M36I, N37E, P39S, R41RK, K55R, R57K, D60DE, Q61N, I62V, L63T, I64V, K70KT, V77ID
 RenG12432RenG12432KT743460PINAM46L, I54V, I84VL24I, G48EL10I, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, I64L, I72T, V82VI, L89M, Q92KD
 RenG13532RenG13532KT744560PINAD30N, M46L, I54IV, V82A, L90ML33F, F53L, N88DL10V, T12Q, I13V, I15V, G16GE, K20R, E35D, M36I, R41K, K55KN, Q61N, L63S, I93ILD
 RenG12108RenG12108KT743136PINAM46L, I54V, L76V, V82AL33FL10V, K20KR, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, I64L, A71V, I93LD
 RenG12305RenG12305KT743333PINAM46L, I54V, V82AL24I, L33F, K43TL10V, I15V, K20R, E35D, M36I, R41K, I62V, L63PD
 RenG12340RenG12340KT743368PINAM46L, I50L, V82VA, N88SL33FL10V, I13V, I15IV, G16E, K20R, E35D, M36I, N37S, P39P*QS, R41K, K45R, R57K, Q61N, L63S, I64IV, I72TD
 RenG13053RenG13053KT744081PINAV32I, M46L, G48GV, I50IL, V82A, L90ML33F, G73GS, L89VL10I, I13V, L19I, L24LF, E34EQ, E35ED, M36I, N37S, R41K, K55HQ, I62IV, L63A, I64L, A71VD
 RenG12872RenG12872KT743900PINAM46L, I54V, I84V, L90ML10F, V11VI, Q58E, G73SI15V, K20KM, M36I, N37E, R41K, K55R, R57RK, I62V, L63P, A71V, N83SD
 RenG10098RenG10098KT741126PINAM46L, I54V, V82AV11I, L24I, K43TL10V, I13V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71T, I72TD
 RenG11659RenG11659KT742687PINAM46L, V82AL24I, Q58EL10V, I15V, L19I, K20R, M36I, R41K, L63P, I64L, H69K, I72V, L89MD
 RenG11672RenG11672KT742700PINAD30N, M46L, I54V, V82ACGS, L90ML33LF, F53L, N88DI15V, K20T, E35N, M36I, N37NT, R41K, Q61H, I62V, L63P, I64L, A71F, V77IL, I93LD
 RenG11284RenG11284KT742312PINAD30N, M46L, I54V, V82ACGS, L90ML33LF, F53L, N88DI15V, K20T, E35N, M36I, N37NT, R41K, Q61H, I62V, L63P, I64L, A71F, V77IL, I93LD
 RenG11491RenG11491KT742519PINAM46L, I54V, V82A, L90MG73TL10I, I15V, G16E, K20R, E35D, M36I, R41K, K55R, R57K, Q61D, A71V, I72R, I93LD
 RenG11079RenG11079KT742107PINAM46L, V82AL24IL10I, I15V, L19V, K20KR, E35D, M36I, P39S, R41K, K55R, R57K, I62V, L63P, A71V, L89LM, I93LD
 RenG11099RenG11099KT742127PINAM46L, I54V, L76V, V82A, L90M L10V, I15V, K20R, M36I, N37D, R41K, I62V, L63P, I64V, H69R, A71V, I72V, I85V, I93LD
 RenG11575RenG11575KT742603PINAM46L, G48A, I50L, V82A L10I, T12K, I15V, G16A, K20R, L24R, E35D, M36I, R41K, K55R, R57K, Q61N, L63P, E65D, H69Y, A71V, I72T, I93LD
 RenG11215RenG11215KT742243PINAM46L, I54V, V82F, I84V, L90ML33F, Q58EL10IV, I15V, K20KR, E35N, M36IV, N37E, R41K, R57RK, I62V, I64V, A71V, I93LD
 RenG10170RenG10170KT741198PINAM46L, I54V, V82A L10I, I13V, G16E, K20R, M36I, N37ND, R41K, Q61N, L63T, I64IL, E65ED, L89MD