<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation M46I
Rx >= 1 PI
IncludeMixtures No
References 13
Patients 85
Isolates 86
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M39M39AY010402NFV M46I, I54V, V82A G16E, K20M, M36I, P39Q, R41K, L63R, I64VD
Montes (2004)MB_patESTU01_ESTU702AJ577887SQV, RTV, NFV, IDV309M46I, I84V, L90MV11I, G73SL10V, I13V, K20I, L33V, I62V, L63PD
Non-B Workgroup (2005)TK1009TK1009a IDV, NFV, RTV, LPV239M46I, I54V, V82AL24IL10I, M36I, N37D, R41K, L63P, I64V, A71AV, I72VD
 TK1014TK1014 RTV, SQV, NFV, IDV246M46I, I84IVL24LIL10LV, I13V, K20I, E35D, M36I, R41K, L63P, H69K, T74S, T80TA, V82X, L89IMD
 TK1028TK1028 RTV, IDV, NFV207M46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028a RTV, IDV, NFV231M46I, I54V, V82TL24IP1PS, L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 TK2001TK2001 SQV, RTV, NFV94M46I, I84VN83DL10I, I13V, A22V, E35G, M36I, I62V, L63P, I64V, A71V, I93LD
Baxter (2006)48-14291429-30424DQ877819PINAM46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 48-14321432-30818DQ877822PINAM46I, I54V, L76V, V82TL24IL10I, I13A, K20I, E35D, M36I, R41K, Q61H, L63P, H69K, T74S, L89ID
 48-14391439-30929DQ877829PINAM46I, I54V, L76LV, V82A, L90ML10FII13V, K20I, E34EK, M36I, R41K, I62V, L63P, I64IV, A71T, L89LI, I93LD
 48-22442244-30722DQ877883PINAV32I, M46I, I54V, V82A, L90MK43T, G73TL10V, I15V, K20R, M36I, R41N, K55R, D60E, L63P, H69HR, K70R, A71V, I93L, C95VD
 48-30563056-30318DQ877968PINAM46I, I54V, L76V, V82TL10F, L89VI13V, K20M, M36I, R41K, I62V, L63P, A71V, I72V, I93LD
 48-50145014-30514DQ878549PINAM46I, I54V, V82A, L90LML10F, Q58EI13V, K20I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, N83SD
von Wyl (2007)310371422EF449968RTV, PINAM46I, I54V, L76V, V82ML24I, L33FL10V, I13V, K20R, E35D, M36I, N37DE, K55R, R57K, D60E, I62V, L63P, V75I, L89M, T91SD
Cardoso (2009)3117BRGO3117FJ638454PINAM46I, I54V, L76V, V82A, L90ML33FL10V, I13V, I15V, K20R, E35D, M36I, K55R, R57K, D60E, I62V, L63P, A71V, I72V, I93LD
Koyalta (2009)68TCHAD-68FJ688199IDV26M46I, L76V T12P, I15V, L19V, K20I, E35N, M36I, N37D, R41K, R57K, D60E, I62V, L63P, I64V, K70R, I85VD
Dau (2010)07823A07823AGU581871PINAM46I, L90M L10V, I13V, N37A, K55R, R57K, I62V, L63P, I64IV, I72IT, T74S, V77I, L89LM, I93LD
 07867A07867AGU581877PINAV32I, M46I, I47A, L90ML10F, L89VT4A, I13V, K20T, L33V, I62V, L63P, H69Y, A71V, I93LD
 13578A13578AGU582074PINAV32I, M46I, I54V, L76V, I84V, L90ML10F, L33F, K43TI13V, K20R, E35D, M36I, R41RK, K55KR, D60E, L63P, I64V, L89ID
Aulicino (2011)ARL636VSQARL636VSQFJ525813PINAM46I, I47V, I54V, V82AL24I, L33F, K43T, F53L, Q58EL10V, G16A, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71V, I93LD
 ARM522BCEARM522BCEFJ525832PINAM46I, I50V, I54V, V82A, L90ML23I, L33F, K43T, F53L, T74PL10I, I13V, K20R, E35N, M36I, K55R, R57K, Q61N, I62V, L63P, L89ID
Jones (2012)163239163239JN670057PINAM46I, V82T, I84VL10FT12K, I13V, G16E, L19P, K20R, M36I, L63T, I64V, E65D, I72T, T74SD
 166308166308JN670124PINAM46I, I54V, V82TL33F, L76IL10V, T12Q, I13V, I15V, L19I, K20KR, E35D, M36IL, R41K, K55R, R57K, Q61N, L63P, I64V, A71V, T74SD
 166915166915JN670139PINAM46I, I54V, V82A L10I, I13A, K20R, A22V, E35ED, M36I, N37D, K55R, R57K, Q61DN, I62IV, L63P, A71T, I72T, T74S, N83S, Q92QK, I93LD
 178433178433JN670483PINAM46I, I54V, L76V, V82F, L90MQ58EL10I, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, I64V, A71V, I72V, I93LD
 193836193836JN670912PINAM46I, I54V, V82A L10I, I13A, K20R, A22V, E35D, M36I, N37D, K55R, R57K, Q61D, I62V, L63P, A71T, I72T, T74S, N83S, Q92K, I93LD
 194683194683JN670947PINAM46I, I54V, L76V, V82A, L90M L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, I72T, I93LD
 195598195598JN670988PINAM46I, V82A L10V, E35D, M36I, R41K, R57K, Q61D, L63T, E65D, I72T, V77ID
 196487196487JN671026PINAM46I, I54V, L76V, V82AQ58EL10V, I15V, L19LI, K20R, M36I, R41K, D60DE, I62V, L63LP, I64IV, L89MD
 200084200084JN671190PINAM46I, I54IV, I84V, L90ML33F, K43KT, T74PL10I, I13V, K20KR, M36I, R41RK, K55KR, I62V, L63P, H69K, K70KT, A71V, T91SD
 203943203943JN671324PINAV32I, M46I, I54V, V82AL24I, L33F, K43T, F53LL10I, I13V, G16E, K20R, E35D, M36I, N37D, P39PS, R57K, Q61N, L63S, E65D, K70Q, A71V, T74S, V77I, L89TD
 204389204389JN671339PINAD30N, M46IN88DL10I, I15V, G17E, K20T, M36I, N37K, R41K, R57K, Q61D, L63P, I72R, I93LD
 207305207305JN671429PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, K20T, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, I64L, C67D, A71V, I72T, I93LD
Kouri (2012)CU373-10CU373-10JQ585388PINAM46I, I54V, L76V, V82AL24I, L33FL10I, I13V, K20R, E35D, M36I, N37D, R41K, D60E, I62V, L63P, A71V, I93LD
 CU691-09CU691-09JQ585261PINAD30N, V32I, M46I, I47V, I54L, V82AL10LF, L33F, F53FL, Q58E, N88DI13V, I15V, L19I, K20R, E35D, M36L, N37T, R41T, K45R, D60E, L63P, H69Q, K70R, I72V, V77I, L89FD
 CU1805-09CU1805-09JQ585313PINAM46I, I54V, V82A, L90M L10I, K20I, M36I, N37D, R41K, K43KR, Q61N, L63P, I64L, H69Q, A71V, I72IV, I93LD
 CU1483-09CU1483-09JQ585297PINAM46I, L90M I13V, E35D, M36I, R41K, L63P, H69QD
Van Zyl (2013)4782100KC423617LPV156M46I, I54V, L76LV, V82AQ58EL10V, T12P, I13V, G16GE, K20R, M36I, R41K, Q61QR, I64V, P79PHD
Diaz (2015)RenG16175RenG16175KT747203PINAM46I, I54V, V82S, L90MV11I, G73STL10I, T12P, I15V, G16A, L19Q, K20I, M36I, K45R, K55R, L63P, C67G, A71V, I72L, I85VD
 RenG17129RenG17129KT748157PINAM46I, I54V, V82A, L90ML33F, K43T, F53L, G73SL10V, L19I, K20R, E35D, M36I, R41K, K55R, R57RK, I62V, L63P, C67L, H69Q, A71V, I72LD
 RenG15889RenG15889KT746917PINAM46I, I54V, L76V, V82AL10F, L24I, L33FI13V, K20R, M36I, N37D, R41K, K55R, R57K, Q61N, L63P, I72V, L89ID
 RenG15645RenG15645KT746673PINAM46I, I54V, I84V, L90ML10F, F53L, T74PI13V, K20R, E35D, M36I, R41K, K55H, R57K, L63P, H69R, A71V, L89I, T91S, Q92KD
 RenG16518RenG16518KT747546PINAM46I, I47V, I54V, V82A, L90MV11I, K43T, F53L, G73C, T74P, L89VL10V, T12K, I13A, I15V, L19I, K20I, E34Q, E35D, M36I, N37E, K55R, I62V, L63T, I72VD
 RenG17296RenG17296KT748324PINAV32I, M46I, I54V, L90ML33I, G73S, N83DL10I, I15IV, Q18E, K20R, E35N, M36I, R41K, R57K, Q61D, L63P, C67Y, G68E, H69Y, A71V, I72RD
 RenG15734RenG15734KT746762PINAM46I, I54V, V82F, I84V L10V, I15V, K20T, E35N, M36I, R41K, I62V, L63P, I64IV, T74AD
 RenG16697RenG16697KT747725PINAM46I, I47V, I54V, V82AF53LW6WG, L10I, I15V, K20R, E35D, M36I, R41K, I62V, L63P, C67SD
 RenG15641RenG15641KT746669PINAM46I, I54L, L76V, I84VL10F, V11VII13V, I15V, L19LQ, K20I, E35NS, M36I, R41K, K55KR, R57RK, D60E, Q61N, I62V, L63P, I64IV, A71V, I72V, N83NH, T91SD
 RenG17468RenG17468KT748496PINAM46I, I54V, V82A, N88SL24I, L33F, Q58EL10I, I13V, I15V, K20T, E35G, M36I, R41K, K55KR, D60E, I62V, L63P, A71TD
 RenG17123RenG17123KT748151PINAM46I, I54A, V82A, L90ML33FL10V, V11L, G16A, L19V, K20R, E35DN, M36I, N37E, R41K, R57K, Q61D, I62IV, L63P, I64L, A71I, I72IT, I93LD
 RenG16766RenG16766KT747794PINAV32I, M46I, I54L, I84V, L90ML10F, V11I, L33F, G73T, L89VI13V, K20M, M36I, I62V, L63P, I66V, A71T, I72V, C95ID
 RenG16020RenG16020KT747048PINAM46I, I54A, V82AL24I, K43TL10I, I15IV, K20R, E35D, M36I, N37H, R41K, I62V, L63E, I64V, A71V, I72V, V77I, I93LD
 RenG15570RenG15570KT746598PINAM46I, I54V, L76V, V82A L10V, L19V, K20R, M36I, N37DE, R41K, I62V, L63P, H69RD
 RenG15602RenG15602KT746630PINAD30N, M46I, V82AL33I, F53L, N88DL10V, I13IV, G17GDE, K20R, E35D, M36I, N37D, D60E, I62V, L63P, I64IV, A71T, I72IT, V75VID
 RenG16534RenG16534KT747562PINAM46I, I54V, L76V, V82A L10V, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71T, I93LD
 RenG15871RenG15871KT746899PINAM46I, I54V, L76V, V82A L10V, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71T, I93LD
 RenG16495RenG16495KT747523PINAM46I, I50L, V82AQ58E, G73SL10V, L33V, E35D, M36I, N37S, R41K, K45R, D60E, I62V, L63P, I64V, I72L, I85VD
 RenG17355RenG17355KT748383PINAM46I, I84V, L90ML10F, G73CSTK20R, E35D, M36I, N37ND, R41K, I62V, L63P, H69K, A71AV, T74S, V77I, I85V, I93LD
 RenG16182RenG16182KT747210PINAM46I, I54V, I84V, L90MV11I, G73SL10I, I13IV, I15V, K20KIM, E21Q, E35D, M36I, N37D, R57RK, D60DE, Q61N, L63P, H69HR, A71V, I72M, I85IV, I93LD
 RenG17289RenG17289KT748317PINAD30N, M46I, I54IV, V82A, L90ML10F, L33F, F53FL, N88DI13V, R41K, I62V, L63P, H69Y, A71T, I72T, V77ID
 RenG17344RenG17344KT748372PINAM46I, I54V, L76V, V82A, L90ML33FL10V, T12I, I13V, G16E, K20R, E35D, M36I, N37T, R41K, R57K, D60E, Q61D, I62V, I72R, L89ID
 RenG13765RenG13765KT744793PINAM46I, I47V, I54V, V82AL24I, K43T, F53LL10V, L19I, K20R, E35D, M36I, N37H, R41K, R57K, Q61N, I62IV, L63V, I64V, E65D, I72V, T74SD
 RenG15014RenG15014KT746042PINAM46I, I54A, V82AL33I, Q58E, N83DL10V, I13A, K14R, K20R, A22V, E35N, M36I, N37D, I62V, L63P, I64V, H69K, A71V, Q92KD
 RenG14787RenG14787KT745815PINAM46I, I47IV, I54V, V82AL10F, L33F, N88DI13V, I15V, E35D, M36I, N37ND, R57K, Q61N, L63P, I64LD
 RenG14705RenG14705KT745733PINAM46I, I47V, I54V, V82AL10FI13V, I15V, L19I, K20I, M36I, R41K, I62IV, L63P, I64V, N83S, T91SD
 RenG15415RenG15415KT746443PINAM46I, N88SQ58EL10V, I13IV, I15V, K20T, K55KR, L63P, A71V, V77I, T91SD
 RenG15039RenG15039KT746067PINAM46I, G48S, I54S, V82ML24I, K43TL10V, L19IV, K20R, E35D, M36I, R41K, F53Y, K55Q, R57K, D60DN, Q61DN, I62V, L63T, I64V, E65D, I72T, T74AD
 RenG14898RenG14898KT745926PINAM46I, I54V, I84V, L90MV11I, G73SL10IM, T12P, K14*, I15V, L19P, K20I, E35D, M36I, N37D, D60DE, Q61N, L63P, H69HR, A71V, I72M, I85V, I93LD
 RenG13686RenG13686KT744714PINAM46I, I47V, I54V, V82F, L90MQ58EL10V, I13V, K20I, E35D, M36I, R41K, I62V, L63P, I64V, A71V, I93LD
 RenG14682RenG14682KT745710PINAM46I, I54V, V82AN88DL10V, I13V, I15V, G16E, K20I, E35N, M36I, R41K, K45R, K55KR, R57K, Q61N, L63Q, I64V, T74SD
 RenG12426RenG12426KT743454PINAM46I, I54V, V82S, I84VK43T, L89VL10I, I15V, L19IV, K20R, M36I, I62IV, L63P, K70R, A71V, I72M, Q92KD
 RenG12366RenG12366KT743394PINAM46I, I54V, V82AL24I, L33F, Q58EL10V, I13V, K20R, M36I, R41K, K55R, R57K, Q61N, L63P, A71T, I72T, T91SD
 RenG12299RenG12299KT743327PINAM46I, I54V, V82AL24I, L33F, F53L, T74PP9PR, L10I, T12TA, I13V, I15V, K20M, E35D, M36I, N37D, R41K, K45I, K55R, I62V, L63E, I64IV, E65D, L89MD
 RenG12639RenG12639KT743667PINAV32I, M46I, I47V, I54M, V82A, L90ML33F, F53L, T74TPL10I, I13V, G16GE, K20R, E34A, E35D, M36I, R41K, K45KR, K55KR, R57K, Q61N, L63S, C67E, I72V, V77VID
 RenG13355RenG13355KT744383PINAV32I, M46I, I47V, I50L, I54V, V82AL23IL10V, I15V, K20R, E35D, M36I, N37S, R41RK, K43I, K55R, R57K, L63PD
 RenG12915RenG12915KT743943PINAM46I, I50L, V82AL33F, F53LK20R, E34N, E35D, M36I, R41K, K55R, R57K, Q61D, L63P, E65D, A71TD
 RenG12984RenG12984KT744012PINAM46I, I54V, V82A, I84V, L90ML33F, K43T, G73TL10V, L19V, K20R, E35D, M36I, R41N, D60E, Q61D, I62V, L63P, H69Y, A71T, I72TD
 RenG12217RenG12217KT743245PINAM46I, I54V, V82F, L90M L10I, I15V, K20T, E35N, M36I, R41KT, K43Q, R57K, D60N, Q61D, I62V, L63P, I64L, V77I, L89I, I93LD
 RenG13236RenG13236KT744264PINAM46I, V82A, N88GSL33F, Q58EL10V, I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71T, I72TD
 RenG12091RenG12091KT743119PINAM46I, I54V, V82A, L90MG73S, L89VL10V, I13V, K20T, L33L_L, M36I, R41K, K55R, I62IV, L63P, I64IL, A71V, I93L, N98ID
 RenG11287RenG11287KT742315PINAM46I, I54V, V82A, L90ML10F, K43T, G73TQ7DE, P9PL, I13M, I15V, K20I, E21EQ, E35N, M36I, R41RK, K55R, R57RK, I62IV, L63P, I64V, A71V, I72T, I85V, I93LD
 RenG11503RenG11503KT742531PINAM46I, I50V, I54V, V82AK43T, F53LL10V, I15V, K20T, E35D, M36I, N37D, R41K, L63LP, I64V, A71V, V77ID
 RenG10704RenG10704KT741732PINAM46I, I50V, V82AL33FL10V, K14R, I15V, Q18E, L19I, E35D, M36I, R41K, I62V, L63P, L89FD
 RenG10088RenG10088KT741116PINAM46I, I54V, I84V, L90MQ58EL10I, I13A, K14IM, L19Q, K20R, A22V, E35D, M36I, K55R, R57K, I62V, L63P, I64V, I66V, V82I, Q92K, I93L, C95FD
 RenG10617RenG10617KT741645PINAV32I, M46I, I47V, I54V, V82A, L90MV11I, L33F, G73S, L89VL10V, I13V, I15V, L19P, K20R, M36I, N37D, K55R, R57K, I62V, L63P, I64L, A71V, I72VD
 RenG10374RenG10374KT741402PINAV32I, M46I, I47V, I54M, V82AL24I, K43T, L89VL10V, I13V, K20R, E35D, M36I, K55R, R57RK, L63P, A71I, I72VD
 RenG11573RenG11573KT742601PINAM46I, I50L, V82AL33F, F53LK20R, E34N, E35D, M36I, R41K, K55R, R57K, Q61D, L63P, E65D, A71TD