<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation K43R
Rx PI-naive
IncludeMixtures No
References 16
Patients 48
Isolates 49
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Cuevas (2002)CU94CU94AF425475None   K20R, E35D, M36I, R41K, K43R, L63P, H69QD
 CU73CU73AF425454None   K14R, L19I, E35D, M36I, N37D, R41K, K43R, Q61D, L63P, H69Q, I93LD
 CU71CU71AF425452None   L10I, K14R, R41K, K43R, L63P, I64L, H69QD
 CU67CU67AF425448None   I13V, K20R, M36I, N37D, R41K, K43R, L63P, H69QD
 CU65CU65AF425446None   E35D, M36I, N37D, R41K, K43R, L63P, I64L, H69Q, K70R, A71T, I72VD
 CU64CU64AF425445None   E35D, M36I, N37D, R41K, K43R, D60E, Q61E, L63P, H69QD
 CU62CU62AF425443None   Q18L, R41K, K43R, L63P, H69QD
 CU61CU61AF425442None  T74PK20R, E35D, M36I, N37D, R41K, K43R, D60E, Q61E, L63P, H69QD
 CU60CU60AF425441None   I13V, K14R, G16E, K20M, E35D, M36I, R41K, K43R, L63P, H69Q, L89MD
 CU40CU40AF425421None   I13V, K20R, M36I, R41K, K43R, Q61E, L63P, H69QD
 CU31CU31AF425412None   E35D, M36I, R41K, K43R, L63P, H69QD
 CU30CU30AF425411None   R41K, K43R, R57K, I62V, L63P, H69Q, A71T, V77I, I93LD
 CU29CU29AF425410None   E35D, M36I, R41K, K43R, D60E, L63P, H69QD
 CU23CU23AF425404None   L5Q, I15V, E35D, M36I, N37D, R41K, K43R, D60E, L63P, H69QD
 CU8CU8AF425389None   K20R, E35D, M36I, N37D, R41K, K43R, L63P, H69Q, V77ID
 CU7CU7AF425388None   E35D, M36I, R41K, K43R, L63P, H69QD
Casado (2005) CU7AY894994None   E35D, M36I, R41K, K43R, L63P, H69QD
 Cu64Cu64AY894995None   E35D, M36I, N37D, R41K, K43R, D60E, Q61E, L63P, H69QD
Dilernia (2007)F099F099EF120131None  L33IR41K, K43R, L63S, A71V, I72E, V77I, I93LD
Church (2008)414210P414210PEU380758None   I13V, E35D, R41K, K43R, L63P, I64V, H69YD
Cuevas (2009)P1293P1293.1EU822625None   L10I, I13V, M36I, R41K, K43R, L63PS, I64VD
Djoko (2010)667CD3864FR666667None   I15V, E35D, M36I, R41K, K43R, R57K, Q61N, I62V, L63HQ, E65ED, H69QD
Hamers (2011)CP076303006CP076303006HQ995071None   I13V, M36I, R41K, K43R, R57K, L63P, I64VD
 CP076301819CP076301819HQ995161None   I13V, M36MI, R41K, K43R, R57K, L63P, I64VD
 CP076301965CP076301965HQ995429None   I13V, N37E, R41K, K43R, D60E, I62V, L63P, I64V, H69Y, I72LD
Delwart (2012)479-2547-7479-2547-7JN215097None   I15V, E35D, M36I, N37D, R41K, K43R, Q61E, L63P, H69Q, A71T, I72V, I93LD
Karlsson (2012)SE_209SE_209JQ698814None   L10I, I13V, I15V, G16E, E35N, M36I, N37D, R41K, K43R, I62V, L63Q, I64V, H69QD
 SE_259SE_259JQ698846None   E35D, N37D, R41K, K43R, L63P, A71T, Q92RD
Machado (2012)CUPL0904CUPL0904HQ655337None   K20R, E35D, M36I, N37S, R41K, K43R, Q61N, L63S, H69QD
 CUPL0909CUPL0909HQ655342None   M36I, R41K, K43R, L63P, H69QD
 CUPL0910CUPL0910HQ655343None   E35D, M36I, R41K, K43R, I62V, L63P, H69Q, I72VD
 CUPL0915CUPL0915HQ655348None   M36I, R41K, K43R, L63P, H69QD
 CUPL0916CUPL0916HQ655349None   M36I, R41K, K43R, L63P, H69Q, I72VD
 CUPL0925CUPL0925HQ655358None   K20R, M36I, R41K, K43R, D60E, I62V, L63P, H69QD
 CUPL1007CUPL1007HQ655384None   M36I, R41K, K43R, I62V, L63P, H69Q, K70R, I72M, V82I, I93LD
 CUPL1048CUPL1048JN000020None   I15V, E35D, M36I, R41K, K43R, L63P, H69Q, V82ID
 CUPL1073CUPL1073JN000045None   M36I, R41K, K43R, Q61E, L63P, H69QD
 CUPL1080CUPL1080JN000052None   E35D, M36I, R41K, K43R, I62V, L63P, H69Q, K70Q, A71T, I93LD
 CUPL1096CUPL1096JN000068None  Q58ET12E, I15V, L19I, E35D, M36I, N37D, R41K, K43R, R57K, D60E, Q61E, L63P, H69Q, I93LD
 CUPL1126CUPL1126JX194205None   E35D, M36I, R41K, K43R, I62V, L63P, H69QD
 CUPL1127CUPL1127JX194206None   M36I, R41K, K43R, L63P, H69QD
 CUPL1132CUPL1132JX194211None   K20R, E35D, M36I, N37D, R41K, K43R, G49E, G51E, Q61E, L63P, H69QD
Nazziwa (2012)51064025106402JX499005None   T12S, L19I, R41K, K43R, I64V, E65D, V77ID
Chow (2013)MY1IM781MY1IM781KC478036None   L10I, I13V, E35D, M36I, N37D, R41K, K43R, L63T, A71V, I72IT, I93LD
Frentz (2013)EHR-60237EHR-60237JX300541None   I13A, K14R, K20I, M36I, R41K, K43R, L63PD
 EHR-75358EHR-75358JX300821None   T12P, K14R, E35D, M36I, R41K, K43R, L63P, H69QD
Lunar (2013)13869-0813869-08JX046414None   I13V, K14KR, I15IV, K20I, M36I, R41K, K43R, L63PD
Temereanca (2013)SR65SR65JX966531None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, R41K, K43R, R57K, L63T, E65D, I72TD
Lee (2014)MBA1042MBA1042KJ906743None   L33LV, E35D, M36I, N37D, R41K, K43R, I64V, H69YD