<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation E35D
Rx >= 1 PI
IncludeMixtures No
References 23
Patients 114
Isolates 120
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Brindeiro (2002)TVSP12TVSP12AY145811RTV55  R8Q, I13V, E35D, M36I, R41K, Q61N, I62V, L63H, H69QD
Cuevas (2002)CU104CU104AF425485IDV   E35D, M36I, R41K, K43R, D60E, L63P, H69QD
 CU80CU80AF425461IDV   L10V, E35D, M36I, R41K, K43R, L63P, H69Q, V82ID
 CU54CU54AF425435SQV, IDV   I13V, E35D, M36I, N37D, R41K, K43R, L63PD
Gibb (2002)DMG9090_w51 NFV1 L23II13V, K20KR, E35D, M36I, R41K, I64V, E65D, V82VID
Holguin (2002)AH_14024AH_14024AF354018IDV, RTV   T12S, E35D, M36I, R41K, I62V, L63P, H69YD
 AH_17335AH_17335AF354017SQV, RTV, NFV, IDV57  T12S, E35D, M36T, R41K, I62V, L63P, H69YD
Tural (2002)226575226575 IDV, NFV131D30N I13V, E35D, M36I, N37H, R41K, Q58*, I62V, L63PD
Vergne (2003)VL01SN160HALD01SN160AJ583742IDV  N88DQ7L, T12S, I15V, E35D, M36I, R41K, Q61N, I62V, L63P, A71TD
Gomez-Carrillo (2004)104461104461AY365704PINAV82L, L90M I15V, L19I, K20R, E35D, M36I, I62V, L63P, H69Q, I72CD
Montes (2004)MB_patMOL00_MOLL719AJ577953SQV, RTV, IDV, NFV143D30N Q7E, E35D, M36I, P39Q, R41K, I62V, L63P, I64L, A71V, I72V, V77I, I93LD
Non-B Workgroup (2005)UK1557UK1557AY900679NFV, SQV104D30NN88DL10V, I13V, E35D, M36I, R41K, L63PD
 UK1979UK1979 NFV D30N I13V, I15V, E35D, M36I, R41K, L63PD
 BR8BR8AY900888NFV43D30N L10I, T12I, I13V, I15V, K20T, E35D, M36I, R41K, K45T, L63P, I64IV, I85IVD
 TK1028TK1028 RTV, IDV, NFV207M46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028a RTV, IDV, NFV231M46I, I54V, V82TL24IP1PS, L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028b RTV, IDV, NFV308M46L, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 TK3011TK3011 SQV, NFV231D30NN88DI13V, I15V, K20T, E35D, M36I, N37NY, R41K, I64V, T74SD
 TK4018TK4018 SQV, IDV, NFV175D30DN, I54IV K20KR, E35D, M36I, N37E, R41K, Q61HN, I62IV, L63LP, I64V, C67Y, H69YD
 TK5003TK5003a LPV39  I13V, K14KR, E35D, M36I, R41K, I64V, K70RD
 TK5013TK5013 SQV, IDV, NFV255D30DN, M46MI, I54IV, V82VAL24LIL10LI, I15IV, K20KR, E35D, M36I, N37DE, R41K, D60DE, Q61QH, I62V, L63LP, I64V, C67CY, H69HYD
  TK5013a SQV, IDV, NFV340D30DN, M46MI, I54IV, V82VAL24LIL10LI, I15IV, K20KR, E35D, M36I, N37DE, R41K, D60DE, I62V, L63P, I64IV, E65ED, C67CY, T74TSD
Weber (2005)C55937C55937AY677437SQV77  E35D, N37S, R41K, I64VD
Baxter (2006)12-14811481-30812DQ876616PINAD30N, I54V, L90ML10F, N88DE35D, M36I, N37S, R41K, I62V, L63P, A71T, I72M, I93LD
 12-22582258-30721DQ876701PINAI54V, V82AL10FI13V, G16E, K20I, E35D, M36I, P39S, R41K, K45A, R57KT, I62V, L63C, I64VD
 12-17561756-30527DQ876870PINAI54V, V82A, L90MK43T, G73SL10I, I15V, K20R, E35D, M36I, I62V, L63P, H69R, A71VD
 12-30773077-30403DQ877151PINAD30NL10F, N88DI13V, K14R, E35D, M36I, R41K, I62IV, L63Q, I64VD
 48-12121212-30812DQ877754PINAM46L, I54V, V82AL24I, L33FL10V, I15V, E35D, M36I, N37ND, R41K, I62V, L63PD
 48-12501250-30522DQ877773PINAL90M L10I, E35D, M36I, R41K, Q61N, I62V, L63R, K70ED
  1250-31215DQ877775PI, RTV, TPV>29L90LM L10I, E35D, M36I, R41K, Q61HN, I62V, L63R, K70E, L89LWD
  1250-40809DQ877774PI, RTV, TPV>64L90M L10I, E35D, M36I, R41K, Q61N, I62V, L63R, K70ED
 48-14291429-30424DQ877819PINAM46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 48-50145014-30514DQ878549PINAM46I, I54V, V82A, L90LML10F, Q58EI13V, K20I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, N83SD
 48-61576157-30704DQ878733PINAG48A, I54V, V82A, I84V, L90ML33F, Q58E, G73GS, L89LVT4S, L10I, K20R, E35D, M36L, R57RK, I62V, L63P, A71V, I72ILM, Q92KD
 48-92949294-30930DQ877624PINAM46MI, V82AL24IL10I, I15IV, E35D, M36I, N37ND, R41K, I62V, L63P, T74SD
 48-90069006-30923DQ877670PINAI54A, V82AL24I, Q58E, L89VL10Y, I13IMV, I15V, K20I, E34KQ, E35D, M36I, N37NS, R41K, R57K, D60E, I62IV, L63P, A71V, I93LD
Laurent (2006)CK2-8402CM-84AM279448NFV105 L10F, L33I, N88GI13V, E35D, M36I, N37E, R41K, V56A, I62V, L63P, H69Y, A71T, I72TD
 CK2-9802CM-98AM279450IDV30  L10V, I15V, E35D, M36I, R41K, L63P, H69QD
von Wyl (2007)2410516511EF449876RTV, PINA  L10V, I13V, E35D, M36I, R41K, I62V, L63H, I64VD
Waleria-Aleixo (2008)08PR06072008PR060720FJ591542PINAI54V, V82TL24I, F53LL10V, I13V, K20R, E35D, M36V, N37T, R41K, R57K, I62V, L63P, I64V, A71V, T74SD
 08RJ06047108RJ060471FJ591665PINA  L10V, I13V, E35D, M36I, R41K, L63PD
 RG44RG44FJ592052PINAM46MI, L90MG73CL10I, K20I, E35D, M36I, I62V, L63P, I64V, T74SD
 08PR04013408PR040134FJ591183PINA  E35D, M36I, R41KD
 RG42RG42FJ592051PINAD30NL33F, N88DL10LV, E35D, M36I, R41K, I62V, L63ADHP, A71T, T74SD
 08PR05023208PR050232FJ591261PINAI54L, V82A, L90ML33F, K43T, F53LL10V, I13V, I15IV, K20R, E35D, M36I, R41K, I62V, L63P, H69K, A71I, T74S, I93IMD
 RES2RES2FJ591822PINAD30N L10I, T12I, I13V, I15V, K20T, E35D, M36I, R41K, K45T, L63P, I64IV, I85IVD
 08RJ06051308RJ060513FJ591705PINA  E35D, M36I, R41K, L63P, A71V, V77I, I93LD
Koyalta (2009)8TCHAD-8FJ688175IDV26V82A L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63P, K70E, A71T, I93LD
Jones (2012)145636145636JN669661PINA  L10I, I13V, E35D, M36I, R41K, Q61D, L63T, K70F, I72TD
Kouri (2012)CU373-10CU373-10JQ585388PINAM46I, I54V, L76V, V82AL24I, L33FL10I, I13V, K20R, E35D, M36I, N37D, R41K, D60E, I62V, L63P, A71V, I93LD
 CU345-10CU345-10JQ585387PINAI54IV, V82VA W6G, L10I, K20R, E35D, M36I, R41K, Q61DN, L63P, H69Q, K70T, I93LD
 CU1484-09CU1484-09JQ585298PINA  W6G, I15V, Q18E, K20R, E35D, M36I, R41K, K43R, I62V, L63P, H69QD
 CU503-10CU503-10JQ585401PINA  E35D, M36I, R41K, K43R, L63P, H69Q, I72VD
 CU322-11CU322-11JQ585490PINA  E35D, M36I, R41K, K43R, Q61H, I62V, L63P, H69Q, V82ID
 CU117-10CU117-10JQ585366PINA  L10V, I15IV, E35D, M36I, R41K, L63P, H69Q, I72VD
 CU1267-09CU1267-09JQ585282PINA  T12A, I15IV, L19I, E35D, M36I, N37D, R41K, K43R, D60E, I62IV, L63P, I64IV, H69QD
 CU691-09CU691-09JQ585261PINAD30N, V32I, M46I, I47V, I54L, V82AL10LF, L33F, F53FL, Q58E, N88DI13V, I15V, L19I, K20R, E35D, M36L, N37T, R41T, K45R, D60E, L63P, H69Q, K70R, I72V, V77I, L89FD
 CU25-10CU25-10JQ585358PINAM46L, I54V, V82A, L90ML33F, K43T, F53L, G73SL10V, I13V, L19LI, K20R, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71I, I93LD
 CU1162-09CU1162-09JQ585276PINA  L10I, E35D, M36I, R41K, I62V, L63P, H69Q, K70Q, I72IV, I93LD
 CU75-11CU75-11JQ585492PINA  I13V, K14R, K20I, E35D, M36I, R41K, I64VD
 CU1316-09CU1316-09JQ585291PINAI84V, L90M E35D, M36I, R41K, L63P, H69K, L89M, I93LD
 CU194-11CU194-11JQ585494PINA  I15V, G16GE, L19LS, K20R, E35D, M36I, N37D, R41K, K43R, D60E, I62V, L63PD
 CU546-11CU546-11JQ585509PINA  T12A, E35D, M36I, R41K, Q61N, I62IV, L63P, H69Q, K70Q, I93LD
 CU1269-09CU1269-09JQ585284PINA  E35D, M36I, N37D, R57K, L63AP, L90LVD
 CU461-09CU461-09JQ585253PINAI54V, L90MG73SL10I, K20R, E35D, M36I, R41K, I62V, L63P, H69Q, A71V, I93LD
 CU116-10CU116-10JQ585365PINA  E35D, M36I, R41K, K43R, R57K, I62V, L63P, I64V, H69Q, A71T, V77I, I93LD
 CU2015-09CU2015-09JQ585347PINA  E35D, M36I, N37D, L63P, I64IM, H69QD
 CU163-10CU163-10JQ585454PINA  Q2H, L10V, I13V, E35D, M36I, R41K, K45R, R57K, D60E, L63P, H69Q, V77ID
 CU1892-09CU1892-09JQ585315PINA  L10I, E35D, M36I, R41K, K43KR, L63P, I64IV, H69QD
 CU736-10CU736-10JQ585412PINA  E35D, M36I, R41K, K43R, L63P, H69Q, I72IV, V82I, I93ILD
 CU422-11CU422-11JQ585500PINA  T12P, L19I, E35D, M36I, R41K, K43R, L63P, I93LD
 CU645-09CU645-09JQ585259PINA  L19I, E35D, M36I, R41K, L63P, V77ID
 CU646-09CU646-09JQ585260PINA  Q7L, K20R, E21EK, E35D, M36I, N37D, R41K, K43R, G52GS, Q61EG, L63P, H69QD
 CU90-10CU90-10JQ585361PINAI50V, I54L, L90ML10F, L33F, K43T, F53L, L89VQ2P, L5F, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37G, R41K, D60E, L63P, H69HY, A71IV, V77I, V82I, I93ILD
 CU1483-09CU1483-09JQ585297PINAM46I, L90M I13V, E35D, M36I, R41K, L63P, H69QD
 CU1708-09CU1708-09JQ585308PINA  L10V, E21K, E35D, M36I, R41K, K43R, I62V, L63P, H69Q, A71T, I72IT, I93LD
 CU1959-09CU1959-09JQ585326PINAM46L, I54L, V82T, L90ML33F, T74PL10I, I13V, E35D, M36I, R41K, K43R, K55R, L63P, H69Q, A71V, I93LD
 CU408-10CU408-10JQ585393PINAI54IV, V82VA L10I, K20KR, E35D, N37S, R41K, R57RS, Q61HN, L63P, H69Q, K70T, V77VI, G78GRS, L89LMD
 CU2043-09CU2043-09JQ585337PINA  I15V, K20R, E35D, M36I, R41K, K43R, I62V, L63P, H69Q, K70E, A71T, I93LD
 CU313-10CU313-10JQ585383PINAI50IV, I54IVL33LFW6G, L10I, I13IV, K20KT, E35D, M36MI, N37NS, R41K, K45KEIV, K55KT, R57RK, L63P, I66IF, V77VI, L89M, I93ILD
 CU311-10CU311-10JQ585381PINAI50V, I54L, L90ML33F, K43T, F53L, L89VV11L, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37D, R41K, D60E, L63P, H69Y, A71I, V77I, V82ID
 CU1283-09CU1283-09JQ585286PINA  T12A, I15IV, L19I, E35D, M36I, N37D, R41K, K43R, D60E, I62IV, L63P, I64IV, H69QD
 CU949-09CU949-09JQ585268PINA  E35D, M36I, R41K, K43R, L63P, H69Q, I72VD
Mollan (2012)MK180MK180w68 RTV, ATV19 Q58EL19V, K20R, E35D, M36I, R41K, R57K, D60E, Q61E, L63Q, C67E, H69K, L89MD
Van Zyl (2013)O8501190KC422951LPV26  I13V, I15V, K20M, E35D, M36I, R41K, I64VD
  1779KC423400LPV78  I13V, I15V, K20M, E35D, M36I, R41K, I64VD
de Lourdes Teixeira (2015)9RJ1103029RJ110302 PINA  I13V, K20KT, E35D, M36I, R41K, L63PD
 9RJ1204419RJ120441 PINA  I13V, E35D, R57K, Q61N, L63SD
Diaz (2015)RenG15645RenG15645KT746673PINAM46I, I54V, I84V, L90ML10F, F53L, T74PI13V, K20R, E35D, M36I, R41K, K55H, R57K, L63P, H69R, A71V, L89I, T91S, Q92KD
 RenG16432RenG16432KT747460PINAI50L, N88SQ58EL10V, G16E, K20R, E35D, M36I, N37T, L63T, E65ED, H69K, A71V, I72T, L89M, I93LD
 RenG15698RenG15698KT746726PINAV32I, M46ML, I47A L10I, I13V, K14KIR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, I62V, L63LP, I64L, H69Y, I93LD
 RenG17218RenG17218KT748246PINA  I15V, L19Q, E35D, M36I, R41K, L63PD
 RenG17128RenG17128KT748156PINAM46I, I50V, L76V, V82AL23LI, V32A, L33F, Q58ET12K, I13V, I15V, L19V, K20T, E34A, E35D, M36I, N37E, R41K, I62IV, I64V, K70R, V77I, L89LIMD
 RenG16876RenG16876KT747904PINAI50L, V82AL33FI13V, K20KT, E35D, M36I, R41K, L63A, A71V, T91SD
 RenG15911RenG15911KT746939PINAL90MG73GSI13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71AITV, T74SD
 RenG16359RenG16359KT747387PINA  L10V, T12I, E35D, M36I, R41K, I62VD
 RenG16523RenG16523KT747551PINA  K14KR, I15V, L19Q, E35D, N37S, R41K, D60DE, I62IV, I64V, E65EDD
 RenG17154RenG17154KT748182PINAN88NS, L90MF53FL, G73GST12M, I13V, I15V, L19V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, V77VI, Q92KD
 RenG15295RenG15295KT746323PINAV32I, M46I, I47V, I50V, I54L, L90MK43T, L89VT12K, I15V, L19I, K20T, E35D, M36I, N37E, R57K, A71V, I85VD
 RenG13699RenG13699KT744727PINA  E35D, M36MI, N37NT, Q61E, L63P, H69QD
 RenG14366RenG14366KT745394PINA  I15V, G16Q, K20R, E35D, M36I, P39Q, R41K, K45RD
 RenG14506RenG14506KT745534PINA  T12E, I15V, G16E, L19I, E35D, M36I, R41K, L63VD
 RenG15468RenG15468KT746496PINA  Q7E, L10I, K14R, E35D, M36I, R41K, L63S, I64V, I72V, V77I, I93LD
 RenG15170RenG15170KT746198PINA G73STL10V, T12S, I15V, K20T, E35D, M36I, N37DE, R41K, K43KR, I62V, L63P, T74S, I93LD
 RenG14393RenG14393KT745421PINA  I15V, L19I, E35D, M36I, L63CD
 RenG13289RenG13289KT744317PINA  I15V, L19I, E35D, M36I, R41K, I62V, I93LD
 RenG12305RenG12305KT743333PINAM46L, I54V, V82AL24I, L33F, K43TL10V, I15V, K20R, E35D, M36I, R41K, I62V, L63PD
 RenG13355RenG13355KT744383PINAV32I, M46I, I47V, I50L, I54V, V82AL23IL10V, I15V, K20R, E35D, M36I, N37S, R41RK, K43I, K55R, R57K, L63PD
 RenG13378RenG13378KT744406PINA  L33V, E35D, M36I, N37D, K43R, D60E, Q61E, L63PD
 RenG13236RenG13236KT744264PINAM46I, V82A, N88GSL33F, Q58EL10V, I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71T, I72TD
 RenG12819RenG12819KT743847PINAI54V, V82S, L90ML33F, F53LQ7D, L10I, I13V, K20T, E34N, E35D, M36I, N37NT, R41K, I62V, L63AP, I64L, A71M, I72V, T74S, V77L, I93LD
 RenG10992RenG10992KT742020PINA  Q7E, T12TP, K14R, E35D, M36I, N37D, R41K, L63P, I64L, A71V, I72IV, V77I, I93LD
 RenG11756RenG11756KT742784PINA  L33V, E35D, M36I, N37D, K43R, D60E, Q61E, L63PD
 RenG10632RenG10632KT741660PINA  W6R, I15V, L19I, E35D, M36I, R41KD
 RenG11632RenG11632KT742660PINAG48V, I54S, V82A, L90MQ58EL10I, I13V, L19T, K20I, L33L*, E34Q, E35D, M36I, N37D, D60E, I62V, L63Q, I64V, T74SD
 RenG11570RenG11570KT742598PINA  L10I, T12K, I15V, L19I, E35D, M36I, N37E, R41K, H69Q, I72VD
 RenG11511RenG11511KT742539PINAI54V, V82AL10F, N88DT12K, I15V, L19I, K20T, E35D, M36I, N37EK, R41N, R57RK, D60E, L63P, A71VD
Sutherland (2015)2222_POSTKT351828LPV   I13V, E35D, M36MI, R41K, R57K, L63P, H69Y, I72V, V77VID
Lopez (2016)2007-0072007-007KT375026PINA  Q18H, L19I, E35D, M36I, R41K, L63P, K70QD
 2007-0012007-001KT375020PINA  E35D, M36I, R41K, L63P, I72VD