<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation E35D
Rx >= 1 PI
IncludeMixtures No
References 17
Patients 124
Isolates 129
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Rousseau (2000)MNR18MNRMP1263AJ405965SQV, NFV69I84V, L90MG73SL10I, L19T, K20R, E35D, M36I, N37D, I62V, L63P, H69Y, A71T, I72TD
Cuevas (2002)CU104CU104AF425485IDV   E35D, M36I, R41K, K43R, D60E, L63P, H69QD
 CU80CU80AF425461IDV   L10V, E35D, M36I, R41K, K43R, L63P, H69Q, V82ID
 CU54CU54AF425435SQV, IDV   I13V, E35D, M36I, N37D, R41K, K43R, L63PD
Gibb (2002)DMG7272_w15 NFV15  E35D, M36MI, R41K, R57K, I62V, L63H, I66IM, I93LD
 DMG9090_w51 NFV1 L23II13V, K20KR, E35D, M36I, R41K, I64V, E65D, V82VID
Holguin (2002)AH_14024AH_14024AF354018IDV, RTV   T12S, E35D, M36I, R41K, I62V, L63P, H69YD
 AH_17335AH_17335AF354017SQV, RTV, NFV, IDV57  T12S, E35D, M36T, R41K, I62V, L63P, H69YD
Vergne (2003)VL01SN160HALD01SN160AJ583742IDV  N88DQ7L, T12S, I15V, E35D, M36I, R41K, Q61N, I62V, L63P, A71TD
Gomez-Carrillo (2004)101028101028AY365623PINAI54V, L76V, V82A L10I, I13V, I15V, K20M, E35D, M36I, R41K, Q61N, L63P, A71V, I72T, L89I, I93LD
 103136103136AY365669PINAD30N, V82AN83D, N88DL10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, Q61N, L63P, A71VD
 103246103246AY365672PINA  G17E, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, V82ID
 104461104461AY365704PINAV82L, L90M I15V, L19I, K20R, E35D, M36I, I62V, L63P, H69Q, I72CD
 113381113381AY365875PINAI54L, V82A, L90ML33F, K43T, F53LT12M, I13V, I15V, Q18H, K20R, E35D, M36I, N37DE, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71I, I72LD
 113575113575AY365879PINAD30N E35D, M36I, N37T, R41RK, L63C, I64V, A71V, I93LD
 118423118423AY365949PINAL90M L10V, I13V, K14R, K20T, E35D, M36I, N37D, R41K, Q61N, L63P, A71T, I72T, T74SD
Montes (2004)MB_patGON02_GONC704AJ577901RTV, IDV, LPV137  I15V, E35D, M36I, R41K, I62V, L63AD
 MB_patMOL00_MOLL719AJ577953SQV, RTV, IDV, NFV143D30N Q7E, E35D, M36I, P39Q, R41K, I62V, L63P, I64L, A71V, I72V, V77I, I93LD
 MB_patDER02_DER736AJ577878NFV179D30NN88DL10Y, I13V, E35D, M36I, I62V, L63P, I64V, T74S, V77ID
Non-B Workgroup (2005)UK1557UK1557AY900679NFV, SQV104D30NN88DL10V, I13V, E35D, M36I, R41K, L63PD
 UK1979UK1979 NFV D30N I13V, I15V, E35D, M36I, R41K, L63PD
 TK1009TK1009 IDV, NFV, RTV177M46ML I13V, K14KR, E35D, M36I, R41K, K45KR, R57RK, L63P, H69KQ, A71AV, L89TD
 TK1014TK1014 RTV, SQV, NFV, IDV246M46I, I84IVL24LIL10LV, I13V, K20I, E35D, M36I, R41K, L63P, H69K, T74S, T80TA, V82X, L89IMD
 TK1028TK1028 RTV, IDV, NFV207M46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028a RTV, IDV, NFV231M46I, I54V, V82TL24IP1PS, L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028b RTV, IDV, NFV308M46L, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 TK3003TK3003 SQV, NFV247I54V, L90M K20T, E35D, M36I, N37DE, R41K, D60E, I62V, L63S, I64V, V77VI, V82ID
 TK3011TK3011 SQV, NFV231D30NN88DI13V, I15V, K20T, E35D, M36I, N37NY, R41K, I64V, T74SD
 TK4018TK4018 SQV, IDV, NFV175D30DN, I54IV K20KR, E35D, M36I, N37E, R41K, Q61HN, I62IV, L63LP, I64V, C67Y, H69YD
 TK5003TK5003a LPV39  I13V, K14KR, E35D, M36I, R41K, I64V, K70RD
 TK5013TK5013 SQV, IDV, NFV255D30DN, M46MI, I54IV, V82VAL24LIL10LI, I15IV, K20KR, E35D, M36I, N37DE, R41K, D60DE, Q61QH, I62V, L63LP, I64V, C67CY, H69HYD
  TK5013a SQV, IDV, NFV340D30DN, M46MI, I54IV, V82VAL24LIL10LI, I15IV, K20KR, E35D, M36I, N37DE, R41K, D60DE, I62V, L63P, I64IV, E65ED, C67CY, T74TSD
Weber (2005)C55937C55937AY677437SQV77  E35D, N37S, R41K, I64VD
Baxter (2006)12-22582258-30721DQ876701PINAI54V, V82AL10FI13V, G16E, K20I, E35D, M36I, P39S, R41K, K45A, R57KT, I62V, L63C, I64VD
 12-30773077-30403DQ877151PINAD30NL10F, N88DI13V, K14R, E35D, M36I, R41K, I62IV, L63Q, I64VD
 48-12121212-30812DQ877754PINAM46L, I54V, V82AL24I, L33FL10V, I15V, E35D, M36I, N37ND, R41K, I62V, L63PD
 48-12501250-30522DQ877773PINAL90M L10I, E35D, M36I, R41K, Q61N, I62V, L63R, K70ED
  1250-31215DQ877775PI, RTV, TPV>29L90LM L10I, E35D, M36I, R41K, Q61HN, I62V, L63R, K70E, L89LWD
  1250-40809DQ877774PI, RTV, TPV>64L90M L10I, E35D, M36I, R41K, Q61N, I62V, L63R, K70ED
 48-14291429-30424DQ877819PINAM46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 48-14321432-30818DQ877822PINAM46I, I54V, L76V, V82TL24IL10I, I13A, K20I, E35D, M36I, R41K, Q61H, L63P, H69K, T74S, L89ID
 48-50145014-30514DQ878549PINAM46I, I54V, V82A, L90LML10F, Q58EI13V, K20I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, N83SD
Laurent (2006)CK2-8402CM-84AM279448NFV105 L10F, L33I, N88GI13V, E35D, M36I, N37E, R41K, V56A, I62V, L63P, H69Y, A71T, I72TD
 CK2-9802CM-98AM279450IDV30  L10V, I15V, E35D, M36I, R41K, L63P, H69QD
von Wyl (2007)2410516511EF449876RTV, PINA  L10V, I13V, E35D, M36I, R41K, I62V, L63H, I64VD
 310371422EF449968RTV, PINAM46I, I54V, L76V, V82ML24I, L33FL10V, I13V, K20R, E35D, M36I, N37DE, K55R, R57K, D60E, I62V, L63P, V75I, L89M, T91SD
Cardoso (2009)3117BRGO3117FJ638454PINAM46I, I54V, L76V, V82A, L90ML33FL10V, I13V, I15V, K20R, E35D, M36I, K55R, R57K, D60E, I62V, L63P, A71V, I72V, I93LD
 3139BRGO3139FJ638463PINA  I15V, K20R, E35D, M36I, N37D, R41K, H69K, V82ID
Koyalta (2009)8TCHAD-8FJ688175IDV26V82A L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63P, K70E, A71T, I93LD
Dau (2010)09705A09705AGU581977PINAM46L, I54V, V82AT, I84V, L90ML33F, F53L, L89VL10I, I13V, I15V, K20T, E35D, M36I, N37D, K55R, D60E, I62V, L63P, I66F, K70E, A71V, Q92KD
 13578A13578AGU582074PINAV32I, M46I, I54V, L76V, I84V, L90ML10F, L33F, K43TI13V, K20R, E35D, M36I, R41RK, K55KR, D60E, L63P, I64V, L89ID
Jones (2012)127025127025JN669433PINAL90M L10I, E35D, M36I, R41K, Q61N, L63S, I64L, I93LD
 127508127508JN669438PINAI54V, V82A, L90ML33I, F53L, G73SL10I, I13V, K20R, E35D, M36I, R41K, K43KE, K55R, R57K, D60EK, Q61N, I62IV, L63P, A71IV, I72V, G94GD, C95LD
 129393129393JN669468PINAV82A, L90MN88DL10I, I13A, A22V, E35D, M36I, N37D, R41K, K45R, R57K, Q61N, L63P, A71VD
 133092133092JN669519PINAL90LM L10LV, I13V, K20R, E35D, M36I, R41K, R57K, Q61N, I64IV, I93ILD
 133389133389JN669521PINAI54L, I84VL33FL10I, K14R, E35D, M36I, R41K, D60E, L63P, A71V, I93LD
 136940136940JN669556PINA  L10I, T12A, I15V, E35D, M36I, R41K, R57K, Q61N, L63C, C67WD
 138394138394JN669572PINA  L10LI, I15IATV, E35D, M36IL, R41K, Q61N, L63ATD
 145636145636JN669661PINA  L10I, I13V, E35D, M36I, R41K, Q61D, L63T, K70F, I72TD
 146099146099JN669672PINAL90LM L10V, I13V, K14R, K20M, E35D, M36I, N37D, R57RK, Q61N, L63P, A71T, I72TD
 147583147583JN669693PINAI54V, V82T, L90M L10I, K20R, E35D, M36I, N37E, R41K, R57K, Q61N, L63A, E65D, A71V, T74S, I93LD
 151637151637JN669765PINAD30NN88NDK14R, I15IV, E35D, M36I, R41K, R57K, Q61N, L63P, I64L, A71AV, I93LD
 156350156350JN669863PINA  L10V, K20KR, E35D, M36I, R41K, R57K, Q61N, L63Q, P79D, I93LD
 156484156484JN669866PINAV82VA, L90MN88NDL10I, I13A, A22V, E35D, M36I, N37D, R41K, K45KR, R57K, Q61N, I62IV, L63PS, A71AVD
 157949157949JN669903PINAM46MI, I54V, L76LV, V82F, L90ML33FL10I, I13V, K20IT, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, I64L, C67D, A71AV, I72IT, I93LD
 159279159279JN669946PINAI47V, I54V, V82A, L90ML33F, G48W, F53L, Q58EL10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, C67E, A71V, I93LD
 159280159280JN669947PINA  L10V, T12I, E35D, M36I, R41K, R57K, Q61N, I72M, V77ID
 159575159575JN669956PINAI54V, V82A L10V, I15V, G16GE, K20M, E35D, M36I, R41K, K45R, R57K, L63PS, A71TD
 159787159787JN669960PINAI54V L10V, I13V, K20R, E35D, M36I, R41K, R57K, Q61N, I64IV, A71V, I72T, T74S, Q92R, I93LD
 161350161350JN670003PINAM46MI, I47IV, I54IV, V82VFL, I84IVV11VI, L33LF, K43KT, N88ND, L89LVL10LIM, I13IV, I15V, E35D, M36I, R41K, K55R, R57K, Q61N, L63AP, A71AV, I85IV, I93LD
 162069162069JN670025PINAL90M L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, A71V, T74S, I93LD
 163678163678JN670068PINAL90LM L10V, I13V, I15V, K20T, E35D, M36I, R41K, K43R, R57K, Q61N, L63T, I64L, I72T, T74S, I93LD
 164953164953JN670088PINA  I13IV, E35D, M36I, N37D, R41K, R57K, L63V, I64V, E65DD
 166308166308JN670124PINAM46I, I54V, V82TL33F, L76IL10V, T12Q, I13V, I15V, L19I, K20KR, E35D, M36IL, R41K, K55R, R57K, Q61N, L63P, I64V, A71V, T74SD
 169815169815JN670212PINA  L10V, T12S, I15V, E35D, M36I, R41K, R57K, D60E, Q61D, L63AD
 170719170719JN670232PINAI54V, V82A, L90ML33IL10I, I13V, K14R, K20M, E35D, M36I, N37D, R41K, Q61N, L63P, A71T, I72TD
 171752171752JN670267PINAD30NN88DL10V, I13V, I15IV, E35D, M36I, N37D, R41K, K45R, R57K, Q61N, L63P, V75I, I93LD
 171784171784JN670271PINAI54IV, V82A, L90ML33LFL10V, I13V, K20KR, E35D, M36I, R41K, R57K, Q61D, I62V, L63PT, A71V, I72T, T74S, I93LD
 171988171988JN670278PINA  L10I, E35D, M36I, R41K, R57K, D60E, Q61N, L63S, I72T, I93LD
 172708172708JN670297PINAD30NN88DI13V, I15V, E35D, M36I, R41K, R57K, Q61N, L63P, A71T, I72TD
 172862172862JN670305PINAM46L, I54V, V82A, L90ML33FL10V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62IV, L63P, I64L, A71V, Q92K, I93LD
 173626173626JN670339PINAI54V, V82T, N88S L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71IV, I93LD
 176223176223JN670390PINA  K14KR, E35D, M36IT, R41K, Q61N, L63PD
 176324176324JN670393PINAD30N K20T, E35D, M36I, N37D, K45Q, R57K, D60E, Q61D, L63A, A71V, I93LD
 177131177131JN670427PINA  L10V, T12A, I13V, K14R, G16GE, E35D, M36I, R41K, Q61D, L63T, I64V, I72TD
 177590177590JN670450PINAD30NN88DL10V, I13V, I15V, K20R, E35D, M36I, R41K, Q61D, L63P, V75I, I93LD
 178433178433JN670483PINAM46I, I54V, L76V, V82F, L90MQ58EL10I, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, I64V, A71V, I72V, I93LD
 179481179481JN670511PINA  L10I, Q18E, E35D, M36I, R41K, Q61N, L63T, I72T, I93LD
 179876179876JN670531PINA  L10V, E35D, M36I, R41K, R57K, Q61D, L63P, I93LD
 181706181706JN670581PINA  T12P, K14R, E35D, N37H, R41K, L63P, H69QD
 182041182041JN670597PINAL90M L10V, I13V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, I93LD
 182997182997JN670632PINAL90M L10LV, I13V, L19I, K20T, E35D, M36I, R41K, Q61N, L63P, A71AT, T74S, I93LD
 183878183878JN670662PINA  L10V, G17E, K20M, E35D, M36I, R41K, D60E, Q61N, L63V, E65D, I72ITD
 183927183927JN670665PINAL90M L10V, I13V, K20R, E35D, M36I, N37D, R41K, R57K, Q61DN, I64V, I72T, I93LD
 184334184334JN670676PINAG48V, L90M L10I, L19Q, K20R, E35D, M36I, N37NT, R41K, R57K, D60E, Q61D, I62V, L63P, A71V, I72T, V82I, I85V, I93LD
 184657184657JN670685PINA  I15IV, E35D, M36I, R41K, R57K, Q61ND
 185340185340JN670703PINA  I15V, E35D, M36I, R41K, K43R, R57K, L63TD
 185641185641JN670705PINAI54LV, V82T, L90ML33F, F53FL, T74PSL10I, I13V, K20R, E35D, M36I, N37E, R41K, R57K, Q61N, L63AT, E65D, A71V, I72V, T80TI, L89LM, I93LD
 185997185997JN670710PINAL90M L10I, I13V, K20T, E35D, M36I, R41K, R57RK, D60E, Q61N, I62V, L63T, I64L, C67D, I72T, V82VI, I93LD
 187220187220JN670729PINAM46L, I54V, I84V, L90MG48E, L89VL10I, I13V, K20MT, E35D, M36I, R57K, Q61N, I62V, L63P, C67Y, G68E, H69Y, A71V, Q92K, I93LD
 187443187443JN670732PINAG48A, I54V, V82A, I84VL33F, N83ND, L89VL10I, K14R, K20KR, E35D, M36I, R41K, D60E, L63P, A71V, T91S, Q92QR, I93LD
 187807187807JN670741PINAM46L, I54V, V82A, L90ML33F, K43T, G73SQ7QH, L10V, I13V, K20R, E35D, M36I, L38LS, R41K, I62V, L63P, H69R, A71T, I72T, V77ID
 189796189796JN670781PINAI54V, L90ML23LIL10V, I13V, I15V, L19LV, K20T, E35D, M36I, N37D, R41RK, R57K, D60E, Q61D, I62V, L63P, A71I, T74S, I93LD
 193544193544JN670904PINAI54LK43T, F53FL, G73ST12K, I13V, I15V, K20T, E35D, M36I, N37S, R41K, R57K, Q61D, I62V, L63P, E65ED, H69HY, A71T, I72R, T74S, V77I, I93IMD
 193836193836JN670912PINAM46I, I54V, V82A L10I, I13A, K20R, A22V, E35D, M36I, N37D, K55R, R57K, Q61D, I62V, L63P, A71T, I72T, T74S, N83S, Q92K, I93LD
 194025194025JN670920PINAM46L, I54V, V82A, L90ML33F, K43T, G73SL10I, I13L, Q18E, K20R, E34Q, E35D, M36I, K55R, R57K, Q61N, I62V, L63P, A71V, I72T, I93LD
 194042194042JN670922PINA  I13V, E35D, M36I, R41K, R57K, D60E, Q61ND
 194683194683JN670947PINAM46I, I54V, L76V, V82A, L90M L10V, I15V, K20R, E35D, M36I, R41K, R57K, Q61N, L63P, A71V, I72T, I93LD
 195176195176JN670967PINAI54V, V82A, L90ML33LI, L89LVL10I, I13V, K14R, K20IM, E35D, M36I, N37D, R41K, Q61N, L63P, A71T, I72TD
 195199195199JN670968PINAD30NL33F, N88DL10M, I13V, I15IV, E35D, M36L, R41K, R57K, Q61N, L63A, I93LD
 195598195598JN670988PINAM46I, V82A L10V, E35D, M36I, R41K, R57K, Q61D, L63T, E65D, I72T, V77ID
 195946195946JN671004PINAI54V, V82A L10V, I15V, K20R, E35D, M36I, N37D, R41K, Q61D, L63P, I93LD
 197657197657JN671076PINA  I13V, I15V, E35D, M36I, R41K, R57K, L63LP, I64V, Q92KD
 198096198096JN671100PINAM46L, I54V, V82A, L90MF53L, Q58E, T74PL10I, I15V, G16A, K20R, E35D, M36I, R41K, I62V, L63P, A71V, I85V, I93LD
 198714198714JN671133PINAL90M K20R, E35D, M36I, R41K, R57K, Q61N, L63GD
 199016199016JN671148PINAG48V, I54V, V82A L10I, I15V, K20R, E35D, M36I, R41K, R57K, D60E, Q61E, L63P, I72TD
 200723200723JN671206PINA  L10V, E35D, M36I, R41K, R57K, D60E, Q61D, L63AD
 201210201210JN671216PINAI54V, V82T, I84VL33F, F53LL10I, I15V, K20R, E35D, M36I, N37D, R41K, Q61N, L63S, I64L, A71V, I72T, T74S, I85V, L89M, I93LD
 201750201750JN671235PINA  I13V, E35D, M36I, R41K, K43R, R57K, D60E, Q61D, I62V, L63C, T91VD
 201919201919JN671244PINAI84V, L90MF53LL10I, T12I, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, A71I, I72TD
 202598202598JN671278PINAL90M L10V, I15V, K20T, E35D, M36I, N37ND, R41K, R57K, Q61D, L63P, I72T, I93LD
 202646202646JN671284PINAI54L, L90ML33FL10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63H, T74S, Q92QKD
 202722202722JN671287PINA  I15V, E35D, M36I, R41K, R57RK, Q61D, L63C, I72ITD
 203943203943JN671324PINAV32I, M46I, I54V, V82AL24I, L33F, K43T, F53LL10I, I13V, G16E, K20R, E35D, M36I, N37D, P39PS, R57K, Q61N, L63S, E65D, K70Q, A71V, T74S, V77I, L89TD
 205762205762JN671371PINA  E35D, M36I, R41K, K43R, K55KE, R57K, Q61D, L63P, L89LPD
 207065207065JN671420PINA  I13V, E35D, M36I, R41K, K45R, R57K, D60E, Q61N, L63C, I72T, L89LMD
 207305207305JN671429PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, K20T, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, I64L, C67D, A71V, I72T, I93LD
 207507207507JN671437PINA  I15V, E35D, M36I, R41K, I62V, L63P, H69Y, A71V, I93LD
Reynolds (2012)E0580E0580-2JN652206Unknown, RTV, LPVNA  E35D, R41K, R57K, L63P, I64V, H69Y, I72VD

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