Protease Inhibitors

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Protease Inhibitors

Subtype	D
Gene	PR
Mutation	L33V
Rx	PI-naive
IncludeMixtures	No

References	29
Patients	78
Isolates	81

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Eshleman (2001)	SE638	SE638	AF388105	None		I13V, L33V, R41K, L63Q, I64V	D
	SE470	SE470	AF388084	None		I13V, L33V, N37S, P39S, R41K, D60E, I64V	D
Hierholzer (2002)	SU005	SU005	AY102488	None		L33V, N37T, P39S, R41K, D60E, I64V, H69Y	D
	SU510	SU510	AY102487	None		T12S, I13V, L19I, L33V, N37T, P39S, R41K, L63P, I64V, E65D, H69Y	D
	SU235	SU235	AY102499	None		K14R, L33V, N37T, P39S, R41K, R57K, I64V	D
	SU049	SU049	AY102492	None		I13V, L33V, N37T, P39S, R41K, D60E, L63P, I64V, H69Y	D
Eshleman (2004)	SE638	SE638p	AY435395	None		I13V, L33V, R41K, L63Q, I64V	D
		SE638_7d	AY428708	None		I13V, L33V, R41K, L63Q, I64V, T96P	D
Eshleman (2004)	ESH_Pat107	ESH509	AY435301	None		I13IV, L33V, R41K	D
	ESH_Pat152	ESH98	AY435259	None		I13V, L33V, N37S, P39S, R41K, I64V	D
	ESH_Pat162	ESH525	AY435294	None		I13V, L33V, M36I, R57K, L63LP, I64V, H69Y, I72V	D
Yang (2004)	98KE176	98KE176	AY492760	None		I13V, K14R, L33V, R41K, I64V, H69Q	D
K'Aluoch (2005)	OK_TC023304	TC023304	DQ079828	None		I13V, L33V, P39S, R41K, R57K, D60E, I64V	D
Tovanabutra (2005)	99US_MSC4068	99US_4068	AY444799	None		I13V, L33V, M36I, R41K, I64V, I72V	D
Baker (2007)	A1059	MBA1059-081105	EF186220	None		I13V, L33V, M36I, N37T, P39S, R41K, L63Q, I64V, I72V, V82VI	D
	AR012	MBAR012-140405	EF186224	None		I13V, L33V, R41K, L63A	D
Brumme (2007)	1075	PR_1075	EF368385	None		L33V, N37T, P39S, R41K, Q61HY, L63P, I64V, H69Y	D
	1101	PR_1101	EF368411	None	D30DE	I13IV, L33V, N37NH, P39PS, R41K, I62IV, L63P, H69Y, I72IV	D
	1602	PRRT_1602	EF368912	None		L33V, R41K, L63Q, I64V, H69Y, V77I	D
Church (2007)	098-116868B	098	EF612011	None		I13V, L33V, N37S, P39S, R41K, I64V	D
	470-126987m	470	EF612037	None		I13V, L33V, N37S, P39S, R41K, D60E, I64V	D
	509-128126K	509	EF612050	None		I13V, L33V, R41K	D
	525-128845B	525	EF612057	None		I13V, L33V, M36I, R57K, I64V, H69Y, I72V	D
	770-141405W	770	EF612139	None		T12TA, I13V, K14KR, G16GE, L33V, M36I, R41K, D60DE, I62V, L63C, I64V	D
Galluzzo (2007)	M20490	UG_M20490	JQ220111	None		I13V, L33V, M36L, R41K, I62V, L63S, I64V, E65D	D
Church (2008)	330957-Y	330957-Y	EU380721	None		T12P, I13V, L33V, R41K, I64V, I72L	D
Ndembi (2008)	IAEM057	IAEM057	EU306780	None		I13V, L33V, R41K, L63P, I64M	D
	IAEM074	IAEM074	EU306791	None		I13V, K20R, L33V, R41K, L63S, I64V, E65D	D
Eshleman (2009)	J05347W1	07-156549	FJ389053	None		I13V, L33V, P39S, R41K, I62V, I64V	D
	B20757W3	07-156919	FJ389063	None		I13V, L33V, R41K, I62V, L63P, I64V, E65D, K70R	D
	C36303W3	07-156922	FJ389064	None		I13V, L33V, R41K, R57K, L63LQ, I64IV, I72V	D
	H15006W2	07-156959	FJ389078	None		I13V, I15IV, L33V, R41K, I64V	D
	E22831W1	07-156982	FJ389088	None		I13V, K20KR, L33V, N37S, I64V, I72V	D
	F07344W1	07-156991	FJ389094	None		I13V, K14R, L33V, R41K, I64V, E65D, P81PL	D
	H13802B6	08-101500	FJ389106	None		I13V, L33V, R41K, I64V, E65D, H69HY, K70KR	D
	J22380W2	08-101535	FJ389116	None		I13V, L33V, R41K, I64V, H69Y, I72T	D
	G32218W2	08-101573	FJ389126	None		I13V, Q18I, L33V, M36I, I64V, C67CY, I72V	D
	J03096W3	08-101793	FJ389135	None		I13V, L33V, R41K, I64V, K70R	D
	G38250W2	08-102896	FJ389151	None		L33V, R41K, H69Y, I72T	D
Vercauteren (2009)	pt1692	31B1W2XiW5	GQ399332	None		I13V, K20R, L33V, M36I, R41K, I62V, L63S, I64V	D
	pt1373	4WujTWbhKX	GQ399651	None		I13V, K20KR, L33V, R41K, I64V, I72IV	D
	pt684	8994198547	GQ400340	None		G16E, L33V, N37Q, P39S, R41K, R57RK, D60E, L63P, L89F	D
Arruda (2010)	1017	16CE081017	JQ230590	None		I13V, K20R, L33V, M36I, P39PT, R41K, R57RK, I62V, L63P, I64V, E65D	D
Djoko (2010)	682	CD4059	FR666682	None		I13V, L33V, R41K, L63P, H69Q	D
Hamers (2010)	300425	CP076300425	HM119849	None		I13V, L19LI, L33V, R41KN, D60E, I62IV, L63P, V75I	D
Ndembi (2010)	14039D_P1	14039	GQ409563	None		I13V, L33V, M36I, R41K, I64V, K70R	D
	14318D_P1	14318	GQ409566	None		I13V, L33V, M36MI, R41K, L63Q, I64V, E65D	D
	16343D_P1	16343	GQ409584	None		L10I, I13V, L33V, R41K, I62V, L63I, I64V, I72T	D
	16496D_P1	16496	GQ409586	None		I13V, L33V, R41K, I64V	D
	16666D_P1	16666	GQ409587	None		I13V, K14R, L33V, R41K, L63P, I64V	D
Towler (2010)	366925-C	366925-C	HM037861	None		I13V, K14R, L33V, R41K, I64V, E65D	D
	413094-D	413094-D	HM037872	None		L10LI, I13V, L33V, R41K, L63PS, I64V, C67CY	D
Hamers (2011)	CP076301557	CP076301557	HQ993599	None		I13V, L19V, L33V, M36I, N37T, R41K, L63P, I72V	D
	CP076301572	CP076301572	HQ993612	None		I13V, L33V, M36L, R41K, R57K, D60E, I62V, I64V, K70KR	D
	CP076304267	CP076304267	HQ993955	None		L33V, M36MI, P39A, D60E, L63P, I64V, H69Y	D
	CP076300886	CP076300886	HQ994966	None		I13V, L33V, P39S, R41K, R57K, I62V, L63A, I64V, E65D	D
	CP076300894	CP076300894	HQ994969	None	Q58E	I13V, L33V, M36I, P39Q, R41K, I62IV, L63Q, I64V, E65D, I72V	D
	CP076301791	CP076301791	HQ994973	None		I13V, I15L, L33V, M36I, R41K, I64V	D
	CP076301803	CP076301803	HQ994977	None		I13V, I15L, L33V, M36I, R41K, I64V	D
	CP076300820	CP076300820	HQ995107	None		L19I, L33V, R41K, L63I, H69Y	D
	CP076300896	CP076300896	HQ995142	None		L10V, I15L, L33V, L63Q, I64V	D
	CP076303045	CP076303045	HQ995229	None		L10I, I13V, L33V, P39Q, R41K, I64V	D
	CP076303115	CP076303115	HQ995291	None		I13IV, L33V, M36MI, R41K, L63P, K70R	D
	CP076303132	CP076303132	HQ995304	None		I13V, L33V, N37S, R41K, I62V, L63P, I64L	D
Kasang (2011)	22121	22121	HM572339	None		L33V, R41K, D60E, I64V, I72T	D
	32645	32645	HM572363	None		L33V, N37C, R41K, I64V, K70E	D
Hassan (2012)	RS09000955	RS09000955	HQ441695	None	V11I	L33V, R41K, D60E, L63P, C67S, H69HY, K70KR	D
	RS11000246	RS11000246	JQ698346	None		I13V, K14R, L19I, L33V, M36I, R41K, I64V	D
	RS11000261	RS11000261	JQ698358	None		I13V, L33V, M36I, R41K, L63P, I64V, H69Y	D
	RS11000282	RS11000282	JQ698372	None		I13V, L33V, P39T, R41K, L63R, I64V, K70I, I72T	D
Karlsson (2012)	SE_107	SE_107	JQ698741	None		I13V, K20KR, L33V, R41K, I64V, I72IV	D
Nazziwa (2012)	3036401	3036401	JX498975	None		I13V, L33V, M36I, R41K, L63Q, I64V, E65D	D
	3037102	3037102	JX498991	None		I13V, G17E, K20R, L33V, R41K, I64V	D
Reynolds (2012)	D0397	D0397-0	JN652146	None		I13V, L33V, R41K, K43KR, R57K, L63S, I64V, E65D	D
		D0397-1	JN652179	None		I13V, L33V, R41K, R57K, L63S, I64V, E65D	D
Ssemwanga (2012)	RCC_TDR_480133	RCC_TDR_480133	JQ266023	None		I13V, K20R, L33V, N37T, R41K, I64V, E65D	D
	RCC_TDR_190330	RCC_TDR_190330	JQ266027	None		I13V, K20R, L33V, N37T, R41K, I64V, E65D	D
	RCC_TDR-820974	RCC_TDR-820974	JQ266083	None	Q58E	I13V, K14R, L33V, R41K, I64V, E65D	D
Yang (2012)	KN-39	KN-39	JQ616934	None		T12S, I13V, L33V, P39T, R41K, D60E, I62V, L63P, H69Y	D
Frentz (2013)	EHR-43863	EHR-43863	JX300279	None		L10I, L33V, M36MI, N37X, P39Q, R41RK, L63P, I93L	D
	EHR-45609	EHR-45609	JX300299	None		I13V, L33V, N37NS, R41K, L63HQ, I64V	D

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