<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L33V
Rx PI-naive
IncludeMixtures No
References 44
Patients 113
Isolates 116
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Eshleman (2001)SE638SE638AF388105None   I13V, L33V, R41K, L63Q, I64VD
 SE470SE470AF388084None   I13V, L33V, N37S, P39S, R41K, D60E, I64VD
Hierholzer (2002)SU005SU005AY102488None   L33V, N37T, P39S, R41K, D60E, I64V, H69YD
 SU510SU510AY102487None   T12S, I13V, L19I, L33V, N37T, P39S, R41K, L63P, I64V, E65D, H69YD
 SU235SU235AY102499None   K14R, L33V, N37T, P39S, R41K, R57K, I64VD
 SU049SU049AY102492None   I13V, L33V, N37T, P39S, R41K, D60E, L63P, I64V, H69YD
Eshleman (2004)SE638SE638pAY435395None   I13V, L33V, R41K, L63Q, I64VD
  SE638_7dAY428708None   I13V, L33V, R41K, L63Q, I64V, T96PD
Eshleman (2004)ESH_Pat107ESH509AY435301None   I13IV, L33V, R41KD
 ESH_Pat152ESH98AY435259None   I13V, L33V, N37S, P39S, R41K, I64VD
 ESH_Pat162ESH525AY435294None   I13V, L33V, M36I, R57K, L63LP, I64V, H69Y, I72VD
Yang (2004)98KE17698KE176AY492760None   I13V, K14R, L33V, R41K, I64V, H69QD
K'Aluoch (2005)OK_TC023304TC023304DQ079828None   I13V, L33V, P39S, R41K, R57K, D60E, I64VD
Tovanabutra (2005)99US_MSC406899US_4068AY444799None   I13V, L33V, M36I, R41K, I64V, I72VD
Baker (2007)A1059MBA1059-081105EF186220None   I13V, L33V, M36I, N37T, P39S, R41K, L63Q, I64V, I72V, V82VID
 AR012MBAR012-140405EF186224None   I13V, L33V, R41K, L63AD
Brumme (2007)1075PR_1075EF368385None   L33V, N37T, P39S, R41K, Q61HY, L63P, I64V, H69YD
 1101PR_1101EF368411None  D30DEI13IV, L33V, N37NH, P39PS, R41K, I62IV, L63P, H69Y, I72IVD
 1602PRRT_1602EF368912None   L33V, R41K, L63Q, I64V, H69Y, V77ID
Church (2007)098-116868B098EF612011None   I13V, L33V, N37S, P39S, R41K, I64VD
 470-126987m470EF612037None   I13V, L33V, N37S, P39S, R41K, D60E, I64VD
 509-128126K509EF612050None   I13V, L33V, R41KD
 525-128845B525EF612057None   I13V, L33V, M36I, R57K, I64V, H69Y, I72VD
 770-141405W770EF612139None   T12TA, I13V, K14KR, G16GE, L33V, M36I, R41K, D60DE, I62V, L63C, I64VD
Galluzzo (2007)M20490UG_M20490JQ220111None   I13V, L33V, M36L, R41K, I62V, L63S, I64V, E65DD
Church (2008)330957-Y330957-YEU380721None   T12P, I13V, L33V, R41K, I64V, I72LD
Ndembi (2008)IAEM057IAEM057EU306780None   I13V, L33V, R41K, L63P, I64MD
 IAEM074IAEM074EU306791None   I13V, K20R, L33V, R41K, L63S, I64V, E65DD
Eshleman (2009)J05347W107-156549FJ389053None   I13V, L33V, P39S, R41K, I62V, I64VD
 B20757W307-156919FJ389063None   I13V, L33V, R41K, I62V, L63P, I64V, E65D, K70RD
 C36303W307-156922FJ389064None   I13V, L33V, R41K, R57K, L63LQ, I64IV, I72VD
 H15006W207-156959FJ389078None   I13V, I15IV, L33V, R41K, I64VD
 E22831W107-156982FJ389088None   I13V, K20KR, L33V, N37S, I64V, I72VD
 F07344W107-156991FJ389094None   I13V, K14R, L33V, R41K, I64V, E65D, P81PLD
 H13802B608-101500FJ389106None   I13V, L33V, R41K, I64V, E65D, H69HY, K70KRD
 J22380W208-101535FJ389116None   I13V, L33V, R41K, I64V, H69Y, I72TD
 G32218W208-101573FJ389126None   I13V, Q18I, L33V, M36I, I64V, C67CY, I72VD
 J03096W308-101793FJ389135None   I13V, L33V, R41K, I64V, K70RD
 G38250W208-102896FJ389151None   L33V, R41K, H69Y, I72TD
Vercauteren (2009)pt169231B1W2XiW5GQ399332None   I13V, K20R, L33V, M36I, R41K, I62V, L63S, I64VD
 pt13734WujTWbhKXGQ399651None   I13V, K20KR, L33V, R41K, I64V, I72IVD
 pt6848994198547GQ400340None   G16E, L33V, N37Q, P39S, R41K, R57RK, D60E, L63P, L89FD
Arruda (2010)101716CE081017JQ230590None   I13V, K20R, L33V, M36I, P39PT, R41K, R57RK, I62V, L63P, I64V, E65DD
Djoko (2010)682CD4059FR666682None   I13V, L33V, R41K, L63P, H69QD
Ndembi (2010)14039D_P114039GQ409563None   I13V, L33V, M36I, R41K, I64V, K70RD
 14318D_P114318GQ409566None   I13V, L33V, M36MI, R41K, L63Q, I64V, E65DD
 16343D_P116343GQ409584None   L10I, I13V, L33V, R41K, I62V, L63I, I64V, I72TD
 16496D_P116496GQ409586None   I13V, L33V, R41K, I64VD
 16666D_P116666GQ409587None   I13V, K14R, L33V, R41K, L63P, I64VD
Towler (2010)366925-C366925-CHM037861None   I13V, K14R, L33V, R41K, I64V, E65DD
 413094-D413094-DHM037872None   L10LI, I13V, L33V, R41K, L63PS, I64V, C67CYD
Hamers (2011)300425CP076300425HM119849None   I13V, L19LI, L33V, R41KN, D60E, I62IV, L63P, V75ID
 CP076301557CP076301557HQ993599None   I13V, L19V, L33V, M36I, N37T, R41K, L63P, I72VD
 CP076301572CP076301572HQ993612None   I13V, L33V, M36L, R41K, R57K, D60E, I62V, I64V, K70KRD
 CP076304267CP076304267HQ993955None   L33V, M36MI, P39A, D60E, L63P, I64V, H69YD
 CP076300886CP076300886HQ994966None   I13V, L33V, P39S, R41K, R57K, I62V, L63A, I64V, E65DD
 CP076300894CP076300894HQ994969None  Q58EI13V, L33V, M36I, P39Q, R41K, I62IV, L63Q, I64V, E65D, I72VD
 CP076301791CP076301791HQ994973None   I13V, I15L, L33V, M36I, R41K, I64VD
 CP076301803CP076301803HQ994977None   I13V, I15L, L33V, M36I, R41K, I64VD
 CP076300820CP076300820HQ995107None   L19I, L33V, R41K, L63I, H69YD
 CP076300896CP076300896HQ995142None   L10V, I15L, L33V, L63Q, I64VD
 CP076303045CP076303045HQ995229None   L10I, I13V, L33V, P39Q, R41K, I64VD
 CP076303115CP076303115HQ995291None   I13IV, L33V, M36MI, R41K, L63P, K70RD
 CP076303132CP076303132HQ995304None   I13V, L33V, N37S, R41K, I62V, L63P, I64LD
Kasang (2011)2212122121HM572339None   L33V, R41K, D60E, I64V, I72TD
 3264532645HM572363None   L33V, N37C, R41K, I64V, K70ED
Yang (2011)KN-39KN-39JQ616934None   T12S, I13V, L33V, P39T, R41K, D60E, I62V, L63P, H69YD
Karlsson (2012)SE_107SE_107JQ698741None   I13V, K20KR, L33V, R41K, I64V, I72IVD
Nazziwa (2012)30364013036401JX498975None   I13V, L33V, M36I, R41K, L63Q, I64V, E65DD
 30371023037102JX498991None   I13V, G17E, K20R, L33V, R41K, I64VD
Ndase (2012)5000686250006862KC900810None   I13V, L19V, L33V, R41K, G52GS, L63LV, I64V, E65DD
 5006028250060282KC900638None   I13V, L33V, M36I, R41K, I64V, E65D, K70KRD
 5406673254066732KC900805None   I13V, L33V, N37T, P39S, R41RK, K43R, I64V, H69HYD
 5500426255004262KC900762None   K14R, L33V, M36I, R41K, R57K, D60E, L63E, I64V, E65DD
Reynolds (2012)D0397D0397-0JN652146None   I13V, L33V, R41K, K43KR, R57K, L63S, I64V, E65DD
  D0397-1JN652179None   I13V, L33V, R41K, R57K, L63S, I64V, E65DD
Ssemwanga (2012)RCC_TDR_480133RCC_TDR_480133JQ266023None   I13V, K20R, L33V, N37T, R41K, I64V, E65DD
 RCC_TDR_190330RCC_TDR_190330JQ266027None   I13V, K20R, L33V, N37T, R41K, I64V, E65DD
 RCC_TDR-820974RCC_TDR-820974JQ266083None  Q58EI13V, K14R, L33V, R41K, I64V, E65DD
Frentz (2013)EHR-43863EHR-43863JX300279None   L10I, L33V, M36MI, N37X, P39Q, R41RK, L63P, I93LD
 EHR-45609EHR-45609JX300299None   I13V, L33V, N37NS, R41K, L63HQ, I64VD
Grgic (2013)cro463cro463HE653280None   I13V, L33V, N37NS, R41K, L63HQ, I64VD
Hassan (2013)RS09000955RS09000955HQ441695None  V11IL33V, R41K, D60E, L63P, C67S, H69HY, K70KRD
 RS11000246RS11000246JQ698346None   I13V, K14R, L19I, L33V, M36I, R41K, I64VD
 RS11000261RS11000261JQ698358None   I13V, L33V, M36I, R41K, L63P, I64V, H69YD
 RS11000282RS11000282JQ698372None   I13V, L33V, P39T, R41K, L63R, I64V, K70I, I72TD
Nzeyimana (2013)102_1137102_1137HG780835None   I13V, L33V, R41K, I64V, V75I, V82ID
Hassan (2014)RS11000383RS11_383KC568504None   I13V, K14R, L19I, L33V, M36I, R41K, I64VD
Lee (2014)MBA1505MBA1505KJ907181None   I13V, K14R, L33V, R41K, I64VD
 MBA1504MBA1504KJ907180None   I13V, L33V, R41K, R57K, I64VD
 MBA1015MBA1015KJ906720None   L10LI, I13V, G16E, L33V, M36I, N37S, P39S, R41K, I62V, L63HKNQ, I64V, H69HY, I72TD
 MBA1112MBA1112KJ906812None   I13V, L33V, M36I, R41K, K45R, L63Q, I64V, E65DD
 MBA1379MBA1379KJ907065None   T12TA, I13V, K14KR, L33V, R41RK, I64V, H69HY, I72IATVD
 MBA1296MBA1296KJ906986None  Q58EI13V, L19LQ, L33V, R41K, I64VD
 MBA1283MBA1283KJ906974None   L10V, I13V, K14KR, L33V, R41K, L63Q, I64VD
 MBA1244MBA1244KJ906938None   I13V, L33V, M36I, R41K, L63LP, I64V, E65D, I72IVD
 MBA1006MBA1006KJ906711None  V11VIR8RQ, L10IV, I13IV, L19LI, L33V, R41K, R57K, L63L*Q, I64V, H69Y, K70KR, I72TD
 MBA1118MBA1118KJ906816None   I13V, L33V, M36I, R41K, K45R, L63Q, I64V, E65DD
 MBA1454MBA1454KJ907133None   L10V, L33V, N37T, R41K, L63S, I64IVD
 MBA1204MBA1204KJ906901None   I13IV, L33V, N37S, R41K, L63V, I64V, E65DD
 MBA1364MBA1364KJ907050None  Q58EL10LI, I13V, K20KT, L33V, M36I, P39S, R41K, I62IV, I64V, H69HYD
 MBA1341MBA1341KJ907027None   L33V, M36MI, R41AT, L63Q, I64V, T74QD
Loubet (2014)LILX011401LILX011401KJ467975None   I13V, L33V, M36MI, P39S, R41K, R57K, D60E, I62IV, L63P, I64V, H69Y, I72T, V82VID
Niculescu (2014)DU3890DU3890KJ194732None   L10V, T12TS, I13IV, L19Q, L33V, M36I, R41K, L63S, I64V, E65D, V82ID
Parczewski (2014)562_2562_2JQ305757None   I13V, L33V, N37S, P39S, R41K, L63HPSY, I64V, T91AD
 A018_1A018_1KM284505None   I13IV, L33V, N37S, P39S, R41K, L63P, I64VD
Hora (2015)DEMD08UG001DEMD08UG001KC596072None   I13V, L33V, R41K, L63T, I64V, E65D, H69Y, I72VD
Meini (2015)109274109274KM438251None   L10I, I13V, L33V, P39S, R41K, I64V, H69YD
Sutherland (2015)1919_PREKT351821None   I13V, L33V, R41K, R57K, Q61E, L63P, E65DD
Ndahimana (2016)14201420KU922787None   I13V, Q18QH, L33V, M36I, R41K, K45R, R57K, L63Q, I64V, E65DD
Otecko (2016)407781407781KX306413None   L33V, R41K, I64V, H69Y, V75ID
Reynolds (2016)H061873R16H061873R16KX944678None   I13V, L33V, R41K, I64V, I72VD
Zeh (2016)0500460_040500460_04KU248647None   L33V, R41K, K45R, I64V, H69Y, I72MD
Onywera (2017)06017020601702KX791002None   I13V, L33V, M36I, R41K, D60E, I62V, L63P, I64VD
 02602020260202KX790997None   L10I, I13V, L33V, M36I, R41K, L63I, I64V, H69QD
 13305011330501KX791029None   I13V, L33V, N37S, R41KD