<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L33F
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 79
Isolates 80
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gomez-Carrillo (2004)113381113381AY365875PINAI54L, V82A, L90ML33F, K43T, F53LT12M, I13V, I15V, Q18H, K20R, E35D, M36I, N37DE, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71I, I72LD
Non-B Workgroup (2005)TK3006TK3006 RTV157I54IV, V82F, L90ML33FI13V, I15V, R41K, I62IV, I64GVD
  TK3006a RTV, NFV194I54V, V82F, L90ML33FI13V, I15V, R41K, I64VD
 TK3023TK3023 RTV221I54V, V82AL33FI13V, L19T, K20R, E35ED, M36I, R41K, L63V, I64VD
Baxter (2006)48-12121212-30812DQ877754PINAM46L, I54V, V82AL24I, L33FL10V, I15V, E35D, M36I, N37ND, R41K, I62V, L63PD
von Wyl (2007)310371422EF449968RTV, PINAM46I, I54V, L76V, V82ML24I, L33FL10V, I13V, K20R, E35D, M36I, N37DE, K55R, R57K, D60E, I62V, L63P, V75I, L89M, T91SD
Cardoso (2009)3117BRGO3117FJ638454PINAM46I, I54V, L76V, V82A, L90ML33FL10V, I13V, I15V, K20R, E35D, M36I, K55R, R57K, D60E, I62V, L63P, A71V, I72V, I93LD
Dau (2010)09705A09705AGU581977PINAM46L, I54V, V82AT, I84V, L90ML33F, F53L, L89VL10I, I13V, I15V, K20T, E35D, M36I, N37D, K55R, D60E, I62V, L63P, I66F, K70E, A71V, Q92KD
 13578A13578AGU582074PINAV32I, M46I, I54V, L76V, I84V, L90ML10F, L33F, K43TI13V, K20R, E35D, M36I, R41RK, K55KR, D60E, L63P, I64V, L89ID
Aulicino (2011)ARL636VSQARL636VSQFJ525813PINAM46I, I47V, I54V, V82AL24I, L33F, K43T, F53L, Q58EL10V, G16A, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71V, I93LD
 ARM522BCEARM522BCEFJ525832PINAM46I, I50V, I54V, V82A, L90ML23I, L33F, K43T, F53L, T74PL10I, I13V, K20R, E35N, M36I, K55R, R57K, Q61N, I62V, L63P, L89ID
 ARN397RLRARN397RLRFJ525859PINAM46L, I54L, V82T, I84VL24I, L33F, K43TE35D, M36I, N37E, R41K, R57K, D60N, Q61N, L63T, I64L, A71I, I72T, L89M, I93LD
Jones (2012)133389133389JN669521PINAI54L, I84VL33FL10I, K14R, E35D, M36I, R41K, D60E, L63P, A71V, I93LD
 157949157949JN669903PINAM46MI, I54V, L76LV, V82F, L90ML33FL10I, I13V, K20IT, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, I64L, C67D, A71AV, I72IT, I93LD
 159279159279JN669946PINAI47V, I54V, V82A, L90ML33F, G48W, F53L, Q58EL10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, C67E, A71V, I93LD
 166308166308JN670124PINAM46I, I54V, V82TL33F, L76IL10V, T12Q, I13V, I15V, L19I, K20KR, E35D, M36IL, R41K, K55R, R57K, Q61N, L63P, I64V, A71V, T74SD
 172862172862JN670305PINAM46L, I54V, V82A, L90ML33FL10V, K20R, E35D, M36I, N37D, R41K, R57K, Q61N, I62IV, L63P, I64L, A71V, Q92K, I93LD
 185641185641JN670705PINAI54LV, V82T, L90ML33F, F53FL, T74PSL10I, I13V, K20R, E35D, M36I, N37E, R41K, R57K, Q61N, L63AT, E65D, A71V, I72V, T80TI, L89LM, I93LD
 187443187443JN670732PINAG48A, I54V, V82A, I84VL33F, N83ND, L89VL10I, K14R, K20KR, E35D, M36I, R41K, D60E, L63P, A71V, T91S, Q92QR, I93LD
 187807187807JN670741PINAM46L, I54V, V82A, L90ML33F, K43T, G73SQ7QH, L10V, I13V, K20R, E35D, M36I, L38LS, R41K, I62V, L63P, H69R, A71T, I72T, V77ID
 194025194025JN670920PINAM46L, I54V, V82A, L90ML33F, K43T, G73SL10I, I13L, Q18E, K20R, E34Q, E35D, M36I, K55R, R57K, Q61N, I62V, L63P, A71V, I72T, I93LD
 195199195199JN670968PINAD30NL33F, N88DL10M, I13V, I15IV, E35D, M36L, R41K, R57K, Q61N, L63A, I93LD
 200084200084JN671190PINAM46I, I54IV, I84V, L90ML33F, K43KT, T74PL10I, I13V, K20KR, M36I, R41RK, K55KR, I62V, L63P, H69K, K70KT, A71V, T91SD
 201210201210JN671216PINAI54V, V82T, I84VL33F, F53LL10I, I15V, K20R, E35D, M36I, N37D, R41K, Q61N, L63S, I64L, A71V, I72T, T74S, I85V, L89M, I93LD
 202646202646JN671284PINAI54L, L90ML33FL10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63H, T74S, Q92QKD
 203943203943JN671324PINAV32I, M46I, I54V, V82AL24I, L33F, K43T, F53LL10I, I13V, G16E, K20R, E35D, M36I, N37D, P39PS, R57K, Q61N, L63S, E65D, K70Q, A71V, T74S, V77I, L89TD
 207305207305JN671429PINAM46I, I54V, L76V, V82F, L90ML33FL10I, I13V, K20T, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, I64L, C67D, A71V, I72T, I93LD
Kouri (2012)CU1373-09CU1373-09JQ585294PINAV32I, M46L, L76V, V82AL10F, L33F, L89VI13V, K20R, M36I, N37D, R41K, K43R, Q61N, L63P, A71V, Q92KD
 CU373-10CU373-10JQ585388PINAM46I, I54V, L76V, V82AL24I, L33FL10I, I13V, K20R, E35D, M36I, N37D, R41K, D60E, I62V, L63P, A71V, I93LD
 CU845-09CU845-09JQ585267PINA L33F, I50IS, N88DM36I, R41K, D60E, I62V, L63P, H69Q, A71TD
 CU691-09CU691-09JQ585261PINAD30N, V32I, M46I, I47V, I54L, V82AL10LF, L33F, F53FL, Q58E, N88DI13V, I15V, L19I, K20R, E35D, M36L, N37T, R41T, K45R, D60E, L63P, H69Q, K70R, I72V, V77I, L89FD
 CU25-10CU25-10JQ585358PINAM46L, I54V, V82A, L90ML33F, K43T, F53L, G73SL10V, I13V, L19LI, K20R, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71I, I93LD
 CU263-10CU263-10JQ585374PINAV32I, I54M, I84VV11I, L33F, F53FLQ2L, L5LF, L10V, I13V, K14E, I15V, G17D, K20R, E35D, M36I, R41K, K45R, R57K, D60E, Q61N, L63P, I64V, A71V, T74E, V82ID
 CU772-10CU772-10JQ585416PINAM46L, I54AV, V82AL33F, T74AP, N83NDL10I, I13V, I15IV, G16E, K20R, E35D, M36I, N37D, R41K, R57K, L63T, E65D, L89MD
 CU90-10CU90-10JQ585361PINAI50V, I54L, L90ML10F, L33F, K43T, F53L, L89VQ2P, L5F, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37G, R41K, D60E, L63P, H69HY, A71IV, V77I, V82I, I93ILD
 CU1209-09CU1209-09JQ585279PINAM46L, I54M, V82AL10F, L24I, L33F, Q58EI13V, K20R, M36I, R41K, K43KR, I62V, L63P, E65ED, A71VD
 CU1959-09CU1959-09JQ585326PINAM46L, I54L, V82T, L90ML33F, T74PL10I, I13V, E35D, M36I, R41K, K43R, K55R, L63P, H69Q, A71V, I93LD
 CU311-10CU311-10JQ585381PINAI50V, I54L, L90ML33F, K43T, F53L, L89VV11L, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37D, R41K, D60E, L63P, H69Y, A71I, V77I, V82ID
Diaz (2015)RenG17129RenG17129KT748157PINAM46I, I54V, V82A, L90ML33F, K43T, F53L, G73SL10V, L19I, K20R, E35D, M36I, R41K, K55R, R57RK, I62V, L63P, C67L, H69Q, A71V, I72LD
 RenG15889RenG15889KT746917PINAM46I, I54V, L76V, V82AL10F, L24I, L33FI13V, K20R, M36I, N37D, R41K, K55R, R57K, Q61N, L63P, I72V, L89ID
 RenG17468RenG17468KT748496PINAM46I, I54V, V82A, N88SL24I, L33F, Q58EL10I, I13V, I15V, K20T, E35G, M36I, R41K, K55KR, D60E, I62V, L63P, A71TD
 RenG17123RenG17123KT748151PINAM46I, I54A, V82A, L90ML33FL10V, V11L, G16A, L19V, K20R, E35DN, M36I, N37E, R41K, R57K, Q61D, I62IV, L63P, I64L, A71I, I72IT, I93LD
 RenG17301RenG17301KT748329PINAI50LV32A, L33F, Q58EL10V, I13V, L19I, K20T, E34N, E35D, M36I, L63P, I64IL, A71V, I72T, V77IL, I93LD
 RenG16766RenG16766KT747794PINAV32I, M46I, I54L, I84V, L90ML10F, V11I, L33F, G73T, L89VI13V, K20M, M36I, I62V, L63P, I66V, A71T, I72V, C95ID
 RenG17021RenG17021KT748049PINAV32I, I47V, I50V, I54L, V82ML33F, K43T, T74PL10I, I13V, I15V, G16E, K20R, E35D, M36I, N37S, R57K, Q61N, L63T, E65D, I72V, L89FD
 RenG15716RenG15716KT746744PINAI50V, I54V, V82AL33FL10V, I13V, G16A, L19I, K20R, M36I, N37D, L63P, A71T, I72V, L89I, L97F, N98KD
 RenG16023RenG16023KT747051PINAV32I, M46L, I47V, I50L, V82A, I84VL33F, Q58ET12N, I13V, I15V, K20R, E35D, M36I, N37E, Q61QH, L63T, I64V, A71V, I72V, G78GV, R87RI, L89MD
 RenG16876RenG16876KT747904PINAI50L, V82AL33FI13V, K20KT, E35D, M36I, R41K, L63A, A71V, T91SD
 RenG17358RenG17358KT748386PINAM46L, I50V, I54IV, V82VAL33F, Q58EL10V, I13IV, I15V, L19I, K20R, E35D, M36I, R41K, K55R, R57K, I62V, L63P, T74S, L89MD
 RenG17289RenG17289KT748317PINAD30N, M46I, I54IV, V82A, L90ML10F, L33F, F53FL, N88DI13V, R41K, I62V, L63P, H69Y, A71T, I72T, V77ID
 RenG17344RenG17344KT748372PINAM46I, I54V, L76V, V82A, L90ML33FL10V, T12I, I13V, G16E, K20R, E35D, M36I, N37T, R41K, R57K, D60E, Q61D, I62V, I72R, L89ID
 RenG14787RenG14787KT745815PINAM46I, I47IV, I54V, V82AL10F, L33F, N88DI13V, I15V, E35D, M36I, N37ND, R57K, Q61N, L63P, I64LD
 RenG14273RenG14273KT745301PINAI50L, V82AL33F, K43KT, G73SL10V, I13V, I15V, K20M, E35G, M36I, R41K, K55KN, R57K, D60E, Q61N, I62V, L63P, A71AITV, I93LD
 RenG14584RenG14584KT745612PINAI54L, V82A, L90MV11I, L33F, K43T, F53L, G73SI13V, I15V, G16GCW, L19V, K20R, E21G, L24F, E35D, M36I, N37T, R41K, K55R, R57K, D60E, Q61H, I62V, L63P, A71V, I72FD
 RenG14846RenG14846KT745874PINAM46L, I54V, V82A, L90ML33FL10V, I15V, G16E, K20M, E35N, M36I, L38LF, R41K, K55R, R57K, Q61D, I62V, L63C, I64IL, E65ED, A71V, I72IT, T74S, T91A, I93LD
 RenG13694RenG13694KT744722PINAV32I, I47V, G48V, I54V, V82A, L90ML33F, F53L, Q58E, L89VL10I, I13V, K14E, I15V, K20R, E34Q, E35D, M36I, N37D, R41K, K55R, V56I, R57K, D60E, I62V, L63P, A71V, I85V, Q92KD
 RenG13605RenG13605KT744633PINAI50L, V82A, L90ML33F, F53L, Q58E, T74PSL10V, T12E, I13V, K14R, I15V, G16E, K20T, E35D, M36I, P39T, R41K, I62V, L63T, I64V, H69K, A71L, V77VL, I93LD
 RenG13674RenG13674KT744702PINAV82A, L90ML33F, K43T, G73SL10V, I13V, I15V, L19I, K20T, E35D, M36I, R41K, L63P, A71V, T74S, V77I, I93LD
 RenG14586RenG14586KT745614PINAI54V, V82A, L90ML33F, F53LL10V, I13V, K20R, L24F, E35D, M36I, N37E, R41K, K55R, R57K, D60E, I62V, L63P, A71I, I93LD
 RenG15072RenG15072KT746100PINAM46L, I54V, L76V, V82A, L90ML33F, Q58EL10V, I13V, K14R, G16E, K20R, E35D, M36I, N37E, P39S, R41RK, K55R, R57K, D60DE, Q61N, I62V, L63T, I64V, K70KT, V77ID
 RenG13639RenG13639KT744667PINAM46ML, I50L, V82AL33F, K43TT12A, I13V, K14R, I15V, E35D, M36I, R41K, R57K, L63P, I64VD
 RenG12366RenG12366KT743394PINAM46I, I54V, V82AL24I, L33F, Q58EL10V, I13V, K20R, M36I, R41K, K55R, R57K, Q61N, L63P, A71T, I72T, T91SD
 RenG13532RenG13532KT744560PINAD30N, M46L, I54IV, V82A, L90ML33F, F53L, N88DL10V, T12Q, I13V, I15V, G16GE, K20R, E35D, M36I, R41K, K55KN, Q61N, L63S, I93ILD
 RenG12108RenG12108KT743136PINAM46L, I54V, L76V, V82AL33FL10V, K20KR, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, I64L, A71V, I93LD
 RenG12299RenG12299KT743327PINAM46I, I54V, V82AL24I, L33F, F53L, T74PP9PR, L10I, T12TA, I13V, I15V, K20M, E35D, M36I, N37D, R41K, K45I, K55R, I62V, L63E, I64IV, E65D, L89MD
 RenG12305RenG12305KT743333PINAM46L, I54V, V82AL24I, L33F, K43TL10V, I15V, K20R, E35D, M36I, R41K, I62V, L63PD
 RenG12639RenG12639KT743667PINAV32I, M46I, I47V, I54M, V82A, L90ML33F, F53L, T74TPL10I, I13V, G16GE, K20R, E34A, E35D, M36I, R41K, K45KR, K55KR, R57K, Q61N, L63S, C67E, I72V, V77VID
 RenG12915RenG12915KT743943PINAM46I, I50L, V82AL33F, F53LK20R, E34N, E35D, M36I, R41K, K55R, R57K, Q61D, L63P, E65D, A71TD
 RenG12984RenG12984KT744012PINAM46I, I54V, V82A, I84V, L90ML33F, K43T, G73TL10V, L19V, K20R, E35D, M36I, R41N, D60E, Q61D, I62V, L63P, H69Y, A71T, I72TD
 RenG13073RenG13073KT744101PINAD30N, I50L, V82AL33F, N88DL10I, I13V, K20R, E35D, M36I, N37E, K45I, I62IV, L63T, I64V, A71AITV, T74S, I93LD
 RenG12340RenG12340KT743368PINAM46L, I50L, V82VA, N88SL33FL10V, I13V, I15IV, G16E, K20R, E35D, M36I, N37S, P39P*QS, R41K, K45R, R57K, Q61N, L63S, I64IV, I72TD
 RenG13236RenG13236KT744264PINAM46I, V82A, N88GSL33F, Q58EL10V, I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71T, I72TD
 RenG12819RenG12819KT743847PINAI54V, V82S, L90ML33F, F53LQ7D, L10I, I13V, K20T, E34N, E35D, M36I, N37NT, R41K, I62V, L63AP, I64L, A71M, I72V, T74S, V77L, I93LD
 RenG13053RenG13053KT744081PINAV32I, M46L, G48GV, I50IL, V82A, L90ML33F, G73GS, L89VL10I, I13V, L19I, L24LF, E34EQ, E35ED, M36I, N37S, R41K, K55HQ, I62IV, L63A, I64L, A71VD
 RenG13259RenG13259KT744287PINAI54V, V82A, L90ML33F, F53L, G73GAL10V, I13V, K20R, L24F, E35D, M36I, N37E, R41K, K55R, R57K, D60E, I62V, L63P, A71I, I93LD
 RenG10704RenG10704KT741732PINAM46I, I50V, V82AL33FL10V, K14R, I15V, Q18E, L19I, E35D, M36I, R41K, I62V, L63P, L89FD
 RenG10136RenG10136KT741164PINAD30N, I50V, I54V, V82A, L90LML33F, N88DL10V, I13V, K20R, E35D, M36I, N37E, R41Y, K45Q, R57K, Q61N, L63ST, E65D, A71L, L89LM, I93LD
 RenG10617RenG10617KT741645PINAV32I, M46I, I47V, I54V, V82A, L90MV11I, L33F, G73S, L89VL10V, I13V, I15V, L19P, K20R, M36I, N37D, K55R, R57K, I62V, L63P, I64L, A71V, I72VD
 RenG11215RenG11215KT742243PINAM46L, I54V, V82F, I84V, L90ML33F, Q58EL10IV, I15V, K20KR, E35N, M36IV, N37E, R41K, R57RK, I62V, I64V, A71V, I93LD
 RenG11573RenG11573KT742601PINAM46I, I50L, V82AL33F, F53LK20R, E34N, E35D, M36I, R41K, K55R, R57K, Q61D, L63P, E65D, A71TD