<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation K20R
Rx PI-naive
IncludeMixtures No
References 54
Patients 171
Isolates 173
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Cornelissen (1997)92UG03892UG038AF009400None   G16E, K20R, M36I, R41K, H69Y, I72VD
Becker-Pergola (2000)42.877BPG42-877AF216996None   K14R, K20R, N37D, R41K, D60E, I64V, C67S, H69Y, V77ID
Eshleman (2001)SE607SE607AF388099None   I13V, K20R, M36I, R41K, I64V, I93ILD
Eshleman (2001)A028AF357631AF357631None   K20R, M36I, R41K, R57K, L63M, I64V, H69YD
Cuevas (2002)CU94CU94AF425475None   K20R, E35D, M36I, R41K, K43R, L63P, H69QD
 CU67CU67AF425448None   I13V, K20R, M36I, N37D, R41K, K43R, L63P, H69QD
 CU61CU61AF425442None  T74PK20R, E35D, M36I, N37D, R41K, K43R, D60E, Q61E, L63P, H69QD
 CU40CU40AF425421None   I13V, K20R, M36I, R41K, K43R, Q61E, L63P, H69QD
 CU8CU8AF425389None   K20R, E35D, M36I, N37D, R41K, K43R, L63P, H69Q, V77ID
Dowling (2002)NKU3006NKU3006AF457090None   I13V, K20R, M36I, N37D, R41K, I64V, E65D, K70RD
Eshleman (2002)148154f148154fAF410250None   I13V, K20R, M36I, R41K, I62V, L63P, I64LD
Fonjungo (2002)CM184CM184AF406716None   G16E, K20R, M36I, R41K, I62V, L63N, I72T, I93LD
Hierholzer (2002)SU273SU273AY102511None   K20R, R41K, Q61H, L63LP, I64IV, H69HYD
Eshleman (2004)ESH_Pat36ESH404AY425349None   G16E, K20R, M36I, P39S, R41K, H69HYD
Eshleman (2004) SE404_7dAY428684None   G16E, K20R, M36I, P39S, R41K, H69HYD
Eshleman (2004)ESH_Pat64ESH410AY435266None   I13V, G16E, K20R, M36I, P39T, R41K, L63C, I64VD
 ESH_Pat67ESH418AY425352None   I13V, K20R, M36I, R41K, I64VD
 ESH_Pat75ESH66AY435235None   I13V, K20R, M36I, R41K, H69K, L89MD
Eshleman (2004) SE66_7dAY428674None   I13V, K20R, M36I, R41K, H69K, L89MD
Eshleman (2004)ESH_Pat96ESH647AY435325None   L10V, I13V, K20R, M36I, R41K, I64V, E65D, I72VD
 ESH_Pat143ESH519AY435299None   I13V, K20R, M36L, N37A, R41K, Q61H, I64VD
Eshleman (2004)99_23799_237AY444270None   I13V, K20R, M36I, R41K, I62IV, I64VD
Grossman (2004)17745Pr11517745Pr115AY529625None   G16E, K20R, M36I, P39S, R41K, D60E, I62V, L63PD
Grossman (2005)1714517145PR424 None   G16E, K20R, M36I, P39S, R41K, D60E, I62V, L63PD
K'Aluoch (2005)OK_TC021104TC021104DQ079838None   T12P, I13V, L19I, K20R, M36I, R41RK, K45KN, Q61E, I64IV, C67W, H69Y, I72V, V77VID
 OK_TC008303TC008303DQ079851None   I13IV, K20R, M36I, R41K, I62V, I64VD
 OK_TC007103TC007103DQ079855None   I13V, K20R, M36I, R41K, R57K, L63P, I64V, H69Y, I72VD
 OK_TC006803TC006803DQ079856None   K20R, M36I, R41K, I62V, I64V, E65D, I72VD
 OK_TC005903TC005903DQ079858None  L33II13V, K20R, N37Q, R41K, I64VD
Non-B Workgroup (2005)UK1446UK1446AY900802None   K20R, M36I, R41K, I62V, I64V, I72VD
 UK4834UK4834 None   I13V, K20R, M36I, R41K, L63P, I64V, H69Y, I72V, V77ID
 UK4684UK4684AY901208None   L10V, I13V, K20R, M36I, N37D, R41K, D60E, I64VD
Rodrigues (2006)BR04RS195BR04RS195DQ070596None   K14T, I15V, L19Q, K20R, M36I, N37K, R41E, R57K, D60Y, Q61N, I62V, L63SD
Vidal (2006)NV_KIST13202.KIST132AM041030None   I13V, K20R, M36I, R41K, I62V, L63P, C67Y, K70RD
 NV_KSFE14102.KSFE141AM040994None   I13V, K20R, M36I, R41K, I64VD
 NV_KSS00602.KSS006AM041047None   T4S, I13V, L19I, K20R, E35D, N37D, D60E, L63P, I72V, V77ID
 NV_KTB24202.KTB242AM040997None   I15V, G16E, K20R, E35D, M36I, R41K, K45R, L63A, H69K, L89M, I93LD
 NV_LBS03802.LBS038AM041035None   K20R, M36I, R41K, Q61E, L89MD
Baker (2007)P0169P0169-300505EF186144None   T12K, I15V, L19Q, K20R, M36I, R41K, L63S, V77ID
 P0285P0285-070905EF186149None   I13V, K20R, M36I, R41K, L63Q, I64VD
 A1040MBA1040-190905EF186213None   I13V, K20R, M36I, P39T, R41K, L63P, A71V, I93LD
 A1043MBA1043-200905EF186214None  I47IMI13V, K20R, M36I, R41K, I64V, E65ED, I72IVD
 A1044MBA1044-200905EF186215None   I13V, K20R, M36I, R41K, I64V, E65DD
Church (2007)418-124277n418EF612023None   I13V, K20R, M36I, R41K, I64V, K70KRD
 519-128295D519EF612055None   I13V, K20R, M36L, N37A, R41K, Q61H, I64VD
 586-131433R586EF612076None   I13IV, K20R, M36I, R41K, I64V, I93ILD
 647-135041K647EF612093None   L10V, I13V, K20R, M36I, R41K, L63LIRS, I64V, E65D, I72VD
Galluzzo (2007)M21740UG_M21740JQ220089None   K20R, M36I, R41K, I62V, L63T, I64V, E65D, H69Y, I72EVD
 M20610UG_M20610JQ220115None  L33LFW6G, I13V, K20R, E35ED, M36IL, N37H, R41K, I62V, L63Q, I64V, H69QD
Ndembi (2008)CMYD-5604CMYD-56DQ990421None   L10V, I13V, G17D, K20R, E35D, M36I, R41K, L63T, H69QD
Ndembi (2008)IAEM035IAEM035EU306766None   I13V, K20R, M36I, R41K, D60E, Q61E, I62V, I64V, V75ID
 IAEM066IAEM066EU306785None   I13V, K20R, M36I, N37S, R41K, R57K, L63Q, I64V, E65DD
 IAEM068IAEM068EU306787None   I13V, K20R, M36I, R41K, I64VD
 IAEM074IAEM074EU306791None   I13V, K20R, L33V, R41K, L63S, I64V, E65DD
Nyombi (2008)TBK061TBK061EU251752None   I13V, K20R, M36I, R41K, I64VD
 TMS132TMS132EU251830None   I13V, K20R, M36I, R41K, R57RK, D60DE, I62V, L63LHQ, I64VD
 TMS213TMS213EU251848None   I13V, G16E, K20R, M36I, P39T, R41K, D60E, I62V, I64VD
Somi (2008)BG-05-580BG-05-580JQ616948None   K20R, M36I, R41K, L63K, I64V, E65D, K70E, I72V, N98NHILD
Aghokeng (2009)HU_0137HU_0137GU191676None   I15V, K20R, M36I, N37ND, R41K, L63A, I64L, I72IT, V75ID
Bartolo (2009)CSE11601AOCSE116EU068199None   L10V, I13V, K14T, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MD
 HAB8501AOHAB85EU068218None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, H69S, L89MD
 HJM11401AOHJM114EU068252None   I13V, K20R, M36I, N37D, R41K, I64VD
Eshleman (2009)D08444W307-156544FJ389051None   L10V, I13V, K20R, M36I, R41K, L63T, I64V, E65D, I72VD
 G49070R907-156545FJ389052None   I13V, K20R, M36I, R41K, L63Q, I64V, E65DD
 E40578W107-156559FJ389054None   I13V, K20R, M36I, R41K, I62V, L63Q, I64V, E65DD
 K13668W307-156999FJ389101None   I13V, G16E, K20R, M36I, R41K, D60E, Q61E, I62V, I64V, I72KD
 H13658W208-101499FJ389105None   I13IV, K20R, E35K, M36I, N37D, R41K, I64VD
 H20818W208-101503FJ389107None   I13V, K14R, K20R, M36I, N37D, R41K, A71TD
 K31818R908-101584FJ389131None   T12A, I13V, K20R, M36I, R41K, I62V, L63S, I64VD
Hawkins (2009)Q234ZZQ234FJ931225None   I15V, K20R, E35D, M36I, R41K, R57RKD
 R61ZZR61FJ931300None   I13V, K20R, M36I, R41K, I62V, L63A, I64V, E65DD
Koyalta (2009)71TCHAD-71FJ688202None   K20R, E35D, M36I, R41K, L63AD
 74TCHAD-74FJ688204None  Q58ET4S, K14R, I15V, K20R, E35D, M36I, R41K, L89MD
 85TCHAD-85FJ688209None  Q58ET4S, K14R, I15V, K20R, E35D, M36I, R41K, L89MD
Vercauteren (2009)pt169231B1W2XiW5GQ399332None   I13V, K20R, L33V, M36I, R41K, I62V, L63S, I64VD
Arruda (2010)101716CE081017JQ230590None   I13V, K20R, L33V, M36I, P39PT, R41K, R57RK, I62V, L63P, I64V, E65DD
Ndembi (2010)13734D_P113734GQ409557None   I13V, G16E, K20R, M36I, P39T, R41K, D60E, I62V, L63P, I64V, I72VD
 14901D_P114901GQ409571None   I13V, K14KR, K20R, M36I, R41K, I62V, I64V, H69Y, I72TD
 15730D_P115730GQ409578None   L19Q, K20R, M36I, N37D, R41K, L63T, I64V, E65DD
 17235D_P117235GQ409592None   I13V, K20R, M36I, R41K, D60E, I62V, I64VD
 DT3479_05_P13479GQ409616None   I13V, K20R, M36I, N37D, R41K, R57K, Q61E, I64V, E65DD
Towler (2010)439553-X439553-XHM037830None   L10V, I13V, G16E, K20R, M36I, P39S, R41K, I62V, L63P, I72VD
 408513-V408513-VHM037871None   I13V, G16E, K20R, M36I, P39T, R41K, I64VD
 436029-H436029-HHM037878None   I13V, K20R, M36I, R41K, I64V, H69Y, I72VD
Yang (2010)20106934442010693444JQ616884None   I13V, G17D, K20R, M36I, R41K, I62IV, L63X, I64IMD
Aghokeng (2011)SK9016-M18SK9016-M18HQ864355None   I13V, Q18QH, L19LM, K20R, M36I, R41K, K45KR, L63AD
Florea (2011)105_2008105_2008JQ083016None   L10V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, L63T, E65D, I72T, T74S, L89MD
 1121_20071121_2007JQ083024None   L10V, T12S, I13V, I15V, G16E, L19I, K20R, E35D, M36I, R57K, L63T, E65D, I72T, L89MD
 1649_20071649_2007JQ083031None   L10V, G16E, K20R, E35D, M36I, R41K, R57K, I62V, L63T, L89MD
 2360_20082360_2008JQ083043None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89MD
 3004_20073004_2007JQ083048None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
 4638_20084638_2008JQ083062None   L10V, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MD
 4646_20074646_2007JQ083068None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, P39T, R41K, L63T, E65D, I72T, L89MD
 4887_20074887_2007JQ083075None   L10V, I13V, I15IV, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
Fokam (2011)CIRCB-8995CIRCB-8995JQ796156None   I15IV, K20R, M36I, R41K, L63AV, K70KR, I72IMD
Hamers (2011)CP076301767CP076301767HQ993753None   I13V, K20R, E35G, M36I, N37D, R41K, I64V, E65DD
 CP076301771CP076301771HQ993757None   I13V, K20R, M36I, R41K, I62IV, L63LP, I64V, H69HY, I72VD
 CP076302206CP076302206HQ993810None   I13V, G16E, K20R, M36I, R41K, I72VD
 CP076304217CP076304217HQ993913None   I13V, K20R, M36I, R41K, L63A, I64V, I72IVD
 CP076304259CP076304259HQ993947None   Q18H, K20R, M36I, R41K, I62V, L63S, I64V, E65D, I72V, I85VD
 CP076303180CP076303180HQ994196None   K14G, I15V, K20R, M36I, R41K, I62V, L63V, E65D, H69K, I72V, T74S, L89MD
 CP076301867CP076301867HQ995002None  Q58EI13V, K20R, M36I, N37D, R41K, R57K, L63V, I64VD
 CP076302065CP076302065HQ995028None   I13V, K20R, M36I, R41K, L63PQ, I64V, E65DD
 CP076302071CP076302071HQ995031None   I13V, K20R, M36I, R41K, I64VD
 CP076302939CP076302939HQ995041None   K14R, L19Q, K20R, M36I, R41K, I64VD
 CP076303000CP076303000HQ995068None   K20R, R41K, L63Q, I64V, E65DD
 CP076303007CP076303007HQ995072None   L10V, I13V, G16E, K20R, M36I, P39S, R41K, I64V, K70KRD
 CP076300884CP076300884HQ995136None   I13V, K14KR, K20R, M36I, R41K, H69Y, I72VD
 CP076301848CP076301848HQ995170None   I13V, G16E, K20R, M36I, P39S, R41K, I64V, K70KRD
 CP076302024CP076302024HQ995193None   L10V, I13V, K20R, E35D, M36I, L63P, H69QD
 CP076302027CP076302027HQ995194None   I13V, K20R, M36I, N37NT, R41K, R57K, L63P, I64V, H69Y, I72VD
 CP076302031CP076302031HQ995196None   I13V, G16E, K20R, M36I, R41K, R57K, I64V, H69YD
 CP076302057CP076302057HQ995205None   I13V, K20R, M36I, R41K, I64VD
 CP076300733CP076300733HQ995322None   I13V, K20R, R41K, D60E, L63P, I64V, H69Y, I72T, V77ID
 CP076301886CP076301886HQ995365None   I13V, G16E, K20R, M36I, R41K, I62V, L63H, I64V, E65DD
 CP076301898CP076301898HQ995377None   I13V, K20R, M36I, R41K, I62V, L63T, I64V, E65D, I72VD
 CP076301909CP076301909HQ995384None   I13V, K20R, M36I, R41K, I64V, I72IVD
 CP076302895CP076302895HQ995468None   I15V, G16E, K20R, M36I, R41K, L63T, E65D, I72TD
Kasang (2011)1718217182HM572343None   K14KR, K20R, E35D, M36I, N37D, L63LPS, I64IV, H69Q, I72VD
 20242024HM572357None   I13V, K20R, M36I, R41K, I62V, L63T, I64IV, E65DD
 3265032650HM572361None   T12TA, I13V, K14KR, K20R, M36I, N37D, R41K, L63C, I64V, H69YD
Avila-Rios (2012)B000M90TS9B000M90TS9KC168115None   T12S, I13V, G16E, L19V, K20R, M36I, R57K, L63S, I64V, E65D, I72VD
 V000MO2NT7V000MO2NT7KC169690None   K20R, E35D, M36I, R41K, Q61H, I62V, L63LPD
 E000M_4KSGE000M_4KSGKC168516None   I13V, K20R, M36I, R57K, L63APS, I64IV, E65ED, H69R, K70TD
Chen (2012)YN09DH0104YN09DH0104JQ658567None   I15V, L19I, K20R, M36V, R41K, I62V, L63P, I93LD
Delwart (2012)480-0722-4480-0722-4JN214951None   I15V, G16E, K20R, M36I, N37K, R41K, Q61E, I62V, L63T, E65D, I72T, V82ID
Gaspareto (2012)PAR4PAR4PTHM752149None   K14T, I15V, K20R, M36I, R41K, R57K, Q61D, E65DD
Hassan (2012)RS09000909RS09000909HQ441654None   I13V, K20R, R41K, L63P, H69Y, V77ID
 RS09000921RS09000921HQ441665None   I13V, K20R, M36I, N37D, R41K, I64VD
Machado (2012)CUPL0904CUPL0904HQ655337None   K20R, E35D, M36I, N37S, R41K, K43R, Q61N, L63S, H69QD
 CUPL0925CUPL0925HQ655358None   K20R, M36I, R41K, K43R, D60E, I62V, L63P, H69QD
 CUPL0941CUPL0941HQ655374None   T12P, L19I, K20R, E35D, M36I, R41K, L63P, H69Q, K70E, A71T, I93LD
 CUPL1030CUPL1030HQ655407None   K20R, E35D, M36I, N37S, R41K, L63P, H69HQD
 CUPL1132CUPL1132JX194211None   K20R, E35D, M36I, N37D, R41K, K43R, G49E, G51E, Q61E, L63P, H69QD
 CUPL1138CUPL1138JX194217None   K20R, E35D, M36I, N37D, R41K, R57K, L63T, E65D, H69R, I72MD
Nazziwa (2012)31111303111130JX498980None   I13V, K20R, M36I, N37T, R41K, I62V, L63P, I64VD
 31537013153701JX498981None   I13V, K20R, M36I, N37D, R41K, L63Q, I64V, E65D, I72VD
 31118013111801JX498984None   I13V, K20R, M36I, N37K, R41K, I64V, K70RD
 30371023037102JX498991None   I13V, G17E, K20R, L33V, R41K, I64VD
Reynolds (2012)F0406F0406-1JN652189None   I13V, K20R, M36I, R41K, I64VD
 F0701F0701-1JN652190None   I13V, K20R, M36I, R41KD
Sigaloff (2012)KEKSN411KEKSN411JN628476None   I13V, G17E, K20R, M36I, R41KD
Ssemwanga (2012)RCC_TDR_356892RCC_TDR_356892JQ266020None   I13V, K20R, M36I, R41K, I64VD
 RCC_TDR_480133RCC_TDR_480133JQ266023None   I13V, K20R, L33V, N37T, R41K, I64V, E65DD
 RCC_TDR_190330RCC_TDR_190330JQ266027None   I13V, K20R, L33V, N37T, R41K, I64V, E65DD
 RCC_TDR_482987RCC_TDR_482987JQ266042None   I13V, K20R, M36I, R41K, I64VD
 RCC_TDR_483644RCC_TDR_483644JQ266043None   G16E, K20R, M36I, P39S, R41K, L63Q, I64V, H69Y, K70KRD
 RCC_TDR_483451RCC_TDR_483451JQ266048None   I13V, K20R, M36I, R41K, L63Q, I64V, E65D, V75ID
 RCC_TDR_483771RCC_TDR_483771JQ266051None   I13V, K20R, M36I, R41K, I64VD
 RCC_TDR_480013RCC_TDR_480013JQ266064None   G16E, K20R, M36I, P39L, R41K, L63Q, I64VD
 RCC_TDR_483555RCC_TDR_483555JQ266068None   G16E, K20R, M36I, P39S, R41K, L63Q, I64VD
 RCC_TDR_480146RCC_TDR_480146JQ266072None   I13V, K20R, M36I, R41K, H69KD
 RCC-TDR-359889RCC-TDR-359889JQ266073None   I13V, K20R, M36I, R41K, W42W*, G51GE, L63A, I64VD
 RCC_TDR_356261RCC_TDR_356261JQ266080None   I13V, K20R, M36I, R41K, H69KD
Ssemwanga (2012)3981HR3981HRJF800200None   I13V, K20R, E35D, M36I, R41N, I62V, I64V, H69YD
 7177HR7177HRJF800219None   I13V, K20R, M36I, N37D, R41K, L63P, I64V, E65D, K70R, I72VD
 2910HR2910HRJF800222None   K20R, M36I, R41K, L63V, E65D, I72VD
Alencar (2013)SP2-0018SP2-0018JQ238044None   T4H, I13V, K14KR, K20R, M36I, R41KD
Frentz (2013)EHR-00912EHR-00912JX299555None   L10V, I13V, I15IV, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
 EHR-20296EHR-20296JX299872None   L10V, I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, T74S, L89MD
 EHR-25339EHR-25339JX299981None   L10V, G16E, K20R, E35D, M36I, R41K, R57K, I62V, L63T, L89MD
 EHR-27129EHR-27129JX300011None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, L89MD
 EHR-42835EHR-42835JX300262None   G16E, K20R, M36I, R41K, Q61E, I64V, H69Y, I72R, V77ID
 EHR-49656EHR-49656JX300366None   T12N, I15V, L19I, K20R, E35D, M36I, R41K, R57K, L63T, I72T, T74S, L89MD
 EHR-64659EHR-64659JX300626None   L10V, I15V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, L63T, E65D, I72T, T74S, L89MD
 EHR-71598EHR-71598JX300747None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, P39T, R41K, L63T, E65D, I72T, L89MD
Temereanca (2013)SR16SR16JX966491None   L10V, I13V, G16E, K20R, E35D, M36I, P39S, R41K, R57K, L63T, E65D, I72T, L89MD
 SR25SR25JX966502None   I15V, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, L89M, T96ND
 SR30SR30JX966507None   L10V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, I72T, I93VD
 SR42SR42JX966518None   L10V, I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63N, L89M, Q92KD
 SR5SR5JX966523None   K14Q, I15V, K20R, T26S, E35D, M36I, R41K, R57K, L63T, E65D, I66V, I72V, L89MD
 SR60SR60JX966527None   L10V, I13V, I15V, G16E, K20R, M36I, R41K, R57K, L63T, E65D, T74S, V82I, L89MD
 SR65SR65JX966531None   L10V, I13V, I15V, G16E, K20R, E35D, M36I, R41K, K43R, R57K, L63T, E65D, I72TD

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