<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation K20R
Rx >= 1 PI
IncludeMixtures No
References 13
Patients 56
Isolates 57
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Weber (2003)2SIRIS2S-48AY140810SQV, RTV52  I13V, K20R, R41K, R57RK, L63P, I64L, H69Q, I72VD
Gomez-Carrillo (2004)104461104461AY365704PINAV82L, L90M I15V, L19I, K20R, E35D, M36I, I62V, L63P, H69Q, I72CD
Non-B Workgroup (2005)TK3023TK3023 RTV221I54V, V82AL33FI13V, L19T, K20R, E35ED, M36I, R41K, L63V, I64VD
 TK4014TK4014 SQV, RTV, NFV98  T12TP, I13V, I15IV, K20R, M36MI, R41K, L63H, I64V, I72IV, V77ID
Baxter (2006)12-17561756-30527DQ876870PINAI54V, V82A, L90MK43T, G73SL10I, I15V, K20R, E35D, M36I, I62V, L63P, H69R, A71VD
 12-11931193-30305DQ876960PINAI54A, V82AL33F, I47IK, N83DL10I, I13V, K20R, M36L, R41N, K45I, D60E, I62V, L63P, I64VD
 48-22442244-30722DQ877883PINAV32I, M46I, I54V, V82A, L90MK43T, G73TL10V, I15V, K20R, M36I, R41N, K55R, D60E, L63P, H69HR, K70R, A71V, I93L, C95VD
 48-30583058-30401DQ877970PINAI54L, V82A, L90ML33F, K43KTL10I, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, T74S, L89M, I93LD
 48-61576157-30704DQ878733PINAG48A, I54V, V82A, I84V, L90ML33F, Q58E, G73GS, L89LVT4S, L10I, K20R, E35D, M36L, R57RK, I62V, L63P, A71V, I72ILM, Q92KD
 48-61816181-30721DQ878753PINAG48M, I50V, I54A, V82A L10I, L19I, K20R, M36I, N37D, I62V, L63P, I64M, A71V, I72V, Q92KD
 48-63726372-30930DQ878882PINAI54V, V82A, L90M L10V, I15V, K20R, M36I, R41K, I62V, L63P, A71V, I93LD
 48-71347134-30729DQ878972PINAV32I, M46L, V82A, L90MK43T, L89VI13V, K20R, M36I, I62V, L63P, A71VD
Waleria-Aleixo (2008)08PR06072008PR060720FJ591542PINAI54V, V82TL24I, F53LL10V, I13V, K20R, E35D, M36V, N37T, R41K, R57K, I62V, L63P, I64V, A71V, T74SD
 08PR05026608PR050266FJ591295PINAI50L T12Q, K14T, I15V, K20R, E35D, M36I, R41K, R57K, A71VD
 08PR05023208PR050232FJ591261PINAI54L, V82A, L90ML33F, K43T, F53LL10V, I13V, I15IV, K20R, E35D, M36I, R41K, I62V, L63P, H69K, A71I, T74S, I93IMD
Charpentier (2010)T076006T076006HQ717826PI, DRV, RTVNAG48M, I54T, V82A, L90ML33F, Q58EL10I, T12M, I13V, G16E, K20R, E35D, M36I, R41K, L63T, E65D, I72T, T74A, L89MD
Jones (2012)163239163239JN670057PINAM46I, V82T, I84VL10FT12K, I13V, G16E, L19P, K20R, M36I, L63T, I64V, E65D, I72T, T74SD
 178433178433JN670483PINAM46I, I54V, L76V, V82F, L90MQ58EL10I, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, I64V, A71V, I72V, I93LD
 196487196487JN671026PINAM46I, I54V, L76V, V82AQ58EL10V, I15V, L19LI, K20R, M36I, R41K, D60DE, I62V, L63LP, I64IV, L89MD
Kouri (2012)CU1373-09CU1373-09JQ585294PINAV32I, M46L, L76V, V82AL10F, L33F, L89VI13V, K20R, M36I, N37D, R41K, K43R, Q61N, L63P, A71V, Q92KD
 CU373-10CU373-10JQ585388PINAM46I, I54V, L76V, V82AL24I, L33FL10I, I13V, K20R, E35D, M36I, N37D, R41K, D60E, I62V, L63P, A71V, I93LD
 CU345-10CU345-10JQ585387PINAI54IV, V82VA W6G, L10I, K20R, E35D, M36I, R41K, Q61DN, L63P, H69Q, K70T, I93LD
 CU1484-09CU1484-09JQ585298PINA  W6G, I15V, Q18E, K20R, E35D, M36I, R41K, K43R, I62V, L63P, H69QD
 CU691-09CU691-09JQ585261PINAD30N, V32I, M46I, I47V, I54L, V82AL10LF, L33F, F53FL, Q58E, N88DI13V, I15V, L19I, K20R, E35D, M36L, N37T, R41T, K45R, D60E, L63P, H69Q, K70R, I72V, V77I, L89FD
 CU25-10CU25-10JQ585358PINAM46L, I54V, V82A, L90ML33F, K43T, F53L, G73SL10V, I13V, L19LI, K20R, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71I, I93LD
 CU749-09CU749-09JQ585263PINAM46L, I84VN83DL10I, I15V, G16E, K20R, M36I, R41K, D60E, I62IV, L63T, V82I, L89LFD
 CU1497-09CU1497-09JQ585299PINA  I15V, Q18R, K20R, L23K, M36I, R41K, K43N, I62V, L63P, H69Q, I85MD
 CU194-11CU194-11JQ585494PINA  I15V, G16GE, L19LS, K20R, E35D, M36I, N37D, R41K, K43R, D60E, I62V, L63PD
 CU461-09CU461-09JQ585253PINAI54V, L90MG73SL10I, K20R, E35D, M36I, R41K, I62V, L63P, H69Q, A71V, I93LD
 CU1288-09CU1288-09JQ585288PINAV32I, M46L, L76V, V82AL33LF, L89VL10I, I13V, K20R, M36I, N37D, R41K, K43R, Q61N, L63P, A71V, Q92KD
 CU646-09CU646-09JQ585260PINA  Q7L, K20R, E21EK, E35D, M36I, N37D, R41K, K43R, G52GS, Q61EG, L63P, H69QD
 CU1209-09CU1209-09JQ585279PINAM46L, I54M, V82AL10F, L24I, L33F, Q58EI13V, K20R, M36I, R41K, K43KR, I62V, L63P, E65ED, A71VD
 CU2043-09CU2043-09JQ585337PINA  I15V, K20R, E35D, M36I, R41K, K43R, I62V, L63P, H69Q, K70E, A71T, I93LD
Mollan (2012)MK180MK180w68 RTV, ATV19 Q58EL19V, K20R, E35D, M36I, R41K, R57K, D60E, Q61E, L63Q, C67E, H69K, L89MD
Reynolds (2012)J0700J0700-0JN652164LPV   L10LI, I13V, K20R, L33V, M36I, R41K, I64V, H69HY, I72IT, V75ID
  J0700-1JN652200LPV   L10LI, I13V, K20R, L33V, M36I, R41K, I64V, H69HY, I72IT, V75ID
Van Zyl (2013)O4782100KC423617LPV156M46I, I54V, L76LV, V82AQ58EL10V, T12P, I13V, G16GE, K20R, M36I, R41K, Q61QR, I64V, P79PHD
Grossman (2014)17301730KF135000SQV, LPV52  G16E, K20R, M36I, N37K, P39S, R41K, K45R, L63LF, I93IL, L97LID
Diaz (2015)RenG16786RenG16786KT747814PINAI54V, L90MF53L, G73SL10I, K14KE, I15V, K20R, E34EAD, E35D, M36I, R41K, L63P, A71VD
 RenG15645RenG15645KT746673PINAM46I, I54V, I84V, L90ML10F, F53L, T74PI13V, K20R, E35D, M36I, R41K, K55H, R57K, L63P, H69R, A71V, L89I, T91S, Q92KD
 RenG16880RenG16880KT747908PINAM46L, I54V, V82ML24I, F53LL10V, T12P, K20R, E35D, M36I, N37Q, R41K, L63P, A71V, V77I, I93LD
 RenG16697RenG16697KT747725PINAM46I, I47V, I54V, V82AF53LW6WG, L10I, I15V, K20R, E35D, M36I, R41K, I62V, L63P, C67SD
 RenG16432RenG16432KT747460PINAI50L, N88SQ58EL10V, G16E, K20R, E35D, M36I, N37T, L63T, E65ED, H69K, A71V, I72T, L89M, I93LD
 RenG15900RenG15900KT746928PINA  L10I, T12S, I15V, K20R, E35D, M36I, R41K, L63TD
 RenG15716RenG15716KT746744PINAI50V, I54V, V82AL33FL10V, I13V, G16A, L19I, K20R, M36I, N37D, L63P, A71T, I72V, L89I, L97F, N98KD
 RenG15698RenG15698KT746726PINAV32I, M46ML, I47A L10I, I13V, K14KIR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, I62V, L63LP, I64L, H69Y, I93LD
 RenG16023RenG16023KT747051PINAV32I, M46L, I47V, I50L, V82A, I84VL33F, Q58ET12N, I13V, I15V, K20R, E35D, M36I, N37E, Q61QH, L63T, I64V, A71V, I72V, G78GV, R87RI, L89MD
 RenG16493RenG16493KT747521PINA  I15V, K20R, M36I, R41K, L63ATD
 RenG13657RenG13657KT744685PINA  W6R, Q7R, L10*, V11C, I15V, K20R, E35D, M36I, R41K, L63T, I72TD
 RenG14366RenG14366KT745394PINA  I15V, G16Q, K20R, E35D, M36I, P39Q, R41K, K45RD
 RenG12426RenG12426KT743454PINAM46I, I54V, V82S, I84VK43T, L89VL10I, I15V, L19IV, K20R, M36I, I62IV, L63P, K70R, A71V, I72M, Q92KD
 RenG12212RenG12212KT743240PINA  L10V, K20R, E35D, M36I, R41K, K45R, I64V, C67SD
 RenG12305RenG12305KT743333PINAM46L, I54V, V82AL24I, L33F, K43TL10V, I15V, K20R, E35D, M36I, R41K, I62V, L63PD
 RenG13355RenG13355KT744383PINAV32I, M46I, I47V, I50L, I54V, V82AL23IL10V, I15V, K20R, E35D, M36I, N37S, R41RK, K43I, K55R, R57K, L63PD
 RenG11659RenG11659KT742687PINAM46L, V82AL24I, Q58EL10V, I15V, L19I, K20R, M36I, R41K, L63P, I64L, H69K, I72V, L89MD
 RenG10085RenG10085KT741113PINA  I15V, K20R, E35D, M36I, R41K, L63T, I72TD
 RenG10617RenG10617KT741645PINAV32I, M46I, I47V, I54V, V82A, L90MV11I, L33F, G73S, L89VL10V, I13V, I15V, L19P, K20R, M36I, N37D, K55R, R57K, I62V, L63P, I64L, A71V, I72VD