<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation I13V
Rx >= 1 PI
IncludeMixtures No
References 26
Patients 102
Isolates 112
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Eshleman (2001)A088AF357774AF357774NFV12 L33IQ7D, I13V, I15IL, L63P, I64V, I72MD
Weidle (2001)PW_UG4391PW_UG4391AF358746RTV43  I13V, I15V, L19I, R41K, I64IL, H69Y, V82ID
Brindeiro (2002)TVSP12TVSP12AY145811RTV55  R8Q, I13V, E35D, M36I, R41K, Q61N, I62V, L63H, H69QD
Cuevas (2002)CU95CU95AF425476IDV   I13V, I15V, K20M, M36I, R41K, L63P, I64L, H69QD
 CU54CU54AF425435SQV, IDV   I13V, E35D, M36I, N37D, R41K, K43R, L63PD
Gibb (2002)DMG8181_w56 NFV55D30NN88DI13V, R41K, L63P, A71T, V77ID
 DMG8989_w21 NFV21  I13V, L33V, N37X, P39PQ, R41K, D60E, L63P, K70KR, N88NKD
 DMG9090_w51 NFV1 L23II13V, K20KR, E35D, M36I, R41K, I64V, E65D, V82VID
Tural (2002)226575226575 IDV, NFV131D30N I13V, E35D, M36I, N37H, R41K, Q58*, I62V, L63PD
Weber (2003)2SIRIS2S-48AY140810SQV, RTV52  I13V, K20R, R41K, R57RK, L63P, I64L, H69Q, I72VD
Montes (2004)MB_patESTU01_ESTU702AJ577887SQV, RTV, NFV, IDV309M46I, I84V, L90MV11I, G73SL10V, I13V, K20I, L33V, I62V, L63PD
 MB_patROD00_ROD734AJ577982IDV82  T12A, I13V, K20I, M36I, R41K, L63PD
Non-B Workgroup (2005)UK1392UK1392AY900799SQV161L90M L10V, I13V, R41K, L63P, I64V, K70R, I72IV, T74SD
 UK1557UK1557AY900679NFV, SQV104D30NN88DL10V, I13V, E35D, M36I, R41K, L63PD
 UK1979UK1979 NFV D30N I13V, I15V, E35D, M36I, R41K, L63PD
 BR8BR8AY900888NFV43D30N L10I, T12I, I13V, I15V, K20T, E35D, M36I, R41K, K45T, L63P, I64IV, I85IVD
 TK1003TK1003 IDV, SQV, RTV100  I13V, I15V, R41K, I62IV, I64V, E65D, V77ID
  TK1003a IDV, SQV, RTV100  I13V, I15V, R41K, I62V, I64V, E65D, V77ID
 TK1011TK1011 IDV2  I13V, L19I, N37S, R41K, D60E, I64VD
  TK1011a IDV, SQV, RTV65  I13V, L19I, N37S, R41K, D60E, L63LP, I64VD
  TK1011b IDV, SQV, RTV95  I13V, L19I, N37S, R41K, D60E, L63LP, I64VD
 TK1024TK1024 IDV, NFV, RTV, LPV234  I13V, K20M, M36I, R41K, K45KR, L63P, I64V, H69HY, I72E, P79PAD
  TK1024a IDV, NFV, RTV, LPV277  I13V, K20M, M36I, R41K, I62IV, L63P, I64V, H69HY, I72E, P79XD
 TK1028TK1028 RTV, IDV, NFV207M46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028a RTV, IDV, NFV231M46I, I54V, V82TL24IP1PS, L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028b RTV, IDV, NFV308M46L, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 TK2001TK2001 SQV, RTV, NFV94M46I, I84VN83DL10I, I13V, A22V, E35G, M36I, I62V, L63P, I64V, A71V, I93LD
  TK2001a SQV, RTV, NFV, LPV97M46MI, I84IVN83NDL10I, I13V, K14KR, A22AV, E35EG, M36I, I62V, L63P, I64V, A71AV, I93ILD
 TK2005TK2005b RTV, IDV, APV, SQV213I54V, V82ATL10LFI13V, I15IV, K20KT, R41K, L63P, I64V, A71AV, T74SD
 TK2016TK2016 IDV, NFV329  I13V, M36I, R41K, I64VD
 TK2025TK2025a IDV, RTV, SQV, LPV347  L10I, I13V, M36I, R41K, D60E, L63T, I64V, I72VD
 TK3006TK3006 RTV157I54IV, V82F, L90ML33FI13V, I15V, R41K, I62IV, I64GVD
  TK3006a RTV, NFV194I54V, V82F, L90ML33FI13V, I15V, R41K, I64VD
 TK3008TK3008 SQV, NFV344I84VN83DL10I, I13V, A22V, M36I, R41K, I62V, L63P, I64V, H69HYD
 TK3011TK3011 SQV, NFV231D30NN88DI13V, I15V, K20T, E35D, M36I, N37NY, R41K, I64V, T74SD
 TK3023TK3023 RTV221I54V, V82AL33FI13V, L19T, K20R, E35ED, M36I, R41K, L63V, I64VD
 TK3037TK3037 RTV196I54V, V82A L10V, T12TA, I13V, K14R, G16A, R41K, K43R, I62V, L63P, A71TD
 TK4014TK4014 SQV, RTV, NFV98  T12TP, I13V, I15IV, K20R, M36MI, R41K, L63H, I64V, I72IV, V77ID
 TK5003TK5003a LPV39  I13V, K14KR, E35D, M36I, R41K, I64V, K70RD
Rhee (2005)CA9792CA34173AY797858LPV79M46I, V82F, I84C L10V, I13V, K20T, R41K, L63P, I64VD
Weber (2005)F75698F75698AY677379NFV39  I13V, R41K, L63Q, I64VD
 F75744F75744AY677393NFV76  I13V, R41K, D60E, L63LP, I64V, H69HY, V77ID
 F63925F63925AY677483SQV97  I13V, L19Q, M36I, R41K, I64V, H69Y, I72VD
Baxter (2006)12-11341134-30326DQ876024PINAV32I, M46I, I47V, I54M, I84V, L90ML10F, L33F, L89VI13V, I15V, K20T, M36I, N37S, R41K, L63P, A71V, G73D, I93LD
 12-22582258-30721DQ876701PINAI54V, V82AL10FI13V, G16E, K20I, E35D, M36I, P39S, R41K, K45A, R57KT, I62V, L63C, I64VD
 12-30773077-30403DQ877151PINAD30NL10F, N88DI13V, K14R, E35D, M36I, R41K, I62IV, L63Q, I64VD
 48-14291429-30424DQ877819PINAM46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 48-14391439-30929DQ877829PINAM46I, I54V, L76LV, V82A, L90ML10FII13V, K20I, E34EK, M36I, R41K, I62V, L63P, I64IV, A71T, L89LI, I93LD
 48-30563056-30318DQ877968PINAM46I, I54V, L76V, V82TL10F, L89VI13V, K20M, M36I, R41K, I62V, L63P, A71V, I72V, I93LD
 48-30833083-30313DQ877992PINAV32I, M46I, I47V, I54V, V82A, L90MK43T, F53L, G73S, L89VL10V, T12I, I13V, G16A, K20I, M36I, K55R, L63P, A71VD
 48-41654165-30410DQ878398PINAM46MI, I54V, V82SL24IL10I, I13V, L19I, K20IM, M36I, R41K, L63P, A71VD
 48-50145014-30514DQ878549PINAM46I, I54V, V82A, L90LML10F, Q58EI13V, K20I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, N83SD
 48-71027102-40225DQ878956PI, RTV, TPV>30M46I, I47A, I84V L10V, I13V, K20T, L33V, M36I, N37C, R57K, L63P, I64VD
 48-71347134-30729DQ878972PINAV32I, M46L, V82A, L90MK43T, L89VI13V, K20R, M36I, I62V, L63P, A71VD
 48-80168016-30826DQ879061PINAM46L, I54LL10F, Q58EI13V, K20T, E35ED, M36I, N37ND, R41K, L63Q, I64VD
Laurent (2006)CK2-8402CM-84AM279448NFV105 L10F, L33I, N88GI13V, E35D, M36I, N37E, R41K, V56A, I62V, L63P, H69Y, A71T, I72TD
von Wyl (2007)2410516511EF449876RTV, PINA  L10V, I13V, E35D, M36I, R41K, I62V, L63H, I64VD
 1285248038EF449884PINAL90ML24IL10I, I13V, E35G, M36I, R41K, I62V, L63P, A71T, T74A, V75ID
Waleria-Aleixo (2008)08PR06072008PR060720FJ591542PINAI54V, V82TL24I, F53LL10V, I13V, K20R, E35D, M36V, N37T, R41K, R57K, I62V, L63P, I64V, A71V, T74SD
 08RJ06047108RJ060471FJ591665PINA  L10V, I13V, E35D, M36I, R41K, L63PD
 08PR06075308PR060753FJ591549PINAV32I, M46MI, I54V, L90ML33I, K43T, F53LL10V, I13V, G16E, L19LI, K20M, E35EG, M36I, L63R, I66F, H69R, A71V, I72IVD
 08PR05023208PR050232FJ591261PINAI54L, V82A, L90ML33F, K43T, F53LL10V, I13V, I15IV, K20R, E35D, M36I, R41K, I62V, L63P, H69K, A71I, T74S, I93IMD
 RES2RES2FJ591822PINAD30N L10I, T12I, I13V, I15V, K20T, E35D, M36I, R41K, K45T, L63P, I64IV, I85IVD
Dau (2010)07059A07059AGU581816PINAM46MI, I54V, V82A, L90LM L10I, I13V, I15V, K20V, M36I, R41K, I62V, L63Q, I64V, E65D, I72V, T74SD
Jones (2012)145636145636JN669661PINA  L10I, I13V, E35D, M36I, R41K, Q61D, L63T, K70F, I72TD
 200084200084JN671190PINAM46I, I54IV, I84V, L90ML33F, K43KT, T74PL10I, I13V, K20KR, M36I, R41RK, K55KR, I62V, L63P, H69K, K70KT, A71V, T91SD
Kouri (2012)CU1373-09CU1373-09JQ585294PINAV32I, M46L, L76V, V82AL10F, L33F, L89VI13V, K20R, M36I, N37D, R41K, K43R, Q61N, L63P, A71V, Q92KD
 CU373-10CU373-10JQ585388PINAM46I, I54V, L76V, V82AL24I, L33FL10I, I13V, K20R, E35D, M36I, N37D, R41K, D60E, I62V, L63P, A71V, I93LD
 CU547-11CU547-11JQ585510PINA  I13V, K14R, M36I, N37D, R41K, K43R, Q61E, L63P, H69QD
 CU691-09CU691-09JQ585261PINAD30N, V32I, M46I, I47V, I54L, V82AL10LF, L33F, F53FL, Q58E, N88DI13V, I15V, L19I, K20R, E35D, M36L, N37T, R41T, K45R, D60E, L63P, H69Q, K70R, I72V, V77I, L89FD
 CU25-10CU25-10JQ585358PINAM46L, I54V, V82A, L90ML33F, K43T, F53L, G73SL10V, I13V, L19LI, K20R, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71I, I93LD
 CU75-11CU75-11JQ585492PINA  I13V, K14R, K20I, E35D, M36I, R41K, I64VD
 CU163-10CU163-10JQ585454PINA  Q2H, L10V, I13V, E35D, M36I, R41K, K45R, R57K, D60E, L63P, H69Q, V77ID
 CU1960-09CU1960-09JQ585327PINAV82VA I13V, K14R, M36I, R41K, R57K, I62V, L63P, I93LD
 CU1288-09CU1288-09JQ585288PINAV32I, M46L, L76V, V82AL33LF, L89VL10I, I13V, K20R, M36I, N37D, R41K, K43R, Q61N, L63P, A71V, Q92KD
 CU90-10CU90-10JQ585361PINAI50V, I54L, L90ML10F, L33F, K43T, F53L, L89VQ2P, L5F, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37G, R41K, D60E, L63P, H69HY, A71IV, V77I, V82I, I93ILD
 CU1483-09CU1483-09JQ585297PINAM46I, L90M I13V, E35D, M36I, R41K, L63P, H69QD
 CU1209-09CU1209-09JQ585279PINAM46L, I54M, V82AL10F, L24I, L33F, Q58EI13V, K20R, M36I, R41K, K43KR, I62V, L63P, E65ED, A71VD
 CU1959-09CU1959-09JQ585326PINAM46L, I54L, V82T, L90ML33F, T74PL10I, I13V, E35D, M36I, R41K, K43R, K55R, L63P, H69Q, A71V, I93LD
 CU54-11CU54-11JQ585475PINA  R8RL, I13V, L19T, R41K, R57K, D60E, Q61E, L63P, V77ID
 CU311-10CU311-10JQ585381PINAI50V, I54L, L90ML33F, K43T, F53L, L89VV11L, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37D, R41K, D60E, L63P, H69Y, A71I, V77I, V82ID
Reynolds (2012)B0715B0715-2JN652205LPV  L33II13V, M36T, P39S, R41K, L63S, I64VD
 G0715G0715-2JN652208LPV   L10V, I13V, R41K, R57K, I64V, T74S, V77ID
 J0594J0594-2JN652209LPV   I13V, M36I, R41K, K45R, I64V, I72VD
 J0700J0700-0JN652164LPV   L10LI, I13V, K20R, L33V, M36I, R41K, I64V, H69HY, I72IT, V75ID
  J0700-1JN652200LPV   L10LI, I13V, K20R, L33V, M36I, R41K, I64V, H69HY, I72IT, V75ID
Alcantara (2013)BRGO4151BRGO4151JN662432LPV   L10V, I13V, G16E, M36I, R41K, L63TD
Inzaule (2013)317317JQ914083NFV   I13V, I15V, M36I, R41K, I62V, L63S, I64V, E65DD
Van Zyl (2013)O8501190KC422951LPV26  I13V, I15V, K20M, E35D, M36I, R41K, I64VD
  1779KC423400LPV78  I13V, I15V, K20M, E35D, M36I, R41K, I64VD
 O17992567KC423747LPV26  L10I, I13V, G16E, M36I, R41K, L63Q, I64V, E65D, H69CD
 O4782100KC423617LPV156M46I, I54V, L76LV, V82AQ58EL10V, T12P, I13V, G16GE, K20R, M36I, R41K, Q61QR, I64V, P79PHD
de Lourdes Teixeira (2015)9RJ1103029RJ110302 PINA  I13V, K20KT, E35D, M36I, R41K, L63PD
 9RJ1204419RJ120441 PINA  I13V, E35D, R57K, Q61N, L63SD
Diaz (2015)RenG15645RenG15645KT746673PINAM46I, I54V, I84V, L90ML10F, F53L, T74PI13V, K20R, E35D, M36I, R41K, K55H, R57K, L63P, H69R, A71V, L89I, T91S, Q92KD
 RenG15698RenG15698KT746726PINAV32I, M46ML, I47A L10I, I13V, K14KIR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, I62V, L63LP, I64L, H69Y, I93LD
 RenG17128RenG17128KT748156PINAM46I, I50V, L76V, V82AL23LI, V32A, L33F, Q58ET12K, I13V, I15V, L19V, K20T, E34A, E35D, M36I, N37E, R41K, I62IV, I64V, K70R, V77I, L89LIMD
 RenG16876RenG16876KT747904PINAI50L, V82AL33FI13V, K20KT, E35D, M36I, R41K, L63A, A71V, T91SD
 RenG15911RenG15911KT746939PINAL90MG73GSI13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71AITV, T74SD
 RenG16632RenG16632KT747660PINAD30N, L90LML23I, L33F, F53L, N88DI13V, K14KR, I15V, K20V, E35G, R41K, D60E, L63P, A71I, T74S, V77I, L89I, I93LD
 RenG17154RenG17154KT748182PINAN88NS, L90MF53FL, G73GST12M, I13V, I15V, L19V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, V77VI, Q92KD
 RenG15230RenG15230KT746258PINA  L10V, I13V, K20KT, M36I, N37D, L63LP, I64IVD
 RenG12125RenG12125KT743153PINA  T12AS, I13V, M36I, N37S, R41K, R57K, L63PD
 RenG13236RenG13236KT744264PINAM46I, V82A, N88GSL33F, Q58EL10V, I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71T, I72TD
 RenG12819RenG12819KT743847PINAI54V, V82S, L90ML33F, F53LQ7D, L10I, I13V, K20T, E34N, E35D, M36I, N37NT, R41K, I62V, L63AP, I64L, A71M, I72V, T74S, V77L, I93LD
 RenG12091RenG12091KT743119PINAM46I, I54V, V82A, L90MG73S, L89VL10V, I13V, K20T, L33L_L, M36I, R41K, K55R, I62IV, L63P, I64IL, A71V, I93L, N98ID
 RenG10814RenG10814KT741842PINA  L10V, T12A, I13V, K14R, M36I, R41K, Q61N, L63P, L89MD
 RenG10884RenG10884KT741912PINAD30N, I54V, V82A, L90ML10F, L33F, F53L, N88DI13V, I15V, G17D, L19I, K20T, E35N, M36I, N37E, R41T, K45V, D60E, Q61N, L63P, K70R, V77I, L89FD
 RenG11632RenG11632KT742660PINAG48V, I54S, V82A, L90MQ58EL10I, I13V, L19T, K20I, L33L*, E34Q, E35D, M36I, N37D, D60E, I62V, L63Q, I64V, T74SD
Sutherland (2015)2222_POSTKT351828LPV   I13V, E35D, M36MI, R41K, R57K, L63P, H69Y, I72V, V77VID
 2323_POSTKT351830LPV   I13V, I15IV, M36I, R41K, I64VD
Ndahimana Jd Riedel (2016)21632163KT982499LPV   I13V, I15V, M36I, R41K, D60E, Q61E, I64VD