Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	D
Gene	PR
Mutation	I13V
Rx	>= 1 PI
IncludeMixtures	No

References	21
Patients	202
Isolates	212

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Weidle (2001)	PW_UG4391	PW_UG4391	AF358746	RTV	43			I13V, I15V, L19I, R41K, I64IL, H69Y, V82I	D
Cuevas (2002)	CU95	CU95	AF425476	IDV				I13V, I15V, K20M, M36I, R41K, L63P, I64L, H69Q	D
	CU54	CU54	AF425435	SQV, IDV				I13V, E35D, M36I, N37D, R41K, K43R, L63P	D
Gibb (2002)	DMG81	81_w56		NFV	55	D30N	N88D	I13V, R41K, L63P, A71T, V77I	D
	DMG89	89_w21		NFV	21			I13V, L33V, N37X, P39PQ, R41K, D60E, L63P, K70KR, N88NK	D
	DMG90	90_w51		NFV	1		L23I	I13V, K20KR, E35D, M36I, R41K, I64V, E65D, V82VI	D
Dumans (2004)	268	268	AY390063	SQV, RTV, NFV	239			I13V, K55R, L63P, V77I, T91I, I93L	D
Gomez-Carrillo (2004)	101028	101028	AY365623	PI	NA	I54V, L76V, V82A		L10I, I13V, I15V, K20M, E35D, M36I, R41K, Q61N, L63P, A71V, I72T, L89I, I93L	D
	103136	103136	AY365669	PI	NA	D30N, V82A	N83D, N88D	L10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, Q61N, L63P, A71V	D
	113381	113381	AY365875	PI	NA	I54L, V82A, L90M	L33F, K43T, F53L	T12M, I13V, I15V, Q18H, K20R, E35D, M36I, N37DE, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71I, I72L	D
	118423	118423	AY365949	PI	NA	L90M		L10V, I13V, K14R, K20T, E35D, M36I, N37D, R41K, Q61N, L63P, A71T, I72T, T74S	D
Montes (2004)	MB_patESTU	01_ESTU702	AJ577887	SQV, RTV, NFV, IDV	309	M46I, I84V, L90M	V11I, G73S	L10V, I13V, K20I, L33V, I62V, L63P	D
	MB_patRAM	01_RAM707	AJ577979	Unknown, RTV, IDV	>90	M46L, G48V, I54V, V82T		L10V, I13V, K20I, M36I, R41K, I66F, H69K, K70R, L89M	D
	MB_patDER	02_DER736	AJ577878	NFV	179	D30N	N88D	L10Y, I13V, E35D, M36I, I62V, L63P, I64V, T74S, V77I	D
Non-B Workgroup (2005)	UK1392	UK1392	AY900799	SQV	161	L90M		L10V, I13V, R41K, L63P, I64V, K70R, I72IV, T74S	D
	UK1557	UK1557	AY900679	NFV, SQV	104	D30N	N88D	L10V, I13V, E35D, M36I, R41K, L63P	D
	UK1979	UK1979		NFV		D30N		I13V, I15V, E35D, M36I, R41K, L63P	D
	TK1003	TK1003		IDV, SQV, RTV	100			I13V, I15V, R41K, I62IV, I64V, E65D, V77I	D
		TK1003a		IDV, SQV, RTV	100			I13V, I15V, R41K, I62V, I64V, E65D, V77I	D
	TK1009	TK1009		IDV, NFV, RTV	177	M46ML		I13V, K14KR, E35D, M36I, R41K, K45KR, R57RK, L63P, H69KQ, A71AV, L89T	D
	TK1011	TK1011		IDV	2			I13V, L19I, N37S, R41K, D60E, I64V	D
		TK1011a		IDV, SQV, RTV	65			I13V, L19I, N37S, R41K, D60E, L63LP, I64V	D
		TK1011b		IDV, SQV, RTV	95			I13V, L19I, N37S, R41K, D60E, L63LP, I64V	D
		TK1011c		IDV, SQV, RTV	107			I13V, L19I, N37S, R41K, D60E, L63LP, I64V	D
	TK1014	TK1014		RTV, SQV, NFV, IDV	246	M46I, I84IV	L24LI	L10LV, I13V, K20I, E35D, M36I, R41K, L63P, H69K, T74S, T80TA, V82X, L89IM	D
	TK1024	TK1024		IDV, NFV, RTV, LPV	234			I13V, K20M, M36I, R41K, K45KR, L63P, I64V, H69HY, I72E, P79PA	D
		TK1024a		IDV, NFV, RTV, LPV	277			I13V, K20M, M36I, R41K, I62IV, L63P, I64V, H69HY, I72E, P79X	D
	TK1028	TK1028		RTV, IDV, NFV	207	M46I, I54V, V82T	L24I	L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93L	D
		TK1028a		RTV, IDV, NFV	231	M46I, I54V, V82T	L24I	P1PS, L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93L	D
		TK1028b		RTV, IDV, NFV	308	M46L, I54V, V82T	L24I	L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93L	D
	TK2001	TK2001		SQV, RTV, NFV	94	M46I, I84V	N83D	L10I, I13V, A22V, E35G, M36I, I62V, L63P, I64V, A71V, I93L	D
		TK2001a		SQV, RTV, NFV, LPV	97	M46MI, I84IV	N83ND	L10I, I13V, K14KR, A22AV, E35EG, M36I, I62V, L63P, I64V, A71AV, I93IL	D
	TK2005	TK2005b		RTV, IDV, APV, SQV	213	I54V, V82AT	L10LF	I13V, I15IV, K20KT, R41K, L63P, I64V, A71AV, T74S	D
	TK2016	TK2016		IDV, NFV	329			I13V, M36I, R41K, I64V	D
	TK2025	TK2025a		IDV, RTV, SQV, LPV	347			L10I, I13V, M36I, R41K, D60E, L63T, I64V, I72V	D
	TK3006	TK3006		RTV	157	I54IV, V82F, L90M	L33F	I13V, I15V, R41K, I62IV, I64GV	D
		TK3006a		RTV, NFV	194	I54V, V82F, L90M	L33F	I13V, I15V, R41K, I64V	D
	TK3008	TK3008		SQV, NFV	344	I84V	N83D	L10I, I13V, A22V, M36I, R41K, I62V, L63P, I64V, H69HY	D
	TK3011	TK3011		SQV, NFV	231	D30N	N88D	I13V, I15V, K20T, E35D, M36I, N37NY, R41K, I64V, T74S	D
	TK3023	TK3023		RTV	221	I54V, V82A	L33F	I13V, L19T, K20R, E35ED, M36I, R41K, L63V, I64V	D
	TK3037	TK3037		RTV	196	I54V, V82A		L10V, T12TA, I13V, K14R, G16A, R41K, K43R, I62V, L63P, A71T	D
	TK4014	TK4014		SQV, RTV, NFV	98			T12TP, I13V, I15IV, K20R, M36MI, R41K, L63H, I64V, I72IV, V77I	D
	TK5003	TK5003a		LPV	39			I13V, K14KR, E35D, M36I, R41K, I64V, K70R	D
Weber (2005)	F75744	F75744	AY677393	NFV	76			I13V, R41K, D60E, L63LP, I64V, H69HY, V77I	D
	F63925	F63925	AY677483	SQV	97			I13V, L19Q, M36I, R41K, I64V, H69Y, I72V	D
Baxter (2006)	12-2258	2258-30721	DQ876701	PI	NA	I54V, V82A	L10F	I13V, G16E, K20I, E35D, M36I, P39S, R41K, K45A, R57KT, I62V, L63C, I64V	D
	12-3077	3077-30403	DQ877151	PI	NA	D30N	L10F, N88D	I13V, K14R, E35D, M36I, R41K, I62IV, L63Q, I64V	D
	48-1429	1429-30424	DQ877819	PI	NA	M46I, I54V, V82T	L24I	L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93L	D
	48-1439	1439-30929	DQ877829	PI	NA	M46I, I54V, L76LV, V82A, L90M	L10FI	I13V, K20I, E34EK, M36I, R41K, I62V, L63P, I64IV, A71T, L89LI, I93L	D
	48-3056	3056-30318	DQ877968	PI	NA	M46I, I54V, L76V, V82T	L10F, L89V	I13V, K20M, M36I, R41K, I62V, L63P, A71V, I72V, I93L	D
	48-4165	4165-30410	DQ878398	PI	NA	M46MI, I54V, V82S	L24I	L10I, I13V, L19I, K20IM, M36I, R41K, L63P, A71V	D
	48-5014	5014-30514	DQ878549	PI	NA	M46I, I54V, V82A, L90LM	L10F, Q58E	I13V, K20I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, N83S	D
	48-5052	5052-30515	DQ878573	PI	NA	M46MI, G48M, I54V, V82A, L90M	F53L, L89IV	T4S, L10IV, I13V, K14R, G17DE, K20I, L33L_L, M36V, R41K, L63P, H69K, K70R, A71T, T74S, Q92K	D
	48-8016	8016-30826	DQ879061	PI	NA	M46L, I54L	L10F, Q58E	I13V, K20T, E35ED, M36I, N37ND, R41K, L63Q, I64V	D
Laurent (2006)	CK2-84	02CM-84	AM279448	NFV	105		L10F, L33I, N88G	I13V, E35D, M36I, N37E, R41K, V56A, I62V, L63P, H69Y, A71T, I72T	D
von Wyl (2007)	24	10516511	EF449876	RTV, PI	NA			L10V, I13V, E35D, M36I, R41K, I62V, L63H, I64V	D
	128	5248038	EF449884	PI	NA	L90M	L24I	L10I, I13V, E35G, M36I, R41K, I62V, L63P, A71T, T74A, V75I	D
	3	10371422	EF449968	RTV, PI	NA	M46I, I54V, L76V, V82M	L24I, L33F	L10V, I13V, K20R, E35D, M36I, N37DE, K55R, R57K, D60E, I62V, L63P, V75I, L89M, T91S	D
Cardoso (2009)	3117	BRGO3117	FJ638454	PI	NA	M46I, I54V, L76V, V82A, L90M	L33F	L10V, I13V, I15V, K20R, E35D, M36I, K55R, R57K, D60E, I62V, L63P, A71V, I72V, I93L	D
Dau (2010)	07059A	07059A	GU581816	PI	NA	M46MI, I54V, V82A, L90LM		L10I, I13V, I15V, K20V, M36I, R41K, I62V, L63Q, I64V, E65D, I72V, T74S	D
	07823A	07823A	GU581871	PI	NA	M46I, L90M		L10V, I13V, N37A, K55R, R57K, I62V, L63P, I64IV, I72IT, T74S, V77I, L89LM, I93L	D
	07867A	07867A	GU581877	PI	NA	V32I, M46I, I47A, L90M	L10F, L89V	T4A, I13V, K20T, L33V, I62V, L63P, H69Y, A71V, I93L	D
	09705A	09705A	GU581977	PI	NA	M46L, I54V, V82AT, I84V, L90M	L33F, F53L, L89V	L10I, I13V, I15V, K20T, E35D, M36I, N37D, K55R, D60E, I62V, L63P, I66F, K70E, A71V, Q92K	D
	13578A	13578A	GU582074	PI	NA	V32I, M46I, I54V, L76V, I84V, L90M	L10F, L33F, K43T	I13V, K20R, E35D, M36I, R41RK, K55KR, D60E, L63P, I64V, L89I	D
Aulicino (2011)	ARL411LCO	ARL411LCO	FJ525808	PI	NA	D30N	N88D	L10Y, I13V, I15V, K20T, E35D, M36I, N37D, R41K, K43R, R57K, Q61N, L63H, I72V, V75I	D
	ARM522BCE	ARM522BCE	FJ525832	PI	NA	M46I, I50V, I54V, V82A, L90M	L23I, L33F, K43T, F53L, T74P	L10I, I13V, K20R, E35N, M36I, K55R, R57K, Q61N, I62V, L63P, L89I	D
	ARM856HJM	ARM856HJM	FJ525843	PI	NA	D30N, M46L, I54V, L90M	N88D	L10V, I13V, I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63P, A71T, I72V, I93L	D
	ARN571EAE	ARN571EAE	FJ525863	PI	NA			L10V, I13V, K14N, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, E65D, A71T, T74S, Q92K	D
	444-O288CCR	444-O288CCR	HQ158164	PI	NA	D30N	N88D	L10I, I13V, I15V, K20T, E35N, M36I, R41K, Q61N, L63P, I72T, T74M, V77I, I93L	D
Jones (2012)	127508	127508	JN669438	PI	NA	I54V, V82A, L90M	L33I, F53L, G73S	L10I, I13V, K20R, E35D, M36I, R41K, K43KE, K55R, R57K, D60EK, Q61N, I62IV, L63P, A71IV, I72V, G94GD, C95L	D
	133092	133092	JN669519	PI	NA	L90LM		L10LV, I13V, K20R, E35D, M36I, R41K, R57K, Q61N, I64IV, I93IL	D
	145636	145636	JN669661	PI	NA			L10I, I13V, E35D, M36I, R41K, Q61D, L63T, K70F, I72T	D
	146099	146099	JN669672	PI	NA	L90LM		L10V, I13V, K14R, K20M, E35D, M36I, N37D, R57RK, Q61N, L63P, A71T, I72T	D
	155242	155242	JN669835	PI	NA			I13V, K14R, G17E, R41K, R57K, Q61N, L63P, I64V, V77VI	D
	157949	157949	JN669903	PI	NA	M46MI, I54V, L76LV, V82F, L90M	L33F	L10I, I13V, K20IT, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, I64L, C67D, A71AV, I72IT, I93L	D
	159279	159279	JN669946	PI	NA	I47V, I54V, V82A, L90M	L33F, G48W, F53L, Q58E	L10V, I13V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63C, C67E, A71V, I93L	D
	159787	159787	JN669960	PI	NA	I54V		L10V, I13V, K20R, E35D, M36I, R41K, R57K, Q61N, I64IV, A71V, I72T, T74S, Q92R, I93L	D
	162069	162069	JN670025	PI	NA	L90M		L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61D, L63P, A71V, T74S, I93L	D
	163239	163239	JN670057	PI	NA	M46I, V82T, I84V	L10F	T12K, I13V, G16E, L19P, K20R, M36I, L63T, I64V, E65D, I72T, T74S	D
	163678	163678	JN670068	PI	NA	L90LM		L10V, I13V, I15V, K20T, E35D, M36I, R41K, K43R, R57K, Q61N, L63T, I64L, I72T, T74S, I93L	D
	166308	166308	JN670124	PI	NA	M46I, I54V, V82T	L33F, L76I	L10V, T12Q, I13V, I15V, L19I, K20KR, E35D, M36IL, R41K, K55R, R57K, Q61N, L63P, I64V, A71V, T74S	D
	170719	170719	JN670232	PI	NA	I54V, V82A, L90M	L33I	L10I, I13V, K14R, K20M, E35D, M36I, N37D, R41K, Q61N, L63P, A71T, I72T	D
	171752	171752	JN670267	PI	NA	D30N	N88D	L10V, I13V, I15IV, E35D, M36I, N37D, R41K, K45R, R57K, Q61N, L63P, V75I, I93L	D
	171784	171784	JN670271	PI	NA	I54IV, V82A, L90M	L33LF	L10V, I13V, K20KR, E35D, M36I, R41K, R57K, Q61D, I62V, L63PT, A71V, I72T, T74S, I93L	D
	172708	172708	JN670297	PI	NA	D30N	N88D	I13V, I15V, E35D, M36I, R41K, R57K, Q61N, L63P, A71T, I72T	D
	173203	173203	JN670314	PI	NA			I13V, K20R, M36I, R41K, R57K, Q61N, L63P, I64L	D
	175535	175535	JN670365	PI	NA			T12V, I13V, L33LV, M36I, R41K, K55R, R57K, Q61N, L63P	D
	177131	177131	JN670427	PI	NA			L10V, T12A, I13V, K14R, G16GE, E35D, M36I, R41K, Q61D, L63T, I64V, I72T	D
	177590	177590	JN670450	PI	NA	D30N	N88D	L10V, I13V, I15V, K20R, E35D, M36I, R41K, Q61D, L63P, V75I, I93L	D
	182041	182041	JN670597	PI	NA	L90M		L10V, I13V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, I93L	D
	182997	182997	JN670632	PI	NA	L90M		L10LV, I13V, L19I, K20T, E35D, M36I, R41K, Q61N, L63P, A71AT, T74S, I93L	D
	183366	183366	JN670645	PI	NA			L10I, I13V, I15V, M36I, N37D, L63T, I64L, I93L	D
	183927	183927	JN670665	PI	NA	L90M		L10V, I13V, K20R, E35D, M36I, N37D, R41K, R57K, Q61DN, I64V, I72T, I93L	D
	185641	185641	JN670705	PI	NA	I54LV, V82T, L90M	L33F, F53FL, T74PS	L10I, I13V, K20R, E35D, M36I, N37E, R41K, R57K, Q61N, L63AT, E65D, A71V, I72V, T80TI, L89LM, I93L	D
	185997	185997	JN670710	PI	NA	L90M		L10I, I13V, K20T, E35D, M36I, R41K, R57RK, D60E, Q61N, I62V, L63T, I64L, C67D, I72T, V82VI, I93L	D
	187220	187220	JN670729	PI	NA	M46L, I54V, I84V, L90M	G48E, L89V	L10I, I13V, K20MT, E35D, M36I, R57K, Q61N, I62V, L63P, C67Y, G68E, H69Y, A71V, Q92K, I93L	D
	187807	187807	JN670741	PI	NA	M46L, I54V, V82A, L90M	L33F, K43T, G73S	Q7QH, L10V, I13V, K20R, E35D, M36I, L38LS, R41K, I62V, L63P, H69R, A71T, I72T, V77I	D
	188898	188898	JN670762	PI	NA	D30N	N88D	L10V, I13V, K14R, G16E, K20M, E35G, M36I, R41K, R57K, Q61N, L63S	D
	189796	189796	JN670781	PI	NA	I54V, L90M	L23LI	L10V, I13V, I15V, L19LV, K20T, E35D, M36I, N37D, R41RK, R57K, D60E, Q61D, I62V, L63P, A71I, T74S, I93L	D
	189993	189993	JN670786	PI	NA			L10V, I13V, G16GE, K20R, M36I, R41K, R57K, Q61N	D
	192858	192858	JN670869	PI	NA			L10I, I13V, L63P, I64V, H69N	D
	193544	193544	JN670904	PI	NA	I54L	K43T, F53FL, G73S	T12K, I13V, I15V, K20T, E35D, M36I, N37S, R41K, R57K, Q61D, I62V, L63P, E65ED, H69HY, A71T, I72R, T74S, V77I, I93IM	D
	194042	194042	JN670922	PI	NA			I13V, E35D, M36I, R41K, R57K, D60E, Q61N	D
	195176	195176	JN670967	PI	NA	I54V, V82A, L90M	L33LI, L89LV	L10I, I13V, K14R, K20IM, E35D, M36I, N37D, R41K, Q61N, L63P, A71T, I72T	D
	195199	195199	JN670968	PI	NA	D30N	L33F, N88D	L10M, I13V, I15IV, E35D, M36L, R41K, R57K, Q61N, L63A, I93L	D
	197657	197657	JN671076	PI	NA			I13V, I15V, E35D, M36I, R41K, R57K, L63LP, I64V, Q92K	D
	200084	200084	JN671190	PI	NA	M46I, I54IV, I84V, L90M	L33F, K43KT, T74P	L10I, I13V, K20KR, M36I, R41RK, K55KR, I62V, L63P, H69K, K70KT, A71V, T91S	D
	201750	201750	JN671235	PI	NA			I13V, E35D, M36I, R41K, K43R, R57K, D60E, Q61D, I62V, L63C, T91V	D
	201919	201919	JN671244	PI	NA	I84V, L90M	F53L	L10I, T12I, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, A71I, I72T	D
	202646	202646	JN671284	PI	NA	I54L, L90M	L33F	L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, I62V, L63H, T74S, Q92QK	D
	203943	203943	JN671324	PI	NA	V32I, M46I, I54V, V82A	L24I, L33F, K43T, F53L	L10I, I13V, G16E, K20R, E35D, M36I, N37D, P39PS, R57K, Q61N, L63S, E65D, K70Q, A71V, T74S, V77I, L89T	D
	207065	207065	JN671420	PI	NA			I13V, E35D, M36I, R41K, K45R, R57K, D60E, Q61N, L63C, I72T, L89LM	D
	207305	207305	JN671429	PI	NA	M46I, I54V, L76V, V82F, L90M	L33F	L10I, I13V, K20T, E35D, M36I, R41K, D60E, Q61N, I62V, L63T, I64L, C67D, A71V, I72T, I93L	D
	207489	207489	JN671435	PI	NA			I13V, K20R, M36I, R41K, R57K, Q61N, L63LP, I64L, I72M	D
Kouri (2012)	CU1373-09	CU1373-09	JQ585294	PI	NA	V32I, M46L, L76V, V82A	L10F, L33F, L89V	I13V, K20R, M36I, N37D, R41K, K43R, Q61N, L63P, A71V, Q92K	D
	CU373-10	CU373-10	JQ585388	PI	NA	M46I, I54V, L76V, V82A	L24I, L33F	L10I, I13V, K20R, E35D, M36I, N37D, R41K, D60E, I62V, L63P, A71V, I93L	D
	CU547-11	CU547-11	JQ585510	PI	NA			I13V, K14R, M36I, N37D, R41K, K43R, Q61E, L63P, H69Q	D
	CU691-09	CU691-09	JQ585261	PI	NA	D30N, V32I, M46I, I47V, I54L, V82A	L10LF, L33F, F53FL, Q58E, N88D	I13V, I15V, L19I, K20R, E35D, M36L, N37T, R41T, K45R, D60E, L63P, H69Q, K70R, I72V, V77I, L89F	D
	CU25-10	CU25-10	JQ585358	PI	NA	M46L, I54V, V82A, L90M	L33F, K43T, F53L, G73S	L10V, I13V, L19LI, K20R, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71I, I93L	D
	CU263-10	CU263-10	JQ585374	PI	NA	V32I, I54M, I84V	V11I, L33F, F53FL	Q2L, L5LF, L10V, I13V, K14E, I15V, G17D, K20R, E35D, M36I, R41K, K45R, R57K, D60E, Q61N, L63P, I64V, A71V, T74E, V82I	D
	CU2073-09	CU2073-09	JQ585339	PI	NA	M46L, I54V, V82A	F53L	L10I, I13V, G16E, K20R, E35D, M36I, N37DE, R41K, K55R, R57K, Q61H, L63T, E65D, I72T, T74A, L89M	D
	CU772-10	CU772-10	JQ585416	PI	NA	M46L, I54AV, V82A	L33F, T74AP, N83ND	L10I, I13V, I15IV, G16E, K20R, E35D, M36I, N37D, R41K, R57K, L63T, E65D, L89M	D
	CU163-10	CU163-10	JQ585454	PI	NA			Q2H, L10V, I13V, E35D, M36I, R41K, K45R, R57K, D60E, L63P, H69Q, V77I	D
	CU1960-09	CU1960-09	JQ585327	PI	NA	V82VA		I13V, K14R, M36I, R41K, R57K, I62V, L63P, I93L	D
	CU90-10	CU90-10	JQ585361	PI	NA	I50V, I54L, L90M	L10F, L33F, K43T, F53L, L89V	Q2P, L5F, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37G, R41K, D60E, L63P, H69HY, A71IV, V77I, V82I, I93IL	D
	CU1483-09	CU1483-09	JQ585297	PI	NA	M46I, L90M		I13V, E35D, M36I, R41K, L63P, H69Q	D
	CU1209-09	CU1209-09	JQ585279	PI	NA	M46L, I54M, V82A	L10F, L24I, L33F, Q58E	I13V, K20R, M36I, R41K, K43KR, I62V, L63P, E65ED, A71V	D
	CU1017-09	CU1017-09	JQ585271	PI	NA	I54V		L10I, I13V, K20RT, E35D, M36I, N37ND, R41K, K45V, K55T, V56VA, R57K, I62V, L63P, V77I, L89M	D
	CU1959-09	CU1959-09	JQ585326	PI	NA	M46L, I54L, V82T, L90M	L33F, T74P	L10I, I13V, E35D, M36I, R41K, K43R, K55R, L63P, H69Q, A71V, I93L	D
	CU311-10	CU311-10	JQ585381	PI	NA	I50V, I54L, L90M	L33F, K43T, F53L, L89V	V11L, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37D, R41K, D60E, L63P, H69Y, A71I, V77I, V82I	D
Reynolds (2012)	B0715	B0715-2	JN652205	LPV			L33I	I13V, M36T, P39S, R41K, L63S, I64V	D
	G0715	G0715-2	JN652208	LPV				L10V, I13V, R41K, R57K, I64V, T74S, V77I	D
	J0594	J0594-2	JN652209	LPV				I13V, M36I, R41K, K45R, I64V, I72V	D
	J0700	J0700-0	JN652164	LPV				L10LI, I13V, K20R, L33V, M36I, R41K, I64V, H69HY, I72IT, V75I	D
		J0700-1	JN652200	LPV				L10LI, I13V, K20R, L33V, M36I, R41K, I64V, H69HY, I72IT, V75I	D
Inzaule (2013)	317	317	JQ914083	NFV				I13V, I15V, M36I, R41K, I62V, L63S, I64V, E65D	D
	410	410	JQ914067	LPV				I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89M	D
Thiam (2013)	3259-HALD	3259-HALD	KC176537	LPV		I54A, V82F	L33I	L10V, I13V, E35D, M36I, R41K, K45V, I62V, L63D, I64V, I72T	D
Van Zyl (2013)	1799	2567	KC423747	LPV	26			L10I, I13V, G16E, M36I, R41K, L63Q, I64V, E65D, H69C	D
	478	2100	KC423617	LPV	156	M46I, I54V, L76LV, V82A	Q58E	L10V, T12P, I13V, G16GE, K20R, M36I, R41K, Q61QR, I64V, P79PH	D
Diaz (2015)	RenG15889	RenG15889	KT746917	PI	NA	M46I, I54V, L76V, V82A	L10F, L24I, L33F	I13V, K20R, M36I, N37D, R41K, K55R, R57K, Q61N, L63P, I72V, L89I	D
	RenG15645	RenG15645	KT746673	PI	NA	M46I, I54V, I84V, L90M	L10F, F53L, T74P	I13V, K20R, E35D, M36I, R41K, K55H, R57K, L63P, H69R, A71V, L89I, T91S, Q92K	D
	RenG17221	RenG17221	KT748249	PI	NA	I54V, V82A		L10I, I13V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, I72V, T74S	D
	RenG15993	RenG15993	KT747021	PI	NA	M46L, I47V, L76V, V82T	F53L, L89V	L10V, I13V, I15V, Q18H, K20I, E34EK, E35EK, M36I, N37E, K55R, I62V, L63P, K70KT, A71V, V77I	D
	RenG15641	RenG15641	KT746669	PI	NA	M46I, I54L, L76V, I84V	L10F, V11VI	I13V, I15V, L19LQ, K20I, E35NS, M36I, R41K, K55KR, R57RK, D60E, Q61N, I62V, L63P, I64IV, A71V, I72V, N83NH, T91S	D
	RenG17196	RenG17196	KT748224	PI	NA	D30N, L90LM	L10F, Q58E, N88D	I13V, I15V, K20T, E35D, M36I, R41K, R57K, Q61N, L63HQ, I64V	D
	RenG17468	RenG17468	KT748496	PI	NA	M46I, I54V, V82A, N88S	L24I, L33F, Q58E	L10I, I13V, I15V, K20T, E35G, M36I, R41K, K55KR, D60E, I62V, L63P, A71T	D
	RenG17301	RenG17301	KT748329	PI	NA	I50L	V32A, L33F, Q58E	L10V, I13V, L19I, K20T, E34N, E35D, M36I, L63P, I64IL, A71V, I72T, V77IL, I93L	D
	RenG16766	RenG16766	KT747794	PI	NA	V32I, M46I, I54L, I84V, L90M	L10F, V11I, L33F, G73T, L89V	I13V, K20M, M36I, I62V, L63P, I66V, A71T, I72V, C95I	D
	RenG17021	RenG17021	KT748049	PI	NA	V32I, I47V, I50V, I54L, V82M	L33F, K43T, T74P	L10I, I13V, I15V, G16E, K20R, E35D, M36I, N37S, R57K, Q61N, L63T, E65D, I72V, L89F	D
	RenG15716	RenG15716	KT746744	PI	NA	I50V, I54V, V82A	L33F	L10V, I13V, G16A, L19I, K20R, M36I, N37D, L63P, A71T, I72V, L89I, L97F, N98K	D
	RenG15698	RenG15698	KT746726	PI	NA	V32I, M46ML, I47A		L10I, I13V, K14KIR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, I62V, L63LP, I64L, H69Y, I93L	D
	RenG16023	RenG16023	KT747051	PI	NA	V32I, M46L, I47V, I50L, V82A, I84V	L33F, Q58E	T12N, I13V, I15V, K20R, E35D, M36I, N37E, Q61QH, L63T, I64V, A71V, I72V, G78GV, R87RI, L89M	D
	RenG16876	RenG16876	KT747904	PI	NA	I50L, V82A	L33F	I13V, K20KT, E35D, M36I, R41K, L63A, A71V, T91S	D
	RenG15646	RenG15646	KT746674	PI	NA			L10V, T12TI, I13V, I15V, K20R, M36I, R41K, R57K, Q61N	D
	RenG15911	RenG15911	KT746939	PI	NA	L90M	G73GS	I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71AITV, T74S	D
	RenG17271	RenG17271	KT748299	PI	NA	M46L, G48Q, I54V, L76V, V82A	L33I, F53L	L10V, I13V, K14KR, L19V, K20M, M36I, D60E, Q61N, I62IV, L63P, T74S, L89I, T91S	D
	RenG16417	RenG16417	KT747445	PI	NA			L10V, I13V, E35D, M36I, R41K, R57K, Q61N, I64V, K70R	D
	RenG16090	RenG16090	KT747118	PI	NA			L10I, T12I, I13V, G16E, K20KR, M36I, R41K, R57K, Q61N, L63S, E65D, I72T	D
	RenG16026	RenG16026	KT747054	PI	NA			R8H, I13V, G17E, E35D, M36I, N37D, R41K, R57RK, Q61DGNS, L63T, I64IV, E65D	D
	RenG17289	RenG17289	KT748317	PI	NA	D30N, M46I, I54IV, V82A, L90M	L10F, L33F, F53FL, N88D	I13V, R41K, I62V, L63P, H69Y, A71T, I72T, V77I	D
	RenG16117	RenG16117	KT747145	PI	NA	D30N	N88D	L10I, T12I, I13V, I15V, E35D, M36I, N37D, R41K, I62V, L63P, K70KR, A71T, I72T, V75I	D
	RenG17344	RenG17344	KT748372	PI	NA	M46I, I54V, L76V, V82A, L90M	L33F	L10V, T12I, I13V, G16E, K20R, E35D, M36I, N37T, R41K, R57K, D60E, Q61D, I62V, I72R, L89I	D
	RenG14914	RenG14914	KT745942	PI	NA	M46L, I54V, V82A, L90M		L10V, I13V, G17E, Q18H, K20I, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63AT, E65D, A71V, I72IV, T74S, I93L	D
	RenG14787	RenG14787	KT745815	PI	NA	M46I, I47IV, I54V, V82A	L10F, L33F, N88D	I13V, I15V, E35D, M36I, N37ND, R57K, Q61N, L63P, I64L	D
	RenG14705	RenG14705	KT745733	PI	NA	M46I, I47V, I54V, V82A	L10F	I13V, I15V, L19I, K20I, M36I, R41K, I62IV, L63P, I64V, N83S, T91S	D
	RenG15230	RenG15230	KT746258	PI	NA			L10V, I13V, K20KT, M36I, N37D, L63LP, I64IV	D
	RenG14273	RenG14273	KT745301	PI	NA	I50L, V82A	L33F, K43KT, G73S	L10V, I13V, I15V, K20M, E35G, M36I, R41K, K55KN, R57K, D60E, Q61N, I62V, L63P, A71AITV, I93L	D
	RenG14584	RenG14584	KT745612	PI	NA	I54L, V82A, L90M	V11I, L33F, K43T, F53L, G73S	I13V, I15V, G16GCW, L19V, K20R, E21G, L24F, E35D, M36I, N37T, R41K, K55R, R57K, D60E, Q61H, I62V, L63P, A71V, I72F	D
	RenG14088	RenG14088	KT745116	PI	NA			I13V, E35D, M36I, R41K, Q61N, L63T, E65D, I72T, L89M	D
	RenG13694	RenG13694	KT744722	PI	NA	V32I, I47V, G48V, I54V, V82A, L90M	L33F, F53L, Q58E, L89V	L10I, I13V, K14E, I15V, K20R, E34Q, E35D, M36I, N37D, R41K, K55R, V56I, R57K, D60E, I62V, L63P, A71V, I85V, Q92K	D
	RenG13605	RenG13605	KT744633	PI	NA	I50L, V82A, L90M	L33F, F53L, Q58E, T74PS	L10V, T12E, I13V, K14R, I15V, G16E, K20T, E35D, M36I, P39T, R41K, I62V, L63T, I64V, H69K, A71L, V77VL, I93L	D
	RenG13674	RenG13674	KT744702	PI	NA	V82A, L90M	L33F, K43T, G73S	L10V, I13V, I15V, L19I, K20T, E35D, M36I, R41K, L63P, A71V, T74S, V77I, I93L	D
	RenG14586	RenG14586	KT745614	PI	NA	I54V, V82A, L90M	L33F, F53L	L10V, I13V, K20R, L24F, E35D, M36I, N37E, R41K, K55R, R57K, D60E, I62V, L63P, A71I, I93L	D
	RenG13686	RenG13686	KT744714	PI	NA	M46I, I47V, I54V, V82F, L90M	Q58E	L10V, I13V, K20I, E35D, M36I, R41K, I62V, L63P, I64V, A71V, I93L	D
	RenG14682	RenG14682	KT745710	PI	NA	M46I, I54V, V82A	N88D	L10V, I13V, I15V, G16E, K20I, E35N, M36I, R41K, K45R, K55KR, R57K, Q61N, L63Q, I64V, T74S	D
	RenG15471	RenG15471	KT746499	PI	NA			I13V, E35D, R41K, R57K, Q61N, L63P, I64L, V77I, L89M, I93L	D
	RenG15072	RenG15072	KT746100	PI	NA	M46L, I54V, L76V, V82A, L90M	L33F, Q58E	L10V, I13V, K14R, G16E, K20R, E35D, M36I, N37E, P39S, R41RK, K55R, R57K, D60DE, Q61N, I62V, L63T, I64V, K70KT, V77I	D
	RenG15342	RenG15342	KT746370	PI	NA			I13V, K20R, M36I, N37E, R57K, Q61N, L63P	D
	RenG13639	RenG13639	KT744667	PI	NA	M46ML, I50L, V82A	L33F, K43T	T12A, I13V, K14R, I15V, E35D, M36I, R41K, R57K, L63P, I64V	D
	RenG14833	RenG14833	KT745861	PI	NA	M46ML, I54V, V82F, L90M		L10V, I13V, I15V, K20IT, E35N, M36I, N37D, R41K, R57K, D60E, Q61N, L63P, I64IV, T74S, V77I, L89LIM, I93L	D
	RenG12366	RenG12366	KT743394	PI	NA	M46I, I54V, V82A	L24I, L33F, Q58E	L10V, I13V, K20R, M36I, R41K, K55R, R57K, Q61N, L63P, A71T, I72T, T91S	D
	RenG12682	RenG12682	KT743710	PI	NA		F53L, G73S	L10V, I13V, I15V, K20R, E35D, M36I, R41K, R57RK, I62IV, L63LP, I64IV, A71AV	D
	RenG13532	RenG13532	KT744560	PI	NA	D30N, M46L, I54IV, V82A, L90M	L33F, F53L, N88D	L10V, T12Q, I13V, I15V, G16GE, K20R, E35D, M36I, R41K, K55KN, Q61N, L63S, I93IL	D
	RenG13216	RenG13216	KT744244	PI	NA	I50L		I13V, I15V, K20R, E35D, M36I, N37NT, R41K, K45R, I62V, L63P, A71V	D
	RenG12299	RenG12299	KT743327	PI	NA	M46I, I54V, V82A	L24I, L33F, F53L, T74P	P9PR, L10I, T12TA, I13V, I15V, K20M, E35D, M36I, N37D, R41K, K45I, K55R, I62V, L63E, I64IV, E65D, L89M	D
	RenG12639	RenG12639	KT743667	PI	NA	V32I, M46I, I47V, I54M, V82A, L90M	L33F, F53L, T74TP	L10I, I13V, G16GE, K20R, E34A, E35D, M36I, R41K, K45KR, K55KR, R57K, Q61N, L63S, C67E, I72V, V77VI	D
	RenG12131	RenG12131	KT743159	PI	NA			L10V, I13V, K20M, E35D, M36I, N37S, P39T, R41K, R57K, Q61D, I64V, E65D, A71AV, I93IL	D
	RenG13073	RenG13073	KT744101	PI	NA	D30N, I50L, V82A	L33F, N88D	L10I, I13V, K20R, E35D, M36I, N37E, K45I, I62IV, L63T, I64V, A71AITV, T74S, I93L	D
	RenG12340	RenG12340	KT743368	PI	NA	M46L, I50L, V82VA, N88S	L33F	L10V, I13V, I15IV, G16E, K20R, E35D, M36I, N37S, P39P*QS, R41K, K45R, R57K, Q61N, L63S, I64IV, I72T	D
	RenG13236	RenG13236	KT744264	PI	NA	M46I, V82A, N88GS	L33F, Q58E	L10V, I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71T, I72T	D
	RenG13330	RenG13330	KT744358	PI	NA			I13V, K20KR, R41K, K43R, L63P, I64V, V77I	D
	RenG12819	RenG12819	KT743847	PI	NA	I54V, V82S, L90M	L33F, F53L	Q7D, L10I, I13V, K20T, E34N, E35D, M36I, N37NT, R41K, I62V, L63AP, I64L, A71M, I72V, T74S, V77L, I93L	D
	RenG13053	RenG13053	KT744081	PI	NA	V32I, M46L, G48GV, I50IL, V82A, L90M	L33F, G73GS, L89V	L10I, I13V, L19I, L24LF, E34EQ, E35ED, M36I, N37S, R41K, K55HQ, I62IV, L63A, I64L, A71V	D
	RenG13474	RenG13474	KT744502	PI	NA	D30N	N88D	L10I, I13V, K14KR, E35D, M36I, R57K, Q61N, L63P, I72IT, L89LM	D
	RenG13259	RenG13259	KT744287	PI	NA	I54V, V82A, L90M	L33F, F53L, G73GA	L10V, I13V, K20R, L24F, E35D, M36I, N37E, R41K, K55R, R57K, D60E, I62V, L63P, A71I, I93L	D
	RenG12091	RenG12091	KT743119	PI	NA	M46I, I54V, V82A, L90M	G73S, L89V	L10V, I13V, K20T, L33L_L, M36I, R41K, K55R, I62IV, L63P, I64IL, A71V, I93L, N98I	D
	RenG10098	RenG10098	KT741126	PI	NA	M46L, I54V, V82A	V11I, L24I, K43T	L10V, I13V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, A71T, I72T	D
	RenG11212	RenG11212	KT742240	PI	NA	D30N, I54L	L10F, L33I, N83D, N88D	I13V, K14R, A22V, E34N, M36I, N37D, L63P, H69K, A71V, I72V, T74S	D
	RenG10552	RenG10552	KT741580	PI	NA	I50IL	F53FL	L10V, I13V, G17E, E34EK, M36I, R57K, D60E, Q61E, L63P, L89F	D
	RenG11291	RenG11291	KT742319	PI	NA		V11VI	L10V, I13V, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, I72IT	D
	RenG11359	RenG11359	KT742387	PI	NA			I13V, K20R, M36I, N37E, R57K, Q61N, L63P	D
	RenG10236	RenG10236	KT741264	PI	NA			L10V, I13V, I15V, G16E, E35D, M36I, R41K, R57K, L63T, E65D, I72V, L89M	D
	RenG10203	RenG10203	KT741231	PI	NA			L10V, I13V, L63P, I64V, E65D	D
	RenG10814	RenG10814	KT741842	PI	NA			L10V, T12A, I13V, K14R, M36I, R41K, Q61N, L63P, L89M	D
	RenG10029	RenG10029	KT741057	PI	NA	I50L		I13V, K20T, E35D, M36I, R41K, K45KI, R57K, D60E, Q61D, L63P, E65D, V77I, L89M	D
	RenG10136	RenG10136	KT741164	PI	NA	D30N, I50V, I54V, V82A, L90LM	L33F, N88D	L10V, I13V, K20R, E35D, M36I, N37E, R41Y, K45Q, R57K, Q61N, L63ST, E65D, A71L, L89LM, I93L	D
	RenG11705	RenG11705	KT742733	PI	NA	L90M		L10IV, T12IV, I13V, G16E, K20IL, E35G, M36I, N37NT, P39Q, R41K, R57K, Q61N, I62K, L63V, I64IV, I72IV, T74S, I93L	D
	RenG10617	RenG10617	KT741645	PI	NA	V32I, M46I, I47V, I54V, V82A, L90M	V11I, L33F, G73S, L89V	L10V, I13V, I15V, L19P, K20R, M36I, N37D, K55R, R57K, I62V, L63P, I64L, A71V, I72V	D
	RenG10374	RenG10374	KT741402	PI	NA	V32I, M46I, I47V, I54M, V82A	L24I, K43T, L89V	L10V, I13V, K20R, E35D, M36I, K55R, R57RK, L63P, A71I, I72V	D
	RenG11317	RenG11317	KT742345	PI	NA			L10V, I13V, G16E, M36I, N37NS, R41K, K45KR, R57K, Q61H, L63Q, I64V, E65D, K70R	D
	RenG10170	RenG10170	KT741198	PI	NA	M46L, I54V, V82A		L10I, I13V, G16E, K20R, M36I, N37ND, R41K, Q61N, L63T, I64IL, E65ED, L89M	D

Protease Inhibitors

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