Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	D
Gene	PR
Mutation	I13V
Rx	>= 1 PI
IncludeMixtures	No

References	26
Patients	102
Isolates	112

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Eshleman (2001)	A088	AF357774	AF357774	NFV	12		L33I	Q7D, I13V, I15IL, L63P, I64V, I72M	D
Weidle (2001)	PW_UG4391	PW_UG4391	AF358746	RTV	43			I13V, I15V, L19I, R41K, I64IL, H69Y, V82I	D
Brindeiro (2002)	TVSP12	TVSP12	AY145811	RTV	55			R8Q, I13V, E35D, M36I, R41K, Q61N, I62V, L63H, H69Q	D
Cuevas (2002)	CU95	CU95	AF425476	IDV				I13V, I15V, K20M, M36I, R41K, L63P, I64L, H69Q	D
	CU54	CU54	AF425435	SQV, IDV				I13V, E35D, M36I, N37D, R41K, K43R, L63P	D
Gibb (2002)	DMG81	81_w56		NFV	55	D30N	N88D	I13V, R41K, L63P, A71T, V77I	D
	DMG89	89_w21		NFV	21			I13V, L33V, N37X, P39PQ, R41K, D60E, L63P, K70KR, N88NK	D
	DMG90	90_w51		NFV	1		L23I	I13V, K20KR, E35D, M36I, R41K, I64V, E65D, V82VI	D
Tural (2002)	226575	226575		IDV, NFV	131	D30N		I13V, E35D, M36I, N37H, R41K, Q58*, I62V, L63P	D
Weber (2003)	2S	IRIS2S-48	AY140810	SQV, RTV	52			I13V, K20R, R41K, R57RK, L63P, I64L, H69Q, I72V	D
Montes (2004)	MB_patESTU	01_ESTU702	AJ577887	SQV, RTV, NFV, IDV	309	M46I, I84V, L90M	V11I, G73S	L10V, I13V, K20I, L33V, I62V, L63P	D
	MB_patROD	00_ROD734	AJ577982	IDV	82			T12A, I13V, K20I, M36I, R41K, L63P	D
Non-B Workgroup (2005)	UK1392	UK1392	AY900799	SQV	161	L90M		L10V, I13V, R41K, L63P, I64V, K70R, I72IV, T74S	D
	UK1557	UK1557	AY900679	NFV, SQV	104	D30N	N88D	L10V, I13V, E35D, M36I, R41K, L63P	D
	UK1979	UK1979		NFV		D30N		I13V, I15V, E35D, M36I, R41K, L63P	D
	BR8	BR8	AY900888	NFV	43	D30N		L10I, T12I, I13V, I15V, K20T, E35D, M36I, R41K, K45T, L63P, I64IV, I85IV	D
	TK1003	TK1003		IDV, SQV, RTV	100			I13V, I15V, R41K, I62IV, I64V, E65D, V77I	D
		TK1003a		IDV, SQV, RTV	100			I13V, I15V, R41K, I62V, I64V, E65D, V77I	D
	TK1011	TK1011		IDV	2			I13V, L19I, N37S, R41K, D60E, I64V	D
		TK1011a		IDV, SQV, RTV	65			I13V, L19I, N37S, R41K, D60E, L63LP, I64V	D
		TK1011b		IDV, SQV, RTV	95			I13V, L19I, N37S, R41K, D60E, L63LP, I64V	D
	TK1024	TK1024		IDV, NFV, RTV, LPV	234			I13V, K20M, M36I, R41K, K45KR, L63P, I64V, H69HY, I72E, P79PA	D
		TK1024a		IDV, NFV, RTV, LPV	277			I13V, K20M, M36I, R41K, I62IV, L63P, I64V, H69HY, I72E, P79X	D
	TK1028	TK1028		RTV, IDV, NFV	207	M46I, I54V, V82T	L24I	L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93L	D
		TK1028a		RTV, IDV, NFV	231	M46I, I54V, V82T	L24I	P1PS, L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93L	D
		TK1028b		RTV, IDV, NFV	308	M46L, I54V, V82T	L24I	L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93L	D
	TK2001	TK2001		SQV, RTV, NFV	94	M46I, I84V	N83D	L10I, I13V, A22V, E35G, M36I, I62V, L63P, I64V, A71V, I93L	D
		TK2001a		SQV, RTV, NFV, LPV	97	M46MI, I84IV	N83ND	L10I, I13V, K14KR, A22AV, E35EG, M36I, I62V, L63P, I64V, A71AV, I93IL	D
	TK2005	TK2005b		RTV, IDV, APV, SQV	213	I54V, V82AT	L10LF	I13V, I15IV, K20KT, R41K, L63P, I64V, A71AV, T74S	D
	TK2016	TK2016		IDV, NFV	329			I13V, M36I, R41K, I64V	D
	TK2025	TK2025a		IDV, RTV, SQV, LPV	347			L10I, I13V, M36I, R41K, D60E, L63T, I64V, I72V	D
	TK3006	TK3006		RTV	157	I54IV, V82F, L90M	L33F	I13V, I15V, R41K, I62IV, I64GV	D
		TK3006a		RTV, NFV	194	I54V, V82F, L90M	L33F	I13V, I15V, R41K, I64V	D
	TK3008	TK3008		SQV, NFV	344	I84V	N83D	L10I, I13V, A22V, M36I, R41K, I62V, L63P, I64V, H69HY	D
	TK3011	TK3011		SQV, NFV	231	D30N	N88D	I13V, I15V, K20T, E35D, M36I, N37NY, R41K, I64V, T74S	D
	TK3023	TK3023		RTV	221	I54V, V82A	L33F	I13V, L19T, K20R, E35ED, M36I, R41K, L63V, I64V	D
	TK3037	TK3037		RTV	196	I54V, V82A		L10V, T12TA, I13V, K14R, G16A, R41K, K43R, I62V, L63P, A71T	D
	TK4014	TK4014		SQV, RTV, NFV	98			T12TP, I13V, I15IV, K20R, M36MI, R41K, L63H, I64V, I72IV, V77I	D
	TK5003	TK5003a		LPV	39			I13V, K14KR, E35D, M36I, R41K, I64V, K70R	D
Rhee (2005)	CA9792	CA34173	AY797858	LPV	79	M46I, V82F, I84C		L10V, I13V, K20T, R41K, L63P, I64V	D
Weber (2005)	F75698	F75698	AY677379	NFV	39			I13V, R41K, L63Q, I64V	D
	F75744	F75744	AY677393	NFV	76			I13V, R41K, D60E, L63LP, I64V, H69HY, V77I	D
	F63925	F63925	AY677483	SQV	97			I13V, L19Q, M36I, R41K, I64V, H69Y, I72V	D
Baxter (2006)	12-1134	1134-30326	DQ876024	PI	NA	V32I, M46I, I47V, I54M, I84V, L90M	L10F, L33F, L89V	I13V, I15V, K20T, M36I, N37S, R41K, L63P, A71V, G73D, I93L	D
	12-2258	2258-30721	DQ876701	PI	NA	I54V, V82A	L10F	I13V, G16E, K20I, E35D, M36I, P39S, R41K, K45A, R57KT, I62V, L63C, I64V	D
	12-3077	3077-30403	DQ877151	PI	NA	D30N	L10F, N88D	I13V, K14R, E35D, M36I, R41K, I62IV, L63Q, I64V	D
	48-1429	1429-30424	DQ877819	PI	NA	M46I, I54V, V82T	L24I	L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93L	D
	48-1439	1439-30929	DQ877829	PI	NA	M46I, I54V, L76LV, V82A, L90M	L10FI	I13V, K20I, E34EK, M36I, R41K, I62V, L63P, I64IV, A71T, L89LI, I93L	D
	48-3056	3056-30318	DQ877968	PI	NA	M46I, I54V, L76V, V82T	L10F, L89V	I13V, K20M, M36I, R41K, I62V, L63P, A71V, I72V, I93L	D
	48-3083	3083-30313	DQ877992	PI	NA	V32I, M46I, I47V, I54V, V82A, L90M	K43T, F53L, G73S, L89V	L10V, T12I, I13V, G16A, K20I, M36I, K55R, L63P, A71V	D
	48-4165	4165-30410	DQ878398	PI	NA	M46MI, I54V, V82S	L24I	L10I, I13V, L19I, K20IM, M36I, R41K, L63P, A71V	D
	48-5014	5014-30514	DQ878549	PI	NA	M46I, I54V, V82A, L90LM	L10F, Q58E	I13V, K20I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, N83S	D
	48-7102	7102-40225	DQ878956	PI, RTV, TPV	>30	M46I, I47A, I84V		L10V, I13V, K20T, L33V, M36I, N37C, R57K, L63P, I64V	D
	48-7134	7134-30729	DQ878972	PI	NA	V32I, M46L, V82A, L90M	K43T, L89V	I13V, K20R, M36I, I62V, L63P, A71V	D
	48-8016	8016-30826	DQ879061	PI	NA	M46L, I54L	L10F, Q58E	I13V, K20T, E35ED, M36I, N37ND, R41K, L63Q, I64V	D
Laurent (2006)	CK2-84	02CM-84	AM279448	NFV	105		L10F, L33I, N88G	I13V, E35D, M36I, N37E, R41K, V56A, I62V, L63P, H69Y, A71T, I72T	D
von Wyl (2007)	24	10516511	EF449876	RTV, PI	NA			L10V, I13V, E35D, M36I, R41K, I62V, L63H, I64V	D
	128	5248038	EF449884	PI	NA	L90M	L24I	L10I, I13V, E35G, M36I, R41K, I62V, L63P, A71T, T74A, V75I	D
Waleria-Aleixo (2008)	08PR060720	08PR060720	FJ591542	PI	NA	I54V, V82T	L24I, F53L	L10V, I13V, K20R, E35D, M36V, N37T, R41K, R57K, I62V, L63P, I64V, A71V, T74S	D
	08RJ060471	08RJ060471	FJ591665	PI	NA			L10V, I13V, E35D, M36I, R41K, L63P	D
	08PR060753	08PR060753	FJ591549	PI	NA	V32I, M46MI, I54V, L90M	L33I, K43T, F53L	L10V, I13V, G16E, L19LI, K20M, E35EG, M36I, L63R, I66F, H69R, A71V, I72IV	D
	08PR050232	08PR050232	FJ591261	PI	NA	I54L, V82A, L90M	L33F, K43T, F53L	L10V, I13V, I15IV, K20R, E35D, M36I, R41K, I62V, L63P, H69K, A71I, T74S, I93IM	D
	RES2	RES2	FJ591822	PI	NA	D30N		L10I, T12I, I13V, I15V, K20T, E35D, M36I, R41K, K45T, L63P, I64IV, I85IV	D
Dau (2010)	07059A	07059A	GU581816	PI	NA	M46MI, I54V, V82A, L90LM		L10I, I13V, I15V, K20V, M36I, R41K, I62V, L63Q, I64V, E65D, I72V, T74S	D
Jones (2012)	145636	145636	JN669661	PI	NA			L10I, I13V, E35D, M36I, R41K, Q61D, L63T, K70F, I72T	D
	200084	200084	JN671190	PI	NA	M46I, I54IV, I84V, L90M	L33F, K43KT, T74P	L10I, I13V, K20KR, M36I, R41RK, K55KR, I62V, L63P, H69K, K70KT, A71V, T91S	D
Kouri (2012)	CU1373-09	CU1373-09	JQ585294	PI	NA	V32I, M46L, L76V, V82A	L10F, L33F, L89V	I13V, K20R, M36I, N37D, R41K, K43R, Q61N, L63P, A71V, Q92K	D
	CU373-10	CU373-10	JQ585388	PI	NA	M46I, I54V, L76V, V82A	L24I, L33F	L10I, I13V, K20R, E35D, M36I, N37D, R41K, D60E, I62V, L63P, A71V, I93L	D
	CU547-11	CU547-11	JQ585510	PI	NA			I13V, K14R, M36I, N37D, R41K, K43R, Q61E, L63P, H69Q	D
	CU691-09	CU691-09	JQ585261	PI	NA	D30N, V32I, M46I, I47V, I54L, V82A	L10LF, L33F, F53FL, Q58E, N88D	I13V, I15V, L19I, K20R, E35D, M36L, N37T, R41T, K45R, D60E, L63P, H69Q, K70R, I72V, V77I, L89F	D
	CU25-10	CU25-10	JQ585358	PI	NA	M46L, I54V, V82A, L90M	L33F, K43T, F53L, G73S	L10V, I13V, L19LI, K20R, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71I, I93L	D
	CU75-11	CU75-11	JQ585492	PI	NA			I13V, K14R, K20I, E35D, M36I, R41K, I64V	D
	CU163-10	CU163-10	JQ585454	PI	NA			Q2H, L10V, I13V, E35D, M36I, R41K, K45R, R57K, D60E, L63P, H69Q, V77I	D
	CU1960-09	CU1960-09	JQ585327	PI	NA	V82VA		I13V, K14R, M36I, R41K, R57K, I62V, L63P, I93L	D
	CU1288-09	CU1288-09	JQ585288	PI	NA	V32I, M46L, L76V, V82A	L33LF, L89V	L10I, I13V, K20R, M36I, N37D, R41K, K43R, Q61N, L63P, A71V, Q92K	D
	CU90-10	CU90-10	JQ585361	PI	NA	I50V, I54L, L90M	L10F, L33F, K43T, F53L, L89V	Q2P, L5F, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37G, R41K, D60E, L63P, H69HY, A71IV, V77I, V82I, I93IL	D
	CU1483-09	CU1483-09	JQ585297	PI	NA	M46I, L90M		I13V, E35D, M36I, R41K, L63P, H69Q	D
	CU1209-09	CU1209-09	JQ585279	PI	NA	M46L, I54M, V82A	L10F, L24I, L33F, Q58E	I13V, K20R, M36I, R41K, K43KR, I62V, L63P, E65ED, A71V	D
	CU1959-09	CU1959-09	JQ585326	PI	NA	M46L, I54L, V82T, L90M	L33F, T74P	L10I, I13V, E35D, M36I, R41K, K43R, K55R, L63P, H69Q, A71V, I93L	D
	CU54-11	CU54-11	JQ585475	PI	NA			R8RL, I13V, L19T, R41K, R57K, D60E, Q61E, L63P, V77I	D
	CU311-10	CU311-10	JQ585381	PI	NA	I50V, I54L, L90M	L33F, K43T, F53L, L89V	V11L, I13V, I15V, Q18L, L19I, K20T, E35D, M36I, N37D, R41K, D60E, L63P, H69Y, A71I, V77I, V82I	D
Reynolds (2012)	B0715	B0715-2	JN652205	LPV			L33I	I13V, M36T, P39S, R41K, L63S, I64V	D
	G0715	G0715-2	JN652208	LPV				L10V, I13V, R41K, R57K, I64V, T74S, V77I	D
	J0594	J0594-2	JN652209	LPV				I13V, M36I, R41K, K45R, I64V, I72V	D
	J0700	J0700-0	JN652164	LPV				L10LI, I13V, K20R, L33V, M36I, R41K, I64V, H69HY, I72IT, V75I	D
		J0700-1	JN652200	LPV				L10LI, I13V, K20R, L33V, M36I, R41K, I64V, H69HY, I72IT, V75I	D
Alcantara (2013)	BRGO4151	BRGO4151	JN662432	LPV				L10V, I13V, G16E, M36I, R41K, L63T	D
Inzaule (2013)	317	317	JQ914083	NFV				I13V, I15V, M36I, R41K, I62V, L63S, I64V, E65D	D
Van Zyl (2013)	O850	1190	KC422951	LPV	26			I13V, I15V, K20M, E35D, M36I, R41K, I64V	D
		1779	KC423400	LPV	78			I13V, I15V, K20M, E35D, M36I, R41K, I64V	D
	O1799	2567	KC423747	LPV	26			L10I, I13V, G16E, M36I, R41K, L63Q, I64V, E65D, H69C	D
	O478	2100	KC423617	LPV	156	M46I, I54V, L76LV, V82A	Q58E	L10V, T12P, I13V, G16GE, K20R, M36I, R41K, Q61QR, I64V, P79PH	D
de Lourdes Teixeira (2015)	9RJ110302	9RJ110302		PI	NA			I13V, K20KT, E35D, M36I, R41K, L63P	D
	9RJ120441	9RJ120441		PI	NA			I13V, E35D, R57K, Q61N, L63S	D
Diaz (2015)	RenG15645	RenG15645	KT746673	PI	NA	M46I, I54V, I84V, L90M	L10F, F53L, T74P	I13V, K20R, E35D, M36I, R41K, K55H, R57K, L63P, H69R, A71V, L89I, T91S, Q92K	D
	RenG15698	RenG15698	KT746726	PI	NA	V32I, M46ML, I47A		L10I, I13V, K14KIR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, I62V, L63LP, I64L, H69Y, I93L	D
	RenG17128	RenG17128	KT748156	PI	NA	M46I, I50V, L76V, V82A	L23LI, V32A, L33F, Q58E	T12K, I13V, I15V, L19V, K20T, E34A, E35D, M36I, N37E, R41K, I62IV, I64V, K70R, V77I, L89LIM	D
	RenG16876	RenG16876	KT747904	PI	NA	I50L, V82A	L33F	I13V, K20KT, E35D, M36I, R41K, L63A, A71V, T91S	D
	RenG15911	RenG15911	KT746939	PI	NA	L90M	G73GS	I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71AITV, T74S	D
	RenG16632	RenG16632	KT747660	PI	NA	D30N, L90LM	L23I, L33F, F53L, N88D	I13V, K14KR, I15V, K20V, E35G, R41K, D60E, L63P, A71I, T74S, V77I, L89I, I93L	D
	RenG17154	RenG17154	KT748182	PI	NA	N88NS, L90M	F53FL, G73GS	T12M, I13V, I15V, L19V, K20T, E35D, M36I, R41K, R57K, Q61N, L63P, T74S, V77VI, Q92K	D
	RenG15230	RenG15230	KT746258	PI	NA			L10V, I13V, K20KT, M36I, N37D, L63LP, I64IV	D
	RenG12125	RenG12125	KT743153	PI	NA			T12AS, I13V, M36I, N37S, R41K, R57K, L63P	D
	RenG13236	RenG13236	KT744264	PI	NA	M46I, V82A, N88GS	L33F, Q58E	L10V, I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, A71T, I72T	D
	RenG12819	RenG12819	KT743847	PI	NA	I54V, V82S, L90M	L33F, F53L	Q7D, L10I, I13V, K20T, E34N, E35D, M36I, N37NT, R41K, I62V, L63AP, I64L, A71M, I72V, T74S, V77L, I93L	D
	RenG12091	RenG12091	KT743119	PI	NA	M46I, I54V, V82A, L90M	G73S, L89V	L10V, I13V, K20T, L33L_L, M36I, R41K, K55R, I62IV, L63P, I64IL, A71V, I93L, N98I	D
	RenG10814	RenG10814	KT741842	PI	NA			L10V, T12A, I13V, K14R, M36I, R41K, Q61N, L63P, L89M	D
	RenG10884	RenG10884	KT741912	PI	NA	D30N, I54V, V82A, L90M	L10F, L33F, F53L, N88D	I13V, I15V, G17D, L19I, K20T, E35N, M36I, N37E, R41T, K45V, D60E, Q61N, L63P, K70R, V77I, L89F	D
	RenG11632	RenG11632	KT742660	PI	NA	G48V, I54S, V82A, L90M	Q58E	L10I, I13V, L19T, K20I, L33L*, E34Q, E35D, M36I, N37D, D60E, I62V, L63Q, I64V, T74S	D
Sutherland (2015)	22	22_POST	KT351828	LPV				I13V, E35D, M36MI, R41K, R57K, L63P, H69Y, I72V, V77VI	D
	23	23_POST	KT351830	LPV				I13V, I15IV, M36I, R41K, I64V	D
Ndahimana Jd Riedel (2016)	2163	2163	KT982499	LPV				I13V, I15V, M36I, R41K, D60E, Q61E, I64V	D

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