<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L10V
Rx PI-naive
IncludeMixtures No
References 66
Patients 134
Isolates 141
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gao (1998)94UG11494UG114U88824None   L10V, I13V, M36I, R41K, L63P, I64LD
 84ZR08584ZR085U88822None   L10V, E35D, M36I, R41K, Q61HD
Neilson (1999)MB2059MB2059AF133821None   L10V, I13V, I15V, G16X, M36I, R41K, I64V, H69RD
Vergne (2000)LVMP634LVMP634AJ286968None   L10V, I15V, L19V, E35D, M36I, R41K, R57K, I62V, L63S, H69Q, K70Q, V77ID
Eshleman (2001)SE816SE816AF388160None   L10V, I13V, K20R, M36I, R41K, L63PD
 SE549SE549AF388149None   L10V, T12A, I13V, M36I, R41K, D60E, L63P, I64VD
Weidle (2001)PW_UG474PW_UG474AF358759None   L10V, I13V, M36I, R41K, L63X, I64VD
  PW_UG474a None   L10V, I13V, M36I, R41K, L63X, I64VD
Eshleman (2002)111982s111982sAF410203None   L10V, I15IV, R41K, H69Y, I93ILD
Fonjungo (2002)CM145CM145AF406712None   L10V, I15V, E35D, M36I, R41K, L63P, H69Q, I93LD
Eshleman (2004)SE816SE816_7dAY428724None   L10V, I13V, K20R, M36I, R41K, L63PD
 SE549SE549_7dAY428693None   L10V, T12A, I13V, M36I, R41K, D60E, L63P, I64VD
Eshleman (2004)ESH_Pat48ESH553AY435307None   L10V, M36I, R41KD
 ESH_Pat96ESH647AY435325None   L10V, I13V, K20R, M36I, R41K, I64V, E65D, I72VD
 ESH_Pat116ESH583AY435309None   L10V, T12A, K14KR, I15IV, M36MI, R41K, D60ED
Gulick (2004)RG224RG224w0 None   L10V, T12I, I13V, N37D, L63P, I93LD
Konings (2004)KF_Pat300CM4869AY359685None   L10V, E35D, R41K, L63PD
 KF_Pat600CM1457AY359688None   L10V, I15V, E35D, M36I, R41K, L63P, H69Q, I93LD
Non-B Workgroup (2005)UK4684UK4684AY901208None   L10V, I13V, K20R, M36I, N37D, R41K, D60E, I64VD
Saad (2005)SM_01YE38601YE386AY795903None   L10V, I13V, K14M, R41K, I64VD
Marechal (2006)JF_012JF_012DQ443634None   L10V, M36I, N37D, R41K, L63P, E65DD
Tebit (2006)A543A543DQ682729None   L10V, I15V, L19T, L38V, R41K, R57K, Q61H, L63P, V77ID
Vergne (2006)LV_02CM-CK1_1802CM-18AM181793None  Q58EL10V, E35D, M36IL, N37E, R41K, R57K, D60T, Q61D, L63P, H69QD
Vidal (2006)NV_KS01702.KS017AM041044None   L10V, I13V, G16A, M36I, R41K, I62V, H69K, A71TD
 NV_LBR03202.LBR032AM041025None   L10V, N37S, R41K, L63Q, I64V, H69Y, V77ID
 NV_LBTB01802.LBTB018AM040998None   L10V, R41K, L63P, H69QD
Baker (2007)9454KI03-9454KIAY803475None   L10V, I13V, M36I, R41K, I64V, E65DD
Church (2007)553-130284W553EF612063None   L10V, I15IV, M36I, R41KD
 647-135041K647EF612093None   L10V, I13V, K20R, M36I, R41K, L63LIRS, I64V, E65D, I72VD
 857-146456T857EF612171None   L10V, I13V, M36I, R41K, L63S, I64VD
Galluzzo (2007)M20810UG_M20810JQ220125None   L10V, I13V, I15V, M36I, R41K, I64VD
von Wyl (2007)12610517835EF449780None   L10V, I15IV, E35D, M36I, R41K, L63PS, I72AVD
Holguin (2008)SP17-340928SP17-340928EU255320None   L10V, I13V, K14R, R41K, R57K, L63P, I64VD
Ndembi (2008)CMYD-5604CMYD-56DQ990421None   L10V, I13V, G17D, K20R, E35D, M36I, R41K, L63T, H69QD
Ndembi (2008)IAEAM009IAEAM009EU306748None   L10V, I13V, G16E, M36I, P39L, R41K, I62V, L63S, I64V, H69Y, I72VD
 IAEM034IAEM034EU306765None   L10V, I13V, R41K, R57K, I64V, H69ID
Nyombi (2008)TMS220TMS220EU251853None   L10V, I13V, E35D, P39Q, R41K, D60E, L63P, I64V, H69K, A71T, V77ID
Aghokeng (2009)CYM078CYM078GU191592None   L10V, G16E, E35D, N37S, R41K, R57K, L63CD
Eshleman (2009)D08444W307-156544FJ389051None   L10V, I13V, K20R, M36I, R41K, L63T, I64V, E65D, I72VD
 C25290W308-102854FJ389144None   L10V, I13V, G16E, M36I, R41K, L63Q, I64V, V75VID
Hawkins (2009)P650ZZP650FJ931154None  L33FL10V, I13V, K20V, M36I, N37S, P39S, R41K, L63T, I64V, E65D, I72VD
Vercauteren (2009)pt15853845737878GQ399439None   L10V, I13V, R41RK, D60E, L63PD
Brennan (2010)Pat114ARC-A117JN697265None   L10V, I13V, I64VD
Castelbranco (2010)090037A090037AHM357748None   L10V, I13V, M36I, R41K, I64V, K70RD
Towler (2010)8338994-EHM037818None   L10V, G17E, R41K, D60DE, L63P, A71AT, I72IVD
  418316-GHM037887None   L10V, G17E, R41K, L63P, A71T, I72V, F99LD
  505503-GHM037899None   L10V, G17DE, R41K, L63P, A71T, I72VD
 439553-X439553-XHM037830None   L10V, I13V, G16E, K20R, M36I, P39S, R41K, I62V, L63P, I72VD
Aghokeng (2011)SK4064-PISK4064-PIHQ864354None   L10V, I15V, E35D, M36I, R41K, I62V, C67D, V82VID
Hamers (2011)CP076301686CP076301686HQ993682None   L10V, I13V, G16E, M36I, R41K, D60DE, L63H, I64V, H69C, I72VD
 CP076301713CP076301713HQ993707None   L10V, T12PQ, I13V, G16E, R41K, L63T, E65D, V77ID
 CP076302306CP076302306HQ993852None   L10V, I13V, L19I, R41K, L63P, I64V, I72ED
 CP076300738CP076300738HQ994929None   L10V, I13V, G16E, E35ED, M36I, N37D, R41KD
 CP076300900CP076300900HQ994971None   L10V, I13V, I15V, R57RK, L63Q, I64VD
 CP076301864CP076301864HQ995000None   L10V, I13V, M36I, R41K, L63P, I64V, E65DD
 CP076302063CP076302063HQ995026None   L10V, I13V, L19T, P39T, R41K, L63P, I64LD
 CP076303007CP076303007HQ995072None   L10V, I13V, G16E, K20R, M36I, P39S, R41K, I64V, K70KRD
 CP076303027CP076303027HQ995090None   L10V, I13V, M36I, R41K, I64VD
 CP076302024CP076302024HQ995193None   L10V, I13V, K20R, E35D, M36I, L63P, H69QD
 CP076302051CP076302051HQ995203None   L10V, I13V, G16E, E35D, R41K, R57K, L63R, I64V, E65D, I72MD
 CP076303041CP076303041HQ995225None   L10V, I13V, M36L, R41K, D60E, Q61E, I62V, L63P, I64VD
 CP076303048CP076303048HQ995231None   L10V, I13V, R41K, D60E, Q61E, L63P, I72VD
 CP076303049CP076303049HQ995232None   L10V, I13V, M36I, L63P, I64V, I72VD
 CP076303056CP076303056HQ995237None   L10V, I13V, M36L, N37D, R41K, L63P, I64V, H69Y, K70T, I72TD
 CP076303089CP076303089HQ995266None   L10V, I13V, M36I, R41KD
 CP076303105CP076303105HQ995281None   L10V, I13V, R41K, L63P, K70RD
 CP076303111CP076303111HQ995287None   L10V, I13V, M36I, R41K, I64L, I72VD
 CP076300705CP076300705HQ995311None   L10V, T12K, I13V, G16E, L19V, N37S, R41K, L63H, I64V, V77ID
 CP076300752CP076300752HQ995330None   L10V, I13V, M36I, R41K, L63LFPS, I64VD
 CP076300772CP076300772HQ995340None   L10V, I13V, G16E, M36I, R41K, L63CD
 CP076301948CP076301948HQ995413None   L10V, I13V, M36IL, N37D, R41K, D60E, L63P, I64V, H69Y, I72V, V77ID
 CP076301963CP076301963HQ995427None   L10V, I13E, I15K, M36I, R41K, I64VD
 CP076301964CP076301964HQ995428None   L10V, M36I, R41K, I64V, C67CYD
 CP076301972CP076301972HQ995436None  V11IL10V, K20V, M36I, P39T, R41K, L63Q, I93MD
 CP076301975CP076301975HQ995439None   L10V, T12K, I13V, L19I, M36I, N37D, R41K, L63P, I64L, I72IVD
 CP076301982CP076301982HQ995443None   L10V, I13V, G17E, M36I, R41KD
 CP076301984CP076301984HQ995445None   L10V, L33LV, M36I, N37S, R41K, I64VD
 CP076301994CP076301994HQ995449None   L10V, M36I, R41K, L63P, I93LD
 CP076302078CP076302078HQ995462None   L10V, M36V, N37NY, R41K, D60E, L63P, I64V, I72IVD
 CP076302079CP076302079HQ995463None   L10V, T12K, G17E, M36I, R41K, L63P, I64L, H69QD
 CP076302897CP076302897HQ995469None   L10V, I13V, M36I, R41K, L63C, I64VD
Kasang (2011)3263832638HM572344None   L10V, I13V, M36I, R41K, L63P, H69YD
 1719317193HM572354None   L10V, T12I, I13V, G16E, M36I, N37T, P39S, R41K, L63C, I64VD
Ndembi (2011)AICPS339AICPS339HQ702643None   L10V, I13V, R41K, L63T, I64V, E65DD
 AICPS337AICPS337HQ702667None   L10V, I13V, I15V, M36I, R41K, I64V, C67YD
Sigaloff (2011)HIV100795HIV100795JN132244None   L10V, I13V, R41K, I64V, H69YD
 HIV100796HIV100796JN132245None   L10V, I13V, I15V, M36I, R41K, L63AV, I64V, E65D, I72VD
Avila-Rios (2012)MF00MB0PUEMF00MB0PUEKC169304None   L10V, T12I, I13V, R41K, L63PD
Hamers (2012)CP076304412CP076304412JQ480178None   L10V, I13V, E35D, M36I, N37S, R41K, I62V, L63PS, I64IVD
Karlsson (2012)SE_265SE_265JQ698851None   L10V, I13V, K14KR, G16GE, M36I, R41RK, I62V, L63N, I64VD
Machado (2012)CUPL1062CUPL1062JN000034None   L10V, E35D, M36I, R41K, D60E, L63P, H69Q, V77ID
Nazziwa (2012)10236201023620JX498972None   L10V, I13V, I15V, E35D, M36I, N37S, R41K, K45R, R57K, L63Q, I64VD
Reynolds (2012)F0703F0703-1JN652191None   L10V, I13V, K14KR, E35D, M36I, R41K, I64V, H69HYD
 G0715G0715-0JN652158None   L10V, I13V, R41K, R57RK, L63LV, I64V, I72IV, T74S, V77ID
  G0715-1JN652194None   L10V, I13V, Q18QR, R41K, R57K, I64V, T74S, V77ID
Sigaloff (2012)KELKN210KELKN210JN628484None   L10V, I13V, I15V, M36L, R41K, L63Q, I64VD
Alencar (2013)MG2-0017MG2-0017JQ238023None   L10V, I13V, I15V, Q18M, M36I, N37D, R41K, L63CD
Hassan (2013)RS09000858RS09000858HQ441603None   L10V, I13V, M36I, N37D, R41K, I64V, H69YD
 RS09000935RS09000935HQ441677None   L10V, T12TK, I13V, M36I, R41K, D60E, L63PD
 RS11000291RS11000291JQ698378None   L10V, I13V, R41K, Q61QE, L63AP, I72EVD
Kemal (2013)71017101JQ364514None   L10V, E35D, M36I, R41KD
Kiertiburanakul (2013)X12TS020X12TS020KC994416None   L10V, I13V, L19IM, E35D, M36MI, N37D, L63PD
Kiptoo (2013)KAP066KAP066KC516924None   L10V, I13V, R41K, T74SD
 SNH007SNH007KC516930None   L10V, I13V, K14KR, G16E, M36I, R41K, L63S, I64V, I72VD
Pircher (2013)B1124B1124JX110311None   L10V, I13V, M36I, R41K, I64VD
Rusine (2013)712H712HKC841736None   L10V, T12TS, I13V, I15IV, G17GE, E35D, M36I, R41K, K45KR, L63P, I72V, L89MD
Sigaloff (2013)JCR111_0JCR111_0JX182003None   L10V, I13V, M36I, R41K, I62V, L63S, I64VD
 MBA049_0MBA049_0JX182019None   L10V, I13V, R41K, D60E, I64V, V77I, N98ID
 JCR047_0JCR047_0JX181988None   P1L, L10V, I13V, G16A, K20M, M36L, R41K, I64V, V75ID
 MBA036_0MBA036_0JX182014None   L10V, I13V, M36I, R41K, L63P, I64VD
 JCR099_0JCR099_0JX181999None   L10V, I13V, G16E, E35D, M36I, P39S, R41K, I62V, L63S, I64V, E65DD
 JCR093_0JCR093_0JX181998None   L10V, I13V, G17E, Q18*, N37S, P39S, R41K, D60E, I62V, L63P, I64V, K70R, V77ID
 JCR113_0JCR113_0JX182004None   L10V, I13V, M36I, R41K, I62V, L63AD
Van Zyl (2013)O478174KC423369None  Q58EL10V, T12P, I13V, K20R, M36I, R41K, D60E, L63P, I64V, C67SD
Lee (2014)MBA1371MBA1371KJ907057None   L10V, K14R, I15V, G16E, I64V, I72T, V77ID
 MBA1150MBA1150KJ906848None   L10V, T12TI, I13V, K14KR, I15IV, R41K, K45KR, L63S, I64V, I72IVD
 MBA1283MBA1283KJ906974None   L10V, I13V, K14KR, L33V, R41K, L63Q, I64VD
 MBA1158MBA1158KJ906856None  Q58EL10V, I13V, R41K, Q61E, L63P, I64VD
 MBA1429MBA1429KJ907112None   L10V, I13V, M36I, R41K, L63A, I64VD
 MBA1454MBA1454KJ907133None   L10V, L33V, N37T, R41K, L63S, I64IVD
 MBA1380MBA1380KJ907066None   L10V, I13V, K14KR, I15IV, R41K, D60E, I64V, I72V, V77VID
 MBA1392MBA1392KJ907078None   L10V, T12K, I13V, K14KR, G16E, K20KR, M36I, R57K, L63T, I64IV, E65D, L89LFD
 AMU069AMU069KJ906687None   L10V, I13V, I15IV, G16GE, N37NT, R41K, D60E, Q61N, I62IV, L63S, E65ED, V77ID
Meixenberger (2014)09-0287009-02870KJ771080None   L10V, I13V, I15L, L33V, R41K, I62V, L63N, I64V, I72V, I93LD
 08-0116108-01161KJ770723None   L10V, I13V, I15L, L33V, R41K, I62V, L63N, I64V, I72V, I93LD
Dauwe (2015)i5_06004i5_06004KT863881None   L10V, M36MI, R41K, I62IV, L63PS, H69Q, A71T, I72V, V77I, I85IVD
Hora (2015)DEURF11UG004DEURF11UG004KF716484None   L10V, I13V, M36I, R41K, D60E, I62V, L63P, I64V, I72VD
Kaleebu (2015)MSK-0095UGA-MSK-0095-2012 None   L10V, I13V, G16E, K20R, M36I, P39S, R41K, D60E, I62V, L63P, I64V, K70RD
Pessoa (2015)10BR_MG017_1MG017_1KJ849792None   L10V, I13V, I15V, Q18M, M36I, N37D, R41K, L63CD
Billings (2016)KE897156V5KE897156V5KT022409None   L10V, I13V, I15V, M36I, P39Q, R41K, L63P, H69YD
 KE543869V2KE543869V2KT022385None   L10V, I13V, M36I, R41K, K45R, I64VD
Castley (2016)P108222840P108222840KT228666None   L10V, I13V, K14KR, G16GE, L19X, I62IV, L63X, I64VD
 P109428830P109428830KT228712None   L10V, I13V, E35D, R41K, I64V, A71V, I72V, I93LD
Hattori (2016)E07_910663E07-50910663-1AB866083None   L10V, I13V, E35D, M36I, R41K, R57K, D60E, I62V, L63P, I64V, H69YD
 F12_99348F12-2099348-1AB866547None   T4AP, L5LF, L10V, T12P, I13V, E35D, M36IV, R41K, K43KR, D60E, L63P, K70R, L89MD
Lam (2016)9902201499022014KR868125None   L10V, G16E, M36I, N37Q, R41K, D60E, L63T, H69K, I72V, I93LD
Pouran Yousef (2016)372308-01161KX466501None   L10V, I13V, I15L, L33V, R41K, I62V, L63N, I64V, I72V, I93LD
  09-02870KX466502None   L10V, I13V, I15L, L33V, R41K, I62V, L63N, I64V, I72V, I93LD
Reynolds (2016)E102420R15E102420R15KX944672None   L10V, I13V, I15V, M36I, R41KD
Onywera (2017)13418081341808KX791012None   L10V, I13V, M36I, R41K, I64VD
 08402010840201KX791025None   L10V, I13V, M36I, R41K, D60E, I64V, K70KRD