<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L10I
Rx PI-naive
IncludeMixtures No
References 57
Patients 101
Isolates 103
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Cornelissen (1997)92UG06792UG067AF009405None   L10I, M36I, N37K, R41K, I64V, H69YD
Pieniazek (1998)LE-4LE4AF025740None   L10I, E35D, M36I, R41K, L63V, H69K, L89M, T91PD
Holguin (2000)AHHC17HolgHC17AF188349None   L10I, E35D, M36I, R41K, L63A, C67D, H69K, L89MD
Si-Mohamed (2000)AS_MWAAS_MWAAF199315None   L10I, I13V, M36I, R41K, L63P, H69QD
Eshleman (2001)SE710SE710AF388156None   L10I, I13V, M36MI, R41K, I64V, H69HYD
 SE765SE765AF388124None   L10I, I13V, K20KR, M36I, R41K, L63Q, I64V, H69QD
Cuevas (2002)CU71CU71AF425452None   L10I, K14R, R41K, K43R, L63P, I64L, H69QD
Eshleman (2002)145350k145350kAF410244None   L10I, I13V, R41K, I64V, C67G, H69Y, V77ID
Pandrea (2002)IP_97CIRMF0897CIRMF08AY140611None  L33IL10I, I13V, M36I, R41K, Q61N, L63S, I64V, C67YD
 IP_97CIRMF1497CIRMF14AY140612None   L10I, I13V, M36I, R41K, Q61N, L63S, I64V, C67Y, I72ED
 IP_97CIRMF0597CIRMF05AY140619None   I3L, L10I, R41K, L63P, I64L, C67S, H69Q, I72V, V77ID
Soares (2003)BRP2087BRP2087AF527301None   L10I, E35D, M36I, R41K, R57K, Q61N, V77ID
Weber (2003)2SIRIS2S-0AY140809None   L10I, I13V, R41K, L63P, I64L, H69Q, I72V, V77ID
Non-B Workgroup (2005)UK2049UK2049 None   L10I, I13V, I15V, P39Q, R41K, L63P, I93LD
Niama (2006)CHU31CHU31FM164913None   L10I, R41K, I62V, L63C, H69Q, A71T, V77ID
Rousseau (2006)Pt6303PS119MB1DQ351238None   L10I, E35D, M36I, R41K, L63Q, H69K, L89MD
Vidal (2006)NV_KP14902.KP149AM040987None   L10I, T12A, L19T, N37D, R41K, L63I, A71T, I72T, V77ID
Vidal (2006)KTB1397.KTB13AM000054None   L10I, I13V, E35D, M36I, R41K, H69K, L89MD
Church (2007)765-140409O765EF612137None   L10I, I13V, K20KR, M36I, R41K, L63Q, I64V, H69QD
Gonsalez (2007)94HIV_94GU288749None   L10I, E35D, M36I, I62V, L63S, A71T, I72M, V77I, I93LD
Ibe (2008)148148AB356197None   L10I, I13V, M36IL, N37D, R41I, R57RK, D60E, L63P, I64V, K70RD
Land (2008)ML1956ML1956EU110089None   L10I, I13V, I15V, M36I, R41K, L63T, H69QD
Matthews (2008)PS119PS119FJ199691None   L10I, E35D, M36I, R41K, L63Q, H69K, L89MD
Nyombi (2008)TBK022TBK022EU251728None   L10I, I13V, M36I, R41K, L63R, I64V, C67G, K70E, I72VD
 TMS201TMS201EU251838None   L10I, I13V, L19Q, M36MI, R41K, I64V, K70R, A71TD
Brumme (2009)F8527F8527GQ371881None   L10I, I13V, G16E, M36I, R41K, L63T, I93LD
Cuevas (2009)P1293P1293.1EU822625None   L10I, I13V, M36I, R41K, K43R, L63PS, I64VD
Eshleman (2009)A05705W307-156996FJ389098None   L10I, I13V, R41K, I64V, C67SD
Vercauteren (2009)pt50XIKx8mkPdWGQ400974None   L10I, I15L, L33V, R41K, L63P, I93LD
 pt4ZumibsvqADGQ401020None   L10I, M36I, R41K, I62V, L63P, I64L, H69Q, I72VD
Ferreira (2011)BRMT1410BRMT1410HQ638786None   L10I, I13V, L19Q, R41K, Q61N, L63A, I64L, C67W, H69K, V77ID
Hamers (2011)CP076301579CP076301579HQ993618None   L10I, I13V, E35D, M36I, R41K, H69K, L89MD
 CP076302198CP076302198HQ993807None   T4S, L10I, I15V, M36I, R41K, I62V, L63S, I64V, E65D, C67NSD
 CP076304223CP076304223HQ993918None   L10I, I13V, G17E, M36L, P39P*QS, R41K, Q61H, I62V, L63T, I64V, E65DD
 CP076300807CP076300807HQ994944None   L10I, I13V, M36I, R41K, D60E, I62V, L63P, C67DD
 CP076302052CP076302052HQ995021None   L10I, I13V, G16E, M36I, R41K, L63T, I64V, C67S, I72IVD
 CP076302082CP076302082HQ995036None   L10I, T12N, M36I, R41K, L63PD
 CP076302982CP076302982HQ995059None   Q7H, L10I, I13V, I15V, Q18H, K20M, M36I, N37D, R41K, L63T, I64V, E65D, K70RD
 CP076303012CP076303012HQ995077None   L10I, I13V, L19M, M36I, R41K, L63V, I64V, E65DD
 CP076303028CP076303028HQ995091None   L10I, I13V, I15V, M36I, R41K, I64V, K70RD
 CP076303031CP076303031HQ995093None   L10I, M36I, R41K, L63H, I64VD
 CP076301840CP076301840HQ995167None   L10I, I13V, L19M, M36I, R41K, L63V, I64V, E65DD
 CP076302049CP076302049HQ995201None   L10I, R41K, R57K, L63S, I64VD
 CP076303045CP076303045HQ995229None   L10I, I13V, L33V, P39Q, R41K, I64VD
 CP076300701CP076300701HQ995309None   L10I, I13V, G16E, M36I, R41K, L63P, I64V, E65DD
 CP076300786CP076300786HQ995350None   L10I, I13V, M36I, R41K, I62V, L63Q, I64V, H69YD
 CP076301966CP076301966HQ995430None   L10I, I13V, E35D, M36I, R41K, L63T, C67Y, H69K, L89MD
 CP076301986CP076301986HQ995446None   L10I, T12TS, I13V, M36I, N37D, R41K, D60E, I62V, L63P, I64V, E65D, I72VD
Truong (2011)0500225605002256 None   L10I, I13V, G16E, R41K, L63ST, I64V, E65DD
Iweriebor (2012)07M20ZA07M20ZAGU201815None   L10I, L19V, M36I, R41K, L63S, H69K, I93LD
Karlsson (2012)SE_209SE_209JQ698814None   L10I, I13V, I15V, G16E, E35N, M36I, N37D, R41K, K43R, I62V, L63Q, I64V, H69QD
Machado (2012)CUPL1015CUPL1015HQ655392None   L10I, E35D, M36I, R41K, L63P, H69Q, K70Q, I93LD
 CUPL1018CUPL1018HQ655395None   L10I, I13V, G16E, E35D, M36I, R41K, I62V, L63S, I64V, H69Q, V75ID
 CUPL1028CUPL1028HQ655405None   L10I, I13V, K14R, I15V, G16E, E35D, M36I, N37S, R41K, I62R, L63P, H69QD
 CUPL1054CUPL1054JN000026None   L10I, I13V, G16E, E35D, M36I, R41K, G49E, I62V, L63S, H69QD
Nazziwa (2012)50691025069102JX499003None   I3L, L10I, I13V, R41K, K45R, L63AD, A71T, I72E, V77ID
Reynolds (2012)F0719F0719-0JN652156None  V11VIL10I, I13V, E35D, M36I, R41K, K45KR, R57RK, L63X, I64IMV, L89LM, L97LID
  F0719-1JN652192None  V11IL10I, I13V, E35D, M36I, R41K, L63Q, I64VD
 G0772G0772-0JN652159None   L10I, V11L, T12P, I13V, L19I, E35D, M36I, R41K, L63*PQS, I64V, I72VD
  G0772-1JN652195None   L10I, V11L, T12P, I13V, L19I, E35D, M36I, R41K, L63Q, I64V, I72VD
 B0708B0708-1JN652172None   L10I, I13V, G16E, M36I, R41K, L63VD
Serrano (2012)20106934362010693436JQ616878None   L10I, I13V, I15V, K20I, E35D, M36I, R41K, Q61H, K70R, A71T, I72ED
 20106934532010693453JQ616908None   L10I, I13V, I15V, K20I, E35D, M36I, R41K, H69L, K70R, A71T, I72ED
Ssemwanga (2012)RCC_TDR_358745RCC_TDR_358745JQ266021None   L10I, I13V, M36I, R41K, L63Q, I64V, I72VD
Ssemwanga (2012)1444HR1444HRJF800193None   L10I, M36I, R41K, L63P, I64V, C67YD
Antoniadou (2013)GR136GR136KF671844None   L10I, I13V, L19I, E35D, M36I, R41K, K45R, R57K, D60E, L63T, C67Y, H69Q, L89MD
Billong (2013)MR091MR091KF192255None   L10I, I15V, Q18K, E35D, M36I, N37DE, R41K, W42WL, R57K, Q61QP, L63P, C67Y, H69Q, K70RD
Frentz (2013)EHR-43863EHR-43863JX300279None   L10I, L33V, M36MI, N37X, P39Q, R41RK, L63P, I93LD
 EHR-65454EHR-65454JX300642None   L10I, I13V, L33LV, M36I, I62V, L63S, I64V, C67E, I72LD
Hassan (2013)RS11000327RS11000327JQ698404None   L10I, I13V, R41K, L63S, I64V, K70KR, I72LM, V77ID
Smolen-Dzirba (2013)LJE610LJE610JN811569None   L10I, I13V, I15V, N37S, P39Q, R41K, I62V, L63P, I93LD
Bartolo (2014)09AOHDP1509AOHDP15KF853772None   L10I, L19V, E35D, M36I, N37D, R41K, Q61N, I62IV, L63S, E65D, I72T, N83NSD
 09AOHDP11609AOHDP116KF853760None   L10I, I13V, K20KR, E35D, M36I, N37D, R41K, L63TD
 09AOHDP12909AOHDP129KF853765None   L10I, P39T, R41K, L63P, A71V, V77I, I93LD
Khairunisa (2014)TD2TD2KM212885None   L10I, K14R, R41K, L63Q, I72V, I93LD
Lee (2014)MBA1432MBA1432KJ907115None   L10I, I13V, M36I, R41K, I62V, L63LI, I64V, I72V, V82VID
 MBA1467MBA1467KJ907145None   L10I, I13V, K20V, M36I, R41K, C67Y, L89MD
 MBA1401MBA1401KJ907087None   L10I, I13V, L19P, M36I, R41K, K45R, L63HP, I64V, K70ITD
 MBA1508MBA1508KJ907184None   L10I, I13V, M36I, R41K, I62V, L63N, I64V, I72ITD
 AMU032AMU032KJ906652None   L10I, I13V, M36I, N37ND, R41K, I64V, I72IVD
 MBA1330MBA1330KJ907016None   L10I, E35D, M36I, R41K, R57RK, L63T, H69KD
 MBA1113MBA1113KJ906813None   L10I, I13V, M36I, R41K, I62V, L63X, I64V, E65ED, I72IVD
 MBA1005MBA1005KJ906710None   L10I, I13V, M36I, N37D, R41K, D60E, I62V, I64VD
 MBA1407MBA1407KJ907092None   L10I, I13V, L19I, K20KR, M36I, R41K, R57K, I62V, I64V, A71T, I72MD
 MBA1294MBA1294KJ906984None   L10I, I13V, K14KR, G16GE, L19P, K20I, M36I, R41K, L63A, E65D, L89MD
 MBA1226MBA1226KJ906920None   L10I, I13V, G16GE, K20R, M36I, R41K, R57K, I64V, C67QD
Parczewski (2014)68_BI1368_BI13KM284423None   L10I, I13V, L19Q, M36I, I62V, L63P, I64V, C67YD
Wallis (2014)4114641146KM458617None   L10I, I13V, M36I, N37D, R41K, D60E, L63T, I64VD
Budambula (2015)MK26MK26KP792020None   L10I, I13V, I15V, M36I, R41K, I62V, L63A, I64V, C67YD
Cheriro (2015)NLHG-121NLHG-121KT370878None   L10I, I13V, L19LI, E35D, R41K, I64V, H69YD
Guimaraes (2015)BRSP718-13BRSP718-13KP115496None   L10I, E35D, M36I, R41K, L63A, H69Q, I93LD
Kouri (2015)AIDS-RP1AIDS-RP1KP688083None   L10I, K14R, I15V, G16E, E35D, M36I, R41K, K43R, L63P, H69K, I93LD
 AIDS-RP7AIDS-RP7KP688132None   L10I, I13V, M36I, R41K, L63P, H69QD
Meini (2015)109258109258KM438243None   L10I, R41K, L63T, I72VD
 109274109274KM438251None   L10I, I13V, L33V, P39S, R41K, I64V, H69YD
Billings (2016)KE963379V4KE963379V4KT022411None   L10I, I13V, I15V, G16E, M36I, R41K, I62V, L63T, I64V, C67W, H69YD
Boillot (2016)MBI17MBI17KT315978None   L10I, L19I, E35D, M36I, Q61N, L63P, I64L, H69Q, V77ID
Delatorre (2016)12BRRJGN1812BRRJGN18KX357236None   L10I, I13V, K14R, M36I, N37ND, R41RK, L63T, I64V, H69Q, I72TD
Lam (2016)9902100499021004KR867777None   L10I, I13V, M36L, R41K, I62V, L63E, I64VD
 9902204399022043KR868216None   I3L, L10I, T12K, I13V, G16E, M36I, R41K, I62V, L63Q, I64LD
Witaningrum (2016)PB35PB35KU596499None   L10I, I13V, I15V, K20I, E35D, M36I, R41K, L63P, I64L, I72TD
 PB6PB6KU596475None   L10I, I13V, I15V, K20I, E35D, M36I, R41K, L63T, I64L, A71T, I72TD
Onywera (2017)02602020260202KX790997None   L10I, I13V, L33V, M36I, R41K, L63I, I64V, H69QD