<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype D
Gene PR
Mutation L10I
Rx >= 1 PI
IncludeMixtures No
References 17
Patients 64
Isolates 71
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gonzales (2001)CA3896CA9647AY030901IDV, SQV, RTV135I54V, L90M L10I, E35D, M36I, R41K, D60E, I62V, L63P, I64V, I93LD
Monno (2003)ML_Pat89ML_Pat89 PINAI54IV, I84V, L90MG73TL10I, I15V, G16E, L19Q, K20M, I62V, L63N, A71V, I72T, P79D, I93LD
Gomez-Carrillo (2004)9827298272AY365573PINAI54V, I84V, L90ML33F, T74PL10I, L19V, I62V, L63P, H69Q, A71V, T91SD
Machado (2004)cs232cs232AY502101Unknown, NFVNAI84V, L90MG73SL10I, E35D, M36I, R41K, L63P, A71VD
Non-B Workgroup (2005)BR8BR8AY900888NFV43D30N L10I, T12I, I13V, I15V, K20T, E35D, M36I, R41K, K45T, L63P, I64IV, I85IVD
 TK1009TK1009a IDV, NFV, RTV, LPV239M46I, I54V, V82AL24IL10I, M36I, N37D, R41K, L63P, I64V, A71AV, I72VD
 TK1028TK1028 RTV, IDV, NFV207M46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028a RTV, IDV, NFV231M46I, I54V, V82TL24IP1PS, L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
  TK1028b RTV, IDV, NFV308M46L, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 TK2001TK2001 SQV, RTV, NFV94M46I, I84VN83DL10I, I13V, A22V, E35G, M36I, I62V, L63P, I64V, A71V, I93LD
  TK2001a SQV, RTV, NFV, LPV97M46MI, I84IVN83NDL10I, I13V, K14KR, A22AV, E35EG, M36I, I62V, L63P, I64V, A71AV, I93ILD
 TK2025TK2025a IDV, RTV, SQV, LPV347  L10I, I13V, M36I, R41K, D60E, L63T, I64V, I72VD
 TK3005TK3005 SQV, IDV, NFV262L90MG73SL10I, G16A, R41K, K45R, Q61N, G68E, H69Q, A71V, V77I, I93LD
  TK3005a SQV, IDV, NFV262L90MG73SL10I, G16A, R41K, K45R, Q61N, G68E, H69Q, A71V, V77I, I93LD
 TK3008TK3008 SQV, NFV344I84VN83DL10I, I13V, A22V, M36I, R41K, I62V, L63P, I64V, H69HYD
 TK5006TK5006 SQV, RTV, NFV79L90MQ58EL10I, R41K, L63A, I64V, I72V, V77I, I93LD
  TK5006b SQV, RTV, NFV, LPV160 Q58EL10I, R41K, L63A, I64V, I72V, V77VI, I93ILD
Rhee (2005)CA1290CA4541AY796605SQV, IDV, NFV, RTV129M46I, G48GV, V82AT, I84IV, L90MK43T, F53FL, G73TL10I, I15V, M36I, N37D, L63P, C67CF, H69K, A71AV, I93LD
 ASRU017ASRU017 SQV, IDV, RTV91I84V, L90M L10I, T12S, I15V, K20T, E35G, M36I, R41K, I64V, A71T, I85V, I93LD
Baxter (2006)12-17561756-30527DQ876870PINAI54V, V82A, L90MK43T, G73SL10I, I15V, K20R, E35D, M36I, I62V, L63P, H69R, A71VD
 12-11931193-30305DQ876960PINAI54A, V82AL33F, I47IK, N83DL10I, I13V, K20R, M36L, R41N, K45I, D60E, I62V, L63P, I64VD
 48-12251225-30417DQ877757PINAI84V, L90LM Q7E, L10I, G16GE, P39S, R41K, D60E, L63P, I64V, V77I, I85IVD
 48-12501250-30522DQ877773PINAL90M L10I, E35D, M36I, R41K, Q61N, I62V, L63R, K70ED
  1250-31215DQ877775PI, RTV, TPV>29L90LM L10I, E35D, M36I, R41K, Q61HN, I62V, L63R, K70E, L89LWD
  1250-40809DQ877774PI, RTV, TPV>64L90M L10I, E35D, M36I, R41K, Q61N, I62V, L63R, K70ED
 48-14291429-30424DQ877819PINAM46I, I54V, V82TL24IL10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93LD
 48-30583058-30401DQ877970PINAI54L, V82A, L90ML33F, K43KTL10I, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, T74S, L89M, I93LD
 48-41654165-30410DQ878398PINAM46MI, I54V, V82SL24IL10I, I13V, L19I, K20IM, M36I, R41K, L63P, A71VD
 48-61576157-30704DQ878733PINAG48A, I54V, V82A, I84V, L90ML33F, Q58E, G73GS, L89LVT4S, L10I, K20R, E35D, M36L, R57RK, I62V, L63P, A71V, I72ILM, Q92KD
 48-61816181-30721DQ878753PINAG48M, I50V, I54A, V82A L10I, L19I, K20R, M36I, N37D, I62V, L63P, I64M, A71V, I72V, Q92KD
von Wyl (2007)1285248038EF449884PINAL90ML24IL10I, I13V, E35G, M36I, R41K, I62V, L63P, A71T, T74A, V75ID
Waleria-Aleixo (2008)RG44RG44FJ592052PINAM46MI, L90MG73CL10I, K20I, E35D, M36I, I62V, L63P, I64V, T74SD
 RES2RES2FJ591822PINAD30N L10I, T12I, I13V, I15V, K20T, E35D, M36I, R41K, K45T, L63P, I64IV, I85IVD
Koyalta (2009)8TCHAD-8FJ688175IDV26V82A L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63P, K70E, A71T, I93LD
Charpentier (2010)T076006T076006HQ717826PI, DRV, RTVNAG48M, I54T, V82A, L90ML33F, Q58EL10I, T12M, I13V, G16E, K20R, E35D, M36I, R41K, L63T, E65D, I72T, T74A, L89MD
Dau (2010)07059A07059AGU581816PINAM46MI, I54V, V82A, L90LM L10I, I13V, I15V, K20V, M36I, R41K, I62V, L63Q, I64V, E65D, I72V, T74SD
Rangel (2010)HIV244bHIV244bGU807502PINA  L10I, R41K, L63T, I93LD
Jones (2012)133389133389JN669521PINAI54L, I84VL33FL10I, K14R, E35D, M36I, R41K, D60E, L63P, A71V, I93LD
 145636145636JN669661PINA  L10I, I13V, E35D, M36I, R41K, Q61D, L63T, K70F, I72TD
 178433178433JN670483PINAM46I, I54V, L76V, V82F, L90MQ58EL10I, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, I64V, A71V, I72V, I93LD
 183366183366JN670645PINA  L10I, I13V, I15V, M36I, N37D, L63T, I64L, I93LD
 187443187443JN670732PINAG48A, I54V, V82A, I84VL33F, N83ND, L89VL10I, K14R, K20KR, E35D, M36I, R41K, D60E, L63P, A71V, T91S, Q92QR, I93LD
 192858192858JN670869PINA  L10I, I13V, L63P, I64V, H69ND
 200084200084JN671190PINAM46I, I54IV, I84V, L90ML33F, K43KT, T74PL10I, I13V, K20KR, M36I, R41RK, K55KR, I62V, L63P, H69K, K70KT, A71V, T91SD
Kouri (2012)CU373-10CU373-10JQ585388PINAM46I, I54V, L76V, V82AL24I, L33FL10I, I13V, K20R, E35D, M36I, N37D, R41K, D60E, I62V, L63P, A71V, I93LD
 CU345-10CU345-10JQ585387PINAI54IV, V82VA W6G, L10I, K20R, E35D, M36I, R41K, Q61DN, L63P, H69Q, K70T, I93LD
 CU749-09CU749-09JQ585263PINAM46L, I84VN83DL10I, I15V, G16E, K20R, M36I, R41K, D60E, I62IV, L63T, V82I, L89LFD
 CU1627-09CU1627-09JQ585302PINAI54V, V82A, I84V, L90M L10I, K20I, E35G, M36I, R41K, D60E, I62V, L63P, H69HQ, A71VD
 CU1806-09CU1806-09JQ585314PINAL90MQ58EL10I, E35DN, M36I, N37D, R41K, L63P, H69Q, A71TD
 CU1805-09CU1805-09JQ585313PINAM46I, I54V, V82A, L90M L10I, K20I, M36I, N37D, R41K, K43KR, Q61N, L63P, I64L, H69Q, A71V, I72IV, I93LD
 CU461-09CU461-09JQ585253PINAI54V, L90MG73SL10I, K20R, E35D, M36I, R41K, I62V, L63P, H69Q, A71V, I93LD
 CU1288-09CU1288-09JQ585288PINAV32I, M46L, L76V, V82AL33LF, L89VL10I, I13V, K20R, M36I, N37D, R41K, K43R, Q61N, L63P, A71V, Q92KD
 CU1959-09CU1959-09JQ585326PINAM46L, I54L, V82T, L90ML33F, T74PL10I, I13V, E35D, M36I, R41K, K43R, K55R, L63P, H69Q, A71V, I93LD
 CU408-10CU408-10JQ585393PINAI54IV, V82VA L10I, K20KR, E35D, N37S, R41K, R57RS, Q61HN, L63P, H69Q, K70T, V77VI, G78GRS, L89LMD
 CU313-10CU313-10JQ585383PINAI50IV, I54IVL33LFW6G, L10I, I13IV, K20KT, E35D, M36MI, N37NS, R41K, K45KEIV, K55KT, R57RK, L63P, I66IF, V77VI, L89M, I93ILD
Van Zyl (2013)O17992567KC423747LPV26  L10I, I13V, G16E, M36I, R41K, L63Q, I64V, E65D, H69CD
Diaz (2015)RenG16786RenG16786KT747814PINAI54V, L90MF53L, G73SL10I, K14KE, I15V, K20R, E34EAD, E35D, M36I, R41K, L63P, A71VD
 RenG16175RenG16175KT747203PINAM46I, I54V, V82S, L90MV11I, G73STL10I, T12P, I15V, G16A, L19Q, K20I, M36I, K45R, K55R, L63P, C67G, A71V, I72L, I85VD
 RenG16031RenG16031KT747059PINAL90MV11IL10I, I15V, L19Q, K20T, E35G, M36I, P39S, R41K, I62V, L63P, H69Y, A71V, I72L, T74SD
 RenG16697RenG16697KT747725PINAM46I, I47V, I54V, V82AF53LW6WG, L10I, I15V, K20R, E35D, M36I, R41K, I62V, L63P, C67SD
 RenG15900RenG15900KT746928PINA  L10I, T12S, I15V, K20R, E35D, M36I, R41K, L63TD
 RenG15698RenG15698KT746726PINAV32I, M46ML, I47A L10I, I13V, K14KIR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, I62V, L63LP, I64L, H69Y, I93LD
 RenG14430RenG14430KT745458PINA  L10I, I15V, E35D, M36I, R41K, I62V, L63A, C67D, I72TD
 RenG14314RenG14314KT745342PINA G73GSQ7E, L10I, R41K, D60DE, I62V, L63P, I72V, V77I, I93LD
 RenG14611RenG14611KT745639PINA  L10I, I15IV, G16E, E35D, M36I, R41K, I62V, L63T, E65D, I72IMD
 RenG12426RenG12426KT743454PINAM46I, I54V, V82S, I84VK43T, L89VL10I, I15V, L19IV, K20R, M36I, I62IV, L63P, K70R, A71V, I72M, Q92KD
 RenG13261RenG13261KT744289PINAM46I, I54V, I84V, L90MV11I, G73CL10I, I13AV, K14KI, I15IV, Q18H, K20I, E35D, M36I, N37ND, I62V, L63P, I64V, C67Y, I72L, T74S, T91TCSD
 RenG12819RenG12819KT743847PINAI54V, V82S, L90ML33F, F53LQ7D, L10I, I13V, K20T, E34N, E35D, M36I, N37NT, R41K, I62V, L63AP, I64L, A71M, I72V, T74S, V77L, I93LD
 RenG13053RenG13053KT744081PINAV32I, M46L, G48GV, I50IL, V82A, L90ML33F, G73GS, L89VL10I, I13V, L19I, L24LF, E34EQ, E35ED, M36I, N37S, R41K, K55HQ, I62IV, L63A, I64L, A71VD
 RenG10591RenG10591KT741619PINAL90ML23I, F53LL10I, T12K, I13L, I15V, L19Q, K20T, E35D, M36I, N37NADT, R41K, K55R, R57K, I62V, L63P, I66IV, A71V, T74S, V75ID
 RenG11277RenG11277KT742305PINA  L10I, I15IV, E35D, M36I, R41K, R57K, I62V, L63C, C67X, I72IVD