<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF02_AG
Gene PR
Mutation L89M
Rx >= 1 PI
IncludeMixtures No
References 24
Patients 92
Isolates 113
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Holguin (2001)AH-2773AH-2773AF247037NFV32 V11IT12S, I13V, L19I, K20I, A22T, M36I, R41K, H69K, L89MCRF02_AG
Thomson (2001)MT-X230MT-X230AY017453IDV I84V I13V, K14R, K20I, M36I, N37D, R41K, I66F, H69K, L89MCRF02_AG
 MT-X98MT-X98AY017454IDV   I13V, K20I, E35D, M36I, R41K, H69K, L89MCRF02_AG
Yahi (2001)NY_M47M47AY010411IDV   L10V, I13V, L19P, K20I, M36I, H69K, L89MCRF02_AG
Gibb (2002)DMG1313_w26 NFV26 V11IL10LI, I13V, I15V, K20V, M36I, N37S, R41K, H69K, L89MCRF02_AG
  13_w35 NFV35 V11II13V, I15V, K20V, M36I, N37S, R41K, H69K, L89MCRF02_AG
 DMG3333_w0 NFV1  I13V, I15V, K20I, E35K, M36I, R41I, K43R, L63LP, H69K, L89MCRF02_AG
Holguin (2002)AH_G4525AH_G4525AF354024IDV19  I13V, K14R, K20I, E35D, M36I, R41K, H69K, K70R, L89MCRF02_AG
Venturi (2002)GV-33GV-33.1AF517285SQV, RTV74  I13V, K20R, E35D, M36I, N37D, R41K, H69K, L89MCRF02_AG
Holguin (2003)SP_LP13SP_LP13AF455611PINA  L19P, K20I, M36I, N37T, R41K, K43R, H69K, K70R, L89MCRF02_AG
 SP_LP15SP_LP15AF455612PINA  I13S, K14R, I15N, G16E, K20I, M36I, R41K, K43R, H69K, K70R, L89MCRF02_AG
 SP_LP3SP_LP3AF455603PINAM46L I13V, K14G, I15V, K20I, M36I, R41K, I64M, H69K, L89MCRF02_AG
 SP_LP38SP_LP38AF455630PINA  I13A, K20I, M36I, N37S, R41K, H69K, L89MCRF02_AG
 SP_LP6SP_LP6AF455605PINA  I13V, K14R, K20I, M36I, N37S, R41K, H69K, K70R, L89MCRF02_AG
Vergne (2003)VL98SN46HALD98SN46AJ583719IDV   I13V, K14R, G17E, K20I, M36I, N37S, R41K, I64M, H69K, L89MCRF02_AG
  00SN46AJ583747IDV   I13V, K14R, G17E, K20I, M36I, R41K, I64M, H69K, L89MCRF02_AG
 VL98SN34hald98SN34AJ583718IDV   I13V, I15L, K20I, M36I, R41K, I64M, H69K, L89MCRF02_AG
  01SN34AJ583745IDV   I13V, I15L, K20I, M36I, R41K, I64M, H69K, L89MCRF02_AG
Montes (2004)MB_patSCHE02_SCHE715AJ578156IDV60  L10V, I13V, G16E, K20I, M36I, R41K, L63H, H69K, K70R, I72V, L89M, I93LCRF02_AG
 MB_patALI01_ALI708AJ577728NFV14  T12E, I13V, K14R, G17E, K20I, M36I, L63P, I64L, H69K, L89MCRF02_AG
  02_ALI705AJ577729NFV16  T12E, I13V, K14R, G17E, K20I, M36I, L63P, I64L, H69K, L89MCRF02_AG
 MB_patFEU02_FEU726AJ577889IDV, SQV, RTV190I84V L10V, I13V, K14R, L19P, K20I, E21D, L33V, M36I, N37D, R41K, F53Y, I64L, H69K, K70R, T74S, L89MCRF02_AG
 MB_patSER00_SER718AJ578159SQV, NFV43  I13V, K14R, I15V, K20I, M36I, R41K, H69K, L89MCRF02_AG
 MB_patGONO00_GONO705AJ577902NFV66  I13A, K14R, K20I, M36I, R41K, H69K, L89MCRF02_AG
Non-B Workgroup (2005)PL3560858508AY900971IDV, NFV M46I, I54V, V82A, L90M I13V, K14KR, I15V, L19V, K20I, E35D, M36I, I64M, H69K, L89MCRF02_AG
 PL743461838AY901078SQV, ATV  T74PI13V, I15V, K20I, M36I, R41K, I64M, H69K, K70R, L89MCRF02_AG
 PL3780663403AY901079SQV   L10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, V77VI, L89MCRF02_AG
 PL4018468632AY901088ATV22  L10IV, T12I, I13V, K14R, G16E, E35D, M36I, R41K, R57RK, H69K, L89MCRF02_AG
 PL3692269089AY901091NFV87L90M L10V, T12S, I13V, K14R, G16E, K20I, E35G, M36I, P39S, R41K, I62IV, I66F, H69K, K70R, L89MCRF02_AG
 IL32IL32b NFV22M46I, N88SL10LFI13V, K20I, M36I, P39L, R41K, I62V, L63P, H69K, L89MCRF02_AG
  IL32cAY901181NFV67M46I, N88S L10V, I13V, K20I, M36I, P39L, R41K, I62V, L63P, H69K, L89MCRF02_AG
 TK1006TK1006 IDV, NFV, RTV104  I13V, K20I, M36I, R41K, I64IM, H69K, K70KR, L89MCRF02_AG
  TK1006a IDV, NFV, RTV, LPV177  I13V, K20I, M36I, R41K, I64IM, H69K, K70R, L89MCRF02_AG
  TK1006b IDV, NFV, RTV, LPV181  I13V, K20I, M36I, R41K, I64IM, H69K, K70R, L89MCRF02_AG
  TK1006c IDV, NFV, RTV, LPV258 L10LFI13V, K20I, M36I, N37NY, R41K, K43KR, I64IM, H69K, K70KR, L89MCRF02_AG
 TK2008TK2008 RTV, IDV, NFV73  L10I, I13V, K20I, M36I, R41K, L63P, C67S, H69K, K70R, L89MCRF02_AG
 TK2019TK2019 NFV, SQV, RTV107  I13V, K20I, M36I, N37DE, R41K, H69K, K70R, T74S, L89MCRF02_AG
  TK2019a NFV, SQV, RTV108  I13V, K20I, M36I, N37D, R41K, H69K, K70R, T74S, L89MCRF02_AG
 TK3002TK3002 SQV, RTV105  L10I, I13V, L19P, K20I, M36I, R41K, H69K, K70R, L89MCRF02_AG
  TK3002a SQV, RTV, IDV207  L10I, I13V, L19P, K20I, E35ED, M36I, R41K, H69K, K70R, L89MCRF02_AG
  TK3002b SQV, RTV, IDV213  L10IV, I13V, L19P, K20I, E35ED, M36I, R41K, L63LP, H69K, K70KR, L89MCRF02_AG
 TK3034TK3034 IDV, NFV191  I13V, K14R, G16E, K20I, M36I, R41K, L63GV, I64M, H69K, L89MCRF02_AG
 TK4015TK4015 NFV32M46ML I13V, K14R, G17E, K20I, E35K, M36I, R41K, I66IF, H69K, L89MCRF02_AG
 PL3191579867 IDV, RTV155 V11VIP1PS, L10V, I13V, K14R, G16E, K20I, M36I, R41K, I64IV, H69K, K70R, I72V, L89MCRF02_AG
  95985 IDV, RTV206 V11VIL10V, I13V, K14R, G16E, L19LP, K20I, M36I, R41K, H69K, K70R, I72V, L89MCRF02_AG
 PL327591552 SQV282I54IV L10IV, I13V, K20I, M36I, R41K, H69K, T74S, V75I, L89MCRF02_AG
  105576 SQV282  L10V, I13V, K20I, M36I, R41K, H69K, T74S, V75I, L89MCRF02_AG
 PL4614882690 IDV65  I13V, K14KT, G16E, K20I, M36I, N37D, R41K, H69K, K70R, I72IV, L89MCRF02_AG
 PL53161101108 NFV52I54V, L90M I13V, G16E, K20I, E35D, M36I, R41K, I66F, H69K, K70R, L89MCRF02_AG
 PL53865102930 IDV226  L10V, I13V, K14R, G16E, L19P, K20V, M36I, R41K, H69K, L89MCRF02_AG
 PL55983108809 RTV, IDV26  I13V, K14R, G16E, K20I, M36I, R41K, H69K, K70R, I72C, L89MCRF02_AG
Weber (2005)01M612201M6122AY677413NFV224N88SL10FI13V, K20I, E35D, M36I, R41K, H69K, L89MCRF02_AG
 30239393023939AY677492APV, LPV239M46I, L76V, V82F, I84C L10I, I13V, G16E, K20I, E35D, M36I, N37NK, R41K, L63M, H69K, K70R, T74S, L89MCRF02_AG
 F83557F83557AY714459NFV30 L33FM36I, P39V, R41K, H69Q, L89MCRF02_AG
Baxter (2006)48-31193119-30326DQ878027PINA  I13V, K20I, M36I, R41K, I64L, H69K, L89MCRF02_AG
Laurent (2006)CK2-4702CM-47AM279442IDV43  T12K, I13A, K14R, K20I, M36I, R41K, H69K, L89MCRF02_AG
 CK2-5902CM-59AM279443IDV61  I13V, K14R, I15V, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
 CK22-3103CM2-31AM279454IDV35  L10IV, I13V, K14R, L19P, K20I, M36I, R41K, H69K, L89MCRF02_AG
 CK22-3303CM2-33AM279455IDV78  I13V, K20I, M36I, R41K, H69K, L89MCRF02_AG
 CK22-47A03CM2-47AM279457IDV98  I13V, K14R, K20I, M36I, N37D, R41K, H69K, L89MCRF02_AG
 CK22-7503CM2-75AM279460IDV63  L10I, I13V, K14R, L19P, K20I, M36I, R41K, L63S, L89MCRF02_AG
Seyler (2007)003CS_003 IDV232  I13V, K20R, M36I, N37D, R41K, L63LP, H69K, K70R, L89MCRF02_AG
 004CS_004 NFV, IDV196  L10V, I13V, K14R, G16E, K20I, M36I, R41K, H69K, K70R, L89MCRF02_AG
 027CS_027 NFV165  L10LV, I13V, K20I, M36I, R41K, I64V, H69K, T74S, L89M, I93MCRF02_AG
 065CS_065 NFV167  L10LV, I13V, K14R, K20I, M36I, R41K, K43KR, L63S, I64M, H69K, A71AV, I72T, L89MCRF02_AG
 145CS_145 IDV101L90LM I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70KR, L89MCRF02_AG
 164CS_164 IDV253  I13V, K20I, E35N, M36I, N37D, L63V, I64M, H69K, L89MCRF02_AG
 179CS_179 IDV119 V11IL10I, I13V, G16E, K20I, M36I, N37ND, R41K, L63T, H69K, K70KR, A71T, L89M, I93LCRF02_AG
 195CS_195 IDV111  L10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, I62IV, H69K, K70KR, T74TS, L89MCRF02_AG
 197CS_197 IDV163  I13V, L19P, K20I, M36I, N37D, R41RK, H69K, L89MCRF02_AG
 239CS_239 IDV71  I13AV, K14R, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
 292CS_292 IDV101 L33IL10V, T12A, I13V, K14KR, G16E, K20R, M36I, R41K, L63T, H69K, K70R, L89MCRF02_AG
 405CS_405 NFV167  I13V, K14R, G16E, K20I, E35D, M36I, N37D, R41K, I64M, H69K, K70R, L89MCRF02_AG
 474CS_474 NFV, IDV177 V11VIL10V, T12PQ, I13V, K14IR, I15IV, G16E, L19P, K20I, M36I, R41K, K43KR, L63LH, H69K, K70KR, I72IT, L89MCRF02_AG
 501CS_501 IDV161  I13V, K14R, G16E, K20I, M36I, N37T, R41K, H69K, L89MCRF02_AG
 518CS_518 IDV163 V11VII13V, K14R, K20I, M36I, R41K, L63S, H69K, V82I, L89MCRF02_AG
 522CS_522 NFV102  I13V, K14R, G16E, K20I, M36I, R41K, H69K, L89MCRF02_AG
 527CS_527 NFV, IDV176  I13V, K14R, L19P, K20I, M36I, R41K, L63LP, H69K, L89MCRF02_AG
 580CS_580 NFV142  I13V, G16E, K20I, M36I, P39PS, R41K, H69K, K70KR, T74A, V77VI, L89MCRF02_AG
 619CS_619 IDV104  I13V, K14R, K20I, M36I, R41K, H69K, L89MCRF02_AG
 643CS_643 NFV120  I13V, K20I, M36I, N37D, R41K, H69K, L89MCRF02_AG
von Wyl (2007)1105247133EF449805PINAN88S L10I, I13V, K14R, G16E, K20I, E35Q, M36I, R41K, R57K, H69K, T74S, L89MCRF02_AG
 105697505EF449819PINA  L10I, I13V, L19P, K20I, M36I, R41K, I64IV, H69K, K70R, L89MCRF02_AG
 1121435894EF449908PINAM46L, N88S I13V, K14R, K20I, E35G, M36I, N37D, R41K, H69K, V77I, L89MCRF02_AG
 15496611EF449962PINA V11VIL10I, I13V, K14KR, I15V, L19P, K20I, E21ED, M36I, N37D, R41K, H69Q, K70R, L89MCRF02_AG
 1601476423EF449906RTV, PINA  I13V, G16E, K20I, M36I, R41K, I64M, H69K, K70R, L89MCRF02_AG
Riddler (2008)RG18536RG18536w52 LPV52  I13AV, K14R, K20I, M36I, L38LF, R41K, L63H, H69K, R87RG, L89MCRF02_AG
 RG3642RG3642w41 LPV37  I13V, I15L, K20I, M36I, R41K, H69K, L89MCRF02_AG
 RG60650RG60650w114 LPV114  I13V, G17E, K20I, E35K, M36I, R41K, L63P, H69K, L89MCRF02_AG
  RG60650w137 LPV137  Q2P, I13V, K14R, G17E, K20I, E35K, M36I, R41K, H69K, L89MCRF02_AG
Rosen-Zvi (2008)4504p45-2 LPV5  I13V, K14R, K20I, M36I, R41K, H69K, K70KR, L89MCRF02_AG
  06p45-3 LPV109  I13V, K14R, K20I, E35D, M36I, R41K, H69K, L89MCRF02_AG
  07p45-4 LPV109  I13V, K14R, K20I, E35ED, M36I, R41K, H69K, L89MCRF02_AG
Sylla (2008)a2521a2521_c1DQ991625IDV   I13V, K14R, G16E, K20I, M36I, R41K, L63H, H69K, L89MCRF02_AG
  a2521_c2DQ991626IDV   I13V, K14R, G16E, K20I, M36I, R41K, L63H, H69K, L89MCRF02_AG
 A2840A2840_C1DQ991637IDV   T12A, I13V, K14R, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
  A2840_C2DQ991638IDV   T12A, I13V, K14R, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
 B7127B7127_C1DQ991643IDV   I13V, G17E, K20I, E35N, M36I, R41K, K45R, R57K, L63S, H69K, K70R, I72T, L89MCRF02_AG
  B7127_C2DQ991644IDV   I13V, G17E, K20I, E35N, M36I, R41K, K45R, R57K, L63S, H69K, K70R, I72T, L89MCRF02_AG
 A1097A1097_C1EF525653IDV   I13V, K14R, K20I, M36I, R41K, I64M, H69K, L89MCRF02_AG
  A1097_C2EF525654IDV   I13V, K14R, K20I, M36I, R41K, I64M, H69K, L89MCRF02_AG
 B7156B7156_C1EF525659IDV   I13V, K14R, I15IV, K20I, M36I, N37ND, R41K, I64M, H69K, K70R, L89MCRF02_AG
Koyalta (2009)78TCHAD-78FJ688207IDV26  L10I, T12K, I13V, K14R, G16E, L19P, K20V, E35D, M36I, R41S, C67Y, H69K, L89MCRF02_AG
Knops (2010)ID0462ID0462-GT1GU271156LPV   L10LV, T12TK, I13V, K14R, G16GE, L19I, K20I, M36I, R41K, H69K, K70KR, I72IV, L89MCRF02_AG
  ID0462-GT2GU271157LPV105M46I, L76V L10V, T12K, I13V, K14R, G16E, L19I, K20I, M36I, R41K, H69K, L89MCRF02_AG
Barber (2012)6078360783JQ361670LPV M46I, I84V L10I, I13V, G16E, Q18QK, L19LP, K20I, E35D, M36I, N37T, P39S, R41K, I62V, H69K, K70R, T74A, L89MCRF02_AG
 4870248702JQ361678LPV I54IV I13V, I15L, L19I, K20I, M36I, N37S, R41K, H69K, L89MCRF02_AG
 6605166051JQ361680LPV I54V, V82A I13V, K14R, K20I, M36I, R41K, I64L, H69K, K70R, L89MCRF02_AG
El Annaz (2012)72307230.PRJN185259PINA  T12S, I13V, K14R, K20I, E35D, M36I, N37K, R41K, H69K, L89MCRF02_AG
 1248112481.PRJN185264PINA  I13V, I15L, K20I, E35DN, M36I, R41K, I64M, H69K, L89MCRF02_AG
 1384213842.PRJN185270PINA V11II13V, K14R, L19I, K20I, M36I, R41K, I64L, H69K, L89MCRF02_AG
Van Zyl (2013)15471115KC422891LPV26  T12K, I13V, G17GE, K20I, M36I, N37S, R41K, I72IM, L89MCRF02_AG
Grossman (2014)554554KF135101LPV65M46I, I54V, V82AL10FI13V, G16Q, K20I, M36I, P39L, I62V, L63P, H69K, L89MCRF02_AG