<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF02_AG
Gene PR
Mutation L89I
Rx >= 1 PI
IncludeMixtures No
References 12
Patients 23
Isolates 26
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Venturi (2002)GV-29GV-29.1AF517281SQV134 V11VII13V, K14R, L19LP, K20I, M36I, R41K, K43R, Q61H, L63P, H69K, V82VI, L89ICRF02_AG
Montes (2004)MB_patALC02_ALC723AJ577727NFV, SQV, RTV91I84V, L90M L10I, I13V, K20I, E35D, M36I, R41K, K43R, L63P, H69K, A71V, L89ICRF02_AG
 MB_patKON00_KON723AJ577921IDV, NFV117I54V L10V, I13V, K14R, K20I, E35G, M36I, R41K, I64M, H69K, A71V, L89ICRF02_AG
Non-B Workgroup (2005)PL3890100322 NFV61L90M I13V, K14R, G16E, K20IV, E35A, M36I, P39PS, R41K, H69K, L89ICRF02_AG
Baxter (2006)48-12441244-30527DQ877767PINAM46L, I54V, V82A, I84VV11VI, L33F, K43T, F53LT4A, L10V, I13V, G16A, L19P, K20M, E21A, E35D, M36L, K55R, Q61H, L63P, H69K, T74AS, L89I, T91SCRF02_AG
 48-30903090-30925DQ877999PINAM46I, I47V, I54V, V82C, I84VV11I, L33I, K43T, F53FLL10I, T12M, I13V, K14R, L19P, K20I, A22V, M36I, R41K, K55R, H69K, K70R, I72V, T74S, L89I, T91SCRF02_AG
 48-32243224-30624DQ878131PINAM46I, I47IV, L76V, I84VL33LI, Q58EL10I, I13A, K20I, A22V, M36I, R41K, L63P, I66F, H69K, K70R, L89I, T91SCRF02_AG
 48-40814081-30228DQ878310PINAM46L, I54V, I84V L10V, I13A, K14R, K20I, A22V, E35D, M36I, N37S, R41K, Q61H, I66F, H69K, K70R, P79S, L89I, T91TSCRF02_AG
 48-41674167-30423DQ878400PINAM46L, I54V, I84V L10I, I13A, L19P, K20I, A22V, E35D, M36I, N37S, R41K, D60E, I66F, H69K, A71V, L89I, T91S, Q92KCRF02_AG
  4167-40203DQ878401PI, RTV, TPV>41M46L, I54V, I84V L10I, I13A, A22V, E35D, M36I, N37S, R41K, D60E, I66F, H69K, A71V, L89I, T91S, Q92KCRF02_AG
 48-50755075-30807DQ878585PINAM46L, G48T, I54V, V82A, I84VV11VILL10I, T12TS, I13V, K14R, L19P, K20I, E35D, M36I, N37NS, R41K, Q61H, H69K, T74S, L89I, T91SCRF02_AG
 48-71247124-30902DQ878967PINAM46I, I47V, L76V, I84VQ58EL10I, I13A, K14IR, L19P, K20I, M36I, N37D, R41K, K55KR, L63P, H69K, K70R, L89ICRF02_AG
von Wyl (2007)1205327019EF449829PINAL90M L10V, I13V, K14R, I15V, K20I, E35G, M36I, R41K, L63P, G68E, H69R, A71T, L89ICRF02_AG
 291845355EF449895PINAL90M I13V, K14R, L19P, K20I, M36I, R41K, H69K, L89ICRF02_AG
Rosen-Zvi (2008)104p1-2 LPV85V82AN83DL10V, I13V, K14R, K20R, M36I, N37D, R41K, Q61H, H69K, K70R, L89ICRF02_AG
  05p1-3 LPV, RTV, APV140M46I, V82A, I84VN83DL10V, I13V, K14R, K20R, A22V, M36I, N37D, R41K, Q61H, H69K, K70R, L89ICRF02_AG
 4600p46-1 RTV, SQV, NFV, APV141M46MIL, I54V, V82M, I84V, L90ML33F, Q58EL10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89ICRF02_AG
Sylla (2008)A4197A4197_C1DQ991639IDV   I13V, G16E, K20I, M36I, P39L, L63S, H69K, L89ICRF02_AG
  A4197_C2DQ991640IDV   L10V, I13V, G16E, K20I, M36I, P39L, L63S, H69K, L89ICRF02_AG
Charpentier (2011)CR-22CR-22FJ688228PINA N83DL10I, I13V, I15IV, K20I, E35KN, M36I, N37E, P39PQ, R41K, K45R, I62V, L63P, H69Q, I72IV, L89ICRF02_AG
Kouri (2012)CU785-09CU785-09JQ585264PINAI54V, L90M I13V, K14R, G16E, K20I, E35D, M36I, N37K, P39S, R41K, I62V, H69K, A71V, I72V, T74S, L89ICRF02_AG
Rawizza (2013)LN4321LN4321KF241489LPV I54V, V82FQ58E, N83DL10V, T12M, I13A, K14KR, G16A, L19P, K20I, A22V, E35N, M36I, N37D, R41RK, Q61QH, L63P, H69K, A71V, L89I, I93MCRF02_AG
 PJ9581PJ9581KF241512LPV M46MI, L76LV I13A, K14R, G16E, K20I, M36I, P39A, R41K, I62V, L63S, H69K, K70R, L89ICRF02_AG
Thiam (2013)471-HALD471-HALDJN673637LPV M46I, I47V, I54V, V82A, I84VV11I, F53LL10I, I13V, L19P, K20I, A22V, M36I, N37S, R41K, Q61H, H69K, A71V, L89I, T91SCRF02_AG
 6667HALD6667HALDJX187625LPV M46I, L76V, I84VL10F, V11II13V, G16E, L19P, K20I, A22AV, M36I, R41K, L63R, H69K, K70R, L89I, T91ACRF02_AG
Grossman (2014)501501 LPV52  I13A, K14R, K20I, M36I, P39PL, R41K, L63LP, H69K, I72M, L89ICRF02_AG