<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF02_AG
Gene PR
Mutation L63S
Rx PI-naive
IncludeMixtures No
References 51
Patients 128
Isolates 135
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Vergne (2000)LVMP971LVMP971AJ286949None   L10I, I13V, L19P, K20I, M36I, R41K, L63S, H69K, L89MCRF02_AG
 LV32HALDLV32HALDAJ286989None   I13V, K14R, I15V, L19M, K20I, M36I, L63S, H69K, K70E, V82I, L89ICRF02_AG
 LV37HALDLV37HALDAJ286990None   I13V, K14R, K20I, M36I, R41K, L63S, H69K, L89MCRF02_AG
 LVMBTB29LVMBTB29AJ287022None   I13V, K14R, K20I, M36I, R41K, L63S, I64M, H69K, L89MCRF02_AG
Yahi (2001)NY_M67M67AY010429None   L10IV, I13V, K14N, G16GE, L19P, K20I, M36I, L63S, C67CY, H69K, L89MCRF02_AG
Fonjungo (2002)CM115CM115AY051224None   T12K, I13V, K20I, E35N, M36I, N37D, R41K, L63S, E65D, H69K, L89M, I93LCRF02_AG
Holguin (2002)AH_2703AH_2703AF354021None   L10V, I13V, I15V, G16E, K20I, E35D, M36I, P39T, L63S, I64L, H69K, G78R, L89MCRF02_AG
Park (2003)PSW_Pat2501KR_PR04AY242880None   I13V, G16E, L19P, K20I, M36I, R41K, Q61X, L63S, H69K, K70R, L89I, T91ACRF02_AG
Kijak (2004)4410HAL01CM.4410AY371142None   I13V, K14R, L19P, K20I, M36I, R41K, L63S, H69K, L89MCRF02_AG
Konings (2004)KF_Pat7500CM1233AY359757None   L10V, T12N, I13V, K20I, E35K, M36I, R41T, L63S, H69K, L89MCRF02_AG
Carr (2005)4410HAL4410HALAY847407None   I13V, K14R, L19P, K20I, M36I, R41K, L63S, H69K, L89MCRF02_AG
Holguin (2005)2072-0101_2072-01AY248297None   T12K, I13V, K14R, K20I, M36I, N37T, R41K, L63S, H69K, L89MCRF02_AG
Kinomoto (2005)Gh_K16Gh_K16AB187540None   I13V, K14R, G16E, K20I, E35Q, M36I, R41K, G49E, L63S, I64M, H69K, L89MCRF02_AG
 Gh_K50Gh_K50AB187549None   I13V, K14R, G16E, K20I, E35Q, M36I, R41K, L63S, I64M, H69K, L89MCRF02_AG
 Gh_T8Gh_T8AB187553None   I13V, K14R, G16E, K20I, E35Q, M36I, R41K, L63S, I64M, H69K, L89MCRF02_AG
 Gh_K26Gh_K26AB187544None   I13V, K14R, G16E, K20I, E35Q, M36I, R41K, L63S, I64M, H69K, L89MCRF02_AG
 Gh_K8Gh_K8AB187539None   I13V, K14R, G16E, K20I, E35Q, M36I, R41K, L63S, I64M, H69K, L89MCRF02_AG
Non-B Workgroup (2005)PL3778466968AY901083None   I13V, K14R, G16E, K20I, M36I, R41K, L63S, I64M, H69K, K70R, I72IM, L89ICRF02_AG
Zeh (2005)99NG106999NG1069AY103317None   I13V, K14R, K20I, M36I, R41K, L63S, H69K, I93LCRF02_AG
 99NG107399NG1073AY103318None  G48EI13V, K14R, K20I, E35D, M36I, G40E, R41K, L63S, H69K, L89M, I93LCRF02_AG
 99NG126399NG1263AY103327None   L10M, I13V, K14R, K20I, M36I, N37D, R41K, L63S, H69K, K70R, L89M, I93LCRF02_AG
Lawrence (2006)03FR703FR7DQ251603None   T12Q, I13V, K14R, K20I, M36I, L38I, L63S, H69K, L89MCRF02_AG
 04FR2804FR28DQ251624None   L19P, K20I, M36I, N37D, R41K, L63S, I64L, H69K, L89MCRF02_AG
 02FR3002FR30DQ251626None   I13V, K14R, K20I, E35D, M36I, R41K, L63S, I64M, H69K, V82I, L89MCRF02_AG
Ndongmo (2006)CM115CBN_CM115DQ394130None   I13V, K20I, M36I, R41K, L63S, H69K, K70R, I72M, L89M, I93LCRF02_AG
 CM384CBN_CM384DQ394176None   I13V, E35D, M36I, N37D, R41K, K43R, L63S, H69K, I72V, L89M, I93LCRF02_AG
Ojesina (2006)AIO_DDJ078AIO_DDJ078DQ273932None   L10I, I13V, L19P, K20I, M36I, R41K, L63S, H69K, K70R, L89MCRF02_AG
Razafindratsimandresy (2006)RR_MAD-GF301MAD-GF301DQ345028None   L10V, I13V, K14R, G16E, L19P, K20I, M36I, R41K, L63S, H69K, K70R, L89MCRF02_AG
Rousseau (2006)Pt4503PS085MB1DQ351236None   I15V, L19T, N37S, R41K, Q61D, L63S, H69K, V77I, L89M, I93LCRF02_AG
Vessiere (2006)AV_M2898NAV_M2898NDQ297243None   I13V, G16E, K20I, E35D, M36I, R41K, L63S, H69K, L89MCRF02_AG
Derache (2007)12391239EF064491None   I13V, K20R, L23H, M36I, R41K, L63S, H69K, L89MCRF02_AG
Holguin (2007)628000628000EF583296None   L10LV, I13V, K14R, I15V, K20I, E35D, M36I, R41K, L63S, H69K, K70KR, T74TS, L89MCRF02_AG
Vicenti (2007)424158645REF376561None   I13V, K14R, K20I, M36I, L38LF, R41K, L63S, I64L, H69K, L89MCRF02_AG
von Wyl (2007)1575875999EF449866None   I13V, K14R, G17E, K20L, E34K, M36L, N37D, R57K, Q61N, I62M, L63S, C67E, H69K, I72T, V77I, L89MCRF02_AG
  4818282EF449875None   I13V, K14R, G17E, K20IL, E34K, M36L, N37D, R57K, Q61N, I62M, L63S, C67E, H69K, V77I, L89MCRF02_AG
Caron (2008)1521Gab1521PEU556470None   I13V, K20I, M36I, R41K, L63S, I64L, H69K, K70R, L89M, I93MCRF02_AG
Delgado (2008)GH_024GH_024EU177900None   I13V, K14R, G16E, K20I, M36I, R41K, K43R, L63S, H69K, K70R, L89ICRF02_AG
 GH_176GH_176EU178013None   I13V, G16E, K20R, E35D, M36I, R41K, L63S, H69K, K70R, L89MCRF02_AG
 GH_212GH_212EU178041None   L10I, I13V, G16E, L19P, K20IV, E35D, M36I, R41K, K43R, L63S, H69R, L89MCRF02_AG
Derache (2008)BKO-901BKO-901EU330657None   T12M, I13A, K14R, L19S, K20I, M36I, N37S, R41K, L63S, H69K, L89MCRF02_AG
 BKO-910BKO-910EU330662None   I13A, K14R, G16E, K20V, A22V, M36I, R41K, K43R, L63S, H69K, L89ICRF02_AG
 BKO-954BKO-954EU330683None   T12A, I13A, K14R, K20I, M36I, R41K, L63S, H69K, L89MCRF02_AG
 BKO-971BKO-971EU330693None   I13V, K14R, G16E, L19P, K20I, E35D, M36I, R41K, L63S, I64M, H69K, L89MCRF02_AG
 BKO-977BKO-977EU330695None   T12K, I13V, K14R, G17E, K20I, M36I, L63S, I64M, H69K, I72M, L89MCRF02_AG
 BKO-978BKO-978EU330696None   I13V, K14R, G17E, L19P, K20I, M36I, R41K, Q61H, L63S, I64M, H69K, K70R, L89MCRF02_AG
 BKO-1014BKO-1014EU330708None   I13A, K14R, K20I, M36I, R41K, L63S, H69N, L89MCRF02_AG
 BKO-1016BKO-1016EU330710None   I13V, I15L, K20I, M36I, R41K, L63S, I64L, H69K, K70R, L89MCRF02_AG
 BKO-1054BKO-1054EU330732None   I13A, I15L, K20I, M36I, R41K, L63S, H69K, L89MCRF02_AG
 SGO-05SGO-05EU330750None  V11IL10I, I13V, L19P, K20I, M36I, N37D, R41K, L63S, C67Y, H69K, K70R, L89MCRF02_AG
 SGO-09SGO-09EU330754None  L89VI13A, K14R, K20I, E35D, M36I, R41K, L63S, H69K, I72MCRF02_AG
 SGO-15SGO-15EU330760None   T4S, T12E, I13V, K14R, G16E, L19I, K20I, M36I, R41K, L63S, I64V, H69K, K70R, I72T, L89MCRF02_AG
 SGO-16SGO-16EU330761None   I13V, K14R, I15V, G17E, K20I, M36I, L63S, I64M, H69K, L89MCRF02_AG
 SGO-29SGO-29EU330773None  V11II13V, K14R, K20I, M36I, R41K, L63S, H69K, V82I, L89MCRF02_AG
 SGO-45SGO-45EU330789None   I13V, K14R, G16E, K20I, E35D, M36I, R41K, K43R, L63S, I64L, H69K, K70R, L89ICRF02_AG
 SGO-55SGO-55EU330799None   I13V, K14R, I15V, G17E, K20I, M36I, L63S, I64M, H69K, L89MCRF02_AG
 SGO-56SGO-56EU330800None   I13V, K14R, I15V, G17E, K20I, M36I, L63S, I64M, H69K, L89MCRF02_AG
 SGO-74SGO-74EU330817None   L10V, I13A, K14R, I15V, L19P, K20I, M36I, R41K, L63S, H69K, K70R, L89MCRF02_AG
 SGO-83SGO-83EU330824None   T4S, T12A, I13V, K14R, I15V, G16E, L19I, K20I, M36I, R41K, L63S, I64V, H69K, K70R, I72T, L89MCRF02_AG
 SGO-84SGO-84EU330825None   T4S, T12A, I13V, K14R, G16E, L19I, K20I, M36I, R41K, L63S, I64V, H69K, K70R, I72T, L89MCRF02_AG
Holguin (2008)SP42-195689SP42-195689EU342748None   I13V, K14R, K20IV, M36I, R41K, L63S, H69K, L89MCRF02_AG
Sylla (2008)A2608A2608_C1DQ991631None  V11IL10I, I13V, I15V, L19P, K20I, M36I, R41K, L63S, H69K, K70R, L89MCRF02_AG
  A2608_C2DQ991632None  V11IL10I, I13V, I15V, L19P, K20I, M36I, R41K, L63S, H69K, K70R, L89MCRF02_AG
 C1078C10781_C1DQ991651None   L10I, I13V, K14R, I15L, K20I, M36I, R41K, L63S, H69K, K70R, L89MCRF02_AG
  C10781_C2DQ991652None   L10I, I13V, K14R, I15L, K20I, M36I, R41K, L63S, H69K, K70R, L89MCRF02_AG
 D604D604_C1DQ991653None   T12I, I13V, K14R, G17E, K20I, E35N, M36I, R41K, I62V, L63S, H69K, T74S, L89MCRF02_AG
  D604_C2DQ991654None   T12I, I13V, K14R, G17E, K20I, E35N, M36I, R41K, I62V, L63S, H69K, T74S, L89MCRF02_AG
 A013A013_C1EF525643None   I13A, K14R, K20I, M36I, N37D, R41K, L63S, H69K, L89MCRF02_AG
  A013_C2EF525644None   I13A, K14R, K20I, M36I, N37D, R41K, L63S, H69K, L89MCRF02_AG
Ayouba (2009)RES609RES609PRGQ351713None   I13V, K14R, I15V, G16E, L19I, K20I, E35K, M36I, N37D, R41K, K43R, I62V, L63S, I64M, H69K, K70R, L89MCRF02_AG
Cuevas (2009)P1682P1682.1EU822744None   I13V, K14R, G17E, K20I, M36I, R41K, L63S, H69K, L89MCRF02_AG
Hawkins (2009)R45ZZR45FJ931271None   I13A, K14R, G16E, K20I, M36I, P39A, R41K, I62V, L63S, H69K, K70R, L89ICRF02_AG
 Q944ZZQ944FJ931288None   I13A, K20I, M36I, P39PL, L63S, H69K, L89MCRF02_AG
 R14ZZR14FJ931307None   L10I, T12K, I13V, I15IL, K20I, M36I, N37H, R41K, L63S, H69K, K70KR, L89MCRF02_AG
 R159ZZR159FJ931349None   I13V, K20I, M36I, R41K, L63S, H69K, L89MCRF02_AG
 R216ZZR216FJ931369None   T12A, I13V, K14R, I15V, K20I, M36I, N37D, R41K, L63S, I64M, H69K, K70R, L89MCRF02_AG
 R466ZZR466FJ931390None   I13V, I15IV, K20I, M36I, L63S, I64M, H69K, L89MCRF02_AG
 R382ZZR382FJ931426None   I13V, K14R, K20R, M36I, R41K, I62V, L63S, I64M, H69K, L89MCRF02_AG
Rhee (2009)CA17687CA41616FJ983451None   L10I, T12N, I13V, L19P, K20I, M36I, R41K, L63S, I64L, H69K, K70R, L89MCRF02_AG
Tebit (2009)TR154TR154FJ577307None  V11IL10I, I13V, K14R, G16E, L19P, K20I, M36I, R41K, L63S, C67Y, H69K, K70R, L89MCRF02_AG
 TR193TR193FJ577327None   I13V, K14R, K20I, M36I, R41K, L63S, H69K, I72M, L89MCRF02_AG
Vercauteren (2009)pt17732700061467GQ399251None  V11II13V, K14R, K20I, M36I, R41K, L63S, I64M, H69K, L89MCRF02_AG
 pt15843852420844GQ399440None   I13V, K14R, K20I, E35D, M36I, L63S, I64M, H69K, L89MCRF02_AG
 pt15334075467778GQ399491None   I13V, K14R, G16E, K20I, M36I, R41K, L63S, H69K, A71AG, P79AT, L89MCRF02_AG
 pt13635047243384GQ399661None   I13AV, K14R, L19LI, K20I, E35ED, M36I, R41K, L63S, I64M, H69K, L89MCRF02_AG
 pt8078340510891GQ400217None   I13V, K14R, G16E, K20I, M36I, R41K, L63S, H69K, K70R, L89MCRF02_AG
 pt7858460143385GQ400239None   V11VG, I13V, K14R, G16E, K20I, E35D, M36I, R41K, L63S, H69K, K70R, L89MCRF02_AG
 pt7088862133520GQ400316None   I13V, K14G, K20I, M36I, L63S, H69K, L89MCRF02_AG
 pt287LOgHh7fBICGQ400737None   T12A, I13V, K14R, I15V, K20I, M36I, R41K, L63S, I64M, H69K, K70E, I72IV, L89MCRF02_AG
 pt192puEFbes1xRGQ400832None   I13A, K20I, M36I, R41K, L63S, H69K, L89ICRF02_AG
Yaotse (2009)HT12706TG.HT127FM955727None   L10I, I13V, K14R, I15V, K20I, E35D, M36I, R41K, L63S, C67Y, G68D, H69K, K70R, L89MCRF02_AG
 HT13106TG.HT131FM955730None   T12A, I13V, K14R, G16E, K20I, M36I, P39S, L63S, I64M, H69K, L89ICRF02_AG
 HT17006TG.HT170FM955746None  V11IL10V, I13V, G16E, L19P, K20I, E35G, M36I, R41K, L63S, H69K, I72IV, V77I, L89MCRF02_AG
Yebra (2009)SP81-385167SP81-385167EU545188None   I13V, L19P, K20I, M36I, N37D, L63S, I64M, H69K, L89MCRF02_AG
Diop-Ndiaye (2010)1719-hald1719-haldFN599787None   I13V, K14R, G17E, K20I, M36I, R41K, L63S, I64M, H69K, L89MCRF02_AG
Djoko (2010)GQ43308GQ433FN557321None   I13V, L19LS, K20I, E35D, M36I, R41K, L63S, I64L, H69K, I72M, L89MCRF02_AG
 GQ19308GQ193FN557334None   I13V, K14R, K20I, M36I, N37D, R41K, L63S, H69K, L89MCRF02_AG
Germanaud (2010)55685568 None   I13A, K14R, I15V, K20I, M36I, N37D, R41K, K43R, L63S, H69K, K70R, L89ICRF02_AG
Yebra (2010)38516707SP385167FJ481705None   L10LI, I13V, G16GE, L19P, K20I, M36I, N37ND, L63S, I64M, H69K, L89MCRF02_AG
 40134607SP401346FJ481710None   T12I, I13V, K14R, K20I, M36I, R41K, L63S, H69K, L89MCRF02_AG
Aghokeng (2011)HJ1915HJ1915JN639462None   L10V, I13V, G16E, K20I, L33V, E34T, M36I, N37T, P39S, I62V, L63S, H69K, L89MCRF02_AG
Avi (2011)077u077uGQ926639None   I13V, K14R, K20I, E35D, M36I, R41K, L63S, H69K, K70R, V82I, L89MCRF02_AG
Charpentier (2011)35CP 001 2127 None   I13V, K14KR, K20I, E35D, M36I, N37ND, R41K, L63S, I64L, H69K, K70R, I72L, L89MCRF02_AG
Dagnra (2011)08TG.T304608TG.T3046FR715261None   I13V, K14R, G16E, K20I, M36L, R41K, L63S, I64L, H69K, L89MCRF02_AG
 08TG.C703008TG.C7030FR715294None   I13V, K14R, K20I, M36I, P39Q, R41K, L63S, I64M, H69K, V82I, L89MCRF02_AG
Fokam (2011)CIRCB-10196CIRCB-10196JQ796128None   L10I, T12K, I13V, G17E, L19LP, K20I, M36I, R41K, K45R, L63S, C67Y, H69K, K70R, L89MCRF02_AG
 CIRCB-10362CIRCB-10362JQ796169None   I13V, G17E, K20I, M36I, L63S, H69K, L89MCRF02_AG
Hamers (2011)CP076304194CP076304194HQ993899None   T12P, I13V, K14R, G16E, K20R, E35D, M36I, N37D, R41K, L63S, H69K, K70KR, V77I, L89M, I93LCRF02_AG
 CP076303577CP076303577HQ994047None   L10V, I13V, G16E, K20I, M36I, P39T, R41K, L63S, I64L, H69K, K70R, L89MCRF02_AG
 CP076303600CP076303600HQ994064None  V11VIL10IV, T12K, I13V, G16E, L19LP, K20I, M36I, N37ND, R41RK, L63S, H69KQ, I72IM, L89MCRF02_AG
 CP076303608CP076303608HQ994070None  L89MVI15V, L19I, K20I, M36I, R41K, L63S, H69K, K70KR, I72IMCRF02_AG
 CP076305141CP076305141HQ994097None   L10LI, I13V, I15IV, L19LP, K20I, M36I, R41K, L63S, L89MCRF02_AG
 CP076305148CP076305148HQ994103None   I13V, K14R, K20IR, M36I, N37D, R41K, K43R, L63S, H69K, L89MCRF02_AG
 CP076305172CP076305172HQ994124None   I13V, K14R, K20I, E35D, M36I, R41K, K43KR, I62IV, L63S, I64M, H69K, K70R, V82I, L89MCRF02_AG
Caron (2012)Gab062003Gab062003HQ541922None   I13V, G17E, K20I, M36I, L63S, H69K, L89MCRF02_AG
 Gab081156Gab081156HQ541931None   T12P, I13V, K14R, G16E, K20I, E35D, M36I, R41K, R57K, L63S, G68E, H69R, L89MCRF02_AG
 Gab021278Gab021278HQ541946None  V11IL10I, I13V, K14R, G16E, K20I, E35D, M36I, R41K, L63S, C67Y, H69K, K70R, L89MCRF02_AG
 Gab082007Gab082007HQ541953None   T12P, I13V, K14R, G16E, K20I, E35D, M36I, R41K, L63S, G68E, H69R, L89MCRF02_AG
 Gab013118Gab013118JN704992None   I13V, K14R, G16E, L19I, K20I, E35D, M36I, R41K, I62V, L63S, I64M, H69K, L89MCRF02_AG
 Gab091163Gab091163JN705006None   I13A, G16E, K20I, E35G, M36I, R41K, L63S, C67Y, H69K, L89MCRF02_AG
Chamberland (2012)C422SC422SHQ267548None   L10V, T12A, I13V, K14R, I15V, G16E, K20I, E35N, M36I, R41K, I62IV, L63S, H69K, I72T, L89MCRF02_AG
 C429SC429SHQ267554None   I13V, K14R, G16E, K20I, M36I, R41K, L63S, H69K, K70R, L89MCRF02_AG
 C475SC475SHQ267585None   I13V, K14R, K20I, E35D, M36I, R41K, L63S, E65D, H69K, V82I, L89MCRF02_AG
 D316TD316THQ267616None   I13V, K14R, K20I, A28V, M36I, R41K, L63S, I64L, H69K, L89MCRF02_AG
 D318TD318THQ267618None   P9X, I13A, G16E, K20I, M36I, I62V, L63S, I64M, H69K, L89ICRF02_AG
 D321TD321THQ267620None   I13V, K14R, I15V, G16E, G17E, K20I, M36I, R41K, L63S, I64L, H69K, L89MCRF02_AG
 D326TD326THQ267623None   I13V, K14R, K20I, E35D, M36I, R41K, K43R, Q58QP, L63S, I64L, H69K, L89MCRF02_AG
 D331TD331THQ267627None   I13V, G16E, L19I, K20I, E35N, M36I, R41K, K43R, L63S, H69K, L89MCRF02_AG
Machado (2012)CUPL1023CUPL1023HQ655400None   I13V, K14R, G16E, K20I, E35D, M36I, R41K, L63S, H69K, K70R, L89M, T91A, Q92PCRF02_AG
Frentz (2013)EHR-23297EHR-23297JX299939None   I13V, K14R, K20I, E35D, M36I, R41K, L63S, I64L, H69N, V82I, L89M, I93LCRF02_AG
 EHR-46061EHR-46061JX300307None   I13V, K14R, G16E, K20I, M36I, R41K, K43R, L63S, I64L, H69K, L89MCRF02_AG
 EHR-69961EHR-69961JX300717None   T12A, I13V, G16E, K20I, E35D, M36I, L63S, I64M, H69K, K70R, L89MCRF02_AG
Hawke (2013)1601010916010109KC237966None   L10I, I13V, G16E, L19P, K20I, E35D, M36I, R41K, K43R, L63S, H69K, K70R, L89MCRF02_AG
 9955655399556553KC238299None   I13V, K14KR, G16E, L19V, K20I, E35D, M36I, R41K, L63S, H69K, K70R, V77VI, L89ICRF02_AG
Tramuto (2013)CV1257_15CV1257_15HQ667672None   I13V, K20I, M36I, R41K, K43KR, L63S, H69K, V82VI, L89MCRF02_AG
 CV1268_21CV1268_21HQ667676None   I13V, K20I, M36I, L38I, R41K, L63S, H69K, L89MCRF02_AG

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