<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF02_AG
Gene PR
Mutation L63P
Rx >= 1 PI
IncludeMixtures No
References 16
Patients 25
Isolates 29
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Si-Mohamed (2000)AS_FANAS_FANAF199275IDV I84V, L90ML89VL10I, I13V, L19P, K20I, M36I, N37S, R41K, L63P, H69K, K70R, A71V, I72MCRF02_AG
Snoeck (2002)BE2BE2AF338979IDV, SQV, RTV, NFV109V32I, I47V, G48V, I54V, V82ATF53FL, L89VL10V, I13V, L19IT, K20I, M36I, R41K, K55H, L63P, C67S, H69R, A71IVCRF02_AG
Venturi (2002)GV-29GV-29.1AF517281SQV134 V11VII13V, K14R, L19LP, K20I, M36I, R41K, K43R, Q61H, L63P, H69K, V82VI, L89ICRF02_AG
Holguin (2003)SP_LP25SP_LP25AF479612PINA  L19Q, N37S, L63P, I64LCRF02_AG
Montes (2004)MB_patROD00_ROD734AJ577982IDV82  T12A, I13V, K20I, M36I, R41K, L63PCRF02_AG
 MB_patALC02_ALC723AJ577727NFV, SQV, RTV91I84V, L90M L10I, I13V, K20I, E35D, M36I, R41K, K43R, L63P, H69K, A71V, L89ICRF02_AG
 MB_patALI01_ALI708AJ577728NFV14  T12E, I13V, K14R, G17E, K20I, M36I, L63P, I64L, H69K, L89MCRF02_AG
  02_ALI705AJ577729NFV16  T12E, I13V, K14R, G17E, K20I, M36I, L63P, I64L, H69K, L89MCRF02_AG
Non-B Workgroup (2005)PL1692558358AY900968NFV M46I, L90ML89VL10V, I13V, K20V, M36I, R41K, L63P, H69K, K70RCRF02_AG
  71340 NFV, UnknownNAM46I, I84V, L90ML33LI, L89VL10V, I13A, K14KR, K20IV, A22AV, E35EG, M36I, R41RK, K55KR, L63P, I66FV, H69K, K70R, P79PACRF02_AG
 IL32IL32b NFV22M46I, N88SL10LFI13V, K20I, M36I, P39L, R41K, I62V, L63P, H69K, L89MCRF02_AG
  IL32cAY901181NFV67M46I, N88S L10V, I13V, K20I, M36I, P39L, R41K, I62V, L63P, H69K, L89MCRF02_AG
 TK2008TK2008 RTV, IDV, NFV73  L10I, I13V, K20I, M36I, R41K, L63P, C67S, H69K, K70R, L89MCRF02_AG
Weber (2005)M86254M86254AY714445LPV, NFV143N88NS L10LV, I13V, K14N, K20I, L33LV, M36I, N37ND, L63P, I66IF, H69K, K70KR, A71AT, T74TS, L89IMCRF02_AG
Baxter (2006)48-12441244-30527DQ877767PINAM46L, I54V, V82A, I84VV11VI, L33F, K43T, F53LT4A, L10V, I13V, G16A, L19P, K20M, E21A, E35D, M36L, K55R, Q61H, L63P, H69K, T74AS, L89I, T91SCRF02_AG
 48-32243224-30624DQ878131PINAM46I, I47IV, L76V, I84VL33LI, Q58EL10I, I13A, K20I, A22V, M36I, R41K, L63P, I66F, H69K, K70R, L89I, T91SCRF02_AG
 48-32833283-30916DQ878190PINAM46I, I54M, L76V, I84VG73A, L89VL10I, I13A, K14KR, L19LI, K20I, L33V, M36I, R41K, K55R, R57RK, D60E, L63P, I66F, H69KCRF02_AG
 48-71247124-30902DQ878967PINAM46I, I47V, L76V, I84VQ58EL10I, I13A, K14IR, L19P, K20I, M36I, N37D, R41K, K55KR, L63P, H69K, K70R, L89ICRF02_AG
Laurent (2006)CK2-5902CM-59AM279443IDV61  I13V, K14R, I15V, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
Seyler (2007)239CS_239 IDV71  I13AV, K14R, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
 282CS_282 NFV, IDV150L90ML89VL10V, T12TK, I13V, L19P, K20I, E35G, M36I, N37ND, Y59YC, L63P, E65EK, H69K, K70R, A71TCRF02_AG
 545CS_545 IDV170I84VL33I, L89VL10I, I13V, K14R, L19P, K20I, A22V, M36I, N37D, L38I, R41K, L63P, H69K, A71V, T74SCRF02_AG
von Wyl (2007)1205327019EF449829PINAL90M L10V, I13V, K14R, I15V, K20I, E35G, M36I, R41K, L63P, G68E, H69R, A71T, L89ICRF02_AG
Riddler (2008)RG60650RG60650w114 LPV114  I13V, G17E, K20I, E35K, M36I, R41K, L63P, H69K, L89MCRF02_AG
Rosen-Zvi (2008)4600p46-1 RTV, SQV, NFV, APV141M46MIL, I54V, V82M, I84V, L90ML33F, Q58EL10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89ICRF02_AG
Sylla (2008)A2840A2840_C1DQ991637IDV   T12A, I13V, K14R, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
  A2840_C2DQ991638IDV   T12A, I13V, K14R, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
Charpentier (2011)2CP 001-032 Unknown, LPVNA L89VL10V, I13V, I15V, L19KR, K20I, E35G, M36I, N37ND, R41K, I62IV, L63P, H69K, K70N, A71T, T74TSCRF02_AG
Grossman (2014)554554KF135101LPV65M46I, I54V, V82AL10FI13V, G16Q, K20I, M36I, P39L, I62V, L63P, H69K, L89MCRF02_AG