<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF02_AG
Gene PR
Mutation L63P
Rx >= 1 PI
IncludeMixtures No
References 21
Patients 44
Isolates 49
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Si-Mohamed (2000)AS_FANAS_FANAF199275IDV I84V, L90ML89VL10I, I13V, L19P, K20I, M36I, N37S, R41K, L63P, H69K, K70R, A71V, I72MCRF02_AG
Snoeck (2002)BE2BE2AF338979IDV, SQV, RTV, NFV109V32I, I47V, G48V, I54V, V82ATF53FL, L89VL10V, I13V, L19IT, K20I, M36I, R41K, K55H, L63P, C67S, H69R, A71IVCRF02_AG
Venturi (2002)GV-29GV-29.1AF517281SQV134 V11VII13V, K14R, L19LP, K20I, M36I, R41K, K43R, Q61H, L63P, H69K, V82VI, L89ICRF02_AG
Holguin (2003)SP_LP25SP_LP25AF479612PINA  L19Q, N37S, L63P, I64LCRF02_AG
Montes (2004)MB_patROD00_ROD734AJ577982IDV82  T12A, I13V, K20I, M36I, R41K, L63PCRF02_AG
 MB_patALC02_ALC723AJ577727NFV, SQV, RTV91I84V, L90M L10I, I13V, K20I, E35D, M36I, R41K, K43R, L63P, H69K, A71V, L89ICRF02_AG
 MB_patALI01_ALI708AJ577728NFV14  T12E, I13V, K14R, G17E, K20I, M36I, L63P, I64L, H69K, L89MCRF02_AG
  02_ALI705AJ577729NFV16  T12E, I13V, K14R, G17E, K20I, M36I, L63P, I64L, H69K, L89MCRF02_AG
Non-B Workgroup (2005)PL1692558358AY900968NFV M46I, L90ML89VL10V, I13V, K20V, M36I, R41K, L63P, H69K, K70RCRF02_AG
  71340 NFV, UnknownNAM46I, I84V, L90ML33LI, L89VL10V, I13A, K14KR, K20IV, A22AV, E35EG, M36I, R41RK, K55KR, L63P, I66FV, H69K, K70R, P79PACRF02_AG
 IL32IL32b NFV22M46I, N88SL10LFI13V, K20I, M36I, P39L, R41K, I62V, L63P, H69K, L89MCRF02_AG
  IL32cAY901181NFV67M46I, N88S L10V, I13V, K20I, M36I, P39L, R41K, I62V, L63P, H69K, L89MCRF02_AG
 TK2008TK2008 RTV, IDV, NFV73  L10I, I13V, K20I, M36I, R41K, L63P, C67S, H69K, K70R, L89MCRF02_AG
Weber (2005)M86254M86254AY714445LPV, NFV143N88NS L10LV, I13V, K14N, K20I, L33LV, M36I, N37ND, L63P, I66IF, H69K, K70KR, A71AT, T74TS, L89IMCRF02_AG
Baxter (2006)48-12441244-30527DQ877767PINAM46L, I54V, V82A, I84VV11VI, L33F, K43T, F53LT4A, L10V, I13V, G16A, L19P, K20M, E21A, E35D, M36L, K55R, Q61H, L63P, H69K, T74AS, L89I, T91SCRF02_AG
 48-32243224-30624DQ878131PINAM46I, I47IV, L76V, I84VL33LI, Q58EL10I, I13A, K20I, A22V, M36I, R41K, L63P, I66F, H69K, K70R, L89I, T91SCRF02_AG
 48-32833283-30916DQ878190PINAM46I, I54M, L76V, I84VG73A, L89VL10I, I13A, K14KR, L19LI, K20I, L33V, M36I, R41K, K55R, R57RK, D60E, L63P, I66F, H69KCRF02_AG
 48-71247124-30902DQ878967PINAM46I, I47V, L76V, I84VQ58EL10I, I13A, K14IR, L19P, K20I, M36I, N37D, R41K, K55KR, L63P, H69K, K70R, L89ICRF02_AG
Laurent (2006)CK2-5902CM-59AM279443IDV61  I13V, K14R, I15V, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
Seyler (2007)239CS_239 IDV71  I13AV, K14R, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
 282CS_282 NFV, IDV150L90ML89VL10V, T12TK, I13V, L19P, K20I, E35G, M36I, N37ND, Y59YC, L63P, E65EK, H69K, K70R, A71TCRF02_AG
 545CS_545 IDV170I84VL33I, L89VL10I, I13V, K14R, L19P, K20I, A22V, M36I, N37D, L38I, R41K, L63P, H69K, A71V, T74SCRF02_AG
von Wyl (2007)1205327019EF449829PINAL90M L10V, I13V, K14R, I15V, K20I, E35G, M36I, R41K, L63P, G68E, H69R, A71T, L89ICRF02_AG
Riddler (2008)RG60650RG60650w114 LPV114  I13V, G17E, K20I, E35K, M36I, R41K, L63P, H69K, L89MCRF02_AG
Rosen-Zvi (2008)4600p46-1 RTV, SQV, NFV, APV141M46MIL, I54V, V82M, I84V, L90ML33F, Q58EL10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89ICRF02_AG
Sylla (2008)A2840A2840_C1DQ991637IDV   T12A, I13V, K14R, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
  A2840_C2DQ991638IDV   T12A, I13V, K14R, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
Charpentier (2011)2CP 001-032 Unknown, LPVNA L89VL10V, I13V, I15V, L19KR, K20I, E35G, M36I, N37ND, R41K, I62IV, L63P, H69K, K70N, A71T, T74TSCRF02_AG
Charpentier (2011)CR-22CR-22FJ688228PINA N83DL10I, I13V, I15IV, K20I, E35KN, M36I, N37E, P39PQ, R41K, K45R, I62V, L63P, H69Q, I72IV, L89ICRF02_AG
 CR-24CR-24FJ688230PINAM46I, N88NSL89VI13V, K14R, K20I, M36I, P39S, R41K, I62V, L63P, H69K, A71TCRF02_AG
 CR-17CR-17FJ688223PINAM46LL89VT4TP, L10V, I13V, K14R, I15V, K20I, E35D, M36I, R41K, L63P, I64M, I66F, H69K, K70R, A71T, I72VCRF02_AG
 CR-25CR-25FJ688231PINAM46I, L76V, I84IV L10I, I13V, K20I, M36I, R41K, L63P, I66F, H69K, L89MCRF02_AG
Kouri (2012)CU294-10CU294-10JQ585376PINAM46L, I54V, I84VQ58E, L89VI13A, L19P, K20I, A22V, L33V, E35D, M36I, N37D, I62IV, L63P, I66F, H69K, A71V, T74A, Q92K, I93IVCRF02_AG
 CU605-11CU605-11JQ585513PINA  T4TN, I13V, K14R, I15V, K20I, E35D, M36I, R41K, K45KR, L63P, H69K, K70Q, L89MCRF02_AG
 CU484-10CU484-10JQ585397PINA  I13V, K14R, G16E, K20I, E35D, M36I, R41K, L63P, H69K, K70R, L89M, T91ACRF02_AG
 CU344-10CU344-10JQ585386PINAM46L, I54V, I84VQ58EI13A, K20I, E35N, M36I, Q61QR, L63P, H69K, K70R, A71V, L89TCRF02_AG
Rawizza (2013)PJ9681PJ9681KF241511LPV I54V, V82AL89VL10V, I13A, K14R, I15V, K20I, A22V, E35D, M36I, R41K, Q61H, L63P, H69KCRF02_AG
 LL5290LL5290KF241477LPV   T12A, I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, K43R, L63P, H69K, L89MCRF02_AG
 LN4321LN4321KF241489LPV I54V, V82FQ58E, N83DL10V, T12M, I13A, K14KR, G16A, L19P, K20I, A22V, E35N, M36I, N37D, R41RK, Q61QH, L63P, H69K, A71V, L89I, I93MCRF02_AG
 PJ0771PJ0771KF241503LPV   I13A, K14R, I15IV, K20I, M36I, N37E, R41K, K43R, L63P, H69K, K70R, L89MCRF02_AG
 PJ2149PJ2149KF241459LPV M46LV, I54V, L76V, V82M, L90ML89IVT4S, L10IV, I13A, K20IV, A22V, E35D, M36I, N37DE, Q61E, I62V, L63P, C67F, H69K, A71I, I72L, P79A, T91S, Q92QKCRF02_AG
 OU9780OU9780KF241513LPV   T12TK, I13V, I15IV, K20I, M36I, R41K, L63P, E65D, H69K, L89MCRF02_AG
 PJ4782PJ4782KF241507LPV I54V, V82A I13V, K14R, G17E, K20I, M36I, I62V, L63P, C67E, H69K, L89MCRF02_AG
 LN3979LN3979KF241473LPV   I13V, K14R, K20I, M36I, R41K, L63P, H69K, L89MCRF02_AG
Thiam (2013)674-HALD674-HALDJN673677LPV M46I, L76V I13V, K14R, K20I, M36I, N37E, L63P, I64L, H69K, K70R, L89IMCRF02_AG
 495-HALD495-HALDJN673647LPV M46I, I47V, I54V, I84V, L90ML33I, L89VT4S, L10I, T12M, I13A, K14M, L19P, K20I, A22V, E35D, M36I, N37D, R41RK, R57K, Q61QH, I62IV, L63P, I66F, H69K, A71VCRF02_AG
Grossman (2014)554554 LPV52M46I, I54V, V82AL10FI13V, G16Q, K20I, M36I, P39L, I62V, L63P, H69K, L89MCRF02_AG
  554KF135101LPV65M46I, I54V, V82AL10FI13V, G16Q, K20I, M36I, P39L, I62V, L63P, H69K, L89MCRF02_AG
Nerrienet (2014)U0302042U0302042JN675764LPV M46I, I54V, V82A, L90ML10F, L33I, K43T, N88DV11L, I13V, L19LV, K20V, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71V, T74S, L89T, T91ACRF02_AG