<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF02_AG
Gene PR
Mutation M46I
Rx >= 1 PI
IncludeMixtures No
References 13
Patients 39
Isolates 42
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Montes (2004)MB_patTAF02_TAF703AJ578163Unknown, NFV>36M46I I13V, G16E, K20I, E35D, M36I, R41K, I64M, H69K, I72V, L89TCRF02_AG
 MB_patKES01_KES716AJ577920NFV136M46I, L90ML89VL10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70R, T74S, V75ICRF02_AG
Non-B Workgroup (2005)PL1692558358AY900968NFV M46I, L90ML89VL10V, I13V, K20V, M36I, R41K, L63P, H69K, K70RCRF02_AG
  71340 NFV, UnknownNAM46I, I84V, L90ML33LI, L89VL10V, I13A, K14KR, K20IV, A22AV, E35EG, M36I, R41RK, K55KR, L63P, I66FV, H69K, K70R, P79PACRF02_AG
 PL3560858508AY900971IDV, NFV M46I, I54V, V82A, L90M I13V, K14KR, I15V, L19V, K20I, E35D, M36I, I64M, H69K, L89MCRF02_AG
 PL3515957564AY901074IDV, NFV160M46I, I54V, I84IV, L90ML89VI13V, K14R, I15V, K20I, E35D, M36I, R41K, H69K, A71TCRF02_AG
 PL3892365841AY901082SQV, ATV M46I I13V, E35N, M36I, N37D, I64M, H69K, T74S, L89TCRF02_AG
 IL32IL32b NFV22M46I, N88SL10LFI13V, K20I, M36I, P39L, R41K, I62V, L63P, H69K, L89MCRF02_AG
  IL32cAY901181NFV67M46I, N88S L10V, I13V, K20I, M36I, P39L, R41K, I62V, L63P, H69K, L89MCRF02_AG
 PL3504797181 IDV, NFV337M46I, L90ML89VL10V, I13V, K14KR, L19LP, K20I, E35G, M36I, N37E, R41K, I62V, H69K, K70R, T74SCRF02_AG
Weber (2005)30239393023939AY677492APV, LPV239M46I, L76V, V82F, I84C L10I, I13V, G16E, K20I, E35D, M36I, N37NK, R41K, L63M, H69K, K70R, T74S, L89MCRF02_AG
Baxter (2006)48-12261226-30417DQ877758PINAM46I, I47V, L76V, I84AV11I, G73S, L89VL10M, I13V, K14R, I15V, Q18I, K20I, M36I, N37D, R41K, H69K, A71V, T74SCRF02_AG
 48-30903090-30925DQ877999PINAM46I, I47V, I54V, V82C, I84VV11I, L33I, K43T, F53FLL10I, T12M, I13V, K14R, L19P, K20I, A22V, M36I, R41K, K55R, H69K, K70R, I72V, T74S, L89I, T91SCRF02_AG
 48-32243224-30624DQ878131PINAM46I, I47IV, L76V, I84VL33LI, Q58EL10I, I13A, K20I, A22V, M36I, R41K, L63P, I66F, H69K, K70R, L89I, T91SCRF02_AG
 48-32833283-30916DQ878190PINAM46I, I54M, L76V, I84VG73A, L89VL10I, I13A, K14KR, L19LI, K20I, L33V, M36I, R41K, K55R, R57RK, D60E, L63P, I66F, H69KCRF02_AG
 48-42214221-30429DQ878456PINAM46I, I84VL10F, L33I, G73SI13V, K14R, K20I, E21ED, A22V, M36I, N37D, R41K, L63LP, H69K, K70R, A71V, L89TCRF02_AG
 48-71247124-30902DQ878967PINAM46I, I47V, L76V, I84VQ58EL10I, I13A, K14IR, L19P, K20I, M36I, N37D, R41K, K55KR, L63P, H69K, K70R, L89ICRF02_AG
Rosen-Zvi (2008)105p1-3 LPV, RTV, APV140M46I, V82A, I84VN83DL10V, I13V, K14R, K20R, A22V, M36I, N37D, R41K, Q61H, H69K, K70R, L89ICRF02_AG
Knops (2010)ID0462ID0462-GT2GU271157LPV105M46I, L76V L10V, T12K, I13V, K14R, G16E, L19I, K20I, M36I, R41K, H69K, L89MCRF02_AG
Charpentier (2011)CR-24CR-24FJ688230PINAM46I, N88NSL89VI13V, K14R, K20I, M36I, P39S, R41K, I62V, L63P, H69K, A71TCRF02_AG
 CR-43CR-43FJ688249PINAM46I, V82FL10FI13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63T, H69K, T74TA, L89M, I93MCRF02_AG
 CR-25CR-25FJ688231PINAM46I, L76V, I84IV L10I, I13V, K20I, M36I, R41K, L63P, I66F, H69K, L89MCRF02_AG
 CR-36CR-36FJ688242PINAM46I, L76V L10V, I13V, K14R, G16E, K20I, E35G, M36I, R41K, I62V, I66F, H69K, K70R, L89MCRF02_AG
 CR-34CR-34FJ688240PINAM46I, I54V, I84V L10I, I13A, K14R, K20I, M36I, R41K, K43R, H69K, K70R, A71I, P79S, L89T, Q92K, I93MCRF02_AG
Barber (2012)6078360783JQ361670LPV M46I, I84V L10I, I13V, G16E, Q18QK, L19LP, K20I, E35D, M36I, N37T, P39S, R41K, I62V, H69K, K70R, T74A, L89MCRF02_AG
Kouri (2012)CU1288-10CU1288-10JQ585421PINAM46I, I54L, I84VV11I, L33F, Q58EL10I, I13V, K14R, I15V, G16E, L19P, K20V, E35N, M36I, N37D, K55R, R57RK, Q61H, L63S, H69K, K70R, I72IM, I85V, L89MCRF02_AG
 CU1213-09CU1213-09JQ585280PINAV32I, M46I, I47V, I54L, I84VL33F, F53L, Q58E, L89VL10I, T12E, I13AV, K14R, I15V, G16Q, K20V, E35G, M36I, P39S, R41RK, D60DN, I64V, I66F, H69K, K70E, A71V, I93IVCRF02_AG
Rawizza (2013)LN3579LN3579KF241472LPV M46I, G48M, I54V, V82SL10F, K43TI13V, K14R, K20I, E35D, M36I, R41K, C67E, H69R, T74S, L89IMCRF02_AG
 LN0319LN0319KF241469LPV M46I, I54V, V82AL10FI13V, K14R, G16E, K20I, E35D, M36I, R41K, K43R, I62V, H69K, T74E, L89MCRF02_AG
 PJ2562PJ2562KF241497LPV M46I, L76V I13V, K14R, G16E, K20I, E35D, M36I, R41K, Q61QH, I64M, H69K, K70R, L89MCRF02_AG
 PJ9959PJ9959KF241498LPV M46I, I54V, V82A L10I, I13V, K14R, G17E, K20I, M36I, N37S, R41K, C67H, H69K, P81PL, L89MCRF02_AG
 LL5309LL5309KF241462LPV M46I, I54V, L76V, V82AL10F, Q58EI13V, I15V, G16E, K20I, E35D, M36I, R41K, L63R, I64M, H69K, K70R, L89M, T91ACRF02_AG
 LN8580LN8580KF241492LPV M46I, I54V, L76V, V82VA, I84IVL89VL10LI, I13V, G16A, K20I, M36I, R41K, H69K, K70R, A71AVCRF02_AG
Thiam (2013)133-HALD133-HALDJN673604PINAM46I, I47V, I54V, I84VL33I, G73SL10I, V11L, I13V, L19P, K20I, M36I, R41K, Q61H, L63V, H69K, K70R, A71V, I72T, P79A, N83S, L89TCRF02_AG
 1837HALD1837HALDJX187611LPV M46I, I54V, L76V, I84VQ58EL10I, I13V, G16E, K20I, M36I, R41K, L63HR, H69K, K70R, I72V, L89MCRF02_AG
 471-HALD471-HALDJN673637LPV M46I, I47V, I54V, V82A, I84VV11I, F53LL10I, I13V, L19P, K20I, A22V, M36I, N37S, R41K, Q61H, H69K, A71V, L89I, T91SCRF02_AG
 674-HALD674-HALDJN673677LPV M46I, L76V I13V, K14R, K20I, M36I, N37E, L63P, I64L, H69K, K70R, L89IMCRF02_AG
 495-HALD495-HALDJN673647LPV M46I, I47V, I54V, I84V, L90ML33I, L89VT4S, L10I, T12M, I13A, K14M, L19P, K20I, A22V, E35D, M36I, N37D, R41RK, R57K, Q61QH, I62IV, L63P, I66F, H69K, A71VCRF02_AG
 6667HALD6667HALDJX187625LPV M46I, L76V, I84VL10F, V11II13V, G16E, L19P, K20I, A22AV, M36I, R41K, L63R, H69K, K70R, L89I, T91ACRF02_AG
Grossman (2014)554554 LPV52M46I, I54V, V82AL10FI13V, G16Q, K20I, M36I, P39L, I62V, L63P, H69K, L89MCRF02_AG
  554KF135101LPV65M46I, I54V, V82AL10FI13V, G16Q, K20I, M36I, P39L, I62V, L63P, H69K, L89MCRF02_AG
Nerrienet (2014)U0302042U0302042JN675764LPV M46I, I54V, V82A, L90ML10F, L33I, K43T, N88DV11L, I13V, L19LV, K20V, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71V, T74S, L89T, T91ACRF02_AG