<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF02_AG
Gene PR
Mutation E35N
Rx PI-naive
IncludeMixtures No
References 56
Patients 107
Isolates 110
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Cornelissen (2000)MC97GH23MC97GH23AF212286None   Q2X, I13V, K14R, K20I, E35N, M36I, N37D, R41K, H69K, K70R, L89MCRF02_AG
Vergne (2000)LVMP631LVMP631AJ286941None   I13V, K14R, K20I, E35N, M36I, N37D, R41K, H69K, K70R, L89MCRF02_AG
 LVMBFE190LVMBFE190AJ287017None   I13V, K20I, E35N, M36I, R41K, I64L, H69K, L89MCRF02_AG
Fonjungo (2002)CM28CM28AY051273None   L10V, I13V, K14R, L19P, K20I, E35N, M36I, N37D, R41K, H69K, K70R, L89M, I93LCRF02_AG
 CM135CM135AY051236None   T12K, I13V, K14R, G16W, K20I, E35N, M36I, R41K, H69K, L89M, I93LCRF02_AG
 CM115CM115AY051224None   T12K, I13V, K20I, E35N, M36I, N37D, R41K, L63S, E65D, H69K, L89M, I93LCRF02_AG
Holguin (2003)SP_LP22SP_LP22AF455619None   I3V, L10I, T12P, I13V, I15V, K20I, E35N, M36I, R41K, I64M, H69K, L89MCRF02_AG
Shafer (2003)A384_27672767aEF548513None   T12TA, I13V, K14R, K20I, E35N, M36I, P39Q, R41K, H69K, L89MCRF02_AG
Toni (2003)TTDdp21TTDdp21AY207671None   I13V, K14R, L19S, K20I, E35N, M36I, N37E, R41K, I64M, G68GE, H69K, K70R, L89MCRF02_AG
 TTDdp48TTDdp48AY207693None   I13V, K20I, E35N, M36I, R41K, H69K, L89M, T91TACRF02_AG
 TTDdp63TTDdp63AY207706None   I13V, K14R, G16E, K20I, E35N, M36I, R41K, H69K, K70R, I72V, L89MCRF02_AG
 TTDpci119TTDpci119AY207745None   I13V, K14R, G16E, K20I, E35N, M36I, P39Q, R41K, H69K, L89MCRF02_AG
 TTDdp50TTDdp50AY207694None   I13V, K14R, K20I, E35N, M36I, N37D, I64L, H69K, L89MCRF02_AG
Konings (2004)KF_Pat7001CM5497AY359752None   I13A, K14R, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
 KF_Pat7200CM2124AY359754None   I13V, K14R, K20I, E35N, M36I, N37E, R41K, H69K, L89MCRF02_AG
Holguin (2005)LP5702_LP57AY248293None   I3V, L10I, I13V, K14R, K20I, E35N, M36I, R41K, L63P, I64M, H69K, V82I, L89MCRF02_AG
Non-B Workgroup (2005)UK1523UK1523AY900808None   I13V, K14R, K20I, E35N, M36I, R41K, R57K, L63P, H69K, K70R, L89MCRF02_AG
Weber (2005)33458243345824AY677498None   I13V, G17E, K20I, E35N, M36I, R41K, I64IR, H69K, V77I, L89MCRF02_AG
Ndongmo (2006)CM14CBN_CM14DQ394111None   I13V, K14R, K20I, E35N, M36I, R41K, H69K, L89M, I93LCRF02_AG
 CM26CBN_CM26DQ394165None   I13V, K20I, E35N, M36I, R41K, D60E, H69K, T74S, L89M, I93LCRF02_AG
Vessiere (2006)AV_M3348NAV_M3348NDQ297251None   I13V, K14R, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
 AV_M6128NAV_M6128NDQ297207None   I13V, K14R, G17E, K20I, E35N, M36I, R41K, K43R, L63P, H69K, V77I, L89MCRF02_AG
Vidal (2006)NV_KP00902.KP009AM041027None   I13V, K14R, K20I, E35N, M36L, R41K, L63P, H69K, V82I, L89MCRF02_AG
Derache (2007)12591259EF064503None   I13V, K14R, G17E, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
 12761276EF064515None   I13V, K14R, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
Holguin (2007)581187581187EF583188None   I3V, L10I, I13V, I15V, K20I, E35N, M36I, R41K, R57RK, I64M, H69K, L89MCRF02_AG
 598078598078EF583226None   I13V, K14R, I15V, K20I, E35N, M36I, R41K, K43R, H69K, T74S, L89MCRF02_AG
Sanchez Onoro (2007)07041700704170 None   I3V, L10I, I13V, I15LV, L19V, K20I, L33LV, E35N, M36I, R41K, L63P, H69K, L89MCRF02_AG
 581187581187 None   I3V, L10I, I13V, I15V, K20I, E35N, M36I, R41K, R57RK, I64M, H69K, L89MCRF02_AG
von Wyl (2007)8496905EF449889None   L10V, T12K, I13V, K14R, G16E, K20I, E35N, M36I, N37D, R41K, I64M, H69K, K70R, L89MCRF02_AG
Delgado (2008)GH_009GH_009EU177886None   I13V, K14R, L19P, K20I, E35N, M36I, N37D, R41K, L63P, H69K, L89MCRF02_AG
Derache (2008)BKO-1032BKO-1032EU330720None   I13V, K20I, E35N, M36V, N37C, R41K, H69K, L89MCRF02_AG
 SGO-28SGO-28EU330772None  V11II13V, K20I, E35N, M36I, R41K, I64M, H69K, K70R, L89MCRF02_AG
Holguin (2008)SP47-353742SP47-353742EU342809None   I13V, K14R, I15V, K20I, E35N, M36I, R41K, I62V, I64M, G68E, H69R, I72V, L89MCRF02_AG
Ndembi (2008)CMYD-3104CMYD-31DQ990402None   I13V, K20I, E35N, M36I, R41K, I64M, H69K, L89MCRF02_AG
Sylla (2008)D604D604_C1DQ991653None   T12I, I13V, K14R, G17E, K20I, E35N, M36I, R41K, I62V, L63S, H69K, T74S, L89MCRF02_AG
  D604_C2DQ991654None   T12I, I13V, K14R, G17E, K20I, E35N, M36I, R41K, I62V, L63S, H69K, T74S, L89MCRF02_AG
Aghokeng (2009)CYO035CYO035GU191587None   I13V, G16A, E35N, M36I, N37D, R41K, I62V, H69K, I72M, L89MCRF02_AG
 CDC2_99CDC2_99GU191625None   T12A, I13V, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
Ayouba (2009)RES027RES027-1PRGQ351735None   I13V, Q18E, K20I, E35N, M36L, R41K, L63P, H69K, L89MCRF02_AG
 29852985HALDPRGQ351965None   I13V, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
 29122912HALDPRGQ351958None   I13V, K14R, K20I, E35N, M36I, R41K, L63P, H69K, L89MCRF02_AG
Bartolo (2009)SNS0401AOSNS04EU068284None   T12K, I13V, K20I, E35N, M36I, N37D, H69K, L89MCRF02_AG
Hawkins (2009)Q772ZZQ772FJ931342None   I13V, K14KR, G17E, K20I, E35N, M36I, R41K, H69K, K70R, L89MCRF02_AG
 R26ZZR26FJ931343None   I13V, K14R, I15V, G16E, K20I, E35N, M36I, R41RK, L63LP, H69K, I72V, L89MCRF02_AG
 Q998ZZQ998FJ931364None   I13V, K14KR, K20I, E35N, M36I, N37DE, R41K, H69K, K70R, L89MCRF02_AG
 R444ZZR444FJ931455None   I13V, K14R, K20I, E35N, M36I, N37D, R41K, H69K, L89MCRF02_AG
Vercauteren (2009)pt13385212793074GQ399686None   I13V, K20I, E35N, M36I, R41K, K45R, R57K, L63P, H69K, K70G, L89MCRF02_AG
 pt5059871067540GQ400519None   L10I, I13V, K20I, E35N, M36I, R41K, I64M, H69K, L89MCRF02_AG
 pt152RsyGASQlDDGQ400872None   I13V, G16E, K20I, E35N, M36L, R41K, I64M, H69K, K70R, L89MCRF02_AG
Yaotse (2009)HT03806TG.HT038FM955683None   I13V, K14R, K20I, E35N, M36I, R41K, I64L, H69K, L89MCRF02_AG
 HT04606TG.HT046FM955687None   I13AV, K14R, I15V, K20I, E35N, M36I, N37D, R41K, H69K, K70R, L89MCRF02_AG
 HT14606TG.HT146FM955736None   I13V, K14R, K20I, E35N, M36I, N37D, R41K, H69K, K70R, L89MCRF02_AG
Yebra (2009)SP22-353742SP22-353742EU255507None   I13V, K14KR, I15V, K20I, E35N, M36I, R41K, I62V, I64M, G68E, H69R, I72V, L89MCRF02_AG
 SP106-287543SP106-287543EU552227None   I13V, K14KR, K20I, E35N, M36I, P39S, R41K, H69K, L89MCRF02_AG
Castelbranco (2010)090038A090038AHM357741None  L33IVI13V, K20I, E35N, M36I, N37E, L63F, H69K, L89MCRF02_AG
Moussa (2010)2239-0851F1HM117946None   L10I, I13V, K20I, E35N, M36I, N37D, R41K, L63P, H69Q, L89MCRF02_AG
Soares (2010)CM05_085CM05_085GU366123None   I13V, K14R, Q18E, K20I, E35N, M36I, R41K, H69K, K70R, L89MCRF02_AG
Yang (2010)20106934342010693434JQ616905None   T12E, I13V, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
 20106934752010693475JQ616913None   I13V, K20I, E35N, M36I, N37E, H69K, K70R, V77I, L89MCRF02_AG
Aghokeng (2011)HJ604HJ604JN639448None   I13V, K14R, I15V, K20I, E35N, M36I, N37D, R41K, K43R, L63P, H69K, L89MCRF02_AG
 HJ1908HJ1908JN639479None   I13V, K20I, E35N, M36I, N37D, R41K, H69K, L89MCRF02_AG
 SK1006-PISK1006-PIHQ864399None   L10V, I13V, K14KR, G17DE, K20I, E35N, M36I, N37ND, L63X, H69K, L89MCRF02_AG
 SK4089-PISK4089-PIHQ864418None   I13V, K14KR, G16GE, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
 SK3014-PISK3014-PIHQ864459None   L10V, I13V, K14R, I15IV, G16GE, K20I, E35N, M36I, N37D, R41K, L63Q, H69K, L89MCRF02_AG
Charpentier (2011)CR-15CR-15FJ688221None   I13V, K20I, E35N, M36I, N37D, R41K, I64IM, H69K, L89MCRF02_AG
Dagnra (2011)08TG.T301308TG.T3013FR715253None   I13V, K14R, G16E, K20I, E35N, M36I, R41K, R57K, H69K, K70R, L89MCRF02_AG
 08TG.E505908TG.E5059FR715283None   T12A, I13V, I15IV, G16E, K20I, E35N, M36I, R41K, R57K, I64M, H69K, L89MCRF02_AG
El Annaz (2011)18221822HQ393251None   I13V, K14R, G17E, K20I, E35N, M36I, R41K, H69K, K70R, L89MCRF02_AG
Fokam (2011)CIRCB-8956CIRCB-8956JQ796106None   I13V, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
 CIRCB-9660CIRCB-9660JQ796108None   I13V, K20I, E35N, M36I, R41K, H69K, V77I, L89MCRF02_AG
 CIRCB-10740CIRCB-10740JQ796114None   I13V, K14R, I15V, K20I, E35N, M36I, R41N, H69K, L89MCRF02_AG
 CIRCB-9626CIRCB-9626JQ796160None   I13IV, K14R, L19LI, K20I, E35N, M36I, R41K, I64M, H69K, L89MCRF02_AG
Hamers (2011)302449CP076302449HM120132None   I13V, K20I, E35N, M36I, R41K, I64L, H69K, L89MCRF02_AG
 CP076303543CP076303543HQ994022None   I13V, K20I, E35N, M36I, N37D, R41K, K43R, R57RK, H69K, T74S, V77I, L89MCRF02_AG
 CP076303548CP076303548HQ994027None   L10I, I13V, L19LP, K20I, E35N, M36I, R41K, H69Q, K70R, L89MCRF02_AG
 CP076303566CP076303566HQ994038None   I13V, K14R, G17E, K20I, E35N, M36I, N37D, R41RK, H69K, L89MCRF02_AG
Caron (2012)Gab014170Gab014170HQ541895None   I13V, K14R, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
 Gab091033Gab091033HQ541940None   L10I, I13V, K14R, K20I, E35N, M36I, N37D, R41K, H69K, L89MCRF02_AG
 Gab091211Gab091211HQ541942None   I13V, K14G, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
Chamberland (2012)C422SC422SHQ267548None   L10V, T12A, I13V, K14R, I15V, G16E, K20I, E35N, M36I, R41K, I62IV, L63S, H69K, I72T, L89MCRF02_AG
 D315TD315THQ267615None   Q2QL, I13V, K14R, I15V, K20V, E35N, M36I, P39S, R41K, H69K, V77I, L89MCRF02_AG
 D331TD331THQ267627None   I13V, G16E, L19I, K20I, E35N, M36I, R41K, K43R, L63S, H69K, L89MCRF02_AG
 D342TD342THQ267637None   L10I, I13V, K14R, G16E, L19P, K20I, E35N, M36I, P39S, R41K, Y59F, H69K, L89MCRF02_AG
De Gascun (2012)IRL55067IRL55067JN622367None   I13V, K20I, E35N, M36I, R41K, I64M, H69K, L89MCRF02_AG
Karlsson (2012)SE_262SE_262JQ698849None   I13IV, K14R, G16E, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
Mollan (2012)MK263MK263w0 None   I13V, K14R, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
  MK263w98 None   I13V, K14R, K20I, E35N, M36I, R41K, H69K, G78GR, L89MCRF02_AG
Somda (2012)44-276-2144-276-21HG529943None   I13V, L19LP, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
 9-1519-229-1519-22HG529952None   T12TA, I13V, K14R, G16E, K20I, E35N, M36I, R41K, H69K, V77I, L89MCRF02_AG
Ugbena (2012)1-1-1411-1-141JX084079None   K20I, E35N, M36I, R41K, H69K, K70KR, L89MCRF02_AG
 1-1-1421-1-142JX084080None   K20I, E35N, M36I, L38LI, P39T, R41K, L63P, H69K, K70R, V77VI, L89MCRF02_AG
 2-1-0232-1-023JX084144None   I15IV, K20I, E35N, M36I, N37D, R41K, H69K, L89MCRF02_AG
 1-1-1331-1-133JX084071None   I15IV, G17GE, K20I, E35N, M36I, R41K, K43KR, I64IM, H69K, K70KR, L89MCRF02_AG
 2-1-1242-1-124JX084238None   G16E, K20I, E35N, M36I, R41K, L63LV, G68GE, H69K, K70KR, V77VI, P79PADH, L89MCRF02_AG
Youngpairoj (2012)cm1090cm1090DQ166391None   I13V, K14R, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
Aghokeng (2013)HJ3220HJ3220JX983035None   L10I, V11T, I13V, G16GE, K20I, E35N, M36I, R41K, Q61QH, H69K, K70R, L89MCRF02_AG
Billong (2013)MR104MR104KF192148None   T12TA, I13V, K14R, I15V, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
Frentz (2013)EHR-27864EHR-27864JX300024None   I13V, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
Kebe (2013)SNA3-196SNA3-196JN193494None   I13V, K14R, I15IV, K20I, E35N, M36I, R41K, L63S, I64M, H69K, L89MCRF02_AG
 SNA3-195SNA3-195HM002541None   I13V, K14R, I15IV, K20I, E35N, M36I, R41K, L63S, I64M, H69K, L89MCRF02_AG
Leye (2013)SN.MS636SN.MS636FM210731None   I13V, L19P, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
Nii-Trebi (2013)894894AB751460None   I13V, I15V, K20I, E35N, M36I, R41K, I64IM, H69K, V77VI, L89MCRF02_AG
 16491649AB751440None   I13V, L19P, K20I, E35N, M36I, R41K, R57K, H69K, K70R, L89MCRF02_AG
 139182139182AB751431None   I13V, I15V, K20I, E35N, M36I, N37E, R41K, I64M, H69K, K70R, L89MCRF02_AG
 KF256KF256AB751490None   I13V, K14S, G16E, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
Pircher (2013)A1029A1029JX110276None   I13V, K14R, K20I, E35N, M36I, R41K, H69K, K70R, I72M, V82I, L89MCRF02_AG
Thiam (2013)2666-HALD2666-HALDJN673686None  V11IT12K, I13V, L19I, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG
Bartolo (2014)09AOHDP21209AOHDP212KF853800None   L10LV, T12TA, I13V, I15IV, K20I, E35N, M36I, N37D, H69K, L89MCRF02_AG
 09AOHDP2009AOHDP20KF853792None   L10V, I13V, G16E, L19P, K20I, E35N, M36I, R41K, H69K, L89MCRF02_AG