<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF02_AG
Gene PR
Mutation E35D
Rx >= 1 PI
IncludeMixtures No
References 22
Patients 63
Isolates 65
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Holguin (2000)AH-HC14HolgHC14AF125294SQV, RTV   I13V, K14R, I15L, L19P, K20I, E21K, E35D, M36I, R41K, H69K, L89MCRF02_AG
Thomson (2001)MT-X98MT-X98AY017454IDV   I13V, K20I, E35D, M36I, R41K, H69K, L89MCRF02_AG
Holguin (2002)AH_G4525AH_G4525AF354024IDV19  I13V, K14R, K20I, E35D, M36I, R41K, H69K, K70R, L89MCRF02_AG
Venturi (2002)GV-33GV-33.1AF517285SQV, RTV74  I13V, K20R, E35D, M36I, N37D, R41K, H69K, L89MCRF02_AG
 GV-56GV-56.1AF517308IDV107 F53FL, L89MVI13V, K14KR, K20R, E35D, M36I, N37D, R41K, H69KCRF02_AG
Montes (2004)MB_patTAF02_TAF703AJ578163Unknown, NFV>36M46I I13V, G16E, K20I, E35D, M36I, R41K, I64M, H69K, I72V, L89TCRF02_AG
 MB_patALC02_ALC723AJ577727NFV, SQV, RTV91I84V, L90M L10I, I13V, K20I, E35D, M36I, R41K, K43R, L63P, H69K, A71V, L89ICRF02_AG
 MB_patKES01_KES716AJ577920NFV136M46I, L90ML89VL10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70R, T74S, V75ICRF02_AG
 MB_patMAK01_MAK707AJ577938SQV, RTV, NFV182I54V, I84V, L90MV32G, F53LL10I, I13V, K14R, G17E, K20I, E35D, M36I, R41K, L63P, H69K, T74A, L89MCRF02_AG
  02_MAK737AJ577940SQV, RTV, NFV, LPV225M46I, I47V, I54V, I84VF53LL10I, I13V, K14R, G17E, K20I, E35D, M36I, N37E, R41K, H69K, T74A, L89MCRF02_AG
Non-B Workgroup (2005)PL3560858508AY900971IDV, NFV M46I, I54V, V82A, L90M I13V, K14KR, I15V, L19V, K20I, E35D, M36I, I64M, H69K, L89MCRF02_AG
 PL3780663403AY901079SQV   L10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, V77VI, L89MCRF02_AG
 TK4009TK4009 IDV336  I13V, K14R, G16E, K20R, E35D, M36I, R41K, H69K, L89M, I93LCRF02_AG
 PL3403155128 IDV, NFV207M46I, I84VL89VL10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71VCRF02_AG
 PL5148796888 SQV, RTV, IDV156  I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, I64M, H69K, K70R, L89MCRF02_AG
 PL53161101108 NFV52I54V, L90M I13V, G16E, K20I, E35D, M36I, R41K, I66F, H69K, K70R, L89MCRF02_AG
 PL55836108386 RTV, IDV74  T12A, I13V, I15V, K20I, E35D, M36I, R41K, I64M, H69K, L89MCRF02_AG
 PL8155102969 IDV190  I13V, K14R, K20I, E35D, M36I, R41K, L63P, I64L, H69K, K70R, L89MCRF02_AG
Weber (2005)30239393023939AY677492APV, LPV239M46I, L76V, V82F, I84C L10I, I13V, G16E, K20I, E35D, M36I, N37NK, R41K, L63M, H69K, K70R, T74S, L89MCRF02_AG
Baxter (2006)48-40814081-30228DQ878310PINAM46L, I54V, I84V L10V, I13A, K14R, K20I, A22V, E35D, M36I, N37S, R41K, Q61H, I66F, H69K, K70R, P79S, L89I, T91TSCRF02_AG
 48-41674167-30423DQ878400PINAM46L, I54V, I84V L10I, I13A, L19P, K20I, A22V, E35D, M36I, N37S, R41K, D60E, I66F, H69K, A71V, L89I, T91S, Q92KCRF02_AG
  4167-40203DQ878401PI, RTV, TPV>41M46L, I54V, I84V L10I, I13A, A22V, E35D, M36I, N37S, R41K, D60E, I66F, H69K, A71V, L89I, T91S, Q92KCRF02_AG
 48-50755075-30807DQ878585PINAM46L, G48T, I54V, V82A, I84VV11VILL10I, T12TS, I13V, K14R, L19P, K20I, E35D, M36I, N37NS, R41K, Q61H, H69K, T74S, L89I, T91SCRF02_AG
Seyler (2007)145CS_145 IDV101L90LM I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70KR, L89MCRF02_AG
 195CS_195 IDV111  L10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, I62IV, H69K, K70KR, T74TS, L89MCRF02_AG
 205CS_205 IDV209 L89MVI13V, K14R, G16E, K20I, E35D, M36I, R41K, I64M, H69K, K70KRCRF02_AG
 405CS_405 NFV167  I13V, K14R, G16E, K20I, E35D, M36I, N37D, R41K, I64M, H69K, K70R, L89MCRF02_AG
von Wyl (2007)1234924247EF449966PINAN88S L10I, I13V, K14R, I15V, G16E, K20M, E35D, M36I, R41K, K43R, R57K, L63H, H69Q, I72V, L89MCRF02_AG
Rosen-Zvi (2008)4506p45-3 LPV109  I13V, K14R, K20I, E35D, M36I, R41K, H69K, L89MCRF02_AG
 4600p46-1 RTV, SQV, NFV, APV141M46MIL, I54V, V82M, I84V, L90ML33F, Q58EL10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89ICRF02_AG
Sylla (2008)C1055C10559_C1EF525666IDV I54V, V82T L10I, I13V, I15V, K20I, E35D, M36I, R41K, L63P, H69K, T74S, L89MCRF02_AG
Koyalta (2009)78TCHAD-78FJ688207IDV26  L10I, T12K, I13V, K14R, G16E, L19P, K20V, E35D, M36I, R41S, C67Y, H69K, L89MCRF02_AG
Knops (2010)ID1585ID1585-GT1GU271168SQV, NFV, RTV, APV I54V, V82M, I84V, L90ML33F, Q58EL10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89ICRF02_AG
Charpentier (2011)CR-43CR-43FJ688249PINAM46I, V82FL10FI13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63T, H69K, T74TA, L89M, I93MCRF02_AG
 CR-17CR-17FJ688223PINAM46LL89VT4TP, L10V, I13V, K14R, I15V, K20I, E35D, M36I, R41K, L63P, I64M, I66F, H69K, K70R, A71T, I72VCRF02_AG
Barber (2012)6078360783JQ361670LPV M46I, I84V L10I, I13V, G16E, Q18QK, L19LP, K20I, E35D, M36I, N37T, P39S, R41K, I62V, H69K, K70R, T74A, L89MCRF02_AG
Betancor (2012)HCIII-00303810HCIII-00303810JX271406PINA  T12TA, I13V, I15V, K20I, E35D, M36I, R41K, H69K, I72M, L89MCRF02_AG
Kouri (2012)CU294-10CU294-10JQ585376PINAM46L, I54V, I84VQ58E, L89VI13A, L19P, K20I, A22V, L33V, E35D, M36I, N37D, I62IV, L63P, I66F, H69K, A71V, T74A, Q92K, I93IVCRF02_AG
 CU727-09CU727-09JQ585262PINAG48V, I54V, V82AF53LL10I, I13V, I15V, K20I, E35D, M36I, R41K, I64M, H69K, T74S, L89MCRF02_AG
Rawizza (2013)PJ9681PJ9681KF241511LPV I54V, V82AL89VL10V, I13A, K14R, I15V, K20I, A22V, E35D, M36I, R41K, Q61H, L63P, H69KCRF02_AG
 LN0319LN0319KF241469LPV M46I, I54V, V82AL10FI13V, K14R, G16E, K20I, E35D, M36I, R41K, K43R, I62V, H69K, T74E, L89MCRF02_AG
 PJ2562PJ2562KF241497LPV M46I, L76V I13V, K14R, G16E, K20I, E35D, M36I, R41K, Q61QH, I64M, H69K, K70R, L89MCRF02_AG
 LL5290LL5290KF241477LPV   T12A, I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, K43R, L63P, H69K, L89MCRF02_AG
 LN2860LN2860KF241486LPV   I13V, K14R, G16E, K20I, E35D, M36I, R41K, I64M, H69K, K70R, L89MCRF02_AG
 LN0239LN0239KF241471LPV   I13A, K20I, E35D, M36I, N37ND, H69K, L89MCRF02_AG
 LL5309LL5309KF241462LPV M46I, I54V, L76V, V82AL10F, Q58EI13V, I15V, G16E, K20I, E35D, M36I, R41K, L63R, I64M, H69K, K70R, L89M, T91ACRF02_AG
 LN2369LN2369KF241493LPV   L10I, T12S, I13V, K14R, G17E, K20I, E35D, M36I, N37S, R41K, L63S, H69K, K70R, L89MCRF02_AG
Kolomeets (2014)210210_283KJ870402NFV L90LIM L10V, I13V, K14R, G16E, K20I, E35D, M36I, N37D, R41K, I64MV, C67CY, H69K, L89MTCRF02_AG
 477477_671KJ870687LPV   I13V, K14R, G16E, K20I, E35D, M36I, N37D, R41K, I64M, C67Y, H69K, K70KR, L89MCRF02_AG
 386386_562KJ870609LPV   I13V, K14R, G16E, K20I, E35D, M36I, N37D, R41K, I64M, H69K, L89MCRF02_AG
 451451_574KJ870617ATV   I13V, K14R, G16E, K20I, E35D, M36I, N37ND, R41K, I64M, H69KCRF02_AG
 465465_568KJ870612APV   I13V, K14R, G16E, K20I, E35D, M36I, N37D, R41K, I64M, C67CY, H69K, L89MCRF02_AG
 200200_221KJ870356ATV   I13V, I15IL, G16E, L19LP, K20I, E35D, M36I, N37D, R41K, I64M, H69K, L89MCRF02_AG
 383383_545KJ870597ATV   I13V, K14R, G16E, K20I, E35D, M36I, N37ND, R41K, K43KR, I64M, H69K, V77VI, L89MCRF02_AG
 377377_501KJ870566LPV   I3V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, I64M, H69K, L89MCRF02_AG
Jenabian (2015)DR39DR39KF735843PINA  I13X, K14KR, I15V, K20I, E35D, M36I, R41K, I64M, H69K, L89MCRF02_AG
 DR38DR38KF735842PINA  T12TA, I13V, K14R, G16E, K20I, E35D, M36I, N37H, R41K, K43R, L63H, I64M, H69K, K70E, L89MCRF02_AG
 DR23DR23KF735829PINA  I13V, G16E, K20I, E35D, M36I, R41K, H69K, K70R, I72V, L89MCRF02_AG
 DR14DR14KF735824PINA  T12TP, I13V, K14R, G16E, K20I, E35D, M36I, R41K, K45R, G68GE, H69K, L89MCRF02_AG
Abdellaziz (2016)1499714997KT339035PINA  L10LV, T12S, I13V, K14R, I15V, G16E, L19T, K20I, E35D, M36I, R41K, L63IV, I64M, H69K, L89MCRF02_AG
 1453514535KT339042PINA  I13V, I15V, L19I, K20I, E35D, M36I, P39T, R41K, K43KR, L63PS, I64M, H69K, L89MCRF02_AG
 1641316413KT339015PINA  I13V, I15L, K20I, E35D, M36I, R41K, I64M, H69K, L89MCRF02_AG
 18863AA18863AAKT338972PINA  I13V, G16E, K20I, E34EG, E35D, M36I, R41K, H69K, T74S, L89MCRF02_AG
 1641716417KT339014PINA  T12A, I13V, I15V, L19T, K20I, E35D, M36I, R41K, L63V, I64M, H69K, L89MCRF02_AG
 1643116431KT339012PINA  I13V, K14R, I15IV, G17E, K20I, E35D, M36I, N37D, L63S, H69K, L89MCRF02_AG