<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF02_AG
Gene PR
Mutation E35D
Rx >= 1 PI
IncludeMixtures No
References 18
Patients 63
Isolates 64
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Thomson (2001)MT-X98MT-X98AY017454IDV   I13V, K20I, E35D, M36I, R41K, H69K, L89MCRF02_AG
Yahi (2001)NY_M31M31AY010395NFV L90M I13V, K14R, I15V, K20T, E35D, M36I, R41K, K45KR, H69K, L89IMCRF02_AG
Holguin (2002)AH_G4525AH_G4525AF354024IDV19  I13V, K14R, K20I, E35D, M36I, R41K, H69K, K70R, L89MCRF02_AG
Venturi (2002)GV-33GV-33.1AF517285SQV, RTV74  I13V, K20R, E35D, M36I, N37D, R41K, H69K, L89MCRF02_AG
 GV-56GV-56.1AF517308IDV107 F53FL, L89MVI13V, K14KR, K20R, E35D, M36I, N37D, R41K, H69KCRF02_AG
Montes (2004)MB_patTAF02_TAF703AJ578163Unknown, NFV>36M46I I13V, G16E, K20I, E35D, M36I, R41K, I64M, H69K, I72V, L89TCRF02_AG
 MB_patALC02_ALC723AJ577727NFV, SQV, RTV91I84V, L90M L10I, I13V, K20I, E35D, M36I, R41K, K43R, L63P, H69K, A71V, L89ICRF02_AG
 MB_patKES01_KES716AJ577920NFV136M46I, L90ML89VL10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70R, T74S, V75ICRF02_AG
Non-B Workgroup (2005)PL3560858508AY900971IDV, NFV M46I, I54V, V82A, L90M I13V, K14KR, I15V, L19V, K20I, E35D, M36I, I64M, H69K, L89MCRF02_AG
 PL3515957564AY901074IDV, NFV160M46I, I54V, I84IV, L90ML89VI13V, K14R, I15V, K20I, E35D, M36I, R41K, H69K, A71TCRF02_AG
 PL3780663403AY901079SQV   L10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, V77VI, L89MCRF02_AG
 PL3568567040AY901084NFV21M46ML, I54IV, L90ML89MVI13AV, K14R, K20I, E35D, M36I, N37ND, R41K, I64X, H69K, A71AV, T74TSCRF02_AG
 PL4018468632AY901088ATV22  L10IV, T12I, I13V, K14R, G16E, E35D, M36I, R41K, R57RK, H69K, L89MCRF02_AG
 PL53161101108 NFV52I54V, L90M I13V, G16E, K20I, E35D, M36I, R41K, I66F, H69K, K70R, L89MCRF02_AG
Weber (2005)01M612201M6122AY677413NFV224N88SL10FI13V, K20I, E35D, M36I, R41K, H69K, L89MCRF02_AG
 30239393023939AY677492APV, LPV239M46I, L76V, V82F, I84C L10I, I13V, G16E, K20I, E35D, M36I, N37NK, R41K, L63M, H69K, K70R, T74S, L89MCRF02_AG
Baxter (2006)48-12441244-30527DQ877767PINAM46L, I54V, V82A, I84VV11VI, L33F, K43T, F53LT4A, L10V, I13V, G16A, L19P, K20M, E21A, E35D, M36L, K55R, Q61H, L63P, H69K, T74AS, L89I, T91SCRF02_AG
 48-40814081-30228DQ878310PINAM46L, I54V, I84V L10V, I13A, K14R, K20I, A22V, E35D, M36I, N37S, R41K, Q61H, I66F, H69K, K70R, P79S, L89I, T91TSCRF02_AG
 48-41674167-30423DQ878400PINAM46L, I54V, I84V L10I, I13A, L19P, K20I, A22V, E35D, M36I, N37S, R41K, D60E, I66F, H69K, A71V, L89I, T91S, Q92KCRF02_AG
  4167-40203DQ878401PI, RTV, TPV>41M46L, I54V, I84V L10I, I13A, A22V, E35D, M36I, N37S, R41K, D60E, I66F, H69K, A71V, L89I, T91S, Q92KCRF02_AG
 48-50755075-30807DQ878585PINAM46L, G48T, I54V, V82A, I84VV11VILL10I, T12TS, I13V, K14R, L19P, K20I, E35D, M36I, N37NS, R41K, Q61H, H69K, T74S, L89I, T91SCRF02_AG
Seyler (2007)145CS_145 IDV101L90LM I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70KR, L89MCRF02_AG
 195CS_195 IDV111  L10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, I62IV, H69K, K70KR, T74TS, L89MCRF02_AG
 205CS_205 IDV209 L89MVI13V, K14R, G16E, K20I, E35D, M36I, R41K, I64M, H69K, K70KRCRF02_AG
 405CS_405 NFV167  I13V, K14R, G16E, K20I, E35D, M36I, N37D, R41K, I64M, H69K, K70R, L89MCRF02_AG
Rosen-Zvi (2008)4506p45-3 LPV109  I13V, K14R, K20I, E35D, M36I, R41K, H69K, L89MCRF02_AG
 4600p46-1 RTV, SQV, NFV, APV141M46MIL, I54V, V82M, I84V, L90ML33F, Q58EL10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89ICRF02_AG
Koyalta (2009)78TCHAD-78FJ688207IDV26  L10I, T12K, I13V, K14R, G16E, L19P, K20V, E35D, M36I, R41S, C67Y, H69K, L89MCRF02_AG
Charpentier (2011)CR-43CR-43FJ688249PINAM46I, V82FL10FI13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63T, H69K, T74TA, L89M, I93MCRF02_AG
 CR-17CR-17FJ688223PINAM46LL89VT4TP, L10V, I13V, K14R, I15V, K20I, E35D, M36I, R41K, L63P, I64M, I66F, H69K, K70R, A71T, I72VCRF02_AG
Barber (2012)6078360783JQ361670LPV M46I, I84V L10I, I13V, G16E, Q18QK, L19LP, K20I, E35D, M36I, N37T, P39S, R41K, I62V, H69K, K70R, T74A, L89MCRF02_AG
El Annaz (2012)72307230.PRJN185259PINA  T12S, I13V, K14R, K20I, E35D, M36I, N37K, R41K, H69K, L89MCRF02_AG
Kouri (2012)CU2137-09CU2137-09JQ585350PINA  I13V, K14R, K20I, E35D, M36I, N37D, H69K, K70Q, L89M, T91VCRF02_AG
 CU294-10CU294-10JQ585376PINAM46L, I54V, I84VQ58E, L89VI13A, L19P, K20I, A22V, L33V, E35D, M36I, N37D, I62IV, L63P, I66F, H69K, A71V, T74A, Q92K, I93IVCRF02_AG
 CU1191-10CU1191-10JQ585353PINA L33LIT4N, L5F, R8G, L10I, T12A, I13V, K14R, K20I, E35D, M36I, R41K, H69K, L89MCRF02_AG
 CU1511-10CU1511-10JQ585432PINA  I13V, K14R, G16E, K20I, E35D, M36I, R41K, I64M, H69K, K70R, L89MCRF02_AG
 CU424-11CU424-11JQ585502PINA  I13V, K14R, G16E, K20I, E35D, M36I, Q61E, H69K, L89IM, Q92KCRF02_AG
 CU604-11CU604-11JQ585512PINA  I13V, K14R, I15IV, K20I, E35D, M36I, R41K, D60E, H69K, T74S, L89MCRF02_AG
 CU605-11CU605-11JQ585513PINA  T4TN, I13V, K14R, I15V, K20I, E35D, M36I, R41K, K45KR, L63P, H69K, K70Q, L89MCRF02_AG
 CU484-10CU484-10JQ585397PINA  I13V, K14R, G16E, K20I, E35D, M36I, R41K, L63P, H69K, K70R, L89M, T91ACRF02_AG
 CU490-11CU490-11JQ585523PINA  I13V, K14R, G16E, K20I, E35D, M36I, R41K, I64M, H69K, K70R, L89MCRF02_AG
 CU1747-09CU1747-09JQ585310PINA  I13V, K14G, G16E, K20I, E35D, M36I, R41K, L63LR, I64IM, H69K, K70R, L89M, T91ACRF02_AG
 CU40-11CU40-11JQ585473PINA  L10I, I13V, K14R, G17E, K20I, E35D, M36I, R41K, L63C, H69K, K70R, T74A, V82I, L89MCRF02_AG
 CU2034-10CU2034-10JQ585468PINA  I13V, K14R, G16E, K20I, E35D, M36I, R41K, I64M, H69K, K70R, L89MCRF02_AG
 CU2245-09CU2245-09JQ585351PINA  I13V, K14KR, G16E, K20I, E35D, M36I, R41K, H69K, L89MCRF02_AG
 CU785-09CU785-09JQ585264PINAI54V, L90M I13V, K14R, G16E, K20I, E35D, M36I, N37K, P39S, R41K, I62V, H69K, A71V, I72V, T74S, L89ICRF02_AG
 CU1968-10CU1968-10JQ585446PINA  I13V, K14R, G16E, Q18R, K20I, E35D, M36I, R41K, H69K, K70R, L89M, N98NKCRF02_AG
 CU601-11CU601-11JQ585530PINA  I13V, K14R, G16E, K20I, E35D, M36I, Q61E, H69K, L89M, Q92KCRF02_AG
 CU432-10CU432-10JQ585395PINA  T12A, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, L89MCRF02_AG
 CU696-11CU696-11JQ585517PINA  I13V, K14R, G16E, K20I, E35D, M36I, R41K, K43R, H69K, K70R, L89MCRF02_AG
 CU209-11CU209-11JQ585495PINA  I13V, K14R, G16E, L19I, K20I, E35D, M36I, N37K, R41K, H69K, L89MCRF02_AG
 CU1598-09CU1598-09JQ585301PINA  T12A, I13V, K14T, G16E, K20I, E21Q, E35D, M36I, R41K, L63LV, I64IM, H69K, K70R, T74TA, L89M, T91ACRF02_AG
Rawizza (2013)LN3579LN3579KF241472LPV M46I, G48M, I54V, V82SL10F, K43TI13V, K14R, K20I, E35D, M36I, R41K, C67E, H69R, T74S, L89IMCRF02_AG
 PJ9681PJ9681KF241511LPV I54V, V82AL89VL10V, I13A, K14R, I15V, K20I, A22V, E35D, M36I, R41K, Q61H, L63P, H69KCRF02_AG
 LN0319LN0319KF241469LPV M46I, I54V, V82AL10FI13V, K14R, G16E, K20I, E35D, M36I, R41K, K43R, I62V, H69K, T74E, L89MCRF02_AG
 PJ2562PJ2562KF241497LPV M46I, L76V I13V, K14R, G16E, K20I, E35D, M36I, R41K, Q61QH, I64M, H69K, K70R, L89MCRF02_AG
 LL5290LL5290KF241477LPV   T12A, I13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, K43R, L63P, H69K, L89MCRF02_AG
 LN2860LN2860KF241486LPV   I13V, K14R, G16E, K20I, E35D, M36I, R41K, I64M, H69K, K70R, L89MCRF02_AG
 PJ2149PJ2149KF241459LPV M46LV, I54V, L76V, V82M, L90ML89IVT4S, L10IV, I13A, K20IV, A22V, E35D, M36I, N37DE, Q61E, I62V, L63P, C67F, H69K, A71I, I72L, P79A, T91S, Q92QKCRF02_AG
 LN0239LN0239KF241471LPV   I13A, K20I, E35D, M36I, N37ND, H69K, L89MCRF02_AG
 LL5309LL5309KF241462LPV M46I, I54V, L76V, V82AL10F, Q58EI13V, I15V, G16E, K20I, E35D, M36I, R41K, L63R, I64M, H69K, K70R, L89M, T91ACRF02_AG
 LN2369LN2369KF241493LPV   L10I, T12S, I13V, K14R, G17E, K20I, E35D, M36I, N37S, R41K, L63S, H69K, K70R, L89MCRF02_AG
Thiam (2013)495-HALD495-HALDJN673647LPV M46I, I47V, I54V, I84V, L90ML33I, L89VT4S, L10I, T12M, I13A, K14M, L19P, K20I, A22V, E35D, M36I, N37D, R41RK, R57K, Q61QH, I62IV, L63P, I66F, H69K, A71VCRF02_AG
Nerrienet (2014)U0302042U0302042JN675764LPV M46I, I54V, V82A, L90ML10F, L33I, K43T, N88DV11L, I13V, L19LV, K20V, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71V, T74S, L89T, T91ACRF02_AG