Protease Inhibitors

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Protease Inhibitors

Subtype	CRF02_AG
Gene	PR
Mutation	V11I
Rx	PI-naive
IncludeMixtures	No

References	41
Patients	80
Isolates	82

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Vergne (2000)	LV57HALD	LV57HALD	AJ286998	None	V11I	L10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70R, L89M	CRF02_AG
Yahi (2001)	NY_M18	M18	AY010380	None	V11I	T12K, I13A, K14R, K20I, M36I, R41K, L63Q, H69K, L89M	CRF02_AG
Fonjungo (2002)	CM142	CM142	AY051240	None	V11I	I13V, K14R, K20I, M36I, R41K, I64M, H69K, L89M, I93L	CRF02_AG
	CM140	CM140	AY051238	None	V11I	I13V, K14R, K20I, E35D, M36I, N37E, R41K, H69K, L89M, I93L	CRF02_AG
Gibb (2002)	DMG13	13_w0		None	V11I	L10LI, I13V, I15V, K20V, M36I, N37S, R41K, H69K, L89M	CRF02_AG
Vergne (2002)	LVLBV30_10	LVLBV30_10	AJ313402	None	V11I	I13A, K20I, M36I, R41K, I62V, L63P, H69K, L89M	CRF02_AG
Eshleman (2004)	ABB01	ABB01	AY444230	None	V11I	T12X, I13V, K14R, G16E, K20I, L33V, E35G, M36I, R41K, K43Q, H69K, K70R, I72V, L89M	CRF02_AG
	ABB05	ABB05	AY444232	None	V11I	L10LV, I13V, K14R, K20I, E34A, M36I, R41K, H69K, L89M	CRF02_AG
Konings (2004)	KF_Pat83	01CM5630	AY359765	None	V11I	I13A, K14R, K20I, M36I, R41K, K43R, H69K, L89I	CRF02_AG
Carr (2005)	3217MN	3217MN	AY847404	None	V11I	L10V, I13A, G16E, K20I, E35D, M36I, R41K, H69K, K70R, L89M	CRF02_AG
Tovanabutra (2005)	99US_MSC1134	99US_1134	AY444809	None	V11I	I13V, K20I, M36I, R41K, L63LP, C67CY, H69K, I72M, L89I	CRF02_AG
Koizumi (2006)	YK_04CM042	YK_04CM042	DQ461845	None	V11I	L10V, I13V, K14R, L19P, K20I, M36I, N37A, R41K, H69K, L89M	CRF02_AG
Ndongmo (2006)	CM31	CBN_CM31	DQ394114	None	V11I	I13V, K14R, K20I, M36I, R41K, L63P, H69K, K70R, I72M, L89I, I93L	CRF02_AG
	CM324	CBN_CM324	DQ394161	None	V11I	I13V, K20I, E34A, N37S, R41K, H69K, L89M, I93L	CRF02_AG
Razafindratsimandresy (2006)	RR_MAD-GP099	MAD-GP099	DQ345015	None	V11I	L10V, I13V, L19P, K20I, M36I, N37D, R41K, Q61N, L63H, H69K, V75VI, L89M	CRF02_AG
Derache (2007)	1282	1282	EF064519	None	V11I	T12P, I13V, K14R, I15V, G17E, K20I, T26P, M36I, N37D, R41K, H69K, L89M	CRF02_AG
Delgado (2008)	GH_011	GH_011	EU177888	None	V11I, L89V	I13A, K20I, M36I, N37D, R41K, L63P, H69K	CRF02_AG
	GH_063	GH_063	EU177931	None	V11I	T12TK, I13V, K14KR, G16E, L19Q, K20I, M36I, R41K, H69K, K70R, L89M	CRF02_AG
	GH_137	GH_137	EU177983	None	V11I	I13V, L19Q, K20I, M36I, N37S, R41K, I64V, H69K, K70R, L89I	CRF02_AG
	GH_138	GH_138	EU177984	None	V11I	I13V, L19Q, K20I, M36I, R41K, H69K, T74M, V82I, L89M	CRF02_AG
	GH_152	GH_152	EU177996	None	V11I	L10V, I13AV, G16GE, L19Q, K20I, M36I, N37ND, R41K, K43KR, L63LP, H69K, K70KR, L89M	CRF02_AG
	GH_194	GH_194	EU178027	None	V11I	I13V, K14R, L19V, K20I, E35ED, M36I, R41K, L63P, H69K, K70R, L89I	CRF02_AG
	GH_231	GH_231	EU178060	None	V11I	I13V, K20I, M36I, R41K, L63M, H69K, V82I, L89M	CRF02_AG
Derache (2008)	BKO-903	BKO-903	EU330659	None	V11I	I13V, K14R, L19P, K20I, M36I, R41K, L63Y, H69K, L89I	CRF02_AG
	BKO-940	BKO-940	EU330675	None	V11I	I13V, K14R, K20I, M36I, R41K, L63P, H69K, L89M	CRF02_AG
	SGO-05	SGO-05	EU330750	None	V11I	L10I, I13V, L19P, K20I, M36I, N37D, R41K, L63S, C67Y, H69K, K70R, L89M	CRF02_AG
	SGO-28	SGO-28	EU330772	None	V11I	I13V, K20I, E35N, M36I, R41K, I64M, H69K, K70R, L89M	CRF02_AG
	SGO-29	SGO-29	EU330773	None	V11I	I13V, K14R, K20I, M36I, R41K, L63S, H69K, V82I, L89M	CRF02_AG
	SGO-30	SGO-30	EU330774	None	V11I	T12P, I13V, K14R, K20I, M36I, N37D, R41K, L63P, G68E, H69K, V82I, L89M	CRF02_AG
	SGO-93	SGO-93	EU330833	None	V11I, N83D	I13V, K14R, K20I, E35D, M36I, R41K, H69K, L89M, C95S	CRF02_AG
Holguin (2008)	SP3-160640	SP3-160640	EU342771	None	V11I	I13V, K14R, K20I, M36I, R41K, H69K, L89M	CRF02_AG
McConnell (2008)	NV25	NV25	EU288110	None	V11I	R8G, T12K, I13V, K14R, K20I, M36I, R41K, L63LP, H69K, L89M	CRF02_AG
Palacios (2008)	41175	41175		None	V11I	T12K, I13V, K20I, E35G, M36I, N37D, R41K, H69K, L89M	CRF02_AG
	41188	41188		None	V11I	W6G, T12K, I13V, K20I, E35AG, M36I, N37DE, R41K, H69K, L89M	CRF02_AG
Sylla (2008)	A2608	A2608_C1	DQ991631	None	V11I	L10I, I13V, I15V, L19P, K20I, M36I, R41K, L63S, H69K, K70R, L89M	CRF02_AG
		A2608_C2	DQ991632	None	V11I	L10I, I13V, I15V, L19P, K20I, M36I, R41K, L63S, H69K, K70R, L89M	CRF02_AG
Aghokeng (2009)	CYM003	CYM003	GU191556	None	V11I	I13V, K14R, G16E, K20I, E35D, M36I, N37NS, P39PS, R41K, H69K, L89M	CRF02_AG
	CYM085	CYM085	GU191571	None	V11I	I13V, K20I, E35ED, M36I, R41K, H69K, L89M	CRF02_AG
Ayouba (2009)	TE10050	TE10050PR	GQ351704	None	V11I	I13V, K20I, M36I, R41K, H69K, L89M	CRF02_AG
	RES632	RES632PR	GQ351723	None	V11I, L33F	L10V, I13V, G16E, K20I, M36I, R41K, E65EK, H69K, K70R, I72V, L89M, I93V	CRF02_AG
	RES024	RES024-1PR	GQ351734	None	V11I	T12S, I13V, K14R, K20I, M36I, R41K, I64M, H69K, L89M	CRF02_AG
	RES226	RES226-8PR	GQ351744	None	V11I	I13V, K14R, K20I, M36I, R41K, L63P, H69K, L89M	CRF02_AG
	RES243	RES243-8PR	GQ351747	None	V11I	T12K, I13V, G16E, L19I, K20I, M36I, N37S, R41K, H69K, L89M	CRF02_AG
	0.653	0.653-UPR	GQ351841	None	V11I	L10V, I13V, G16E, K20I, M36I, R41K, C67G, H69K, K70R, L89M	CRF02_AG
	2885	2885HALDPR	GQ351983	None	V11I	L10LV, T12TA, I13V, K20I, M36I, N37S, R41K, H69K, L89I	CRF02_AG
Bartolo (2009)	CSE118	01AOCSE118	EU068201	None	V11I	L10I, I13V, I15V, G16E, K20I, E35D, M36I, N37K, R41K, L63T, H69Q, L89M, I93L	CRF02_AG
	HDC252	93AOHDC252	EU068317	None	V11I	I13V, K14R, K20I, M36I, R41K, H69K, L89M	CRF02_AG
Cuevas (2009)	P0853	P0853.1	EU822520	None	V11I	I13V, K20I, M36I, R41K, H69K, L89M	CRF02_AG
	P1261	P1261.1	EU822614	None	V11I	I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70KR, L89M	CRF02_AG
	P0957	P0957.1	EU822783	None	V11I	I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, L89M	CRF02_AG
Hawkins (2009)	R120	ZZR120	FJ931316	None	V11I	T12A, I13V, K14R, K20I, M36I, R41K, L63P, H69K, L89I	CRF02_AG
	R224	ZZR224	FJ931383	None	V11I	L10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70R, L89M	CRF02_AG
Tebit (2009)	TR154	TR154	FJ577307	None	V11I	L10I, I13V, K14R, G16E, L19P, K20I, M36I, R41K, L63S, C67Y, H69K, K70R, L89M	CRF02_AG
	TR216	TR216	FJ577339	None	V11I	I13A, K20I, M36I, R41K, L63P, H69K, K70R, L89I	CRF02_AG
	TR261	TR261	FJ577362	None	V11I	L10V, I13V, L19P, K20I, M36I, R41K, H69K, L89M	CRF02_AG
Vercauteren (2009)	pt1773	2700061467	GQ399251	None	V11I	I13V, K14R, K20I, M36I, R41K, L63S, I64M, H69K, L89M	CRF02_AG
	pt1480	4401747108	GQ399544	None	V11I	T12A, I13V, K20I, M36I, R41K, H69K, I72M, L89I	CRF02_AG
Yaotse (2009)	HT112	06TG.HT112	FM955719	None	V11I	T12K, I13A, K14R, I15V, K20I, M36I, R41K, H69K, L89M	CRF02_AG
	HT124	06TG.HT124	FM955725	None	V11I	I13V, L19P, K20I, M36I, N37D, R41K, Q61H, H69K, L89M	CRF02_AG
	HT170	06TG.HT170	FM955746	None	V11I	L10V, I13V, G16E, L19P, K20I, E35G, M36I, R41K, L63S, H69K, I72IV, V77I, L89M	CRF02_AG
Carr (2010)	3217MN	02CM.3217MN	GU201514	None	V11I	L10V, I13A, G16E, K20I, E35D, M36I, R41K, H69K, K70R, L89M	CRF02_AG
Diop-Ndiaye (2010)	57HALD	57HALD	FN599724	None	V11I	L10V, I13V, K14R, G16E, K20I, E35D, M36I, R41K, H69K, K70R, L89M	CRF02_AG
Soares (2010)	CM04_088	CM04_088	GU366125	None	V11I	L10I, I13V, K14R, L19P, K20I, M36I, N37D, R41K, L63P, H69K, K70R, L89M	CRF02_AG
Yang (2010)	2010693474	2010693474	JQ616900	None	V11I	L10I, T12Q, I13V, K14KR, I15V, L19P, K20I, E35D, M36I, R41K, L63T, H69K, L89M	CRF02_AG
Aghokeng (2011)	SK8033-PI	SK8033-PI	HQ864346	None	V11I, L33F	T12K, I13V, K14KR, K20I, E35D, M36I, R41K, H69K, K70R, L89M	CRF02_AG
	SK4009-PI	SK4009-PI	HQ864384	None	V11I	I13V, K20I, M36I, R41K, H69K, K70KR, V82I, L89M	CRF02_AG
Dagnra (2011)	08TG.T3017	08TG.T3017	FR715254	None	V11I	T12A, I13A, K14R, I15IV, G16GE, K20I, M36I, R41K, I62V, L63H, H69K, L89I	CRF02_AG
	08TG.T3039	08TG.T3039	FR715257	None	V11I	T12A, I13V, K14R, I15V, K20I, M36I, R41K, L63P, H69K, A71AT, L89I	CRF02_AG
Kousiappa (2011)	CY192	CY192	JF683745	None	V11I	L10I, T12E, I13V, K20I, M36I, R41K, L63P, C67Y, H69K, K70R, I72V, L89M	CRF02_AG
	CY256	CY256	JF683799	None	V11I	L10I, I13V, K14R, L19P, K20I, E35D, M36I, N37D, R41K, L63PS, H69K, L89IM	CRF02_AG
Akrim (2012)	N229AGAG	N229AGAG	JQ316592	None	V11I	T12A, I13V, K20I, M36I, R41K, Q61QH, H69K, L89M	CRF02_AG
Caron (2012)	Gab021278	Gab021278	HQ541946	None	V11I	L10I, I13V, K14R, G16E, K20I, E35D, M36I, R41K, L63S, C67Y, H69K, K70R, L89M	CRF02_AG
Chamberland (2012)	C412S	C412S	HQ267542	None	V11I, L33F	I13V, K14R, K20I, E35D, M36I, R41K, H69K, L89M	CRF02_AG
	C425S	C425S	HQ267551	None	V11I	I13V, G16E, K20I, E35D, M36I, R41K, H69K, K70R, L89M	CRF02_AG
	D334T	D334T	HQ267629	None	V11I	T12TA, I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89M	CRF02_AG
De Gascun (2012)	IRL14981	IRL14981	JN622252	None	V11I	I13V, K14R, K20I, M36L, N37S, R41K, L63P, H69K, L89I	CRF02_AG
	IRL58518	IRL58518	JN622363	None	V11I	T12KN, I13V, K14R, K20I, M36I, N37ND, R41K, L63T, I64IM, H69KR, I72IT, L89M	CRF02_AG
El Annaz (2012)	13842	13842.PR	JN185270	None	V11I	I13V, K14R, L19I, K20I, M36I, R41K, I64L, H69K, L89M	CRF02_AG
Youngpairoj (2012)	cm1660	cm1660	DQ166406	None	V11I	I13V, K14R, K20I, M36I, R41K, H69K, L89M	CRF02_AG
Frentz (2013)	EHR-00407	EHR-00407	JX299542	None	V11I	L10V, I13V, K14R, L19P, K20I, M36I, R41K, H69K, L89M	CRF02_AG
	EHR-19066	EHR-19066	JX299854	None	V11I	I13V, K14R, K20I, M36L, N37S, R41K, L63P, H69K, L89I	CRF02_AG
	EHR-41925	EHR-41925	JX300249	None	V11I	T12E, I13V, K14RS, L19LP, K20I, M36I, R41K, L63H, H69K, L89I	CRF02_AG

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