<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF01_AE
Gene PR
Mutation L89M
Rx >= 1 PI
IncludeMixtures No
References 16
Patients 89
Isolates 98
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG108108_w28 NFV28  L10V, I13V, G16E, K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
Ariyoshi (2003)JPN26JPN26AY900687NFV, IDV51  L10LI, K20R, E35D, M36I, R41K, H69K, L89M, I93LCRF01_AE
 JPN44JPN44A IDV, SQV, RTV88  K20R, E35D, M36I, N37D, L63P, H69K, L89M, I93LCRF01_AE
  JPN44BAY900691IDV, SQV, RTV, LPV204  K20R, E35D, M36I, N37D, L63P, H69K, L89M, I93LCRF01_AE
 JPN11JPN11 IDV75  I13V, K20KR, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 JPN12JPN12A SQV77 Q58EI13V, K20I, E35D, M36I, R41K, H69K, V82I, L89MCRF01_AE
  JPN12BAY900696SQV92 Q58EI13V, K20I, E35D, M36I, R41K, H69K, V82I, L89MCRF01_AE
 JPN14JPN14AY900697NFV7  K20R, E35D, M36I, R41K, K45R, H69X, L89M, I93LCRF01_AE
 JPN15JPN15AY900698NFV, IDV113I54V, L90ML10F, L33II13V, K20R, E35D, M36I, R41K, I64V, H69K, L89MCRF01_AE
 JPN32JPN32AY900701NFV116  L10LI, I13V, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 JPN17JPN17A IDV68  I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
  JPN17BAY900702IDV80  I13V, E35D, M36I, R41K, W42WL, K45KE, H69K, L89MCRF01_AE
 JPN33JPN33 NFV8  I15IV, E35D, M36I, R41K, H69K, L89M, I93LCRF01_AE
 JPN34JPN34AY900860IDV, SQV76G48V, I54IVL33LF, N83NDL10LI, I13V, I15V, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 JPN19JPN19A NFV59N88SL10FG16E, K20IT, E35D, M36I, R41K, L63T, I64V, H69K, L89M, I93LCRF01_AE
  JPN19BAY900861NFV77N88SL10FG16E, K20I, E35D, M36I, R41K, L63T, I64V, H69K, L89M, I93LCRF01_AE
 JPN35JPN35AY900862IDV, NFV140M46I, L90M L10V, I13V, K20T, E35D, M36I, R41K, Q61H, L63P, I64V, H69K, K70R, T74S, R87X, L89M, I93LCRF01_AE
 JPN37JPN37A IDV45  I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
  JPN37BAY900864IDV, SQV, RTV128  I13V, E35D, M36I, R41K, H69K, I72IV, L89MCRF01_AE
 JPN38JPN38 IDV, NFV129I54V, V82F L10I, I13V, G16E, K20I, E35D, M36I, R41K, K45V, L63LH, H69K, K70R, L89M, F99FLCRF01_AE
 JPN39JPN39AY900865NFV200M46I, N88SL10FI13V, K20I, E35D, M36I, R41RK, I64V, H69K, T74S, V77VI, L89M, I93LCRF01_AE
 JPN3JPN3 IDV56V82VF L10I, I13V, I15V, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 JPN6JPN6 NFV1 L24LII13V, I15V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 JPN7JPN7AY900867NFV7  L10I, I13V, E35D, M36I, G40GR, R41K, H69K, I72V, L89MCRF01_AE
 JPN22JPN22 NFV1  I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 JPN40JPN40A IDV, SQV, NFV179 L10FT12A, I13V, I15V, E35D, M36I, R41K, R57K, I64V, H69K, L89MCRF01_AE
  JPN40BAY900871IDV, SQV, NFV218 L10LFT12A, I13V, I15IV, E35D, M36I, R41K, R57K, I64IV, H69K, L89MCRF01_AE
 JPN41JPN41A IDV, SQV, NFV125G48ST, I54V, V82F, L90M L10I, I13V, G16E, K20I, E35D, M36I, P39Q, R41K, K45V, I62V, L63P, H69K, L89MCRF01_AE
  JPN41BAY900873IDV, SQV, NFV, APV195I54V, V82F, L90LM L10I, I13V, G16E, K20I, E35DN, M36I, P39Q, R41K, K45V, G48X, I62V, L63P, H69K, L89MCRF01_AE
Montes (2004)MB_patMOU00_MOUL723AJ577956SQV160  I13V, K14R, G17E, K20I, M36I, R41K, L63T, I64M, H69K, T74A, L89MCRF01_AE
 MB_patBRI00_BRI706AJ577745SQV, NFV, RTV111  Q7P, I13V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, H69K, T74S, L89MCRF01_AE
  01_BRI705AJ577746SQV, NFV, RTV, LPV146I54V, V82AL33F, F53L, T74PL10I, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, H69K, K70R, L89MCRF01_AE
 MB_patPOI01_POI735AJ577975SQV, NFV, RTV160  I13V, E35D, M36I, N37D, R41K, L63P, H69K, K70R, L89MCRF01_AE
Nukoolkarn (2004)7474 RTV I54V, V82AL33F, N83DL10I, I13V, E35D, M36I, R41K, D60E, Q61D, L63T, C67Y, H69K, L89MCRF01_AE
 238238 LPV L90M L10I, I13V, E35D, M36I, R41K, L63P, H69K, T74S, L89MCRF01_AE
 245245 SQV, RTV, IDV I54V, V82FL33IL10I, I13V, E35D, M36I, R41K, L63H, H69K, L89MCRF01_AE
 276276 RTV, IDV   I13V, E35D, M36I, R41K, H69K, V82I, L89MCRF01_AE
 321321 NFV L90M I13V, K20I, E35D, M36I, R41K, I64V, H69K, L89MCRF01_AE
Hsu (2005)BAA148356BAA148356AY870142IDV, NFV134N88S I13V, E35D, M36I, R41K, I64IV, H69K, L89MCRF01_AE
 BAA148357BAA148357AY870143IDV, SQV, RTV65  I13V, I15V, E35D, M36I, R41K, L63V, H69K, L89M, I93LCRF01_AE
 BAA148358BAA148358AY870144SQV, RTV52  I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 BAA148363BAA148363AY870148SQV, RTV35I84V, L90M L10V, I13V, K20R, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 BAA148375BAA148375AY870150SQV, RTV4  I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 BAA150617BAA150617AY870156SQV, RTV17  I13IV, E35D, M36I, R41KN, L63P, H69K, K70R, L89MCRF01_AE
 BAA154758BAA154758AY870160IDV152  T12P, I13V, G16E, E35D, M36I, N37D, L63H, H69K, L89MCRF01_AE
 BAA154760BAA154760AY870162NFV113  K20I, E35N, M36I, N37D, R41K, L63P, H69K, T74A, L89M, I93LCRF01_AE
 BAA154762BAA154762AY870163SQV, RTV113  I13V, I15IV, E35D, M36I, R41K, H69K, K70KR, L89MCRF01_AE
 BAA154770BAA154770AY870168IDV52  I13V, K20I, E35D, M36I, R41K, H69K, V82I, L89MCRF01_AE
 BAA154777BAA154777AY870169SQV, NFV182  I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 BAA157663BAA157663AY870170SQV   I13IV, L33LV, E35D, M36I, P39PS, R41K, H69K, L89MCRF01_AE
 BAA157674BAA157674AY870179RTV, IDV22  I13V, G17E, K20I, E35D, M36I, R41K, L63S, H69K, L89MCRF01_AE
 BAA157675BAA157675AY870180RTV, IDV4  I13V, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 BAA157678BAA157678AY870183SQV, RTV131G48VL33F, N83DI13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 BAA157679BAA157679AY870184IDV231M46MI, L90M K14R, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89M, I93LCRF01_AE
 BAA157683BAA157683AY870187SQV, RTV22  I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 BAA161416BAA161416AY870225IDV309  I13V, G16GE, E35D, M36I, R41K, H69K, L89MCRF01_AE
 BAA161422BAA161422AY870228IDV317M46ML, I54IV, V82F L10LI, I13V, K20KI, E35D, M36I, R41K, I62V, H69K, T74A, L89MCRF01_AE
 BAA161428BAA161428AY870230IDV39 L33FI13V, E35D, M36I, R41K, H69K, L89M, I93VCRF01_AE
 BAA161429BAA161429AY870231RTV, IDV78  L10V, K20R, E35D, M36I, R41K, H69K, I72V, L89MCRF01_AE
 BAA161436BAA161436AY870234SQV, RTV26 L33FL10I, I13V, R41K, I62V, L63I, H69K, K70R, V82I, L89MCRF01_AE
 BAA161445BAA161445AY870238SQV, RTV61  I13V, G16E, E35D, M36I, R41K, H69K, K70R, L89MCRF01_AE
 BAA161449BAA161449AY870242SQV, RTV100G48GMRV, I54V, I84IV, L90MQ58QEL10I, I13V, G16E, K20I, E35D, M36I, R41K, H69K, L89MCRF01_AE
 BAA161450BAA161450AY870243SQV, RTV148  I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 BAA161452BAA161452AY870245SQV, RTV70  I13V, E35D, M36I, R41K, I62V, H69K, T74S, L89MCRF01_AE
Non-B Workgroup (2005)TH_130TH_130AY605552RTV, IDV   I13V, E35D, M36I, R41K, H69K, V82I, L89MCRF01_AE
 TH_160TH_160AY605572RTV, IDV   I13V, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 TH_161TH_161AY605574SQV, RTV   I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 TH_215TH_215AY605617NFV N88S, L90ML10FI13V, I15V, K20T, E35D, M36I, R41K, I64V, H69K, L89MCRF01_AE
 TH_220TH_220AY605624IDV   L10I, I13V, G16E, K20R, E35D, M36I, R41K, I62V, H69K, L89M, L97ICRF01_AE
 TH_223TH_223AY605628IDV   L10I, I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 TK1018TK1018 RTV, SQV, IDV184I84VL33F, N83DL10V, I13V, E34Q, M36I, N37S, R41K, L63P, H69K, L89M, I93LCRF01_AE
 TK1029TK1029 IDV172  I13V, L19M, E35D, M36I, R41K, H69K, L89MCRF01_AE
 TK4002TK4002 IDV, RTV145  I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 TK5004TK5004a SQV, IDV, NFV, RTV, LPV151  I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
Baxter (2006)48-30333033-30227DQ877944PINAG48Q, I50V, I54A, V82MK43T, F53LL10I, I13V, G16E, L19R, K20I, E35D, M36I, R41K, Q61D, L63C, I66F, H69K, L89MCRF01_AE
 48-41434143-30408DQ878375PINAG48V, I54A, V82S L10V, I15V, L19I, K20R, E35D, M36I, R41K, I62V, L63V, H69K, T74S, L89M, I93LCRF01_AE
Tee (2006)MYKL136403MYKL1364AY960927RTV, IDV   I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 MYKL136803MYKL1368AY960928RTV, IDV61  I13V, G16E, E35D, M36I, R41K, H69K, L89MCRF01_AE
 MYKL140903MYKL1409AY960934PINAM46I I13V, M36I, R41K, H69K, L89MCRF01_AE
 MYKL151003MYKL1510AY960941IDV22  I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 MYKL174304MYKL1743AY960952RTV, IDV V82F I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 MYKL177904MYKL1779AY960953LPV   I13V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 MYKL181404MYKL1814AY960954RTV, IDV I54V, V82T L10I, E35D, M36I, R41K, I62V, I66F, H69K, A71V, I72V, L89MCRF01_AE
 MYKL194904MYKL1949AY960958IDV65  L10V, I13V, G16A, E35D, M36I, R41K, H69K, L89MCRF01_AE
 MYKL195804MYKL1958AY960959RTV, IDV M46I, L76V I13V, K14R, K20I, E35N, M36I, R41K, K55R, R57K, L63P, H69K, K70R, I72V, L89MCRF01_AE
von Wyl (2007)461798027EF449810PINA  I13V, G16E, E35D, M36I, R41K, H69K, A71AV, L89M, Q92KCRF01_AE
 791477616EF449916PINA  I13V, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
Riddler (2008)RG82111RG82111w55 LPV36  G16E, T26TS, T31TP, E35D, M36I, R41K, R57K, L63P, H69K, L89M, I93LCRF01_AE
Rosen-Zvi (2008)1602p16-1 SQV, RTV, IDV47  L10I, T12A, I13V, E35D, M36I, R41K, R57K, L63LAPV, H69K, K70KR, L89MCRF01_AE
 3606p36-2 LPV155  L10V, T12I, I13A, I15V, G16E, E35D, M36I, R41K, K45R, L63T, H69K, L89MCRF01_AE
  06p36-3 LPV155  L10V, T12I, I13AV, I15IV, G16E, E35D, M36I, R41K, K45R, L63T, H69K, I72IV, L89MCRF01_AE
 8207p82-2 LPV92  I13V, I15V, E35D, M36I, R41K, H69K, L89MCRF01_AE
 8309p83-4 LPV63  L10V, I13V, G16GE, E35D, M36I, N37D, R41K, L63PS, H69K, K70R, L89MCRF01_AE
Ferradini (2011)40739PRHM026302LPV24V82A L10V, I13V, G16E, K20R, E35D, M36I, R41K, L63C, H69K, T74A, L89MCRF01_AE
Barber (2012)7740677406JQ361675LPV M46IL10F, T74TPI13V, I15IV, E35D, M36I, R41K, L63C, H69K, N83S, L89MCRF01_AE
El Annaz (2012)1376113761.PRJN185269IDV52M46I, L76V I13V, K20I, E35D, M36I, N37D, I62IV, L63P, I66F, H69K, L89MCRF01_AE
Van Zyl (2013)4631671KC423313LPV26  L10I, I13V, G16E, K20R, E35D, M36I, R41K, R57K, E65D, H69K, I72V, L89MCRF01_AE
Grossman (2014)16871687KC184219LPV52  Q7QK, L10I, K14R, G17GR, E35D, M36I, N37D, R41K, C67Y, H69K, L89MCRF01_AE