<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF01_AE
Gene PR
Mutation L89I
Rx PI-naive
IncludeMixtures No
References 37
Patients 94
Isolates 94
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Lan (2003)NTHvr180NTHvr180AY238215None   I13V, G16E, E35D, M36I, R41K, H69K, L89ICRF01_AE
 NTHvr72NTHvr72AY238312None   L10I, I13V, G16GE, M36I, R41K, L63C, H69K, K70KR, L89ICRF01_AE
Tovanabutra (2003)02TH_OUR133202_1332AF529573None   I13V, I15V, E35D, M36I, R41K, R57K, H69K, I72V, L89ICRF01_AE
Montes (2004)MB_patRAI01_RAI715AJ577978None   L10V, I13V, G16E, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
Hsu (2005)LYH_AY870218BAA161407AY870218None  L33FI13V, G16E, E35D, M36I, R41K, L63S, H69K, K70R, L89I, I93LCRF01_AE
 BAA150613BAA150613AY870154None   I13V, G16E, E35D, M36I, R41K, H69K, V82I, L89ICRF01_AE
 BAA157677BAA157677AY870182None   I13V, I15V, E35D, M36I, R41K, R57K, H69K, V77I, L89I, T91VCRF01_AE
 BAA157681BAA157681AY870186None   L10I, I13IV, G16GE, K20M, E35D, M36I, R41K, H69K, L89ICRF01_AE
Ly (2005)NL_KHM_CA35KHM_CA35DQ013542None   I13V, E35D, M36I, R41K, H69K, L89ICRF01_AE
 NL_KHM_POP5KHM_POP5DQ013605None   T12P, I13V, G16GE, E35D, M36I, R41K, L63H, H69K, K70Q, L89ICRF01_AE
Derache (2007)12661266EF064505None   I13V, K14R, K20I, M36I, R41K, L63P, C67H, H69K, L89ICRF01_AE
Gatanaga (2007)C03-51110041-1C03-51110041-1AB640141None   K20R, E35D, M36I, R41K, H69K, K70R, L89I, T91ACRF01_AE
Liu (2007)fj07fj07EF432662None  V11II13V, G16E, K20I, M36I, R41K, I64V, H69K, L89I, Q92RCRF01_AE
 fj10fj10EF432719None   L10V, I13V, M36I, R41K, H69K, L89ICRF01_AE
Chang (2008)TW11250TW11250EU164923None   I13V, E35D, M36I, R41K, Q58QR, L63S, H69K, K70R, L89ICRF01_AE
 TW10012aTW10012a None   I13V, E35D, M36I, R41K, L63S, H69K, K70R, L89ICRF01_AE
Ibe (2008)333333AB356330None   L10I, I13V, E35D, M36I, R41K, H69K, K70R, V82VI, L89I, L97LICRF01_AE
Sirivichayakul (2008)NBC-18NBC-18PrJQ364318None   K20R, M36I, R41K, L63P, H69K, I72E, L89I, I93HCRF01_AE
 NBC-37NBC-37PrJQ364337None   L10I, I13V, G16E, E35D, M36I, N37D, R41K, H69K, K70R, I72V, P79H, L89ICRF01_AE
Auwanit (2009)42AE-PR42FJ463518None   K14R, I15IV, L19LQ, E35D, M36I, R41K, I62V, L63ST, H69K, K70R, V82I, L89ICRF01_AE
Ayouba (2009)FD0435FD0435PIGQ352108None   I13V, K14KR, E35D, M36I, R41K, H69K, L89ICRF01_AE
Ishizaki (2009)A2_424A2_424FJ007095None   L10I, I13V, M36I, R41K, H69K, L89ICRF01_AE
 A70A70FJ007137None   I13V, G16E, E35D, M36I, R41K, R57K, H69K, L89I, Q92KCRF01_AE
Vercauteren (2009)pt18532146907658GQ399171None   I13V, M36I, R41K, H69K, L89ICRF01_AE
 pt133sUWqTcMx34GQ400891None   E35D, M36I, R41K, R57K, H69K, V82I, L89ICRF01_AE
Hattori (2010)F08-5112145F08-5112145AB866781None   I13V, G16E, E35D, M36L, P39T, D60E, L63P, H69K, L89ICRF01_AE
Phan (2010)O942O942AB519512None   I13V, G16E, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
 NB27NB27AB519539None   T12P, G16E, E35D, M36I, N37D, R41K, L63C, H69K, K70R, L89ICRF01_AE
 AH18AH18AB519570None   L10I, I13V, M36I, L38X, R41K, H69K, L89ICRF01_AE
 ND09ND09AB519597None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, H69K, I72T, L89ICRF01_AE
 ND34ND34AB519603None   L10I, I13V, G16E, M36I, R41K, H69K, L89ICRF01_AE
Bontell (2011)Pat04508.VL772HsHQ852871None   L10I, I13V, G16E, L19LI, E35D, M36I, R41K, L63T, H69K, L89ICRF01_AE
Dean (2011)IVVI7283IVVI7283JQ312415None   I13V, G16A, E35D, M36I, N37D, R41K, R57K, G68GE, H69K, K70R, L89ICRF01_AE
 IVVI7392IVVI7392JQ312420None   I13V, G16A, E35D, M36I, N37D, R41K, R57K, G68GE, H69K, K70R, L89ICRF01_AE
Hamers (2011)CP076301920CP076301920HQ995392None   I13V, E35D, M36I, R41K, R57K, L63P, I64M, H69K, L89ICRF01_AE
Lazaro (2011)AG-M12AG-M12HQ542622None   L10I, I13V, M36I, R41K, H69K, V82I, L89ICRF01_AE
Ngo-Giang-Huong (2011)PHPT2972PHPT2972PR-RTHQ996523None   L10I, T12A, I13V, E35D, M36I, R41K, R57K, H69K, L89ICRF01_AE
Su (2011)LZ2034LZ2034HQ588196None   I13V, E35D, M36I, R41K, H69K, L89ICRF01_AE
De Gascun (2012)IRL39742IRL39742JN622230None   I13V, G16E, E35D, M36I, R41K, H69K, L89I, Q92RCRF01_AE
Karlsson (2012)SE_155SE_155JQ698774None   E35D, M36I, R41K, R57K, H69K, V82I, L89ICRF01_AE
Rolland (2012)AA063a_WG35AA063a_WG35JX447408None   I13V, E35D, M36I, R41K, K45R, R57K, H69K, L89ICRF01_AE
Tran (2012)HPA409HPA409AB690942None   L10LI, I13V, G16E, E35D, M36I, R41K, L63T, H69K, L89ICRF01_AE
Zeng (2012)CN1211CN1211JQ028224None   I13V, I15V, M36I, R41K, H69K, K70R, L89ICRF01_AE
Chow (2013)10MYKJ07710MYKJ077KC478001None   I13V, G16E, E35D, M36I, L63F, H69K, I72V, L89ICRF01_AE
 10MYKJ05710MYKJ057KC477983None   T12P, I13V, K14R, M36I, K43KR, L63P, H69K, L89ICRF01_AE
Frentz (2013)EHR-02073EHR-02073JX299579None   I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, L89I, Q92KCRF01_AE
 EHR-06236EHR-06236JX299643None   I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, L89I, Q92KCRF01_AE
 EHR-501156EHR-501156JX300371None   I13V, G16E, E35D, M36I, R41K, H69K, K70R, L89I, I93LCRF01_AE
Kiertiburanakul (2013)R71091R71091KC921818None   L10I, T12I, I13V, I15V, E35D, M36I, N37D, R41K, R57K, H69K, L89ICRF01_AE
 R71TS178R71TS178KC921653None   T12P, I13V, G16E, E35D, M36I, P39T, D60E, L63T, H69K, L89ICRF01_AE
 R12010R12010KC994169None   I13V, I15V, M36I, R41K, H69K, I72V, V82VI, L89ICRF01_AE
 R72100R72100KC867637None   L10I, I13V, G16E, E35D, M36I, R41K, H69K, L89ICRF01_AE
 R71230R71230KC921460None   I13A, G16E, L19I, E35D, M36I, R41K, L63S, H69K, L89I, Q92KCRF01_AE
 R12111R12111KC994251None   L10I, I13V, M36I, R41K, H69K, K70R, V82I, L89ICRF01_AE
 R71090R71090KC921411None   L10V, I13V, G16E, E35D, M36I, R41K, L63S, H69K, K70R, L89I, Q92ECRF01_AE
 R71117R71117KC921833None   L10V, I13V, Q18H, E35D, M36I, R41K, L63A, H69K, L89ICRF01_AE
 R73246R73246KC810519None   L10I, I13V, E35D, M36I, N37D, H69K, L89ICRF01_AE
 R71TS029R71TS029KC921509None   I13V, M36I, R41N, H69K, K70R, V82I, L89ICRF01_AE
 R74019R74019KC791239None   I13V, M36I, R41K, H69K, L89ICRF01_AE
 R73030R73030KC810321None   L10I, I13V, E35D, M36I, R41K, I62V, H69K, V82I, L89ICRF01_AE
 R73001R73001KC810557None   I13V, G16E, E35D, M36I, P39S, R41K, R57K, H69K, K70R, I72V, L89ICRF01_AE
 R73043R73043KC810334None   I13V, G16E, K20R, E35D, M36I, R41K, K43R, L63T, I64L, H69K, L89I, Q92KCRF01_AE
 R73167R73167KC810444None   L10I, I13V, G16E, E35D, M36I, R41K, H69K, L89ICRF01_AE
 R71TS066R71TS066KC921545None   L10I, I13V, G16E, E35D, M36L, P39T, D60E, H69K, L89ICRF01_AE
 R71229R71229KC921459None   T12A, I13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89ICRF01_AE
 R51TS002R51TS002KF059651None   K14R, L19LV, K20R, M36I, R41K, K45R, H69K, L89I, I93LCRF01_AE
 R71TS055R71TS055KC921534None   I13V, E35D, M36I, R41K, H69K, L89ICRF01_AE
 R71TS158R71TS158KC921635None   I13V, G16E, E35D, M36I, P39S, R41K, H69K, L89ICRF01_AE
 R73240R73240KC810514None   I13V, G16E, K20KR, E35D, M36I, R41K, L63H, H69K, L89I, I93LCRF01_AE
 R71035R71035KC921789None   G16E, K20R, E35D, M36I, R41K, L63I, H69K, V82I, L89I, I93LCRF01_AE
 R71TS120R71TS120KC921597None   L10I, I13V, G16E, L23K, E35D, M36I, R41K, L63V, C67Y, H69K, L89ICRF01_AE
 R73052R73052KC810343None   I13V, Q18E, K20R, M36I, R41K, L63P, H69K, L89I, I93LCRF01_AE
 R72108R72108KC867644None   L10I, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
 R73250R73250KC810523None   L10IV, I13V, K20R, M36I, R41K, H69K, L89ICRF01_AE
 R74037R74037KC791257None   L10IV, I13V, G16GE, M36I, R41K, L63V, C67CG, H69K, I72IV, L89ICRF01_AE
 R12TS007R12TS007KC994319None   E35D, M36I, R41K, H69K, V77I, L89ICRF01_AE
 R12145R12145KC994279None   L10V, I13V, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
 R41027R41027KC970865None   I13V, K20R, M36I, R41K, L63P, H69K, V82I, L89I, I93LCRF01_AE
 R73069R73069KC810359None   L10I, I13V, G16E, E35D, M36I, R41K, L63Q, H69K, L89ICRF01_AE
 R73TS001R73TS001KC810558None   I13V, G16E, E35D, M36I, P39S, R41K, R57K, H69K, K70R, I72V, L89ICRF01_AE
 R71TS077R71TS077KC921556None   L10I, I13V, G16E, K20R, L33T, M36I, R41K, L63V, H69K, I72E, L89I, I93LCRF01_AE
 R72288R72288KC857104None   W6C, L10I, I13V, G16GE, E35D, M36I, R41K, H69K, L89ICRF01_AE
Kiptoo (2013)KAP038KAP038KC516891None   I13V, G16E, E35D, M36I, R41K, R57K, H69K, I72K, L89ICRF01_AE
Sigaloff (2013)JCR061_0JCR061_0JX181990None   I15V, E35D, M36I, R41K, R57K, H69K, L89ICRF01_AE
Telan (2013)1111785211117852AB747500None   K20R, M36I, R41K, L63P, H69K, L89I, I93LCRF01_AE
Wu (2013)HFP103HFP103KC203309None   G16E, E35D, M36I, R41K, H69K, V77I, L89ICRF01_AE
Khairunisa (2014)TD65TD65KM212926None   I13V, G16E, K20R, E35D, M36I, R41K, L63T, H69K, V77I, L89I, I93LCRF01_AE
Meixenberger (2014)06-0036906-00369KJ770232None   I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, L89I, Q92KCRF01_AE
 11-0235411-02354KJ771541None  V11VIL10V, T12TA, I13V, K14GR, G16E, K20R, E35D, M36I, R41K, R57K, L63T, H69K, K70R, L89ICRF01_AE
 12-0179812-01798KJ771751None   I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, L89I, Q92KCRF01_AE
 08-0118308-01183KJ770729None   I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, L89I, Q92KCRF01_AE
 11-0227011-02270KJ771539None   I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, L89I, Q92KCRF01_AE
 10-0262210-02622KJ771394None   I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, L89I, Q92KCRF01_AE
 06-0036806-00368KJ770231None   I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, L89I, Q92KCRF01_AE

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