<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF01_AE
Gene PR
Mutation L89I
Rx >= 1 PI
IncludeMixtures No
References 10
Patients 50
Isolates 51
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Chantratita (2002)VL245VL245AF191208PINAG48V, L90ML33F, F53L, N83DL10I, I13V, E35D, M36I, R41K, K43Q, L63P, H69K, L89ICRF01_AE
 G73G73AF240396PINAM46L, I84VL33I, N83DL10V, I13V, A22V, E35D, M36I, R41K, H69K, T74S, L89ICRF01_AE
 G72G72AF240395PINAG48M, I54V, V82A L10I, I13V, K20I, E35D, M36I, R41K, H69K, L89ICRF01_AE
 G70G70AF240394PINAG48V, I54V, V82AF53LL10I, I13V, K20I, E35D, M36I, R41K, H69K, T74S, L89ICRF01_AE
 G63G63AF240388PINAG48V, I54V, V82A L10I, I13V, A22V, E35D, M36I, R41K, I62V, L63P, H69K, L89ICRF01_AE
 G59G59AF240386PINAI84VL33I, N83DL10Y, I13V, E35D, M36I, R41K, F53I, L63P, H69K, L89ICRF01_AE
Ariyoshi (2003)JPN42JPN42A SQV104I54V, V82F, L90ML33F, I84LL10V, I13V, I15IV, G16E, K20I, E35D, M36I, N37ND, R41K, H69K, T74S, L89I, Q92KCRF01_AE
 JPN30JPN30 NFV71L90M L10V, I13V, K20T, E35D, M36I, R41K, H69K, K70R, T74S, L89ICRF01_AE
Chantratita (2005)14-012214-0122DQ130488PINAM46IN83DW6R, I13V, I15V, A22V, E35G, M36I, R41K, K55R, I62V, L63P, H69K, L89I, I93LCRF01_AE
 14-013414-0134DQ130499PINAL90M W6R, I13V, K20I, E35D, M36I, R41K, Q61E, L63P, H69K, A71T, T74S, L89ICRF01_AE
 G513G513DQ130109PINAM46LN83DI13V, A22V, E35D, M36I, R41K, R57K, H69K, L89ICRF01_AE
 G522G522DQ130114PINAM46I, L90MQ58EL10I, I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, H69K, A71V, T74S, V77I, V82I, L89I, I93L, L97MCRF01_AE
 G526G526DQ130117PINA  W6R, I13V, K20R, E35D, M36I, R41K, L63P, H69K, K70R, L89ICRF01_AE
 G531G531DQ130121PINAG48V L10I, I13V, E35D, M36I, R41K, H69K, K70R, T74S, L89ICRF01_AE
 G569G569DQ130138PINAI54V, I84VF53LL10I, I13V, I15V, K20R, E35D, M36I, R41K, D60E, L63P, I66F, H69K, A71V, L89ICRF01_AE
 G594G594DQ130155PINA  I13V, M36I, R41K, H69K, V82I, L89ICRF01_AE
 G602G602DQ130159PINAI54V, I84VN83DL10I, I13V, A22V, L33M, E35D, M36I, R41K, I62V, H69K, T74A, L89ICRF01_AE
 G605G605DQ130161PINAI54V, V82AL33F, Q58E, N83DL10V, I13V, E35D, M36I, R41K, H69K, L89ICRF01_AE
 G629G629DQ130177PINAG48V, I54V, V82AF53LL10I, I13V, K20R, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
 G720G720DQ130220PINAI84V, L90ML10FI13V, K20R, E35D, M36I, R41K, L63P, H69K, A71I, L89ICRF01_AE
 G724G724DQ130222PINA  I13V, K20I, E35D, M36I, R41K, R57K, H69K, T74S, L89ICRF01_AE
 G734G734DQ130228PINAG48V, I54A, V82A I13V, K20I, E35D, M36I, R41K, I62V, L63P, H69K, K70R, T74S, L89ICRF01_AE
 NP129NP129DQ130245PINA  L10I, I13V, M36I, N37D, R41K, H69K, K70R, L89ICRF01_AE
 NP138NP138DQ130253PINAI47V, G48V, I54A, V82A L10I, I13V, G16E, L19P, K20I, E35D, M36I, R41K, H69K, A71V, I72R, L89ICRF01_AE
 NP144NP144DQ130258PINAG48V, V82AL33I, F53LL10I, I13V, E35D, M36I, R41K, H69K, T74S, L89ICRF01_AE
 NP164NP164DQ130268PINAM46IL33I, N83DL10V, I13V, K14N, G16A, K20T, A22V, E35D, M36I, R41K, I62V, L63V, H69K, K70R, T74S, V82I, L89I, I93LCRF01_AE
 NP174NP174DQ130278PINA  L10V, I13V, K20T, E35D, M36I, N37D, R41K, D60E, H69K, A71T, T74S, L89ICRF01_AE
 NP184NP184DQ130288PINA  I13V, K14T, K20R, M36I, R41K, I64L, H69K, V82I, L89ICRF01_AE
 NP234NP234DQ130319PINAI84V L10V, I13V, K20R, E35D, M36I, R41K, R57K, I62V, L63P, H69K, T74A, L89ICRF01_AE
 NP254NP254DQ130336PINAG48V, L90MQ58EW6R, L10I, I13V, K20R, E35D, M36I, R41K, L63P, H69K, L89ICRF01_AE
 NP293NP293DQ130373PINAG48M, I54V, V82AF53L, N83DL10V, I13V, G16E, K20R, A22V, E35D, M36I, P39S, R41K, I62V, L63H, H69K, I72V, L89I, T91SCRF01_AE
 NP299NP299DQ130379PINAG48V, I54V, V82A L10I, I13V, A22V, E35D, M36I, R41K, I62V, L63P, H69K, K70R, L89I, T91SCRF01_AE
 NP315NP315DQ130393PINAG48V, I54V, V82A L10I, I15V, E35D, M36I, R41K, Q61E, L63P, H69K, L89I, I93LCRF01_AE
 NP316NP316DQ130394PINAL90M I13V, K20T, E35D, M36I, R41K, H69K, A71T, V82I, L89ICRF01_AE
 NP333NP333DQ130410PINAL90M K14N, G16E, K20T, E35D, M36I, P39S, R41K, I62V, H69K, K70R, A71V, V82I, L89I, I93MCRF01_AE
Hsu (2005)BAA150624BAA150624AY870158SQV, RTV31G48V, I84VL33F, Q58E, N83DL10V, I13V, K14KN, K20R, E35D, M36I, R41K, L63LP, H69K, L89ICRF01_AE
 BAA161430BAA161430AY870232IDV, SQV88G48V, I54V, V82AF53LL10I, I13V, L19LV, K20R, E35D, M36I, N37D, R41K, I62V, L63LP, H69K, A71T, T74S, L89ICRF01_AE
Non-B Workgroup (2005)TK5004TK5004 SQV, IDV, NFV, RTV, LPV145G48V, I54A, V82A L10I, V11VL, I13V, K14R, I15IV, K20I, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
Baxter (2006)48-14261426-30225DQ877815PINAG48V, I54A, V82A T4TS, L10I, V11L, I13V, K14R, I15V, K20I, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
 48-41134113-30319DQ878344PINAI54V, V82A L10I, I13V, G16E, L19I, K20I, E35D, M36I, P39S, R41K, D60DE, I62V, H69K, K70R, A71IV, I72V, T74A, L89ICRF01_AE
von Wyl (2007)345869337EF449787PINAI54VN83DL10I, I13V, G16A, A22V, E35D, M36I, R41K, L63V, H69K, L89ICRF01_AE
Rosen-Zvi (2008)1606p16-2 SQV, RTV, IDV, LPV287V82F L10I, T12A, I13V, E35D, M36I, R41K, R57K, H69K, L89ICRF01_AE
Ferradini (2011)50789PRHM026303APV, LPV24M46I, L76V, I84VL10FI13V, G16E, E21K, E35D, M36I, R41K, H69K, I72R, L89ICRF01_AE
Nerrienet (2014)S0815116S0815116JN675751LPV V32I, I47AL10FI13V, M36I, R41K, H69K, L89ICRF01_AE
 55JN675803LPV   W6R, Q18R, K20R, E35D, M36I, R41K, H69K, K70R, I72E, V77E, T80A, L89I, L90W, T91PCRF01_AE
 R0917161R0917161JN675781LPV   L10I, I13V, G16E, M36I, R41K, H69K, L89ICRF01_AE
 T0826079T0826079JN675758LPV M46I, I47A, I84V, L90ML10F, L33I, F53LI13V, G16A, L19I, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, C67F, H69K, K70R, L89I, T91VCRF01_AE
 R0130090R0130090JN675745LPV M46I, L76V, I84VL10FI13V, G16E, E21K, E35D, M36I, R41K, H69K, I72R, L89ICRF01_AE
 S0916071S0916071JN675753LPV M46I, I54V, V82F, L90M L10V, K20I, E35D, M36I, R41K, Q61H, I62V, L63C, H69K, T74S, L89ICRF01_AE
 R0606212R0606212JN675746LPV I54V, V82AL10F, N83DI13V, K20R, A22V, M36I, N37D, R41K, L63LP, H69K, L89I, T91ACRF01_AE
 T0518207T0518207JN675755LPV M46MI, I54V, V82AL10F, L33LI, Q58EI13V, E35D, M36I, H69K, K70R, L89ICRF01_AE