<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF01_AE
Gene PR
Mutation V77I
Rx PI-naive
IncludeMixtures No
References 69
Patients 307
Isolates 308
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Lan (2003)NTHvr75NTHvr75AY238315None   I13IV, E35D, M36I, R41K, L63LP, H69K, V77I, V82I, L89M, I93LCRF01_AE
Brown (2005)BB_96TH_NI114996TH_1149AY713426None   I13V, E35D, M36I, R41K, H69K, V77I, L89M, T91VCRF01_AE
Hsu (2005)BAA157677BAA157677AY870182None   I13V, I15V, E35D, M36I, R41K, R57K, H69K, V77I, L89I, T91VCRF01_AE
Ly (2005)NL_KHM_HM35KHM_HM35DQ013599None   I13V, E35D, M36I, R41K, D60E, H69K, V77I, L89M, I93LCRF01_AE
Tee (2005)04MYKL189704_1897AY904609None   I13V, E35D, M36I, R41K, L63P, H69T, K70R, A71V, I72V, V77I, I93LCRF01_AE
 03MYKL135803_1358AY904534None   I13V, E35D, M36I, R41K, H69K, V77I, L89M, T91NCRF01_AE
 03MYKL152103_1521AY904553None   I13V, K20R, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
Marechal (2006)JF_005JF_005DQ443627None   L10V, I13V, K14R, G16A, E35D, M36I, N37DE, R41K, R57K, D60E, Q61N, L63M, C67E, H69K, V77I, L89MCRF01_AE
Tee (2006)KL04305_043.1DQ366666None   G16E, H69K, V77I, I93LCRF01_AE
Baker (2007)P0018P0018-240105EF186133None   I13V, K14R, I15V, E35D, M36L, N37D, R41K, L63T, H69K, V77I, L89MCRF01_AE
Gatanaga (2007)C03-2066174-1C03-2066174-1AB640471None   L10V, I13V, G16AE, E35D, M36I, R41K, K45KR, R57K, I62IV, L63LP, H69K, V77I, L89MCRF01_AE
Liu (2007)fj44fj44EF432677None  L33FI13V, M36I, R41K, L63I, H69K, V77I, L89M, I93LCRF01_AE
 fj88fj88EF432707None   I13V, E35D, M36I, R41K, K55R, L63P, H69K, I72V, V77ICRF01_AE
Ibe (2008)164164AB356211None   E35D, M36I, R41K, L63P, H69K, I72V, T74S, V77I, L89M, I93LCRF01_AE
Nguyen (2008)046VN046 None   I13V, E35D, M36I, R41K, D60E, H69K, V77I, L89M, T91V, F99XCRF01_AE
Sirivichayakul (2008)NBC-9NBC-9PrJQ364309None   I13V, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
Ayouba (2009)FD0471FD0471PIGQ352070None   I13V, E35D, M36I, R41K, L63P, H69K, V77I, L89MCRF01_AE
Fujisaki (2009)631631AB442295None   I13V, K20R, E35D, M36I, R41K, H69K, V77I, L89M, L97ICRF01_AE
Ishizaki (2009)A1A1FJ007113None   I13V, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
Lee (2009)S07026S07026EU715185None   K20R, E35D, M36I, R41K, R57K, H69K, V77I, L89M, I93L, L97ICRF01_AE
Sahbandar (2009)IDJKT070IDJKT070AB468573None   I13V, K20R, E35D, M36I, R41K, K45R, H69K, V77I, L89M, L97ICRF01_AE
Carr (2010)0096MA01CM.0096MAGU201497None   I13V, G17E, K20I, E34K, M36I, P39S, R57K, Q61N, I62L, L63S, C67E, H69K, V77I, L89MCRF01_AE
Han (2010)LN105LN105FJ531409None   I13V, L19M, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 LN123LN123FJ531420None   L19M, E35D, M36I, R41K, R57K, H69K, K70R, V77I, L89MCRF01_AE
Hattori (2010)C06-2066282C06-2066282AB864020None   I13V, K20R, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 C04-20671366C04-20671366AB863983None   T12P, I13V, K20R, E35D, M36I, R41K, R57K, H69K, V77I, L89M, I93L, L97ICRF01_AE
 C06-51110444C06-51110444AB864851None   I13V, E35D, M36I, R41K, L63P, H69K, V77I, L89MCRF01_AE
 F07-20701F07-20701AB866458None   I13V, G16E, K20R, E35D, M36I, R41K, R57RK, I62V, H69K, V77I, L89MCRF01_AE
Phan (2010)NB01NB01AB519523None   I15V, G16E, E35D, M36I, R41K, H69R, V77I, V82I, L89M, I93LCRF01_AE
 NB24NB24AB519536None   L10I, I13V, G16E, E35D, M36I, R41K, H69K, K70R, V77I, L89MCRF01_AE
 AH01AH01AB519558None   I13V, I15V, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 NB07NB07AB519609None   I13V, G16E, E35D, M36I, R41K, H69K, K70R, V77I, L89MCRF01_AE
Zolfo (2010)A13412A 13412 M18HM565700None   L10I, I13V, G16E, K20I, E35D, M36I, R41K, H69K, K70G, V77I, L89MCRF01_AE
  A 13412 M24HM565661None   L10I, I13V, G16E, K20I, E35DN, M36I, R41K, H69K, K70GR, V77I, L89MCRF01_AE
Kao (2011)Pat33826584HQ657702None   I13V, I15V, L19M, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 Pat28527003HQ657755None   I13V, G16E, K20R, E35D, M36I, N37ND, R41K, R57RK, I62V, H69K, V77I, L89MCRF01_AE
Lazaro (2011)TG-M6TG-M6HQ542676None   I13V, K14KR, Q18H, E35D, M36I, R41K, R57RK, L63PS, H69K, V77I, L89MCRF01_AE
Ng (2011)HM004HM004HQ539039None   Q7R, I13V, G16E, K20R, E35D, M36I, R41K, H69K, V77I, L89M, T91A, L97ICRF01_AE
 HM104HM104HQ539130None   I13V, K20R, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
Su (2011)LZ2123LZ2123HQ588216None   T12A, I13V, M36I, R41K, H69R, V77I, L89M, I93LCRF01_AE
 LZ2130LZ2130HQ588217None   T12A, I13V, M36I, R41K, H69R, V77I, L89M, I93LCRF01_AE
Ye (2011)BJ07425BJ07425JF906641None   I13V, L19I, E35D, M36I, R41K, H69K, K70R, V77I, L89MCRF01_AE
 BJ07546BJ07546JF906667None   I13V, L19T, E35D, M36I, R41K, H69K, I72V, V77I, L89MCRF01_AE
An (2012)09LNA02509LNA025JX960634None   I13V, L19M, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89MCRF01_AE
Chamberland (2012)C405SC405SHQ267537None   I13V, G17E, K20I, E35G, M36I, N37S, R41K, I62V, H69K, I72M, V77I, L89MCRF01_AE
Chen (2012)YN09DH0001YN09DH0001JQ658474None   I13V, E35D, M36I, R41K, H69K, I72IV, V77I, V82I, L89MCRF01_AE
 YN09DH0002YN09DH0002JQ658475None   I13V, E35D, M36I, R41K, H69K, V77I, V82I, L89MCRF01_AE
 YN09DH0155YN09DH0155JQ658612None   I13V, E35D, M36I, N37D, R41K, L63P, H69K, V77I, L89MCRF01_AE
Rolland (2012)AA001a12LAA001a12LJX446647None   I13V, L19M, E35D, M36I, R41K, I62V, L63P, H69K, V77I, V82I, L89MCRF01_AE
 AA049a_WG11AA049a_WG11JX447266None   L10I, I13V, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 AA080a13LAA080a13LJX447597None   I13V, A28AV, E35D, M36I, R41K, L63P, H69K, V77I, L89MCRF01_AE
 AA127a01LAA127a01LJX448278None   I13V, E35D, M36I, L63P, H69K, V77I, L89MCRF01_AE
Yang (2012)GZ007GZ007JN848841None   I13V, G16E, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 GZ023GZ023JN848849None   I13V, G16E, E35D, M36I, R41K, K43KR, L63A, H69K, I72V, V77I, L89MCRF01_AE
 GZ154GZ154JN848876None   I13IV, E35D, M36I, R41K, L63P, I64IM, H69K, V77I, L89M, I93IFCRF01_AE
 GZ055GZ055JN848889None   I13V, E35D, M36I, R41K, L63P, I64IM, H69K, V77I, L89MCRF01_AE
Zeng (2012)CN1222CN1222JQ028232None   G16E, E35D, M36I, L63C, H69K, V77I, L89MCRF01_AE
Aghokeng (2013)HJ3153HJ3153JX983032None   G16A, E35D, M36I, R41K, R57K, V77I, L89LMCRF01_AE
 HJ3061HJ3061JX982982None   L10I, I13V, K14R, E35D, M36I, N37D, R41K, L63P, H69K, V77I, L89MCRF01_AE
Avidor (2013)21122112KC184361None   I13V, K20R, E35D, M36I, N37D, R41K, H69K, V77I, L89M, L97ICRF01_AE
Billong (2013)MR025MR025KF192213None  L33FI13V, K14R, E35N, N37E, R41K, H69K, V77I, L89M, I93MCRF01_AE
Chow (2013)MY2KA791MY2KA791KC478055None   I13V, K20R, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
Frentz (2013)EHR-04649EHR-04649JX299622None   I13V, K14R, E35D, M36I, R41K, K45R, L63P, H69K, V77I, L89M, I93LCRF01_AE
 EHR-24162EHR-24162JX299960None   E35D, M36I, R41K, R57K, H69K, V77I, L89MCRF01_AE
 EHR-62720EHR-62720JX300589None   T12TAS, I13V, K14KR, L19LV, E35D, M36I, R41K, L63P, H69K, I72IV, V77I, L89M, I93LCRF01_AE
Han (2013)BJ136BJ136KC888516None   G16E, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 10LN30056110LN300561KC888269None   E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 09SH90040209SH900402KC888447None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 BJ84BJ84KC888608None   I15V, K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 10LN30050110LN300501KC888242None   I15IV, L19V, E35D, M36I, R41K, H69K, K70R, T74S, V77I, L89M, I93LCRF01_AE
 09SH90036509SH900365KC888442None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 BJ88BJ88KC888609None   I15V, K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 09SH90033609SH900336KC888440None   K20R, E35D, M36I, R41K, L63T, H69K, K70R, V77I, L89MCRF01_AE
 10LN30048710LN300487KC888235None   I13V, K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89MCRF01_AE
 09BJ16309BJ163KC888471None   E35D, M36I, R41K, H69K, K70R, V77I, L89MCRF01_AE
 BJ193BJ193KC888537None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 09SH90049609SH900496KC888452None   K20R, E35D, M36I, R41K, L63T, H69K, K70R, V77I, L89M, I93LCRF01_AE
Jiamsakul (2013)R71143R71143KJ868883None   I13V, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
Kiertiburanakul (2013)R71TS284R71TS284KC921753None   T12P, I13V, I15V, E35D, M36I, R41K, L63S, H69K, V77I, L89MCRF01_AE
 R12065R12065KC994212None   I13V, E35D, M36I, R41K, I62IV, L63P, H69K, K70R, V77I, V82VI, L89M, I93IMCRF01_AE
 R71TS293R71TS293KC921760None   E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 R71TS248R71TS248KC921719None   E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 R41163R41163KC970899None   H69K, T74S, V77I, L89M, I93LCRF01_AE
 R71112R71112KC921417None   I13V, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89MCRF01_AE
 R71TS228R71TS228KC921699None   I13V, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 R41058R41058KC970943None   I13V, E35D, M36I, R41K, K45R, L63P, H69K, V77I, L89MCRF01_AE
 R71TS244R71TS244KC921715None   I13V, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 R73019R73019KC810568None   I13V, E35D, M36I, R41K, L63P, H69K, K70R, I72V, V77I, L89MCRF01_AE
 R41131R41131KC970855None   G16E, E35D, M36I, R41K, H69K, K70R, V77I, L89MCRF01_AE
 R71TS221R71TS221KC921692None   L10V, I13V, L19V, L33V, E35D, M36I, R41K, L63P, H69K, V77I, L89MCRF01_AE
 R12TS007R12TS007KC994319None   E35D, M36I, R41K, H69K, V77I, L89ICRF01_AE
 R73045R73045KC810336None   I13V, E35D, M36I, R41K, R57RK, L63A, H69K, V77I, G78R, L89MCRF01_AE
 R71144R71144KC921847None   I13V, E35D, M36I, R41K, L63P, H69K, I72V, V77I, L89MCRF01_AE
 R72146R72146KC856975None   I13V, E35D, M36I, N37D, R41K, L63P, H69K, K70R, V77I, L89M, I93IVCRF01_AE
 R72122R72122KC856954None   I13V, G16E, K20I, E35DN, M36I, N37D, R41K, H69K, K70R, I72IV, V77I, L89MCRF01_AE
Li (2013)28492849JQ901058None   T12P, L19LI, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
Li (2013)22162216JQ302684None   E35D, M36I, R41K, L63P, H69K, V77I, L89MCRF01_AE
Lunar (2013)3571-073571-07JX046416None   L10V, I13V, G16E, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
Ong (2013)08MYKL00508MYKL005KC181246None   I13V, K20R, E35D, M36I, R41K, H69K, V77I, L89M, L97ICRF01_AE
Rusine (2013)734H734HKC841755None   I13V, I15V, E35D, M36I, R41K, R57K, D60E, Q61E, L63P, H69K, V77I, L89MCRF01_AE
Telan (2013)1108462211084622AB747460None   K20R, M36I, R41K, H69K, K70R, V77I, L89M, I93LCRF01_AE
 1112847611128476AB747503None   T12P, I13V, E35D, M36I, R41K, L63C, H69K, T74S, V77I, L89MCRF01_AE
Wu (2013)HFP108HFP108KC203310None   K20KR, E35D, M36I, R41K, R57K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 BB77Frag1BB77Frag1KC183775None   I13V, G16E, E35D, M36I, R41K, H69K, K70KR, V77I, L89MCRF01_AE
 HFP103HFP103KC203309None   G16E, E35D, M36I, R41K, H69K, V77I, L89ICRF01_AE
Khairunisa (2014)TD48TD48KM212918None   I13V, K20R, E35D, M36I, R41K, R57K, H69K, V77I, L89MCRF01_AE
 TD63TD63KM212924None   G16A, K20R, E35D, M36I, R41K, H69K, V77I, L89M, L97ICRF01_AE
 TD65TD65KM212926None   I13V, G16E, K20R, E35D, M36I, R41K, L63T, H69K, V77I, L89I, I93LCRF01_AE
 IP2IP2KM212933None   I13V, K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89MCRF01_AE
 TD30TD30KM212905None   T12P, I15V, K20R, E35D, M36I, R41K, F53V, L63P, H69K, V77I, L89M, I93L, L97I, F99LCRF01_AE
 TD47TD47KM212917None   I13V, K20R, E35D, M36I, R41K, H69K, V77I, L89M, I93LCRF01_AE
 TD11TD11KM212892None   I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, V77I, L89MCRF01_AE
 IP22IP22KM212939None   I13V, K20R, E35D, M36I, N37D, R41K, H69K, V77I, L89M, L97ICRF01_AE
 IP6IP6KM212935None   I13V, K20R, E35D, M36I, N37D, R41K, K45R, H69K, V77I, L89M, L97ICRF01_AE
 TD21TD21KM212900None   I13V, K20R, E35D, M36I, R41K, H69K, V77I, L89M, L97ICRF01_AE
 TD39TD39KM212913None   I13V, K20R, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 DT3DT3KM212883None   I13V, G16E, K20R, E35D, M36I, R41K, I62V, H69K, V77I, L89MCRF01_AE
 TD54TD54KM212920None   I13V, I15V, K20R, E35D, M36I, N37D, R41K, G51R, H69K, V77I, L89MCRF01_AE
 TD41TD41KM212914None   I13V, K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93L, L97ICRF01_AE
 TD9TD9KM212890None   I13V, K20R, E35D, M36I, R41K, L63P, H69K, V77I, V82I, L89M, I93L, L97ICRF01_AE
 TD26TD26KM212903None   I13V, K20R, E35D, M36I, R41K, R57K, H69K, V77I, L89M, L97ICRF01_AE
Lee (2014)MBA1228MBA1228KJ906922None   I13V, G16GE, E35D, M36I, R41K, K45R, R57K, I62IV, L63LP, H69K, K70KR, V77I, L89MCRF01_AE
 MBA1085MBA1085KJ906785None   I13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, K70KR, V77I, L89MCRF01_AE
Parczewski (2014)10_BI1110_BI11KM283901None   I13V, K14R, E35D, M36I, R41K, H69K, V77I, L89M, I93LCRF01_AE
 186_BI11186_BI11KM284017None   I13V, K14R, E35D, M36I, R41K, H69K, V77I, L89M, I93LCRF01_AE
 305_BI12305_BI12KM284157None   I13V, K14R, E35D, M36I, R41K, R57RK, H69K, V77I, L89M, I93L, T96NCRF01_AE
Zhao (2014)HJK0624HJK0624KJ401656None   K20R, E35D, M36I, R41K, L63P, H69K, K70KR, V77I, L89M, I93LCRF01_AE
 YGJ0219YGJ0219KJ401758None   E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 kang079kang079KJ401475None   E35D, M36I, R41K, H69K, V77I, L89M, I93LCRF01_AE
 CXA080CXA080KJ401606None   T12TA, I13V, K14KR, E35D, M36I, R41K, L63P, H69K, V77I, V82VI, L89MCRF01_AE
Alexiev (2015)552_0707552_0707JQ259109None   I13V, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
Budambula (2015)MK104MK104KP792098None   I13V, E35D, M36I, R41K, R57K, L63P, H69K, V77I, L89MCRF01_AE
Gashnikova (2015)Tomsk25Tomsk25KM676174None   I13V, G16E, E35D, M36I, R41K, R57K, H69K, V77I, L89M, I93LCRF01_AE
 Tomsk33Tomsk33KM676175None   G16E, E35D, M36I, R41K, L63T, H69K, V77I, L89M, I93LCRF01_AE
 Tomsk41Tomsk41KM676177None   G16E, E35D, M36I, R41K, L63T, H69K, V77I, L89M, I93LCRF01_AE
Guo (2015)YZU35-2011YZU35-2011KJ724189None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
Jiamsakul (2015)R71TS191R71TS191KM065813None   I13V, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
Laga (2015)AM059AM059KM023158None   I13V, L19I, E35D, M36I, R41K, R57K, H69K, V77I, L89M, I93LCRF01_AE
 ARM058ARM058KF692180None   I13IV, E35D, M36I, R41K, R57K, H69K, V77I, L89MCRF01_AE
Li (2015)SF121616SF121616KR187912None   I15V, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF100045SF100045KR187317None   I15V, K20R, E35D, M36I, R41K, L63T, H69K, V77I, L89M, I93LCRF01_AE
 SF090973SF090973KR187281None   K20R, E35D, M36I, R41K, L63T, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF100685SF100685KR187367None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF101837SF101837KR187496None   K20R, E35D, M36I, N37D, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF130066SF130066KR188010None   K20R, E35D, M36I, R41K, R57K, H69K, V77I, L89MCRF01_AE
 SF100167SF100167KR187327None   K14R, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120050SF120050KR187725None   K20R, E35D, M36I, N37D, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF090797SF090797KR187262None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120841SF120841KR187797None   I13IV, L19LQ, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF090611SF090611KR187236None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120362SF120362KR187748None   K20R, E35D, M36I, R41K, K45R, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF100375SF100375KR187338None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF111153SF111153KR187641None   K20R, E35D, M36I, R41K, K45R, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF13G258SF13G258KR188294None   K20R, E35D, M36I, R41K, R57RK, I62V, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF121926SF121926KR187996None   K14KR, K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF090884SF090884KR187275None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, L90V, I93LCRF01_AE
 SF090621SF090621KR187241None   K20R, E35D, M36I, R41K, L63T, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF121830SF121830KR187966None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF120028SF120028KR187721None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF090906SF090906KR187277None   K20R, E35D, M36I, R41K, L63T, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF13G038SF13G038KR188171None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF090267SF090267KR187199None   K20R, E35D, M36I, R41K, I62IV, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF13G481SF13G481KR188417None   K20R, E35D, M36I, R41K, L63APS, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF101069SF101069KR187420None   K20KR, E35D, M36I, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF090024SF090024KR187188None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF110064SF110064KR187522None   K14R, G16GA, E35D, M36I, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF130067SF130067KR188011None   G16GE, K20R, E35D, M36I, R41K, K45R, L63T, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF101068SF101068KR187419None   K20R, E35D, M36I, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF120099SF120099KR187734None   K20R, E35D, M36I, R41K, Q61E, I62V, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF130160SF130160KR188030None   K20R, E35D, M36I, R41K, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF110726SF110726KR187587None   K20R, E35D, M36I, R41K, L63T, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF090739SF090739KR187250None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF100389SF100389KR187343None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF131398SF131398KR188111None   I15V, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF130054SF130054KR188006None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF090257SF090257KR187194None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF111086SF111086KR187629None  L10F, V11IT12P, E35D, M36I, R41K, H69R, V77I, L89MCRF01_AE
 SF121336SF121336KR187859None   T12P, K20R, E35D, M36I, N37ND, R41K, L63P, H69K, K70KQR, V77I, L89M, I93LCRF01_AE
 SF091145SF091145KR187310None   I15IV, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF13G238SF13G238KR188285None   G16E, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120468SF120468KR187762None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF110957SF110957KR187606None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF100952SF100952KR187399None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120518SF120518KR187766None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF110532SF110532KR187573None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, V82I, L89M, I93LCRF01_AE
 SF120679SF120679KR187778None   T12TP, K14KR, K20R, E35D, M36I, R41K, R57RK, L63P, H69K, K70R, V77I, V82I, L89M, I93LCRF01_AE
 SF13G425SF13G425KR188390None   G16E, K20R, E35D, M36I, R41K, K45R, H69K, V77I, L89M, I93LCRF01_AE
 SF130093SF130093KR188018None   T12P, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120675SF120675KR187776None   G17E, K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF13G014SF13G014KR188157None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF13G177SF13G177KR188252None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF110295SF110295KR187539None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF091071SF091071KR187285None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF121736SF121736KR187932None   K20KR, E35D, M36I, R41K, K45R, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF111213SF111213KR187648None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF100166SF100166KR187326None   K20R, E34A, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120255SF120255KR187739None   I15IV, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF100620SF100620KR187354None   T12P, I15V, K20R, E35D, M36I, R41K, L63S, H69K, I72V, V77I, L89M, I93LCRF01_AE
 SF091138SF091138KR187309None   K20R, E35D, M36I, R41K, L63T, H69K, K70R, I72V, V77I, L89M, I93LCRF01_AE
 SF111111SF111111KR187637None   K20R, E35D, M36I, R41K, L63T, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF110085SF110085KR187527None   K20R, E35D, M36I, R41K, L63S, H69K, V77I, L89M, I93LCRF01_AE
 SF121635SF121635KR187917None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF131635SF131635KR188121None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF120276SF120276KR187741None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF100016SF100016KR187313None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF110511SF110511KR187565None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF091096SF091096KR187295None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF091093SF091093KR187292None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF121418SF121418KR187877None   L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF101285SF101285KR187433None   K14R, E35D, M36I, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF101131SF101131KR187426None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120394SF120394KR187755None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, V82I, L89M, I93LCRF01_AE
 SF101055SF101055KR187414None   K20R, E35D, M36I, R41K, L63T, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120582SF120582KR187767None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF13G247SF13G247KR188288None   T12P, I15V, K20R, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, K70KR, V77I, L89M, I93LCRF01_AE
 SF13G473SF13G473KR188413None   L10I, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, I93LCRF01_AE
 SF121787SF121787KR187948None   T12TP, K14KR, K20R, E35D, M36I, R41K, R57RK, L63P, H69K, K70R, V77I, V82I, L89M, I93LCRF01_AE
 SF13G535SF13G535KR188446None   K20R, T26TP, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF13G046SF13G046KR188177None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF111417SF111417KR187683None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF100712SF100712KR187368None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF100824SF100824KR187384None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF13G007SF13G007KR188151None   T12P, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, V82VI, L89M, I93LCRF01_AE
 SF101063SF101063KR187418None   G17GE, K20R, E35D, M36I, R41K, L63S, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF090750SF090750KR187255None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, L90LV, I93LCRF01_AE
 SF111084SF111084KR187628None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF101789SF101789KR187489None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF101473SF101473KR187460None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF120680SF120680KR187779None   K20R, E35D, M36I, R41K, L63C, H69K, K70R, V77I, L89M, I93ILCRF01_AE
 SF13G055SF13G055KR188183None   K20R, E35D, M36I, R41K, R57K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF130200SF130200KR188040None   K20R, E35D, M36I, R41K, R57K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120040SF120040KR187724None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF101755SF101755KR187482None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF121671SF121671KR187925None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, V82I, L89M, I93LCRF01_AE
 SF120372SF120372KR187752None   T12P, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF130096SF130096KR188020None   I15V, K20R, E35D, M36I, R41K, K45R, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF121644SF121644KR187919None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120512SF120512KR187764None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF090732SF090732KR187248None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF121469SF121469KR187885None   G16E, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF100771SF100771KR187372None   E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF121820SF121820KR187960None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, V82I, L89M, I93LCRF01_AE
 SF090935SF090935KR187278None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF121053SF121053KR187818None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF13G179SF13G179KR188254None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF130726SF130726KR188082None   T12A, L19I, K20R, E35D, M36I, R41K, K45R, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF121417SF121417KR187876None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120701SF120701KR187783None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF13G265SF13G265KR188298None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF121892SF121892KR187985None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF120055SF120055KR187727None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF101889SF101889KR187505None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF13G401SF13G401KR188377None   K14R, K20R, E35D, M36I, R41K, R57RK, L63P, H69K, V77I, V82I, L89M, I93LCRF01_AE
 SF111570SF111570KR187714None   L19I, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF090861SF090861KR187264None   K20R, E35N, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF101081SF101081KR187422None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF110133SF110133KR187531None   I15V, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF110529SF110529KR187571None   K20R, E35D, M36I, R41K, L63S, H69K, V77I, L89M, I93LCRF01_AE
 SF121815SF121815KR187958None   G16E, K20R, E35D, M36I, R41K, L63T, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SF13G108SF13G108KR188214None   I15V, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 SF100993SF100993KR187404None   Q18E, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
Li (2015)JS11S0046JS11S0046KR823674None   T12TP, I13IV, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 BJ14S0121BJ14S0121KR823134None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 ZJ12S0018ZJ12S0018KR823980None   I13V, G16E, E35D, M36I, R41K, I62V, H69K, K70R, V77I, L89MCRF01_AE
 BJ11S0015BJ11S0015KR822902None   L10I, I13V, L19M, E35D, M36I, R41K, L63LP, H69K, K70KR, V77I, L89M, F99FLCRF01_AE
 BJ09SS021BJ09SS021KR822843None   E35D, M36I, R41K, H69K, K70R, V77I, L89MCRF01_AE
 BJ12S0032BJ12S0032KR822960None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 HN11S0037HN11S0037KR823471None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 HA11S0021HA11S0021KR823390None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 ZJ12S0043ZJ12S0043KR823996None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 HN14S0070HN14S0070KR823587None   I13V, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 HN13S0004HN13S0004KR823498None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 ZJ09S1056ZJ09S1056KR823916None   G16E, K20R, E35D, M36I, R41K, I62IV, L63PST, H69K, K70R, V77I, L89M, I93LCRF01_AE
 BJ14S0102BJ14S0102KR823120None   I13V, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 BJ14S0091BJ14S0091KR823109None   K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 BJ10S0058BJ10S0058KR822895None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 BJ13S0329BJ13S0329KR822992None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 ZJ12S0013ZJ12S0013KR823976None   K20R, E35D, M36I, R41K, K55R, L63S, H69K, K70R, V77I, L89M, I93LCRF01_AE
 ZJ12S0012ZJ12S0012KR823975None   K20R, L23P, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 ZJ10S0014ZJ10S0014KR823936None   K20R, E35D, M36I, R41K, R57K, L63A, H69K, K70KR, V77I, L89M, I93LCRF01_AE
 BJ13S0106BJ13S0106KR822988None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
Lu (2015)SJ13069SJ13069KR605064None   L10I, I13V, E35D, M36I, R41K, L63P, C67Y, H69K, V77I, L89ICRF01_AE
Wang (2015)193193KP250722None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 136136KP250683None   G16E, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 ya6ya6KP250828None   W6*, L10I, E35D, M36I, R41K, C67F, H69K, V77I, L89MCRF01_AE
 163163KP250701None   E35D, M36I, R41K, H69K, K70R, V77I, L89MCRF01_AE
 8888KP250798None   I15V, K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 8484KP250795None   I15V, K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
Wang (2015)0907009070KM395760None   I13V, K20I, E35D, M36I, R41K, H69K, T74S, V77I, L89MCRF01_AE
Yan (2015)SMS_VMI22SMS_VMI22KP418595None   K20R, E35D, M36I, R41K, K45R, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 SMS_VMR101SMS_VMR101KP418599None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, I93LCRF01_AE
Zhang (2015)HZ130436HZ130436KM258743None   K20R, E35D, M36I, R41K, L63T, H69K, V77I, L89M, I93LCRF01_AE
 HZ130364HZ130364KM258729None   K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 HZ131097HZ131097KM258835None   I13V, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 HZ131095HZ131095KM258833None   L10V, I15IV, G16GE, K20R, E35D, M36I, R41K, L63A, H69K, K70R, V77I, L89M, I93LCRF01_AE
 HZ130440HZ130440KM258747None   K20R, E35D, M36I, R41K, R57K, L63T, H69K, K70R, V77I, L89M, I93LCRF01_AE
 HZ130264HZ130264KM258723None   G16E, K20R, E35D, M36I, R41K, L63T, H69K, K70R, V77I, L89M, I93LCRF01_AE
 HZ130359HZ130359KM258726None   I15IV, K20R, E35D, M36I, R41K, L63P, H69K, K70R, V77I, L89M, I93LCRF01_AE
 HZ130573HZ130573KM258758None   G17E, K20R, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 HZ130984HZ130984KM258822None   K20R, E35D, M36I, R41K, L63T, H69K, K70R, V77I, L89M, I93LCRF01_AE
 HZ130994HZ130994KM258828None   K20R, E35D, M36I, R41K, I62V, H69K, K70KR, V77I, L89M, I93LCRF01_AE
Billings (2016)KE295198V5KE295198V5KT022401None   E35D, M36I, R41K, R57K, L63S, H69K, V77I, L89M, N98DCRF01_AE
Onsongo (2016)124124KM376212None   E35D, M36I, R41K, K45R, R57K, L63S, H69K, V77I, L89MCRF01_AE
Van Tran (2016)VI-245VI-245LC101099None   L10M, I13V, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 VI-349VI-349LC101184None   I13V, E35D, M36I, R41K, D60DE, Q61QE, L63C, H69K, V77I, V82I, L89MCRF01_AE
 VI-224VI-224LC101080None   K14KR, D25DN, E35D, M36I, R41K, L63P, H69K, V77I, L89M, I93LCRF01_AE
 VI-235VI-235LC101091None   I13IV, L19LV, E35D, M36I, R41K, L63S, H69K, I72IV, V77I, L89MCRF01_AE
 VI-044VI-044LC100930None   I13V, G17E, E35D, M36I, N37D, R41K, L63P, H69K, K70R, V77I, L89MCRF01_AE

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