<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF01_AE
Gene PR
Mutation L63P
Rx >= 1 PI
IncludeMixtures No
References 16
Patients 124
Isolates 127
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Chantratita (2002)VL337VL337AF172706PINAG48V, V82AF53L, L89VL10I, I13V, K20I, E35D, M36I, N37D, L63P, H69K, A71V, T74SCRF01_AE
 VL245VL245AF191208PINAG48V, L90ML33F, F53L, N83DL10I, I13V, E35D, M36I, R41K, K43Q, L63P, H69K, L89ICRF01_AE
 GEN15GEN15AF191199PINAM46I, L90MT74PL10V, K20R, E35D, M36I, R41K, K55R, I62V, L63P, H69K, L89MCRF01_AE
 G26G26AF193894PINAM46IL10FI13V, E35D, M36I, R41K, L63P, H69K, L89TCRF01_AE
 G67G67AF240392PINAI54V, V82F, L90M L10I, I13V, K20I, E35N, M36I, R41K, L63P, H69K, T74S, L89M, I93MCRF01_AE
 G66G66AF240391PINAI54V, V82F, L90M L10I, I13V, K20I, E35N, M36I, R41K, L63P, H69K, T74S, L89M, I93MCRF01_AE
 G65G65AF240390PINAG48V, I54M, V82AL33F, F53L, N83DL10I, G16A, K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74S, L89M, I93LCRF01_AE
 G63G63AF240388PINAG48V, I54V, V82A L10I, I13V, A22V, E35D, M36I, R41K, I62V, L63P, H69K, L89ICRF01_AE
 G59G59AF240386PINAI84VL33I, N83DL10Y, I13V, E35D, M36I, R41K, F53I, L63P, H69K, L89ICRF01_AE
 G57G57AF240384PINAM46IL10FI13V, K20I, E35D, M36I, R41K, K55R, I62V, L63P, H69K, L89TCRF01_AE
 G51G51AF240378PINAI84V, L90ML10FI13V, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
Ariyoshi (2003)JPN44JPN44A IDV, SQV, RTV88  K20R, E35D, M36I, N37D, L63P, H69K, L89M, I93LCRF01_AE
  JPN44BAY900691IDV, SQV, RTV, LPV204  K20R, E35D, M36I, N37D, L63P, H69K, L89M, I93LCRF01_AE
 JPN45JPN45A IDV64N88SL10F, L33LI, L89VI13V, K20T, E35D, M36I, R41K, I62IV, L63P, H69K, A71AT, T74TSCRF01_AE
  JPN45BAY900693IDV, APV, LPV68N88SL10F, L89VI13V, K20T, E35D, M36I, P39PS, R41K, L63P, H69K, A71TCRF01_AE
 JPN34JPN34AY900860IDV, SQV76G48V, I54IVL33LF, N83NDL10LI, I13V, I15V, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 JPN35JPN35AY900862IDV, NFV140M46I, L90M L10V, I13V, K20T, E35D, M36I, R41K, Q61H, L63P, I64V, H69K, K70R, T74S, R87X, L89M, I93LCRF01_AE
 JPN41JPN41A IDV, SQV, NFV125G48ST, I54V, V82F, L90M L10I, I13V, G16E, K20I, E35D, M36I, P39Q, R41K, K45V, I62V, L63P, H69K, L89MCRF01_AE
  JPN41BAY900873IDV, SQV, NFV, APV195I54V, V82F, L90LM L10I, I13V, G16E, K20I, E35DN, M36I, P39Q, R41K, K45V, G48X, I62V, L63P, H69K, L89MCRF01_AE
Montes (2004)MB_patPOI01_POI735AJ577975SQV, NFV, RTV160  I13V, E35D, M36I, N37D, R41K, L63P, H69K, K70R, L89MCRF01_AE
 MB_patCAL00_CAL703AJ577857SQV, IDV, RTV98I84V I13V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89TCRF01_AE
Nukoolkarn (2004)220220 RTV, IDV I54V, V82AG48I, F53L, L89VL10I, I13V, K20I, E35D, M36I, N37D, R41K, L63P, H69K, A71VCRF01_AE
 238238 LPV L90M L10I, I13V, E35D, M36I, R41K, L63P, H69K, T74S, L89MCRF01_AE
Chantratita (2005)14-001314-0013DQ130429PINA  I13V, E35D, M36I, R41K, R57K, L63P, H69K, L89MCRF01_AE
 14-002314-0023DQ130436PINA  E35D, M36I, R41K, D60E, Q61D, L63P, H69K, K70R, L89M, I93LCRF01_AE
 14-003314-0033DQ130437PINA  I13V, G16E, K20R, E35D, M36I, R41K, K43R, L63P, H69K, L89M, I93LCRF01_AE
 14-004014-0040DQ130442PINA  K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 14-004214-0042DQ130443PINA  L10V, I15V, E35D, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 14-005114-0051DQ130447PINA  W6R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 14-006214-0062DQ130450PINA  W6R, I13V, K20R, E35D, M36I, R41K, I62V, L63P, H69K, K70R, L89MCRF01_AE
 14-007114-0071DQ130457PINA  W6R, L10V, G16E, K20R, E35D, M36I, R41K, D60E, I62V, L63P, H69K, L89M, I93LCRF01_AE
 14-008414-0084DQ130460PINAI54A L10V, I13V, K20V, E35N, M36I, R41K, I62V, L63P, H69K, A71L, T74SCRF01_AE
 14-008514-0085DQ130461PINA L10FE35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 14-010014-0100DQ130471PINA  W6R, I13V, E35D, M36I, R41K, K45R, D60E, Q61E, L63P, H69K, L89MCRF01_AE
 14-010314-0103DQ130473PINA L33F, I54C, N83DI13V, G16A, K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74A, L89MCRF01_AE
 14-011014-0110DQ130478PINA  W6R, E35D, M36I, R41K, I62V, L63P, H69K, L89MCRF01_AE
 14-012214-0122DQ130488PINAM46IN83DW6R, I13V, I15V, A22V, E35G, M36I, R41K, K55R, I62V, L63P, H69K, L89I, I93LCRF01_AE
 14-012514-0125DQ130491PINA  W6R, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 14-013814-0138DQ130503PINA  K20R, E35D, M36I, R41K, L63P, H69K, L89M, L90V, I93LCRF01_AE
 14-014614-0146DQ130511PINAM46I, I54V, L76V, V82FL33FW6R, L10I, E35D, M36I, R41K, K55R, Q61H, L63P, H69K, T74S, L89M, I93LCRF01_AE
 G522G522DQ130114PINAM46I, L90MQ58EL10I, I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, H69K, A71V, T74S, V77I, V82I, L89I, I93L, L97MCRF01_AE
 G526G526DQ130117PINA  W6R, I13V, K20R, E35D, M36I, R41K, L63P, H69K, K70R, L89ICRF01_AE
 G556G556DQ130131PINA  W6R, I13V, E35D, M36I, R41K, L63P, H69K, I72K, V77I, L89MCRF01_AE
 G560G560DQ130133PINA  I13V, E35D, M36I, R41K, L63P, H69K, V77I, L89MCRF01_AE
 G569G569DQ130138PINAI54V, I84VF53LL10I, I13V, I15V, K20R, E35D, M36I, R41K, D60E, L63P, I66F, H69K, A71V, L89ICRF01_AE
 G571G571DQ130140PINA  I13V, E35D, M36I, R41K, R57K, I62V, L63P, H69K, L89MCRF01_AE
 G575G575DQ130141PINA  I13V, G17E, E35D, M36I, R41K, L63P, H69K, K70R, L89MCRF01_AE
 G590G590DQ130153PINAI54V L10V, I13V, K20V, E35N, M36I, R41K, I62V, L63P, H69K, A71L, T74SCRF01_AE
 G636G636DQ130181PINA  K20R, M36I, N37D, R41K, L63P, H69K, I72V, L89M, I93LCRF01_AE
 G637G637DQ130182PINA  E35D, M36I, R41K, L63P, H69KCRF01_AE
 G639G639DQ130183PINAM46I, L90ML10F, N88GI13V, K20V, E35D, M36I, R41K, I62V, L63P, I64V, H69K, L89MCRF01_AE
 G668G668DQ130195PINA  E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 G676G676DQ130200PINA L89VL10I, I13V, A22V, E35D, M36I, R41K, I62V, L63P, H69KCRF01_AE
 G688G688DQ130208PINA  E35D, M36L, R41K, K45R, Q61E, L63P, H69K, L89M, I93LCRF01_AE
 G710G710DQ130218PINA  I13V, K20R, E35D, M36I, N37D, R41K, L63P, H69K, L89TCRF01_AE
 G720G720DQ130220PINAI84V, L90ML10FI13V, K20R, E35D, M36I, R41K, L63P, H69K, A71I, L89ICRF01_AE
 G721G721DQ130221PINA  I13V, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 G730G730DQ130225PINA  E35D, M36I, R41K, I62V, L63P, H69K, I72T, L89MCRF01_AE
 G732G732DQ130227PINA L33FL10I, I13V, E35D, M36I, R41K, L63P, H69K, L89M, T91ICRF01_AE
 G734G734DQ130228PINAG48V, I54A, V82A I13V, K20I, E35D, M36I, R41K, I62V, L63P, H69K, K70R, T74S, L89ICRF01_AE
 G741G741DQ130232PINA  L10V, I13V, M36I, R41K, L63P, H69K, V82I, L89MCRF01_AE
 G748G748DQ130235PINA  L10V, I13V, I15V, E35D, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 G770G770DQ130239PINA  I13V, E35D, M36I, R41K, L63P, H69K, I72V, L89MCRF01_AE
 NP142NP142DQ130256PINA  I13V, E35D, M36I, R41K, L63P, H69K, K70R, L89MCRF01_AE
 NP146NP146DQ130260PINA  I13V, E35D, M36I, R41K, L63P, H69K, I72V, L89MCRF01_AE
 NP163NP163DQ130267PINA Q58EL10I, I13V, K20R, E35D, M36I, R41K, R57K, L63P, H69K, L89MCRF01_AE
 NP183NP183DQ130287PINAL90ML89VI13V, K20T, E35D, M36I, R41K, I62V, L63P, H69K, I72M, T74S, V77I, V82ICRF01_AE
 NP188NP188DQ130292PINA  L10I, I13V, G16E, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 NP234NP234DQ130319PINAI84V L10V, I13V, K20R, E35D, M36I, R41K, R57K, I62V, L63P, H69K, T74A, L89ICRF01_AE
 NP237NP237DQ130321PINAM46I, I54V, L76V, V82FQ58EL10I, I13V, K20I, E35G, M36I, R41K, F53Y, K55R, L63P, H69K, L89MCRF01_AE
 NP250NP250DQ130333PINA  I13V, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 NP254NP254DQ130336PINAG48V, L90MQ58EW6R, L10I, I13V, K20R, E35D, M36I, R41K, L63P, H69K, L89ICRF01_AE
 NP255NP255DQ130337PINA  W6R, I13V, M36I, L63P, H69K, V82I, L89MCRF01_AE
 NP260NP260DQ130342PINA  K20R, E35D, M36I, R41K, L63P, H69K, T74S, L89M, I93LCRF01_AE
 NP261NP261DQ130343PINA  W6S, R8Q, I13L, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 NP267NP267DQ130349PINAD30NL10F, N88DI13V, G17E, K20T, E35D, M36I, R41K, L63P, H69K, A71V, T74S, L89TCRF01_AE
 NP272NP272DQ130354PINA  E35D, M36I, R41K, L63P, H69K, V82I, L89M, I93LCRF01_AE
 NP276NP276DQ130358PINA  I13V, E35D, M36I, R41K, L63P, H69K, K70R, L89MCRF01_AE
 NP280NP280DQ130361PINA  W6R, E35D, M36I, R41K, I62V, L63P, H69K, I72V, V82I, L89MCRF01_AE
 NP285NP285DQ130366PINA  I13V, E35D, M36I, P39S, R41K, I62V, L63P, H69K, L89MCRF01_AE
 NP291NP291DQ130371PINA  W6R, I13V, I15V, G17A, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 NP292NP292DQ130372PINA  W6R, I13V, E35D, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 NP297NP297DQ130377PINAM46IL10FI13V, E35D, M36I, N37S, R41K, L63P, H69K, K70R, L89MCRF01_AE
 NP299NP299DQ130379PINAG48V, I54V, V82A L10I, I13V, A22V, E35D, M36I, R41K, I62V, L63P, H69K, K70R, L89I, T91SCRF01_AE
 NP300NP300DQ130380PINA  E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 NP309NP309DQ130389PINAM46I, N88SL10F, Q58E, L89VI13V, K20T, E35D, M36I, R41K, I62V, L63P, H69KCRF01_AE
 NP315NP315DQ130393PINAG48V, I54V, V82A L10I, I15V, E35D, M36I, R41K, Q61E, L63P, H69K, L89I, I93LCRF01_AE
 NP321NP321DQ130399PINAN88SL10FI13V, K20I, E35D, M36I, R41K, I62V, L63P, H69K, T74A, L89M, I93LCRF01_AE
 NP330NP330DQ130407PINA  W6L, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 NP332NP332DQ130409PINA  I13V, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 VC884VC884DQ130414PINA  I13V, E35D, M36I, R41K, L63P, H69K, V77I, L89MCRF01_AE
Hsu (2005)BAA148363BAA148363AY870148SQV, RTV35I84V, L90M L10V, I13V, K20R, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 BAA150617BAA150617AY870156SQV, RTV17  I13IV, E35D, M36I, R41KN, L63P, H69K, K70R, L89MCRF01_AE
 BAA150627BAA150627AY870159SQV, RTV61G48V, I54IV, V82AL33F, F53L, N83DL10I, I13V, M36L, R41K, I62IV, L63P, H69K, T74S, L89IM, I93IVCRF01_AE
 BAA154760BAA154760AY870162NFV113  K20I, E35N, M36I, N37D, R41K, L63P, H69K, T74A, L89M, I93LCRF01_AE
 BAA157675BAA157675AY870180RTV, IDV4  I13V, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 BAA157679BAA157679AY870184IDV231M46MI, L90M K14R, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89M, I93LCRF01_AE
Non-B Workgroup (2005)TK1018TK1018 RTV, SQV, IDV184I84VL33F, N83DL10V, I13V, E34Q, M36I, N37S, R41K, L63P, H69K, L89M, I93LCRF01_AE
Tee (2006)MYKL195804MYKL1958AY960959RTV, IDV M46I, L76V I13V, K14R, K20I, E35N, M36I, R41K, K55R, R57K, L63P, H69K, K70R, I72V, L89MCRF01_AE
Riddler (2008)RG82111RG82111w55 LPV36  G16E, T26TS, T31TP, E35D, M36I, R41K, R57K, L63P, H69K, L89M, I93LCRF01_AE
Steegen (2009)BV223BV223-1EU872135LPV4  I13V, E35D, M36I, P39Q, R41K, L63P, H69K, L89MCRF01_AE
Hamkar (2010)17Ir-HIV-DR-17GU724820PINA L23IQ2H, T12P, K14R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93F, T96PCRF01_AE
 30Ir-HIV-DR-30GU724833PINA  T12P, K14R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
El Annaz (2012)1376113761.PRJN185269IDV52M46I, L76V I13V, K20I, E35D, M36I, N37D, I62IV, L63P, I66F, H69K, L89MCRF01_AE
Agyingi (2014)LB086LB086KF576441PINA  E21X, E35N, M36I, N37D, R41K, L63P, C67Y, H69K, V77I, L89MCRF01_AE
Nerrienet (2014)R0115235R0115235JN675779LPV   I13V, L33V, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 T0826079T0826079JN675758LPV M46I, I47A, I84V, L90ML10F, L33I, F53LI13V, G16A, L19I, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, C67F, H69K, K70R, L89I, T91VCRF01_AE
 Q0920081Q0920081JN675744LPV M46I, I54V, V82SL24I, L33I, Q58E, L89VL10I, I13V, K20KR, E35D, M36I, N37DE, K55KR, R57K, I62V, L63P, H69K, T74SCRF01_AE
 U0406170U0406170JN675809LPV   E35D, M36I, R41K, L63P, H69K, V82I, L89M, I93LCRF01_AE
 T1022129T1022129JN675762LPV M46L, I54V, I84VL10F, V11I, L33I, Q58E, N83D, L89VT4P, I13V, K14R, K20R, A22V, E35S, M36I, R41K, D60E, I62V, L63P, H69K, A71V, T91G, Q92ECRF01_AE
 U0316214U0316214JN675765LPV G48V, I54V, V82AL89VT4S, L10I, V11L, I13V, K20I, E35D, M36I, I62IV, L63P, H69K, A71TCRF01_AE
 S0428149S0428149JN675749LPV M46I, L76V, I84VF53LL10I, I13V, I15V, K20I, E35D, M36I, R41K, K55R, D60E, L63P, I66F, H69K, K70R, L89MCRF01_AE
 S0723170S0723170JN675784LPV   L10I, I13V, M36I, R41K, L63P, H69K, L89M, Q92KCRF01_AE
 U0302042U0302042JN675764LPV M46I, I54V, V82A, L90ML10F, L33I, K43T, N88DV11L, I13V, L19LV, K20V, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71V, T74S, L89T, T91ACRF01_AE
 T0506285T0506285JN675754LPV M46I, I47V, I54V, I84VL10F, L24IK20I, E35N, M36I, K55R, I62V, L63P, H69K, A71V, T74A, L89M, I93LCRF01_AE
 S0721226S0721226JN675785LPV   Q18E, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 S0822156S0822156JN675752LPV M46L, I47V, G48V, I54V, V82T, I84VF53L, L89VL10I, I13A, K20I, M36I, R41K, L63P, I66F, H69K, A71VCRF01_AE
 U0719200U0719200JN675770LPV M46I, I47A, I84V, L90ML89VL10V, I13A, K20I, M36I, K55R, L63P, H69K, A71V, I93MCRF01_AE
Zain (2015)MYHIVDR138MYHIVDR138KT281525PINA  I13V, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 MYHIVDR119MYHIVDR119KT281521PINA  I13V, Q18E, E35D, M36I, L63P, H69K, L89MCRF01_AE
 MYHIVDR045MYHIVDR045KT281515PINA  T12P, E35D, M36I, R57K, L63P, H69K, V82I, L89M, I93LCRF01_AE
 MYHIVDR041MYHIVDR041KT281513PINAM46I, I54IV, V82A K20R, E35D, M36I, Q61E, L63P, H69K, L89X, I93LCRF01_AE
 MYHIVDR020MYHIVDR020KT281509PINA  Q18QE, K20R, E35D, M36I, R41K, K45KR, R57RK, L63P, H69K, L89M, I93LCRF01_AE
 MYHIVDR011MYHIVDR011KT281505PINA  I13V, I15V, M36I, R57K, L63P, H69K, K70RCRF01_AE
 MYHIVDR334MYHIVDR334KT281504PINA  I13V, E35D, M36I, N37D, L63P, H69K, K70R, L89MCRF01_AE
 MYHIVDR165MYHIVDR165KT281489PINA  I13V, I15V, M36I, R41K, L63P, H69K, I72V, V82I, L89M, I93LCRF01_AE
Lopez (2016)2001-0032001-003KT374386PINA  E35D, M36I, R41K, L63P, L89M, F99XCRF01_AE