<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF01_AE
Gene PR
Mutation M46I
Rx >= 1 PI
IncludeMixtures No
References 13
Patients 50
Isolates 51
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Chantratita (2002)GEN15GEN15AF191199PINAM46I, L90MT74PL10V, K20R, E35D, M36I, R41K, K55R, I62V, L63P, H69K, L89MCRF01_AE
 G26G26AF193894PINAM46IL10FI13V, E35D, M36I, R41K, L63P, H69K, L89TCRF01_AE
 G78G78AF240399PINAM46I, L76V, V82F L10I, I13V, K20I, E35N, M36I, R41K, Q61H, L63C, H69K, K70R, L89MCRF01_AE
 G58G58AF240385PINAM46I, L90ML89VI13V, K20T, E35D, M36I, R41K, I62V, H69K, A71T, T74SCRF01_AE
 G57G57AF240384PINAM46IL10FI13V, K20I, E35D, M36I, R41K, K55R, I62V, L63P, H69K, L89TCRF01_AE
Ariyoshi (2003)JPN35JPN35AY900862IDV, NFV140M46I, L90M L10V, I13V, K20T, E35D, M36I, R41K, Q61H, L63P, I64V, H69K, K70R, T74S, R87X, L89M, I93LCRF01_AE
 JPN39JPN39AY900865NFV200M46I, N88SL10FI13V, K20I, E35D, M36I, R41RK, I64V, H69K, T74S, V77VI, L89M, I93LCRF01_AE
 JPN21JPN21A IDV, NFV124M46I, N88SL10F, T74TP, L89VK20I, M36I, L63LP, H69K, I85V, I93LCRF01_AE
  JPN21BAY900869IDV, NFV132M46I, N88SL10F, L89VK20I, M36I, H69K, I85V, I93LCRF01_AE
 JPN25JPN25AY900874NFV73M46I, N88SL10F, L33I, Q58QE, L89VI13V, K20T, E35D, M36I, R41K, I62IV, H69KCRF01_AE
Nukoolkarn (2004)267267 RTV, IDV M46I L63T, I72T, L89MCRF01_AE
Chantratita (2005)14-001214-0012DQ130428PINAM46I, V82F L10I, I13V, G16E, E35D, M36I, R41K, H69K, L89M, I93MCRF01_AE
 14-012214-0122DQ130488PINAM46IN83DW6R, I13V, I15V, A22V, E35G, M36I, R41K, K55R, I62V, L63P, H69K, L89I, I93LCRF01_AE
 14-013214-0132DQ130497PINAV32I, M46IL23II13V, E35D, M36I, R41K, Q61K, H69K, V82I, R87Q, L89MCRF01_AE
 14-014614-0146DQ130511PINAM46I, I54V, L76V, V82FL33FW6R, L10I, E35D, M36I, R41K, K55R, Q61H, L63P, H69K, T74S, L89M, I93LCRF01_AE
 14-014814-0148DQ130513PINAM46I, I54A, V82A L10I, I13V, G16E, K20I, E35D, M36I, R41K, L63T, I64L, H69K, L89MCRF01_AE
 G522G522DQ130114PINAM46I, L90MQ58EL10I, I13V, I15V, K20T, E35D, M36I, R41K, I62V, L63P, H69K, A71V, T74S, V77I, V82I, L89I, I93L, L97MCRF01_AE
 G563G563DQ130136PINAD30N, M46IN88DW6R, L10V, K20R, E35D, M36I, R41K, L63P, H69K, V77I, I93LCRF01_AE
 G614G614DQ130166PINAM46I, I54A, V82A L10I, I13V, G16E, K20I, E35D, M36I, R41K, L63T, I64L, H69K, T74S, L89MCRF01_AE
 G639G639DQ130183PINAM46I, L90ML10F, N88GI13V, K20V, E35D, M36I, R41K, I62V, L63P, I64V, H69K, L89MCRF01_AE
 NP164NP164DQ130268PINAM46IL33I, N83DL10V, I13V, K14N, G16A, K20T, A22V, E35D, M36I, R41K, I62V, L63V, H69K, K70R, T74S, V82I, L89I, I93LCRF01_AE
 NP237NP237DQ130321PINAM46I, I54V, L76V, V82FQ58EL10I, I13V, K20I, E35G, M36I, R41K, F53Y, K55R, L63P, H69K, L89MCRF01_AE
 NP258NP258DQ130340PINAM46I K20I, E35D, M36I, R41K, H69K, I72V, L89MCRF01_AE
 NP294NP294DQ130374PINAM46II50NL10N, I13V, G16E, G17E, E35D, M36I, R41K, K43R, I62V, L63S, H69K, L89MCRF01_AE
 NP297NP297DQ130377PINAM46IL10FI13V, E35D, M36I, N37S, R41K, L63P, H69K, K70R, L89MCRF01_AE
 NP309NP309DQ130389PINAM46I, N88SL10F, Q58E, L89VI13V, K20T, E35D, M36I, R41K, I62V, L63P, H69KCRF01_AE
Tee (2006)MYKL140903MYKL1409AY960934PINAM46I I13V, M36I, R41K, H69K, L89MCRF01_AE
 MYKL182204MYKL1822AY960956RTV, IDV M46I, I84VL89VL10I, I13A, K14R, K20I, E35D, M36I, R41K, K55R, I66F, H69K, A71TCRF01_AE
 MYKL195804MYKL1958AY960959RTV, IDV M46I, L76V I13V, K14R, K20I, E35N, M36I, R41K, K55R, R57K, L63P, H69K, K70R, I72V, L89MCRF01_AE
Charpentier (2011)CR-50CR-50FJ688256PINAM46IL10FK20I, E35D, M36I, N37D, R41K, I62IV, L63T, H69K, T74A, V77VI, I85IV, L89M, I93LCRF01_AE
Ferradini (2011)50789PRHM026303APV, LPV24M46I, L76V, I84VL10FI13V, G16E, E21K, E35D, M36I, R41K, H69K, I72R, L89ICRF01_AE
Barber (2012)7740677406JQ361675LPV M46IL10F, T74TPI13V, I15IV, E35D, M36I, R41K, L63C, H69K, N83S, L89MCRF01_AE
El Annaz (2012)1376113761.PRJN185269IDV52M46I, L76V I13V, K20I, E35D, M36I, N37D, I62IV, L63P, I66F, H69K, L89MCRF01_AE
Jones (2012)180281180281JN670543PINAV32I, M46I, I47V, I50L, V82AK43TK20R, E35ED, M36I, L63D, I64V, I72T, I93LCRF01_AE
 180949180949JN670562PINAV32I, M46I, I47V, I50L, V82AK43TK20R, E35ED, M36I, L63D, I64V, I72T, I93LCRF01_AE
Kim (2013)Tx22307KC120891IDV, ATV V32I, M46I, I47V, I84VL33LF, F53L, L89VL10Y, T12V, I13V, G16E, K20M, E35D, M36I, N37ND, R41K, R57K, H69K, A71I, I72RCRF01_AE
Nerrienet (2014)U0331085U0331085JN675766LPV M46I, I54IV, V82A I13V, G16E, K20R, E35D, M36I, R41K, H69K, K70R, L89MCRF01_AE
 T1005142T1005142JN675761LPV M46I, I54V, V82A, L90M L10V, G16E, K20R, E35D, M36V, P39S, R41K, K55R, I62V, L63P, H69K, A71V, I93LCRF01_AE
 T0826079T0826079JN675758LPV M46I, I47A, I84V, L90ML10F, L33I, F53LI13V, G16A, L19I, E35D, M36I, N37D, R41K, R57K, Q61N, L63P, C67F, H69K, K70R, L89I, T91VCRF01_AE
 Q0920081Q0920081JN675744LPV M46I, I54V, V82SL24I, L33I, Q58E, L89VL10I, I13V, K20KR, E35D, M36I, N37DE, K55KR, R57K, I62V, L63P, H69K, T74SCRF01_AE
 T0630085T0630085JN675756LPV M46I, I50V, I54V, V82AL33F, T74PL10I, I13V, G16A, M36I, R41K, L63V, H69K, K70R, L89MCRF01_AE
 R1113090R1113090JN675748LPV M46I, I47V, L76V, I84VL10FI13V, G16Q, L19V, K20I, E35D, M36I, P39S, R41K, K55R, D60E, I66F, H69K, A71AV, L89MCRF01_AE
 S0428149S0428149JN675749LPV M46I, L76V, I84VF53LL10I, I13V, I15V, K20I, E35D, M36I, R41K, K55R, D60E, L63P, I66F, H69K, K70R, L89MCRF01_AE
 R0130090R0130090JN675745LPV M46I, L76V, I84VL10FI13V, G16E, E21K, E35D, M36I, R41K, H69K, I72R, L89ICRF01_AE
 S0916071S0916071JN675753LPV M46I, I54V, V82F, L90M L10V, K20I, E35D, M36I, R41K, Q61H, I62V, L63C, H69K, T74S, L89ICRF01_AE
 T0807129T0807129JN675757LPV M46I, I47V, L76V, V82FQ58EL10I, I13V, G16E, K20I, E35DN, M36I, N37ND, K55R, L63T, I64V, H69K, I72T, L89MCRF01_AE
 U0302042U0302042JN675764LPV M46I, I54V, V82A, L90ML10F, L33I, K43T, N88DV11L, I13V, L19LV, K20V, E35D, M36I, N37D, R41K, K55R, L63P, H69K, K70T, A71V, T74S, L89T, T91ACRF01_AE
 T0506285T0506285JN675754LPV M46I, I47V, I54V, I84VL10F, L24IK20I, E35N, M36I, K55R, I62V, L63P, H69K, A71V, T74A, L89M, I93LCRF01_AE
 T0910001T0910001JN675759LPV M46I L10V, I13V, G16E, K20T, M36I, G40R, R41K, H69K, L89MCRF01_AE
 U0719200U0719200JN675770LPV M46I, I47A, I84V, L90ML89VL10V, I13A, K20I, M36I, K55R, L63P, H69K, A71V, I93MCRF01_AE
Zain (2015)MYHIVDR041MYHIVDR041KT281513PINAM46I, I54IV, V82A K20R, E35D, M36I, Q61E, L63P, H69K, L89X, I93LCRF01_AE