<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF01_AE
Gene PR
Mutation K43R
Rx PI-naive
IncludeMixtures No
References 45
Patients 130
Isolates 132
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Lan (2003)NTHvr29NTHvr29AY238176None  V11VII13V, G16E, K20KR, E35D, M36I, R41K, K43R, R57K, H69K, K70R, L89MCRF01_AE
 NTHvr43NTHvr43AY238149None   I13V, K20R, E35D, M36I, R41K, K43R, L63C, H69K, L89M, C95VCRF01_AE
 NTHvr90NTHvr90AY238303None   G16E, E35D, M36I, R41K, K43R, I62IM, L63C, H69K, L89MCRF01_AE
 NTHvr91NTHvr91AY238304None   I13IV, G16GE, K20R, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Maljkovic (2003)MI_Pat1698SE14962AY165194None   I13V, M36I, N37S, R41K, K43R, Q61H, H69K, L89MCRF01_AE
Tovanabutra (2003)02TH_OUR133102_1331AF529572None  L33II13V, E35D, M36I, R41K, K43R, H69K, T74S, L89MCRF01_AE
Eshleman (2004)Thai207Thai207AY444225None   I13V, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Snoeck (2004)BE29BE29 None   I13V, K20KR, M36I, R41K, K43R, H69K, L89MCRF01_AE
Liu (2007)fj52fj52EF432685None   L10I, G16E, M36I, R41K, K43R, R57K, Q61D, A71T, I72R, I93LCRF01_AE
 fj53fj53EF432686None   L10I, I13V, E35D, M36I, R41K, K43R, L63P, H69K, V82I, L89M, I93V, F99LCRF01_AE
Chang (2008)TW5407aTW5407a None   I13V, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Ayouba (2009)R20R20_PRGQ352121None   I13V, G16E, E35D, M36I, R41K, K43R, L63C, H69K, L89MCRF01_AE
 R22R22_PRGQ352123None   G16E, E35D, M36I, R41KN, K43R, L63C, H69K, L89M, I93LCRF01_AE
 R65R65_PRGQ352162None   I13V, G16E, K20R, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Ishizaki (2009)A2_195A2_195FJ007035None   I13V, G16E, L19I, K20I, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 A2_314A2_314gFJ007063None   I13V, M36I, R41K, K43R, H69K, K70R, L89MCRF01_AE
 A2_398A2_398FJ007085None   I13V, E35D, M36I, N37D, R41K, K43R, H69K, L89MCRF01_AE
 A2_399A2_399gFJ007086None   I13V, K20R, E35D, M36I, N37D, R41K, K43R, H69K, L89MCRF01_AE
 A35A35gaFJ007121None   I13V, E35D, M36I, N37D, R41K, K43R, H69K, V82I, L89MCRF01_AE
 A271A271FJ007243None   I13V, L19V, E35D, M36I, G40E, R41K, K43R, H69K, L89MCRF01_AE
 A2_65A2_65FJ007363None   I13V, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Vercauteren (2009)pt11186510659522GQ399906None   I13V, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Hattori (2010)C05-2069062C05-2069062AB867762None   L10V, I13V, G16E, K20R, E35D, M36I, N37D, R41K, K43R, D60E, L63S, H69K, L89M, I93LCRF01_AE
 C05-206804C05-206804AB864591None   I13V, K14KR, G16GA, E35D, M36I, R41K, K43R, L63P, H69K, K70R, L89MCRF01_AE
 C06-504607C06-504607AB864594None   L10I, I13V, K14R, G16E, E35D, M36I, R41K, K43R, L63C, H69K, L89LMCRF01_AE
 C05-51110324C05-51110324AB864731None   L10I, I13V, E35D, M36I, R41K, K43R, R57K, L63P, L89MCRF01_AE
 C08-6000C176C08-6000C176AB865839None   I13V, K20R, E35D, M36I, N37D, R41K, K43R, H69K, L89MCRF01_AE
 C08-6000C177C08-6000C177AB865840None   I13V, K20R, E35D, M36I, N37D, R41K, K43R, H69K, L89MCRF01_AE
Phan (2010)NB03NB03AB519525None   I13V, E35D, M36I, N37D, R41K, K43R, H69K, L89MCRF01_AE
 NB23NB23AB519535None   I13V, K20R, M36I, N37D, R41K, K43R, H69K, L89MCRF01_AE
 NB48NB48AB519554None   I13V, E35D, M36I, N37D, R41K, K43R, L63R, H69K, L89MCRF01_AE
 NB49NB49AB519555None   I13V, I15V, G16E, E35D, M36I, N37D, R41K, K43R, H69K, I72V, L89MCRF01_AE
 AH49AH49AB519595None   I13V, K20R, M36I, N37D, R41K, K43R, Q61E, L63P, H69K, L89M, I93LCRF01_AE
 NB06NB06AB519608None   I13V, G16E, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Towler (2010)400541-A400541-AHM037869None   I13V, G16E, K20R, E35D, M36I, R41K, K43R, H69K, K70R, L89MCRF01_AE
Zolfo (2010)A13557A 13557 M24HM565657None   L10I, I13V, G16E, L19LP, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
  A 13557 M30HM565654None   L10I, I13V, G16E, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Aghokeng (2011)SK4003-M18SK4003-M18HQ864328None   I13V, L19I, K20I, E35S, M36I, N37D, K43R, L63P, I64IM, H69K, L89MCRF01_AE
Lazaro (2011)AG-M7AG-M7HQ542617None   I13V, E35D, M36I, R41K, K43R, L63C, H69K, V82VI, L89MCRF01_AE
 DT-M15DT-M15HQ542700None   G16E, E35D, M36I, R41K, K43R, L63C, H69K, L89M, I93LCRF01_AE
Ng (2011)FREE068FREE068HQ539032None   I13V, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Caron (2012)Gab081183Gab081183HQ541932None   I13V, G17E, L19I, E35D, M36I, N37D, R41K, K43R, L63P, H69K, L89MCRF01_AE
Duc (2012)37253725JQ617201None   I13V, G16A, E35D, M36I, N37D, R41K, K43R, C67CY, H69K, K70R, L89MCRF01_AE
 37443744JQ617220None   W6WL, L10I, I13V, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Mollan (2012)MK9MK9w0 None   I13V, I15V, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
  MK9w107 None   I13V, I15IV, K20KR, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Rolland (2012)AA023a11LAA023a11LJX446974None   I13V, E35D, M36I, R41K, K43R, I62V, L63P, H69K, V82I, L89MCRF01_AE
 AA051b03LAA051b03LJX447291None   L10I, I13V, K14R, E35D, M36I, R41K, K43R, I62V, L63S, H69K, V82I, L89MCRF01_AE
 AA073a_LH5AA073a_LH5JX447512None   L10V, I13V, E35D, M36I, R41K, K43R, H69K, V82I, L89MCRF01_AE
 AA122a09LAA122a09LJX448211None   L10V, I13V, K14R, G16E, E34K, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Tran (2012)HPC050HPC050AB690955None   I13V, I15V, G16A, E35D, M36I, N37D, R41K, K43R, H69K, K70R, L89MCRF01_AE
Trinh (2012)VN-109VN-109GQ161883None   I13V, K20R, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 VN-6VN-6HQ876669None   E35D, M36I, R41K, K43R, L63P, H69K, L89M, I93LCRF01_AE
Zeng (2012)CN0971CN0971JQ028341None   I13V, G16E, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Aghokeng (2013)HJ3169HJ3169JX983028None   I13V, E35D, M36I, N37D, R41K, K43R, R57K, L63P, H69K, I72V, L89MCRF01_AE
Billong (2013)MR078MR078KF192231None   L10IV, I13V, L19I, E35N, M36I, N37D, R41K, K43R, L63A, H69K, L89MCRF01_AE
 MR124MR124KF192214None   I13V, G16A, E35DN, M36I, N37D, R41RK, K43R, H69K, L89MCRF01_AE
Chow (2013)10MYKJ01710MYKJ017KC477951None   I13V, I15V, E35D, M36I, R41K, K43R, R57K, I62V, I64V, H69K, L89LMCRF01_AE
Frentz (2013)EHR-13563EHR-13563JX299761None   I13V, E35D, M36I, R41K, W42WR, K43R, I62IV, L63PS, H69K, L89MCRF01_AE
 EHR-606204EHR-606204JX300549None   I13V, K14R, I15V, M36I, N37D, R41K, K43R, L63T, I64M, H69K, L89MCRF01_AE
Kiertiburanakul (2013)R71TS143R71TS143KC921620None   L10V, I13V, G16E, E35D, M36I, R41K, K43R, H69K, K70R, L89MCRF01_AE
 R12174R12174KC994300None   E35D, M36I, R41K, K43R, L63LP, H69K, L89MCRF01_AE
 R41194R41194KC970951None  L33FI13V, E35D, M36I, R41K, K43R, R57K, H69K, K70R, L89M, L97ICRF01_AE
 R73091R73091KC810379None   I13V, I15V, E35D, M36I, R41K, K43R, L63PS, H69K, L89M, I93LCRF01_AE
 R12032R12032KC994185None   L10V, I13V, I15V, E35D, M36I, R41K, K43R, R57RK, H69K, L89MCRF01_AE
 R73065R73065KC810355None  I47IKL10V, I13V, G16E, K20R, E35D, M36I, R41K, K43R, R57K, H69K, K70R, L89MCRF01_AE
 R71TS222R71TS222KC921693None  L33FL10I, T12P, I13V, L19V, M36I, R41K, K43R, H69K, L89MCRF01_AE
 R71TS174R71TS174KC921650None   I13V, E35D, M36I, R41K, K43R, R57K, I64M, H69K, L89MCRF01_AE
 R71TS246R71TS246KC921717None   L5F, I15V, L19I, E35D, M36I, R41K, K43R, H69K, I72M, L89MCRF01_AE
 R73212R73212KC810487None   L10V, T12P, I13V, E35D, M36I, R41K, K43R, L63T, H69K, L89MCRF01_AE
 R12129R12129KC994267None   I13V, G16E, K20I, E35D, M36I, N37D, R41K, K43R, L63P, H69K, K70R, A71AT, L89M, Q92KCRF01_AE
 R74162R74162KC791381None   T12P, I13V, G16E, M36I, R41K, K43R, L63PS, G68GE, H69K, K70R, I72IT, V82I, L89M, I93VCRF01_AE
 R73043R73043KC810334None   I13V, G16E, K20R, E35D, M36I, R41K, K43R, L63T, I64L, H69K, L89I, Q92KCRF01_AE
 R71137R71137KC921421None   I13V, G16E, E35D, M36I, R41K, K43R, L63R, H69K, L89MCRF01_AE
 R74135R74135KC791354None   I13V, K20I, M36I, R41K, K43R, L63S, H69K, V82I, L89IMCRF01_AE
 R71TS212R71TS212KC921683None  L33FI13V, K14R, K20I, M36I, R41K, K43R, H69K, L89M, I93VCRF01_AE
 R71TS141R71TS141KC921618None  L76II13V, E35D, M36I, R41K, K43R, R57K, H69K, L89MCRF01_AE
 R74103R74103KC791322None   I13V, K20R, M36I, N37D, R41K, K43R, L63LP, H69K, L89M, I93LCRF01_AE
 R71TS240R71TS240KC921711None   I13V, K20I, E35N, M36I, R41K, K43R, R57K, H69K, K70R, L89MCRF01_AE
 R72135R72135KC856965None   I13V, I15V, E35D, M36I, R41K, K43R, R57K, H69K, V82VI, L89MCRF01_AE
 R72254R72254KC857075None   L10I, I13V, I15V, G16E, K20I, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Kijak (2013)05TH84174905TH841749JN248356None   I13V, E35D, M36I, R41K, K43R, L63S, H69K, L89M, I93TCRF01_AE
Li (2013)20072007JQ302549None   I13V, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Wu (2013)XCP49XCP49KC203275None   T12P, L19IM, E35D, M36I, R41K, K43R, H69K, V82VI, L89MCRF01_AE
Hassan (2014)RS09000800RS09_800KC568488None   I13V, K20R, E35D, M36I, N37D, R41K, K43R, R57K, L63P, H69K, L89MCRF01_AE
 RS11000495RS11_495KC568525None  L33II13V, G16E, E35D, M36I, R41K, K43R, R57K, H69K, L89MCRF01_AE
Khairunisa (2014)TD7TD7KM212888None  L76FI13V, G16E, K20R, E35D, M36I, R41K, K43R, H69K, T74A, V77T, L89MCRF01_AE
Lee (2014)MBA1444MBA1444KJ907126None   I13V, E35D, M36I, N37D, K43R, R57K, L63P, H69K, L89MCRF01_AE
 MBA1517MBA1517KJ907191None   L10V, I15V, E35D, M36I, R41K, K43R, R57K, L63P, H69K, L89MCRF01_AE
 MBA1419MBA1419KJ907104None   I13V, E35D, M36I, N37D, K43R, R57K, L63PS, H69K, L89MCRF01_AE
Meixenberger (2014)08-0048008-00480KJ770680None   L10I, I13V, G16E, K20R, E35D, M36I, P39S, R41K, K43R, H69K, L89M, Q92K, F99LCRF01_AE
Wallis (2014)4150041500KM458505None   I13V, E35D, M36I, R41K, K43R, L63A, H69K, K70R, L89MCRF01_AE
 4143741437KM458516None   I13V, I15V, G16E, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 4199141991KM458502None   L10I, I13V, E35D, M36I, R41K, K43R, R57K, H69K, L89M, L97ICRF01_AE
Zhao (2014)kang002akang002aKJ401416None   I13V, L19MV, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 kang192kang192KJ401548None   I13V, L19V, E35D, M36I, R41K, K43R, R57RK, H69K, L89MCRF01_AE
Zhou (2014)08mLDTD02408mLDTD024KC913748None   L10I, I13V, G16E, E35D, M36I, R41K, K43R, L63T, H69K, I72V, L89ICRF01_AE
Alexiev (2015)440_0907440_0907JQ259089None   L10V, I13V, G16E, E35D, M36I, R41K, K43R, R57K, H69K, L89MCRF01_AE
Li (2015)SF13G152SF13G152KR188237None   I15V, L19M, E35D, M36I, R41K, K43R, H69K, L89M, I93LCRF01_AE
 SF131464SF131464KR188116None   L19M, E35D, M36I, R41K, K43R, H69K, K70R, L89MCRF01_AE
 SF13G526SF13G526KR188441None   L19M, E35D, M36I, R41K, K43R, H69K, L89M, I93LCRF01_AE
 SF130788SF130788KR188088None   I13V, L19M, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 SF13G093SF13G093KR188202None   I13V, L19M, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 SF110306SF110306KR187543None   L19I, E35D, M36I, R41K, K43R, L63T, H69K, L89LMCRF01_AE
 SF13G339SF13G339KR188339None   K14R, I15V, L19I, E35D, M36V, R41K, K43R, L63Q, H69K, L89M, I93ILCRF01_AE
 SF13G318SF13G318KR188325None   L19M, E35D, M36I, R41K, K43R, H69K, V82I, L89MCRF01_AE
 SF101125SF101125KR187425None   T12P, L19M, E35D, M36I, R41K, K43R, H69K, I72M, L89MCRF01_AE
 SF121344SF121344KR187862None   I13V, L19M, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 SF13G387SF13G387KR188369None   L19M, K20KR, E35D, M36I, R41K, K43R, L63P, H69K, K70R, L89M, I93LCRF01_AE
 SF13G525SF13G525KR188440None   I13V, L19V, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 SF13G310SF13G310KR188321None   L19M, E35D, M36I, R41K, K43R, H69K, V82I, L89MCRF01_AE
 SF110443SF110443KR187549None   L19IM, E35D, M36I, R41K, K43R, L63P, H69K, L89M, I93LCRF01_AE
 SF13G440SF13G440KR188399None   L19M, E35D, M36I, R41K, K43R, L63P, H69K, K70R, L89M, I93LCRF01_AE
 SF111273SF111273KR187663None   I13V, L19M, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 SF121156SF121156KR187826None   I13V, L19M, E35D, M36I, R41K, K43R, H69K, K70R, L89MCRF01_AE
 SF131717SF131717KR188129None   T12P, L19V, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 SF121882SF121882KR187982None   G16E, E35D, M36I, R41K, K43R, R57K, H69K, L89MCRF01_AE
 SF13G443SF13G443KR188401None   I13V, G16E, L19M, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Wang (2015)197197KP250724None   I13V, I15V, E35D, M36I, R41K, K43R, G68G*, H69K, L89MCRF01_AE
 127127KP250675None   I13V, L19M, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 3535KP250763None   I13V, L19M, E35D, M36I, R41K, K43R, K45KR, H69K, L89M, I93LCRF01_AE
 128128KP250676None   I13V, L19M, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 165165KP250703None   I13V, L19M, E35D, M36I, R41K, K43R, R57K, H69K, L89MCRF01_AE
 ya130ya130KP250812None   I13V, L19M, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 3131KP250759None   I13V, I15V, L19M, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 201201KP250727None   I13V, L19M, E35D, M36I, R41K, K43R, L63T, C67Y, H69K, L89MCRF01_AE
 209209KP250733None   I13V, L19M, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
Wang (2015)0307103071KM395733None   I13V, K20I, E35D, M36I, K43R, K45Q, F53C, R57G, Q61H, H69K, L89M, Q92HCRF01_AE
Yan (2015)SMS_VMI149SMS_VMI149KP418593None   I13V, K14E, L19M, E35D, M36I, R41K, K43R, H69K, L89M, Q92HCRF01_AE
Zhang (2015)HZ130061HZ130061KM258678None   L10I, I13V, L19M, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE
 HZ130108HZ130108KM258683None   I13V, L19M, E35D, M36I, R41K, K43R, H69K, K70R, L89MCRF01_AE
 HZ130574HZ130574KM258759None   L10I, I13V, L19M, E35D, M36I, R41K, K43R, H69K, L89MCRF01_AE