<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype CRF01_AE
Gene PR
Mutation K20R
Rx >= 1 PI
IncludeMixtures No
References 14
Patients 118
Isolates 120
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Chantratita (2002)GEN19GEN19AF191202PINAG48VL33F, F53L, N83DL10V, I13V, G16E, K20R, E35D, M36I, P39S, R41K, H69K, K70R, T74S, L89MCRF01_AE
 GEN15GEN15AF191199PINAM46I, L90MT74PL10V, K20R, E35D, M36I, R41K, K55R, I62V, L63P, H69K, L89MCRF01_AE
 G27G27AF193895PINA  I13V, K14R, I15V, K20R, E35D, M36I, N37D, R41K, H69K, T74S, L89MCRF01_AE
 G24G24AF193892PINA  I13V, K20R, E35D, M36I, R41K, I62V, H69K, L89MCRF01_AE
 G65G65AF240390PINAG48V, I54M, V82AL33F, F53L, N83DL10I, G16A, K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74S, L89M, I93LCRF01_AE
 G50G50AF240377PINA  L10V, I13V, G16E, K20R, E35D, M36I, R41K, I62V, H69K, L89MCRF01_AE
Gibb (2002)DMG108108_w28 NFV28  L10V, I13V, G16E, K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 DMG9898_w55 NFV55  I13V, K20R, E35D, M36I, N37D, R41K, Q61QE, H69K, I72IV, L89MCRF01_AE
Ariyoshi (2003)JPN26JPN26AY900687NFV, IDV51  L10LI, K20R, E35D, M36I, R41K, H69K, L89M, I93LCRF01_AE
 JPN44JPN44A IDV, SQV, RTV88  K20R, E35D, M36I, N37D, L63P, H69K, L89M, I93LCRF01_AE
  JPN44BAY900691IDV, SQV, RTV, LPV204  K20R, E35D, M36I, N37D, L63P, H69K, L89M, I93LCRF01_AE
 JPN14JPN14AY900697NFV7  K20R, E35D, M36I, R41K, K45R, H69X, L89M, I93LCRF01_AE
 JPN15JPN15AY900698NFV, IDV113I54V, L90ML10F, L33II13V, K20R, E35D, M36I, R41K, I64V, H69K, L89MCRF01_AE
Montes (2004)MB_patBRI00_BRI706AJ577745SQV, NFV, RTV111  Q7P, I13V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, H69K, T74S, L89MCRF01_AE
  01_BRI705AJ577746SQV, NFV, RTV, LPV146I54V, V82AL33F, F53L, T74PL10I, I13V, I15V, K20R, E35D, M36I, N37D, R41K, K55R, R57K, H69K, K70R, L89MCRF01_AE
Chantratita (2005)14-003314-0033DQ130437PINA  I13V, G16E, K20R, E35D, M36I, R41K, K43R, L63P, H69K, L89M, I93LCRF01_AE
 14-003914-0039DQ130441PINA  G16A, K20R, E35D, M36I, R41K, H69K, L89M, I93LCRF01_AE
 14-004014-0040DQ130442PINA  K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 14-005114-0051DQ130447PINA  W6R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 14-006214-0062DQ130450PINA  W6R, I13V, K20R, E35D, M36I, R41K, I62V, L63P, H69K, K70R, L89MCRF01_AE
 14-006614-0066DQ130453PINA  L10H, I13V, G16E, K20R, E35D, M36I, R41K, H69K, K70R, L89M, I93VCRF01_AE
 14-007114-0071DQ130457PINA  W6R, L10V, G16E, K20R, E35D, M36I, R41K, D60E, I62V, L63P, H69K, L89M, I93LCRF01_AE
 14-010314-0103DQ130473PINA L33F, I54C, N83DI13V, G16A, K20R, E35D, M36I, N37D, R41K, L63P, H69K, T74A, L89MCRF01_AE
 14-010714-0107DQ130476PINA  K20R, E35D, M36I, R41K, H69K, L89M, I93LCRF01_AE
 14-011314-0113DQ130481PINA  I13V, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89MCRF01_AE
 14-012414-0124DQ130490PINA  W6T, G17E, K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 14-012914-0129DQ130494PINA  I13V, K20R, E35D, M36I, R41K, H69K, V77I, L89M, L97ICRF01_AE
 14-013514-0135DQ130500PINAM46LL33I, N83DP9A, L10R, I13V, K20R, A22V, M36I, N37D, R41K, I62V, I64V, H69K, K70R, L89MCRF01_AE
 14-013614-0136DQ130501PINA  I13V, G16E, K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 14-013714-0137DQ130502PINA  W6R, I13V, K20R, E35D, M36I, R41K, R57K, H69K, I72V, L89MCRF01_AE
 14-013814-0138DQ130503PINA  K20R, E35D, M36I, R41K, L63P, H69K, L89M, L90V, I93LCRF01_AE
 G526G526DQ130117PINA  W6R, I13V, K20R, E35D, M36I, R41K, L63P, H69K, K70R, L89ICRF01_AE
 G527G527DQ130118PINA  L10V, I13V, K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 G545G545DQ130124PINA  W6R, I13V, K20R, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 G546G546DQ130125PINA  I13V, K20R, M36I, R41K, H69K, K70R, L89MCRF01_AE
 G549G549DQ130126PINA  I13V, K20R, M36I, R41K, I62V, H69K, V82I, L89MCRF01_AE
 G555G555DQ130130PINA  I13V, I15V, K20R, E35D, M36I, R41K, K43R, D60E, I62V, H69K, L89MCRF01_AE
 G569G569DQ130138PINAI54V, I84VF53LL10I, I13V, I15V, K20R, E35D, M36I, R41K, D60E, L63P, I66F, H69K, A71V, L89ICRF01_AE
 G578G578DQ130143PINA  I13V, G16E, K20R, E35D, M36I, R41K, H69K, I72V, L89MCRF01_AE
 G581G581DQ130146PINA  K20R, E35D, M36I, L38V, R41K, H69K, K70R, L89MCRF01_AE
 G596G596DQ130156PINA  I13V, K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 G604G604DQ130160PINA  I13V, G16E, K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 G611G611DQ130164PINA  K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 G617G617DQ130168PINAI54A, V82F, L90ML33F, L89VL10I, I13V, K20R, E35D, M36I, R41K, H69K, A71VCRF01_AE
 G629G629DQ130177PINAG48V, I54V, V82AF53LL10I, I13V, K20R, E35D, M36I, R41K, H69K, K70R, L89ICRF01_AE
 G630G630DQ130178PINA  I13V, K20R, E35D, M36I, R41K, H69R, L89MCRF01_AE
 G633G633DQ130179PINA  I13V, I15V, K20R, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 G636G636DQ130181PINA  K20R, M36I, N37D, R41K, L63P, H69K, I72V, L89M, I93LCRF01_AE
 G642G642DQ130185PINA  I15V, K20R, E35D, M36I, R41K, H69K, L89M, I93LCRF01_AE
 G695G695DQ130210PINA  K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 G697G697DQ130211PINA  I13V, K20R, E35D, M36I, R41K, H69K, V82I, L89MCRF01_AE
 G710G710DQ130218PINA  I13V, K20R, E35D, M36I, N37D, R41K, L63P, H69K, L89TCRF01_AE
 G720G720DQ130220PINAI84V, L90ML10FI13V, K20R, E35D, M36I, R41K, L63P, H69K, A71I, L89ICRF01_AE
 G727G727DQ130223PINA  K20R, E35D, M36I, R41K, L63T, H69K, V82I, L89M, I93LCRF01_AE
 G731G731DQ130226PINA  K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 G751G751DQ130236PINA  I13V, K20R, M36I, R41K, I64V, H69KCRF01_AE
 G753G753DQ130237PINA  L10Q, V11F, K20R, E35D, M36I, R41K, H69K, K70R, L89MCRF01_AE
 G774G774DQ130241PINAM46L I13V, K20R, M36I, R41K, H69K, I72V, L89MCRF01_AE
 G776G776DQ130243PINA  I13V, K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 NP134NP134DQ130249PINA  W6M, I13V, K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 NP140NP140DQ130255PINA  I13V, K20R, M36I, H69K, V82I, L89MCRF01_AE
 NP145NP145DQ130259PINA  L10V, I13V, G16E, K20R, E35D, M36I, P39S, R41K, H69K, K70R, T74S, L89MCRF01_AE
 NP159NP159DQ130263PINA D30DYI13V, I15V, K20R, E35D, M36I, N37E, R41K, H69K, L89MCRF01_AE
 NP163NP163DQ130267PINA Q58EL10I, I13V, K20R, E35D, M36I, R41K, R57K, L63P, H69K, L89MCRF01_AE
 NP165NP165DQ130269PINA  I13V, I15V, K20R, E35D, M36I, N37D, R41K, H69K, L89M, N98SCRF01_AE
 NP170NP170DQ130274PINA  L10V, G16E, K20R, E35D, M36I, R41K, H69K, I72V, L89M, I93LCRF01_AE
 NP184NP184DQ130288PINA  I13V, K14T, K20R, M36I, R41K, I64L, H69K, V82I, L89ICRF01_AE
 NP192NP192DQ130296PINA  I13V, G16E, K20R, E35D, M36I, R41K, H69K, K70R, I72T, L89MCRF01_AE
 NP215NP215DQ130302PINA  I13V, K14N, G16E, K20R, E35D, M36I, R41K, H69K, K70R, L89MCRF01_AE
 NP221NP221DQ130306PINA  K20R, E35D, M36I, N37D, R41K, D60E, H69K, L89M, I93LCRF01_AE
 NP225NP225DQ130310PINA  K20R, E35D, M36I, R41K, H69K, L89M, I93LCRF01_AE
 NP227NP227DQ130312PINA  L10I, I13V, G17R, K20R, M36I, R41K, H69K, K70R, L89MCRF01_AE
 NP228NP228DQ130313PINA  I13V, I15V, K20R, E35D, M36I, N37E, R41K, H69K, L89MCRF01_AE
 NP234NP234DQ130319PINAI84V L10V, I13V, K20R, E35D, M36I, R41K, R57K, I62V, L63P, H69K, T74A, L89ICRF01_AE
 NP253NP253DQ130335PINA  I13V, G16E, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89MCRF01_AE
 NP254NP254DQ130336PINAG48V, L90MQ58EW6R, L10I, I13V, K20R, E35D, M36I, R41K, L63P, H69K, L89ICRF01_AE
 NP257NP257DQ130339PINA  I13V, I15V, K20R, E35D, M36I, R41K, I62V, H69K, V82I, L89MCRF01_AE
 NP260NP260DQ130342PINA  K20R, E35D, M36I, R41K, L63P, H69K, T74S, L89M, I93LCRF01_AE
 NP268NP268DQ130350PINA  I13V, K20R, E35D, M36I, R41K, K45R, H69K, L89MCRF01_AE
 NP271NP271DQ130353PINA  L10V, I13V, K20R, E35D, M36I, N37D, R41K, K43R, D60E, Q61E, H69K, L89MCRF01_AE
 NP275NP275DQ130357PINA  L10I, I13V, K20R, M36I, R41K, H69K, K70R, L89MCRF01_AE
 NP278NP278DQ130360PINA  I13V, K20R, E35D, M36I, N37D, R41K, H69K, K70R, L89MCRF01_AE
 NP281NP281DQ130362PINA  L10I, I13V, I15V, K20R, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 NP283NP283DQ130364PINA  W6R, I13V, K20R, M36I, R41K, H69K, L89MCRF01_AE
 NP286NP286DQ130367PINA  I13V, K20R, E35D, M36I, N37H, R41K, K45R, H69K, L89MCRF01_AE
 NP293NP293DQ130373PINAG48M, I54V, V82AF53L, N83DL10V, I13V, G16E, K20R, A22V, E35D, M36I, P39S, R41K, I62V, L63H, H69K, I72V, L89I, T91SCRF01_AE
 NP295NP295DQ130375PINA  W6R, I13V, K20R, E35D, M36I, R41K, R57K, H69K, L89MCRF01_AE
 NP306NP306DQ130386PINA  Q7P, I13V, K14R, I15V, G17E, K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 NP324NP324DQ130402PINAG48V, I50V, I54S, V82AL33F, F53L, N83DL10I, I13V, K20R, E34V, E35D, M36I, I62V, I66F, H69K, T74A, L89MCRF01_AE
 NP330NP330DQ130407PINA  W6L, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
 VC890VC890DQ130420PINA  I13V, I15V, K20R, E34G, E35D, M36I, R41K, H69K, L89M, I93LCRF01_AE
Hsu (2005)BAA148363BAA148363AY870148SQV, RTV35I84V, L90M L10V, I13V, K20R, E35D, M36I, R41K, L63P, H69K, L89MCRF01_AE
 BAA150624BAA150624AY870158SQV, RTV31G48V, I84VL33F, Q58E, N83DL10V, I13V, K14KN, K20R, E35D, M36I, R41K, L63LP, H69K, L89ICRF01_AE
 BAA161429BAA161429AY870231RTV, IDV78  L10V, K20R, E35D, M36I, R41K, H69K, I72V, L89MCRF01_AE
 BAA161430BAA161430AY870232IDV, SQV88G48V, I54V, V82AF53LL10I, I13V, L19LV, K20R, E35D, M36I, N37D, R41K, I62V, L63LP, H69K, A71T, T74S, L89ICRF01_AE
Non-B Workgroup (2005)TH_220TH_220AY605624IDV   L10I, I13V, G16E, K20R, E35D, M36I, R41K, I62V, H69K, L89M, L97ICRF01_AE
 TK2004TK2004 IDV181  I13V, K20R, E35D, M36I, R41K, R57K, H69K, K70R, L89MCRF01_AE
Hamkar (2010)17Ir-HIV-DR-17GU724820PINA L23IQ2H, T12P, K14R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93F, T96PCRF01_AE
 30Ir-HIV-DR-30GU724833PINA  T12P, K14R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LCRF01_AE
Charpentier (2011)51CP0012273 Unknown, LPVNA  T12P, I13V, G16E, K20R, E35D, M36I, R41K, K55K*, L63T, E65EG, G68GE, H69KR, L89MCRF01_AE
Ferradini (2011)40739PRHM026302LPV24V82A L10V, I13V, G16E, K20R, E35D, M36I, R41K, L63C, H69K, T74A, L89MCRF01_AE
Kim (2013)Tx022KC120827LPV   I13V, K20R, E35D, M36I, R41K, H69K, L89M, I93LCRF01_AE
Rawizza (2013)LL0499LL0499KF241476LPV M46L, G48V, L90ML33F, N83DL10V, I13V, K20R, E35DN, M36I, N37E, P39Q, R41K, D60E, Q61E, H69K, L89IMCRF01_AE
Nerrienet (2014)U0331085U0331085JN675766LPV M46I, I54IV, V82A I13V, G16E, K20R, E35D, M36I, R41K, H69K, K70R, L89MCRF01_AE
 55JN675803LPV   W6R, Q18R, K20R, E35D, M36I, R41K, H69K, K70R, I72E, V77E, T80A, L89I, L90W, T91PCRF01_AE
 Q0208194Q0208194JN675743LPV I54V, V82AL10FV, L33F, T74PI13V, G16GE, K20R, E35D, M36I, N37D, R41K, L63C, H69K, L89MCRF01_AE
 T1022129T1022129JN675762LPV M46L, I54V, I84VL10F, V11I, L33I, Q58E, N83D, L89VT4P, I13V, K14R, K20R, A22V, E35S, M36I, R41K, D60E, I62V, L63P, H69K, A71V, T91G, Q92ECRF01_AE
 Q0703207Q0703207JN675775LPV   K20R, E35D, M36I, R41K, H69K, L89MCRF01_AE
 U0831207U0831207JN675812LPV   K20R, E35D, M36I, R41K, L63C, G68GE, H69K, L89M, I93LCRF01_AE
 T0929127T0929127JN675760LPV I54V, V82AL10FT12P, I13V, G16E, K20R, E35D, M36I, R41K, K45I, L63T, H69K, L89MCRF01_AE
 S0613189S0613189JN675750LPV V82A L10V, I13V, G16E, K20R, E35D, M36I, R41K, L63C, H69K, T74A, L89MCRF01_AE
 U0406184U0406184JN675810LPV   I13IV, K20R, M36I, R41K, I64IV, H69KCRF01_AE
 R0606212R0606212JN675746LPV I54V, V82AL10F, N83DI13V, K20R, A22V, M36I, N37D, R41K, L63LP, H69K, L89I, T91ACRF01_AE
 T0226205T0226205JN675790LPV   I13V, G16E, K20R, E35D, M36I, P39PS, R41K, K45KR, R57K, H69K, K70R, I72V, V77VI, L89MCRF01_AE
 U0519246U0519246JN675768LPV V82A L10I, I13V, G16E, K20R, E35D, M36I, R41K, L63T, H69K, T74A, L89M, I93VCRF01_AE
Zain (2015)MYHIVDR129MYHIVDR129KT281524PINA  L10V, I13V, K20R, E35D, M36I, R41K, H69K, V77I, L89MCRF01_AE
 MYHIVDR125MYHIVDR125KT281522PINA  I15V, K20R, E35D, M36I, R41K, K45KR, H69K, V82VI, L89M, I93LCRF01_AE
 MYHIVDR041MYHIVDR041KT281513PINAM46I, I54IV, V82A K20R, E35D, M36I, Q61E, L63P, H69K, L89X, I93LCRF01_AE
 MYHIVDR020MYHIVDR020KT281509PINA  Q18QE, K20R, E35D, M36I, R41K, K45KR, R57RK, L63P, H69K, L89M, I93LCRF01_AE
 MYHIVDR059MYHIVDR059KT281495PINA  G16E, K20R, E35D, M36I, R41K, K45R, I62V, H69K, I72V, L89MCRF01_AE